TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 287.212 | Formula: C9H14N5O4P
H donors: 4 H acceptors: 7 LogP: -1.49 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: Nc1nc(O)c2c(n1)n(CCCCP(=O)(O)O)cn2
InChi: 1S/C9H14N5O4P/c10-9-12-7-6(8(15)13-9)11-5-14(7)3-1-2-4-19(16,17)18/h5H,1-4H2,(H2,16,17,18)(H3,10,12,13,15)
InChiKey: UYWGTMUIXYERMZ-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0154	0.1208	0.1833
Echinococcus multilocularis		0.0149	0.1137	0.1725
Loa Loa (eye worm)	TK/KIN16 protein kinase	0.0334	0.3754	0.5697
Loa Loa (eye worm)	CAMK/PKD protein kinase	0.0134	0.0931	0.1413
Schistosoma mansoni	tyrosine kinase	0.0255	0.2638	0.4003
Schistosoma mansoni	neuroglian	0.0221	0.2163	0.3282
Brugia malayi	Protein kinase domain containing protein	0.0084	0.0222	0.0336
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0154	0.1208	0.1833
Brugia malayi	protein unc-22	0.0156	0.1239	0.188
Loa Loa (eye worm)	hypothetical protein	0.0221	0.2163	0.3282
Brugia malayi	Protein kinase domain containing protein	0.0074	0.0089	0.0135
Echinococcus granulosus	protein kinase C gamma type	0.0214	0.2057	0.3122
Schistosoma mansoni	titin	0.0154	0.1208	0.1833
Schistosoma mansoni	diacylglycerol kinase theta	0.0072	0.0058	0.0088
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.0076	0.0115	0.0175
Trichomonas vaginalis	AGC family protein kinase	0.0084	0.0222	1
Loa Loa (eye worm)	hypothetical protein	0.0154	0.1208	0.1833
Echinococcus granulosus	twitchin	0.0364	0.4169	0.6326
Schistosoma mansoni	tyrosine kinase	0.0255	0.2638	0.4003
Echinococcus multilocularis	titin	0.0154	0.1208	0.1833
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0156	0.1241	1
Echinococcus granulosus	melanoma receptor tyrosine protein kinase	0.0314	0.3462	0.5254
Echinococcus granulosus	epidermal growth factor receptor	0.0536	0.659	1
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0208	0.1975	0.2997
Loa Loa (eye worm)	hypothetical protein	0.0204	0.1913	0.2903
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0154	0.1208	0.1833
Loa Loa (eye worm)	hypothetical protein	0.0221	0.2163	0.3282
Brugia malayi	Myb-like DNA-binding domain containing protein	0.0154	0.1208	0.1833
Brugia malayi	Prion-like-	0.0154	0.1208	0.1833
Onchocerca volvulus	Putative titin	0.0154	0.1208	0.3404
Brugia malayi	kettin	0.0154	0.1208	0.1833
Schistosoma mansoni	protein kinase C	0.0079	0.0154	0.0233
Echinococcus granulosus	Protein kinase C brain isozyme	0.0286	0.307	0.4659
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0154	0.1208	0.1833
Loa Loa (eye worm)	hypothetical protein	0.0154	0.1208	0.1833
Echinococcus multilocularis	guanine nucleotide exchange factor VAV2	0.0076	0.0115	0.0175
Loa Loa (eye worm)	hypothetical protein	0.0076	0.012	0.0183
Brugia malayi	p70 ribosomal S6 kinase beta	0.0079	0.0159	0.0241
Schistosoma mansoni	subfamily M23B non-peptidase homologue (M23 family)	0.0154	0.1208	0.1833
Echinococcus multilocularis	serine threonine protein kinase	0.0214	0.2057	0.3122
Echinococcus multilocularis		0.0154	0.1208	0.1833
Echinococcus granulosus	protein kinase c epsilon type	0.0307	0.3371	0.5115
Schistosoma mansoni	cell adhesion molecule	0.0221	0.2163	0.3282
Echinococcus multilocularis	transfer RNA-Phe	0.0154	0.1208	0.1833
Echinococcus multilocularis	hemicentin 1	0.0221	0.2163	0.3282
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0154	0.1208	0.1833
