Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | oxidoreductase, aldo/keto reductase family protein | 0.0034 | 1 | 0.5 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0034 | 1 | 1 |
Leishmania major | prostaglandin f2-alpha synthase/D-arabinose dehydrogenase | 0.0034 | 1 | 0.5 |
Trichomonas vaginalis | dihydrodiol dehydrogenase, putative | 0.0034 | 1 | 0.5 |
Trichomonas vaginalis | aldo/keto reductase, putative | 0.0034 | 1 | 0.5 |
Echinococcus multilocularis | aldo keto reductase | 0.0034 | 1 | 1 |
Loa Loa (eye worm) | oxidoreductase | 0.0034 | 1 | 0.5 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0034 | 1 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0034 | 1 | 0.5 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0034 | 1 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0034 | 1 | 0.5 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0034 | 1 | 0.5 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0034 | 1 | 0.5 |
Trypanosoma brucei | aldo-keto reductase, putative | 0.0034 | 1 | 0.5 |
Brugia malayi | oxidoreductase, aldo/keto reductase family protein | 0.0034 | 1 | 0.5 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0034 | 1 | 1 |
Trypanosoma brucei | prostaglandin f synthase | 0.0034 | 1 | 0.5 |
Schistosoma mansoni | pol-related | 0.0034 | 1 | 0.5 |
Onchocerca volvulus | 0.0034 | 1 | 0.5 | |
Trichomonas vaginalis | dihydrodiol dehydrogenase, putative | 0.0034 | 1 | 0.5 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0034 | 1 | 0.5 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0034 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase | 0.0034 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 1 | 0.5 |
Trichomonas vaginalis | aldo/keto reductase, putative | 0.0034 | 1 | 0.5 |
Echinococcus granulosus | aldo keto reductase | 0.0034 | 1 | 1 |
Onchocerca volvulus | 0.0034 | 1 | 0.5 | |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0034 | 1 | 0.5 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0034 | 1 | 0.5 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0034 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase | 0.0034 | 1 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0034 | 1 | 0.5 |
Schistosoma mansoni | aldo-keto reductase | 0.0034 | 1 | 0.5 |
Trichomonas vaginalis | aldo/keto reductase, putative | 0.0034 | 1 | 0.5 |
Loa Loa (eye worm) | oxidoreductase | 0.0034 | 1 | 0.5 |
Trypanosoma cruzi | aldo/keto reductase, putative | 0.0034 | 1 | 0.5 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0034 | 1 | 0.5 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0034 | 1 | 1 |
Loa Loa (eye worm) | oxidoreductase | 0.0034 | 1 | 0.5 |
Echinococcus granulosus | hypothetical protein | 0.0034 | 1 | 1 |
Leishmania major | aldo-keto reductase-like protein | 0.0034 | 1 | 0.5 |
Brugia malayi | oxidoreductase, aldo/keto reductase family protein | 0.0034 | 1 | 0.5 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0034 | 1 | 1 |
Leishmania major | prostaglandin f synthase, putative | 0.0034 | 1 | 0.5 |
Onchocerca volvulus | 0.0034 | 1 | 0.5 | |
Loa Loa (eye worm) | oxidoreductase | 0.0034 | 1 | 0.5 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0034 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0034 | 1 | 1 |
Trichomonas vaginalis | dihydrodiol dehydrogenase, putative | 0.0034 | 1 | 0.5 |
Onchocerca volvulus | 0.0034 | 1 | 0.5 | |
Onchocerca volvulus | 0.0034 | 1 | 0.5 | |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0034 | 1 | 0.5 |
Leishmania major | aldehyde reductase, putative,oxidoreductase, putative | 0.0034 | 1 | 0.5 |
Echinococcus multilocularis | aldo keto reductase | 0.0034 | 1 | 1 |
Trypanosoma cruzi | aldo-keto reductase | 0.0034 | 1 | 0.5 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0034 | 1 | 0.5 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0034 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase | 0.0034 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase | 0.0034 | 1 | 1 |
Entamoeba histolytica | aldose reductase, putative | 0.0034 | 1 | 0.5 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0034 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0034 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0034 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0034 | 1 | 1 |
Giardia lamblia | Aldose reductase | 0.0034 | 1 | 0.5 |
Entamoeba histolytica | aldose reductase, putative | 0.0034 | 1 | 0.5 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0034 | 1 | 1 |
Mycobacterium ulcerans | oxidoreductase | 0.0034 | 1 | 0.5 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0034 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0034 | 1 | 1 |
Loa Loa (eye worm) | oxidoreductase | 0.0034 | 1 | 0.5 |
Schistosoma mansoni | aldo-keto reductase | 0.0034 | 1 | 0.5 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0034 | 1 | 0.5 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0034 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0034 | 1 | 1 |
Entamoeba histolytica | aldose reductase, putative | 0.0034 | 1 | 0.5 |
Toxoplasma gondii | aldose reductase, putative | 0.0034 | 1 | 0.5 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0034 | 1 | 0.5 |
Giardia lamblia | Aldose reductase | 0.0034 | 1 | 0.5 |
Onchocerca volvulus | 0.0034 | 1 | 0.5 | |
Mycobacterium leprae | PROBABLE OXIDOREDUCTASE | 0.0034 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (binding) | M-1 s-1 | Inhibition of Cathepsin B (fluorogenic assay); not determined | ChEMBL. | No reference |
k obs / 1 (binding) | = 7000 M-1 s-1 | Apparent second order rate constant for inhibition of calpain-1 by fluorogenic assay. | ChEMBL. | No reference |
k obs / 1 (binding) | = 7000 M-1 s-1 | Apparent second order rate constant for inhibition of calpain-1 by fluorogenic assay. | ChEMBL. | No reference |
ND (binding) | 0 M-1 s-1 | Inhibition of Cathepsin B (fluorogenic assay); not determined | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.