Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | histamine receptor H4 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium falciparum | cysteine repeat modular protein 1 | 0.0402 | 1 | 1 |
Brugia malayi | Kringle domain containing protein | 0.0402 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0402 | 1 | 1 |
Giardia lamblia | NADH oxidase lateral transfer candidate | 0.0071 | 0 | 0.5 |
Plasmodium falciparum | thioredoxin reductase | 0.0205 | 0.404 | 0.404 |
Toxoplasma gondii | kringle domain-containing protein | 0.0402 | 1 | 1 |
Brugia malayi | Thioredoxin reductase | 0.0205 | 0.404 | 0.404 |
Loa Loa (eye worm) | hypothetical protein | 0.0402 | 1 | 1 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase, LpdB | 0.0071 | 0 | 0.5 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0402 | 1 | 1 |
Mycobacterium ulcerans | flavoprotein disulfide reductase | 0.0071 | 0 | 0.5 |
Brugia malayi | glutathione reductase | 0.0205 | 0.404 | 0.404 |
Toxoplasma gondii | thioredoxin reductase | 0.0205 | 0.404 | 0.404 |
Trichomonas vaginalis | mercuric reductase, putative | 0.0071 | 0 | 0.5 |
Trypanosoma brucei | trypanothione reductase | 0.0205 | 0.404 | 1 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0205 | 0.404 | 0.404 |
Loa Loa (eye worm) | TK/ROR protein kinase | 0.0402 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0071 | 0 | 0.5 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase | 0.0071 | 0 | 0.5 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0071 | 0 | 0.5 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0205 | 0.404 | 0.404 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0205 | 0.404 | 0.404 |
Leishmania major | trypanothione reductase | 0.0205 | 0.404 | 0.404 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0071 | 0 | 0.5 |
Echinococcus granulosus | tissue type plasminogen activator | 0.0402 | 1 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0402 | 1 | 1 |
Trichomonas vaginalis | glutathione reductase, putative | 0.0071 | 0 | 0.5 |
Chlamydia trachomatis | dihydrolipoyl dehydrogenase | 0.0071 | 0 | 0.5 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0205 | 0.404 | 0.404 |
Echinococcus multilocularis | tissue type plasminogen activator | 0.0402 | 1 | 1 |
Plasmodium vivax | cysteine repeat modular protein 1, putative | 0.0402 | 1 | 1 |
Onchocerca volvulus | 0.0402 | 1 | 0.5 | |
Plasmodium falciparum | glutathione reductase | 0.0205 | 0.404 | 0.404 |
Treponema pallidum | NADH oxidase | 0.0071 | 0 | 0.5 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0205 | 0.404 | 1 |
Plasmodium vivax | glutathione reductase, putative | 0.0205 | 0.404 | 0.404 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Kd (functional) | = 8.1 | Antagonistic activity at human histamine H4 receptor in SK-N-MC cells by inhibition of forskolin-stimulated cAMP-mediated reporter gene activity | ChEMBL. | 16366610 |
Ki (binding) | = 1.824 | Antagonist activity at Homo sapiens (human) histamine H4 receptor | ChEMBL. | No reference |
Ki (binding) | = 7.5 | Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells | ChEMBL. | 22749391 |
Ki (binding) | = 7.6 | Displacement of [3H]histamine from wild type human histamine H4 receptor transfected in HEK293T cells after 1.5 hrs by liquid scintillation counting analysis | ChEMBL. | No reference |
Ki (binding) | = 15 nM | Displacement of [3H]- histamine from the recombinant human histamine H4 receptor | ChEMBL. | 12954048 |
Ki (binding) | = 15 nM | Displacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cells | ChEMBL. | 16366610 |
Ki (binding) | = 15 nM | Displacement of [3H]- histamine from the recombinant human histamine H4 receptor | ChEMBL. | 12954048 |
Ki (binding) | = 15 nM | Displacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cells | ChEMBL. | 16366610 |
Ki (binding) | = 15 nM | Antagonist activity at Homo sapiens (human) histamine H4 receptor | ChEMBL. | No reference |
pA2 (functional) | = 8.1 | Antagonistic activity at human histamine H4 receptor in SK-N-MC cells by inhibition of forskolin-stimulated cAMP-mediated reporter gene activity | ChEMBL. | 16366610 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
3 literature references were collected for this gene.