Echinococcus granulosus	myotubularin protein 13	0.0076	0.012	0.0183
Brugia malayi	Cytochrome P450 family protein	0.0082	0.02	0.0304
Loa Loa (eye worm)	CAMK protein kinase	0.0156	0.1239	0.188
Echinococcus multilocularis	N chimaerin	0.0076	0.0115	0.0175
Schistosoma mansoni	protein kinase C mu	0.0072	0.0058	0.0088
Loa Loa (eye worm)	TK/INSR protein kinase	0.0209	0.199	0.302
Loa Loa (eye worm)	AGC/RSK/P70 protein kinase	0.0079	0.0159	0.0241
Brugia malayi	Protein kinase c protein 2	0.0209	0.1987	0.3015
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0154	0.1208	0.1833
Echinococcus multilocularis	roundabout 2	0.0221	0.2163	0.3282
Schistosoma mansoni	cell adhesion molecule	0.0276	0.293	0.4446
Echinococcus multilocularis	serine:threonine protein kinase MRCK beta	0.0074	0.0089	0.0135
Echinococcus granulosus	guanine nucleotide exchange factor VAV2	0.0076	0.0115	0.0175
Schistosoma mansoni	titin	0.0154	0.1208	0.1833
Echinococcus granulosus	NDR protein kinase	0.0079	0.0159	0.0241
Echinococcus multilocularis	Immunoglobulin	0.0208	0.1975	0.2997
Loa Loa (eye worm)	hypothetical protein	0.0276	0.293	0.4446
Onchocerca volvulus	Peroxidasin homolog	0.0154	0.1208	0.3404
Loa Loa (eye worm)	CAMK/MLCK protein kinase	0.0156	0.1239	0.188
Trichomonas vaginalis	AGC family protein kinase	0.0079	0.0159	0.3308
Schistosoma mansoni	slit	0.0154	0.1208	0.1833
Echinococcus granulosus	ribosomal protein s6 kinase beta 1	0.0079	0.0159	0.0241
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0154	0.1208	0.1833
Loa Loa (eye worm)	AGC/PKC/IOTA protein kinase	0.017	0.1437	0.2181
Echinococcus multilocularis	insulin growth factor 1 receptor beta	0.0209	0.199	0.302
Echinococcus multilocularis	down syndrome cell adhesion	0.0154	0.1208	0.1833
Schistosoma mansoni	titin	0.0154	0.1208	0.1833
Brugia malayi	diacylglycerol kinase	0.0072	0.0058	0.0088
Echinococcus multilocularis	myotubularin protein 13	0.0076	0.012	0.0183
Echinococcus multilocularis	serine:threonine protein kinase 38	0.0079	0.0159	0.0241
Echinococcus granulosus	roundabout 2	0.0221	0.2163	0.3282
Onchocerca volvulus		0.0154	0.1208	0.3404
Loa Loa (eye worm)	hypothetical protein	0.0208	0.1976	0.2998
Loa Loa (eye worm)	Ras association domain family 1 isoform A	0.0072	0.0058	0.0088
Schistosoma mansoni	hypothetical protein	0.0154	0.1208	0.1833
Schistosoma mansoni	vesicular amine transporter	0.0208	0.1975	0.2997
Loa Loa (eye worm)	hypothetical protein	0.0128	0.0847	0.1286
Schistosoma mansoni	nephrin related	0.0154	0.1208	0.1833
Echinococcus multilocularis	roundabout 2	0.0221	0.2163	0.3282
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0221	0.2163	0.3282
Echinococcus granulosus	contactin	0.0221	0.2163	0.3282
Echinococcus multilocularis	Ribosomal protein S6 kinase beta 2	0.0079	0.0159	0.0241
Loa Loa (eye worm)	hypothetical protein	0.0079	0.0154	0.0233
Brugia malayi	RhoGAP domain containing protein	0.0076	0.0115	0.0175
Echinococcus granulosus	Ribosomal protein S6 kinase beta 2	0.0079	0.0159	0.0241
Trichomonas vaginalis	AGC family protein kinase	0.0084	0.0222	1
Loa Loa (eye worm)	hypothetical protein	0.0208	0.1975	0.2997
Echinococcus granulosus	neuroglian	0.0362	0.4138	0.6279
Loa Loa (eye worm)	disorganized muscle protein 1	0.0154	0.1208	0.1833
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.0212	0.2032	0.3083
Schistosoma mansoni	tyrosine kinase	0.0209	0.199	0.302
Trichomonas vaginalis	AGC family protein kinase	0.0084	0.0222	1
Echinococcus multilocularis	epidermal growth factor receptor	0.0314	0.3462	0.5254
Trichomonas vaginalis	AGC family protein kinase	0.0084	0.0222	1
Trichomonas vaginalis	AGC family protein kinase	0.0084	0.0222	1
Loa Loa (eye worm)	AGC/RSK/MSK protein kinase	0.0079	0.0159	0.0241
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0221	0.2163	0.3282
Echinococcus granulosus	neurotracting:lsamp:neurotrimin:obcam	0.0276	0.293	0.4446
Echinococcus multilocularis	protein kinase c epsilon type	0.0307	0.3371	0.5115
Echinococcus granulosus	Opioid binding protein:cell adhesion molecule	0.0154	0.1208	0.1833
Brugia malayi	Variant SH3 domain containing protein	0.0076	0.0115	0.0175
Loa Loa (eye worm)	raf kinase	0.0072	0.0058	0.0088
Loa Loa (eye worm)	AGC/RSK/RSK protein kinase	0.0079	0.0159	0.0241
Schistosoma mansoni	vav2	0.008	0.0178	0.027
Loa Loa (eye worm)	hypothetical protein	0.0154	0.1208	0.1833
Echinococcus granulosus	unc 13 munc13	0.0079	0.0154	0.0233
Schistosoma mansoni	hemicentin	0.0154	0.1208	0.1833
Echinococcus multilocularis	titin	0.0156	0.1239	0.188
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0154	0.1208	0.1833
Brugia malayi	Leucine Rich Repeat family protein	0.0154	0.1208	0.1833
Loa Loa (eye worm)	hypothetical protein	0.0154	0.1208	0.1833
Brugia malayi	Phorbol esters/diacylglycerol binding domain	0.0206	0.1944	0.295
Loa Loa (eye worm)	hypothetical protein	0.0154	0.1208	0.1833
Loa Loa (eye worm)	hypothetical protein	0.0072	0.0058	0.0088
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0221	0.2163	0.3282
Loa Loa (eye worm)	CAMK/MLCK protein kinase	0.0224	0.2194	0.3329
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0221	0.2163	0.3282
Loa Loa (eye worm)	RhoGAP domain-containing protein	0.0076	0.0115	0.0175
Loa Loa (eye worm)	cytochrome P450 family protein	0.0082	0.02	0.0304
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0334	0.3754	0.5697
Echinococcus multilocularis	Diacylglycerol kinase theta	0.0072	0.0058	0.0088
Schistosoma mansoni	hypothetical protein	0.0154	0.1208	0.1833
Echinococcus multilocularis	protein kinase c eta type	0.0072	0.0058	0.0088
Brugia malayi	diacylglycerol kinase	0.0072	0.0058	0.0088
Onchocerca volvulus		0.0154	0.1208	0.3404
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0221	0.2163	0.3282
Schistosoma mansoni	hypothetical protein	0.0154	0.1208	0.1833
Brugia malayi	Furin-like cysteine rich region family protein	0.0536	0.659	1
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0221	0.2163	0.3282
Echinococcus multilocularis	receptor type tyrosine protein phosphatase F	0.0221	0.2163	0.3282
Echinococcus multilocularis	RNA directed DNA polymerase	0.0128	0.0847	0.1286
Loa Loa (eye worm)	hypothetical protein	0.0208	0.1975	0.2997
Onchocerca volvulus		0.0154	0.1208	0.3404
Loa Loa (eye worm)	hypothetical protein	0.0221	0.2163	0.3282
Echinococcus granulosus	peroxidasin	0.0221	0.2163	0.3282
Schistosoma mansoni	titin	0.0154	0.1208	0.1833
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0221	0.2163	0.3282
Entamoeba histolytica	protein kinase, putative	0.0079	0.0159	0.0855
Loa Loa (eye worm)	hypothetical protein	0.0208	0.1975	0.2997
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0221	0.2163	0.3282
Echinococcus granulosus	Diacylglycerol kinase theta	0.0072	0.0058	0.0088
Loa Loa (eye worm)	hypothetical protein	0.0154	0.1208	0.1833
Onchocerca volvulus		0.0208	0.1976	0.5883
Brugia malayi	Pleckstrin Homology Domain	0.0076	0.012	0.0183
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0221	0.2163	0.3282
Loa Loa (eye worm)	AGC/PKC/ALPHA protein kinase	0.0137	0.0974	0.1478
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0154	0.1208	0.1833
Echinococcus multilocularis	insulin receptor	0.0209	0.199	0.302
Loa Loa (eye worm)	AGC/NDR protein kinase	0.0079	0.0159	0.0241
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0154	0.1208	0.1833
Schistosoma mansoni	unc-13 (munc13)	0.0079	0.0154	0.0233
Echinococcus multilocularis	twitchin	0.0156	0.1239	0.188
Echinococcus granulosus	titin	0.0156	0.1239	0.188
Echinococcus granulosus	serine:threonine protein kinase N2	0.0079	0.0159	0.0241
Loa Loa (eye worm)	hypothetical protein	0.043	0.5093	0.7729
Schistosoma mansoni	neurotracting/lsamp/neurotrimin/obcam related cell adhesion molecule	0.0221	0.2163	0.3282
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0154	0.1208	0.1833
Onchocerca volvulus		0.0132	0.09	0.241
Brugia malayi	C1-like domain containing protein	0.0206	0.1944	0.295
Trichomonas vaginalis	AGC family protein kinase	0.0084	0.0222	1
Toxoplasma gondii	AGC kinase	0.0079	0.0159	0.0102
Echinococcus multilocularis	Opioid binding protein:cell adhesion molecule	0.0154	0.1208	0.1833
Schistosoma mansoni	diacylglycerol kinase theta	0.0072	0.0058	0.0088
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0154	0.1208	0.1833
Echinococcus granulosus	pro neuregulin 2 membrane bound	0.0154	0.1208	0.1833
Schistosoma mansoni	serine/threonine protein kinase	0.0074	0.0089	0.0135
Schistosoma mansoni	serine/threonine protein kinase	0.0074	0.0089	0.0135
Echinococcus multilocularis	protein kinase c iota type	0.024	0.2428	0.3685
Schistosoma mansoni	cell adhesion molecule	0.0154	0.1208	0.1833
Schistosoma mansoni	septate junction protein	0.0221	0.2163	0.3282
Loa Loa (eye worm)	hypothetical protein	0.0221	0.2163	0.3282
Echinococcus multilocularis	tyrosine protein kinase otk	0.0221	0.2163	0.3282
Echinococcus granulosus	protein kinase c iota type	0.024	0.2428	0.3685
Loa Loa (eye worm)	hypothetical protein	0.0378	0.4365	0.6624
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0154	0.1208	0.1833
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0154	0.1208	0.1833
Onchocerca volvulus		0.0154	0.1208	0.3404
Loa Loa (eye worm)	animal heme peroxidase	0.0154	0.1208	0.1833
Echinococcus granulosus	RNA directed DNA polymerase	0.0128	0.0847	0.1286
Loa Loa (eye worm)	projectin	0.0154	0.1208	0.1833
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0154	0.1208	0.1833
Loa Loa (eye worm)	TK/EGFR protein kinase	0.0536	0.659	1
Loa Loa (eye worm)	hypothetical protein	0.0154	0.1208	0.1833
Brugia malayi	hypothetical protein	0.0208	0.1975	0.2997
Schistosoma mansoni	serine/threonine kinase	0.0079	0.0159	0.0241
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0154	0.1208	0.1833
Schistosoma mansoni	hypothetical protein	0.0072	0.0058	0.0088
Loa Loa (eye worm)	hypothetical protein	0.0221	0.2163	0.3282
Loa Loa (eye worm)	hypothetical protein	0.0154	0.1208	0.1833
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0221	0.2163	0.3282
Echinococcus granulosus	C2 calcium dependent membrane targeting	0.0079	0.0154	0.0233
Brugia malayi	Prion-like-	0.0154	0.1208	0.1833
Schistosoma mansoni	unc-13 (munc13)	0.0079	0.0154	0.0233
Echinococcus multilocularis	peroxidasin	0.0221	0.2163	0.3282
Schistosoma mansoni	cell adhesion molecule	0.0154	0.1208	0.1833
Schistosoma mansoni	hypothetical protein	0.0154	0.1208	0.1833
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0212	0.2032	0.3083
Schistosoma mansoni	serine/threonine protein kinase	0.0286	0.307	0.4659
Brugia malayi	Fibronectin type III domain containing protein	0.0208	0.1975	0.2997
Schistosoma mansoni	tyrosine kinase	0.028	0.2987	0.4533
Echinococcus multilocularis	basement membrane specific heparan sulfate	0.0208	0.1975	0.2997
Loa Loa (eye worm)	hypothetical protein	0.0208	0.1975	0.2997
Loa Loa (eye worm)	hypothetical protein	0.0299	0.3251	0.4933
Trichomonas vaginalis	AGC family protein kinase	0.0084	0.0222	1
Schistosoma mansoni	serine/threonine protein kinase	0.0079	0.0159	0.0241
Onchocerca volvulus	Basement membrane proteoglycan homolog	0.0221	0.2163	0.6488
Echinococcus multilocularis	neurotracting:lsamp:neurotrimin:obcam	0.0221	0.2163	0.3282
Echinococcus granulosus	tyrosine protein kinase otk	0.0221	0.2163	0.3282
Brugia malayi	Disorganized muscle protein 1	0.0154	0.1208	0.1833
Schistosoma mansoni	defective proboscis extension response (dpr)-related	0.0208	0.1975	0.2997
Echinococcus granulosus	serine:threonine protein kinase N2	0.0152	0.1179	0.1789
Echinococcus multilocularis	raf serine:threonine protein kinase	0.013	0.0882	0.1338
Brugia malayi	Protein kinase domain containing protein	0.0079	0.0159	0.0241
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0221	0.2163	0.3282
Loa Loa (eye worm)	TK/ROR protein kinase	0.0212	0.2032	0.3083
Brugia malayi	Prion-like-	0.0221	0.2163	0.3282
Brugia malayi	Prion-like-	0.0154	0.1208	0.1833
Schistosoma mansoni	serine/threonine protein kinase	0.0156	0.1239	0.188
Schistosoma mansoni	titin	0.0156	0.1239	0.188
Loa Loa (eye worm)	hypothetical protein	0.0371	0.4264	0.647
Onchocerca volvulus		0.0299	0.3251	1
Loa Loa (eye worm)	hypothetical protein	0.0221	0.2163	0.3282
Echinococcus multilocularis	leucine rich repeats and immunoglobulin	0.0154	0.1208	0.1833
Echinococcus granulosus	titin	0.0156	0.1239	0.188
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0156	0.1239	0.188
Brugia malayi	protein kinase C II.	0.0307	0.3371	0.5115
Echinococcus granulosus	down syndrome cell adhesion	0.0154	0.1208	0.1833
Loa Loa (eye worm)	hypothetical protein	0.0154	0.1208	0.1833
Schistosoma mansoni	titin	0.0221	0.2163	0.3282
Echinococcus multilocularis	titin	0.0154	0.1208	0.1833
Loa Loa (eye worm)	CAMK/PKD protein kinase	0.0206	0.1944	0.295
Schistosoma mansoni	roundabout	0.0221	0.2163	0.3282
Echinococcus multilocularis	roundabout 2	0.043	0.5093	0.7729
Schistosoma mansoni	cell adhesion molecule	0.0154	0.1208	0.1833
Schistosoma mansoni	serine/threonine protein kinase	0.0079	0.0159	0.0241
Loa Loa (eye worm)	hypothetical protein	0.0154	0.1208	0.1833
Schistosoma mansoni	nephrin	0.0362	0.4138	0.6279
Trichomonas vaginalis	AGC family protein kinase	0.0079	0.0159	0.3308
Echinococcus granulosus	insulin growth factor binding	0.0154	0.1208	0.1833
Entamoeba histolytica	protein kinase, putative	0.0084	0.0222	0.1383
Schistosoma mansoni	Neurotrimin precursor (hNT)	0.0208	0.1975	0.2997
Echinococcus granulosus	Immunoglobulin	0.0208	0.1975	0.2997
Echinococcus multilocularis	telomerase reverse transcriptase subunit	0.0128	0.0847	0.1286
Echinococcus multilocularis	titin	0.0154	0.1208	0.1833
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.0212	0.2032	0.3083
Trichomonas vaginalis	AGC family protein kinase	0.0079	0.0159	0.3308
Brugia malayi	Hr1 repeat family protein	0.0079	0.0159	0.0241
Echinococcus granulosus	titin	0.0154	0.1208	0.1833
Schistosoma mansoni	tyrosine kinase	0.0314	0.3462	0.5254
Loa Loa (eye worm)	hypothetical protein	0.0072	0.0058	0.0088
Echinococcus granulosus	insulin growth factor 1 receptor beta	0.0209	0.199	0.302
Onchocerca volvulus	Netrin receptor homolog	0.0154	0.1208	0.3404
Schistosoma mansoni	tyrosine kinase	0.0536	0.659	1
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0154	0.1208	0.1833
Echinococcus multilocularis	unc 13 (munc13)	0.0079	0.0154	0.0233
Echinococcus granulosus	titin	0.0154	0.1208	0.1833
Echinococcus granulosus	epidermal growth factor receptor	0.0314	0.3462	0.5254
Echinococcus multilocularis	insulin growth factor binding	0.0154	0.1208	0.1833
Trypanosoma brucei	rac serine-threonine kinase, putative	0.0084	0.0222	0.5
Echinococcus multilocularis	Immunoglobulin	0.0208	0.1975	0.2997
Loa Loa (eye worm)	hypothetical protein	0.0299	0.3251	0.4933
Onchocerca volvulus	Tyrosine kinase homolog	0.0212	0.2032	0.6065
Schistosoma mansoni	tyrosine kinase	0.0209	0.199	0.302
Schistosoma mansoni	serine/threonine protein kinase	0.0079	0.0159	0.0241
Loa Loa (eye worm)	hypothetical protein	0.0132	0.09	0.1366
Loa Loa (eye worm)	hypothetical protein	0.0154	0.1208	0.1833
Schistosoma mansoni	hypothetical protein	0.0154	0.1208	0.1833
Trichomonas vaginalis	AGC family protein kinase	0.0084	0.0222	1
Loa Loa (eye worm)	hypothetical protein	0.0154	0.1208	0.1833
Brugia malayi	Animal haem peroxidase family protein	0.0154	0.1208	0.1833
Loa Loa (eye worm)	TK protein kinase	0.0212	0.2032	0.3083
Echinococcus granulosus	neuroglian	0.0221	0.2163	0.3282
Loa Loa (eye worm)	RasGEF domain-containing protein	0.0072	0.0058	0.0088
Loa Loa (eye worm)	hypothetical protein	0.0072	0.0058	0.0088
Schistosoma mansoni	nephrin	0.0221	0.2163	0.3282
Entamoeba histolytica	protein kinase, putative	0.0084	0.0222	0.1383
Loa Loa (eye worm)	hypothetical protein	0.0208	0.1975	0.2997
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0154	0.1208	0.1833
Loa Loa (eye worm)	AGC/PKC/ETA protein kinase	0.0307	0.3371	0.5115
Echinococcus granulosus	protein kinase c eta type	0.0072	0.0058	0.0088
Onchocerca volvulus		0.0154	0.1208	0.3404
Loa Loa (eye worm)	hypothetical protein	0.0154	0.1208	0.1833
Echinococcus granulosus	leucine rich repeat containing protein 4	0.0154	0.1208	0.1833
Schistosoma mansoni	hypothetical protein	0.0154	0.1208	0.1833
Brugia malayi	Protein kinase domain containing protein	0.0079	0.0159	0.0241
Loa Loa (eye worm)	hypothetical protein	0.0154	0.1208	0.1833
Echinococcus multilocularis	Protein kinase C, brain isozyme	0.0286	0.307	0.4659
Echinococcus granulosus	insulin receptor	0.0209	0.199	0.302
Schistosoma mansoni	serine/threonine protein kinase	0.0156	0.1239	0.188
Echinococcus granulosus	leucine rich repeats and immunoglobulin	0.0154	0.1208	0.1833
Echinococcus granulosus	ribosomal protein S6 kinase alpha 3	0.0079	0.0159	0.0241
Echinococcus multilocularis	hemicentin 1	0.0221	0.2163	0.3282
Loa Loa (eye worm)	hypothetical protein	0.043	0.5093	0.7729
Schistosoma mansoni	cell adhesion molecule	0.0221	0.2163	0.3282
Loa Loa (eye worm)	hypothetical protein	0.0154	0.1208	0.1833
Loa Loa (eye worm)	hypothetical protein	0.0154	0.1208	0.1833
Echinococcus granulosus	hemicentin 1	0.0221	0.2163	0.3282
Brugia malayi	RhoGAP domain containing protein	0.0072	0.0058	0.0088
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.0076	0.0115	0.0175
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0154	0.1208	0.1833
Schistosoma mansoni	serine/threonine protein kinase	0.0307	0.3371	0.5115
Onchocerca volvulus		0.0154	0.1208	0.3404
Schistosoma mansoni	serine/threonine protein kinase	0.0079	0.0159	0.0241
Onchocerca volvulus		0.0154	0.1208	0.3404
Echinococcus multilocularis	serine:threonine protein kinase N2	0.0228	0.2262	0.3433
Brugia malayi	Protein kinase domain containing protein	0.0209	0.199	0.302
Loa Loa (eye worm)	AGC/PKN protein kinase	0.0079	0.0159	0.0241
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0154	0.1208	0.1833
Echinococcus granulosus	N chimaerin	0.0076	0.0115	0.0175
Schistosoma mansoni	titin	0.0154	0.1208	0.1833
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0221	0.2163	0.3282
Echinococcus granulosus	defective proboscis extension response	0.0208	0.1975	0.2997
Echinococcus multilocularis	neuroglian	0.0362	0.4138	0.6279
Echinococcus multilocularis	pro neuregulin 2, membrane bound	0.0154	0.1208	0.1833
Schistosoma mansoni	cell adhesion molecule	0.0221	0.2163	0.3282
Schistosoma mansoni	myosin-binding protein-related	0.0154	0.1208	0.1833
Brugia malayi	Ras association domain family 1 isoform A	0.0072	0.0058	0.0088
Loa Loa (eye worm)	hypothetical protein	0.0072	0.0058	0.0088
Loa Loa (eye worm)	hypothetical protein	0.02	0.186	0.2823
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0154	0.1208	0.1833
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0221	0.2163	0.3282
Onchocerca volvulus		0.0154	0.1208	0.3404
Onchocerca volvulus		0.0154	0.1208	0.3404
Echinococcus granulosus	tyrosine protein kinase Lyn	0.0069	0.0013	0.002
Schistosoma mansoni	rac gtpase activating protein	0.0072	0.0058	0.0088
Echinococcus granulosus	roundabout 2	0.043	0.5093	0.7729
Schistosoma mansoni	tyrosine kinase	0.0314	0.3462	0.5254
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0221	0.2163	0.3282
Echinococcus granulosus	titin	0.0154	0.1208	0.1833
Echinococcus granulosus	raf serine:threonine protein kinase	0.013	0.0882	0.1338
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0154	0.1208	0.1833
Brugia malayi	protein kinase C3,putative	0.0163	0.1345	0.2041
Echinococcus granulosus	roundabout 2	0.0221	0.2163	0.3282
Loa Loa (eye worm)	hypothetical protein	0.0154	0.1208	0.1833
Echinococcus multilocularis	C2 calcium dependent membrane targeting	0.0079	0.0154	0.0233
Schistosoma mansoni	titin	0.0154	0.1208	0.1833
Schistosoma mansoni	serine/threonine protein kinase	0.0286	0.307	0.4659
Loa Loa (eye worm)	AGC/AKT protein kinase	0.0084	0.0222	0.0336
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0221	0.2163	0.3282
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0072	0.0058	0.0088
Schistosoma mansoni	tyrosine kinase	0.0255	0.2638	0.4003
Echinococcus granulosus	nephrin	0.0154	0.1208	0.1833
Schistosoma mansoni	protein kinase C mu	0.0206	0.1944	0.295
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0154	0.1208	0.1833
Loa Loa (eye worm)	one IG domain family member	0.0154	0.1208	0.1833
Echinococcus multilocularis	contactin neuroglian septate junction protein	0.0221	0.2163	0.3282
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0221	0.2163	0.3282
Loa Loa (eye worm)	AGC/DMPK/GEK protein kinase	0.0079	0.0159	0.0241
Onchocerca volvulus		0.0156	0.1239	0.3504
Loa Loa (eye worm)	hypothetical protein	0.0221	0.2163	0.3282
Onchocerca volvulus		0.0204	0.1913	0.5681
Echinococcus multilocularis	Rac GTPase activating protein 1	0.0072	0.0058	0.0088
Onchocerca volvulus		0.0154	0.1208	0.3404
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0154	0.1208	0.1833
Echinococcus granulosus	lachesin	0.0221	0.2163	0.3282
Entamoeba histolytica	protein kinase, putative	0.0079	0.0159	0.0855
Brugia malayi	Wrapper/rega-1/klingon homolog protein 1	0.0154	0.1208	0.1833
Echinococcus granulosus	Rac GTPase activating protein 1	0.0072	0.0058	0.0088
Loa Loa (eye worm)	hypothetical protein	0.0132	0.09	0.1366
Onchocerca volvulus	Peroxidasin homolog	0.0154	0.1208	0.3404
Echinococcus multilocularis	serine:threonine protein kinase N2	0.0079	0.0159	0.0241
Loa Loa (eye worm)	hypothetical protein	0.0221	0.2163	0.3282
Schistosoma mansoni	serine/threonine protein kinase	0.013	0.0882	0.1338
Loa Loa (eye worm)	hypothetical protein	0.0299	0.3251	0.4933
Loa Loa (eye worm)	hypothetical protein	0.0072	0.0058	0.0088
Loa Loa (eye worm)	hypothetical protein	0.0208	0.1975	0.2997
Echinococcus multilocularis	ribosomal protein s6 kinase beta 1	0.0079	0.0159	0.0241
Echinococcus granulosus	Serine/threonine-protein kinase Genghis Khan	0.0074	0.0089	0.0135
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0154	0.1208	0.1833
Schistosoma mansoni	septate junction protein	0.0221	0.2163	0.3282
Schistosoma mansoni	atypical protein kinase C	0.0247	0.2521	0.3825
Brugia malayi	RhoGEF domain containing protein	0.0072	0.0058	0.0088
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0154	0.1208	0.1833
Echinococcus multilocularis	lachesin	0.0221	0.2163	0.3282
Echinococcus multilocularis	neuroglian	0.0221	0.2163	0.3282
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0154	0.1208	0.1833
Echinococcus multilocularis	ribosomal protein S6 kinase alpha 3	0.0079	0.0159	0.0241
Brugia malayi	Peroxidasin	0.0221	0.2163	0.3282
Loa Loa (eye worm)	hypothetical protein	0.0072	0.0058	0.0088
Schistosoma mansoni	hypothetical protein	0.0154	0.1208	0.1833
Echinococcus multilocularis	epidermal growth factor receptor	0.0536	0.659	1
Loa Loa (eye worm)	hypothetical protein	0.0154	0.1208	0.1833

Activities

Activity type	Activity value	Assay description	Source	Reference
ID50 (functional)	0 ug ml-1	Evaluated for the antiviral activity against Human cytomegalovirus (HCMV) strain AD-169 by the plaque reduction assay; Not tested	ChEMBL.	2157012
ID50 (functional)	> 100 ug ml-1	Evaluated for the antiviral activity against Herpes simplex virus type 1 (HSV-1) strain BWS by the plaque reduction assay	ChEMBL.	2157012
ID50 (functional)	> 100 ug ml-1	Evaluated for the antiviral activity against Herpes simplex virus type 2 (HSV-2) with strain G by the plaque reduction assay	ChEMBL.	2157012
ID50 (functional)	= 100 ug ml-1	Evaluated for the antiviral activity against Vero cells by proliferation assays (in uninfected cells)	ChEMBL.	2157012
Ki (binding)	= 21 uM	Inhibition of human HGPRT	ChEMBL.	22178188
pKa2 (ADMET)	= 7.08	Evaluated for the dissociation constant	ChEMBL.	2157012

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL19784

Bibliographic References

2 literature references were collected for this gene.

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Detailed information for compound 22301