Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.104 | 0.1077 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.005 | 0.0968 | 0.0968 |
Echinococcus multilocularis | polycomb protein SCMH1 | 0.0053 | 0.104 | 0.1114 |
Echinococcus granulosus | endonuclease exonuclease phosphatase | 0.0207 | 0.6228 | 0.6673 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0408 | 0.0397 |
Loa Loa (eye worm) | hypothetical protein | 0.03 | 0.9333 | 1 |
Echinococcus multilocularis | histone acetyltransferase MYST2 | 0.006 | 0.1284 | 0.1376 |
Echinococcus granulosus | chromobox protein 1 | 0.0077 | 0.1853 | 0.1985 |
Brugia malayi | Bromodomain containing protein | 0.0042 | 0.0692 | 0.0618 |
Loa Loa (eye worm) | acyltransferase | 0.03 | 0.9333 | 1 |
Plasmodium vivax | 1-acyl-sn-glycerol-3-phosphate acyltransferase, putative | 0.03 | 0.9333 | 0.5 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0066 | 0.1484 | 0.159 |
Onchocerca volvulus | Polycomb protein Sfmbt homolog | 0.0053 | 0.104 | 1 |
Schistosoma mansoni | bromodomain containing protein | 0.007 | 0.1616 | 0.1616 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.005 | 0.0968 | 0.1037 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0043 | 0.072 | 0.2714 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0025 | 0.0124 | 0.0091 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.072 | 0.0733 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.005 | 0.0968 | 0.1037 |
Schistosoma mansoni | chromobox protein | 0.0077 | 0.1853 | 0.1853 |
Brugia malayi | mbt repeat family protein | 0.0053 | 0.104 | 0.0995 |
Schistosoma mansoni | transcription factor | 0.0287 | 0.892 | 0.892 |
Schistosoma mansoni | acetyl-CoA C-acetyltransferase | 0.0025 | 0.011 | 0.011 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0025 | 0.0124 | 0.0091 |
Onchocerca volvulus | Heterochromatin protein 1 homolog | 0.0043 | 0.072 | 0.4939 |
Echinococcus granulosus | 1 acyl sn glycerol 3 phosphate acyltransferase | 0.03 | 0.9333 | 1 |
Schistosoma mansoni | sex comb on midleg homolog | 0.0053 | 0.104 | 0.104 |
Trichomonas vaginalis | chromobox protein, putative | 0.0077 | 0.1853 | 1 |
Brugia malayi | C2-HC type zinc finger protein C.e-MyT1 | 0.006 | 0.1284 | 0.126 |
Leishmania major | 1-acyl-sn-glycerol-3-phosphateacyltransferase-like protein, putative | 0.03 | 0.9333 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.005 | 0.0968 | 0.1037 |
Schistosoma mansoni | chromobox protein | 0.0077 | 0.1853 | 0.1853 |
Echinococcus multilocularis | suppression of tumorigenicity 18 protein | 0.006 | 0.1284 | 0.1376 |
Loa Loa (eye worm) | heterochromatin protein 1 | 0.0077 | 0.1853 | 0.1951 |
Echinococcus multilocularis | fetal alzheimer antigen, falz | 0.0025 | 0.011 | 0.0118 |
Brugia malayi | chromobox protein homolog 3 | 0.0043 | 0.072 | 0.0648 |
Loa Loa (eye worm) | mbt repeat family protein | 0.0053 | 0.104 | 0.1077 |
Echinococcus multilocularis | endonuclease exonuclease phosphatase | 0.0207 | 0.6228 | 0.6673 |
Brugia malayi | Heterochromatin protein 1 | 0.0077 | 0.1853 | 0.1878 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.005 | 0.0968 | 0.0968 |
Trypanosoma brucei | 1-acyl-sn-glycerol-3-phosphate acyltransferase, putative | 0.03 | 0.9333 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0023 | 0.0039 | 0.0039 |
Trypanosoma cruzi | 1-acyl-sn-glycerol-3-phosphate acyltransferase, putative | 0.03 | 0.9333 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0047 | 0.0853 | 0.0876 |
Brugia malayi | Bromodomain containing protein | 0.0083 | 0.205 | 0.2092 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.004 | 0.0605 | 0.0648 |
Loa Loa (eye worm) | MBCTL1 | 0.006 | 0.1284 | 0.134 |
Echinococcus granulosus | fetal alzheimer antigen falz | 0.0025 | 0.011 | 0.0118 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.004 | 0.0605 | 0.0648 |
Echinococcus granulosus | polycomb protein SCMH1 | 0.0053 | 0.104 | 0.1114 |
Mycobacterium leprae | POSSIBLE TRANSMEMBRANE PHOSPHOLIPID BIOSYNTHESIS BIFUNCTIONAL ENZYME PLSC: PUTATIVE L-3-PHOSPHOSERINE PHOSPHATASE (O-PHOSPHOSERI | 0.03 | 0.9333 | 0.5 |
Loa Loa (eye worm) | CYP4Cod1 | 0.0025 | 0.0124 | 0.0091 |
Echinococcus granulosus | Phospholipid glycerol acyltransferase | 0.03 | 0.9333 | 1 |
Toxoplasma gondii | acyltransferase domain-containing protein | 0.03 | 0.9333 | 0.5 |
Schistosoma mansoni | scm-relatedprotein containing 4 mbt domains (sfmbt) | 0.0053 | 0.104 | 0.104 |
Echinococcus granulosus | histone acetyltransferase MYST2 | 0.006 | 0.1284 | 0.1376 |
Schistosoma mansoni | myelin transcription factor 1 myt1 | 0.006 | 0.1284 | 0.1284 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0043 | 0.072 | 0.2714 |
Mycobacterium ulcerans | bifunctional transmembrane phospholipid biosynthesis enzyme PlsC | 0.03 | 0.9333 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.0695 | 0.0706 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.1284 | 0.134 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.005 | 0.0968 | 0.1037 |
Plasmodium falciparum | 1-acyl-sn-glycerol-3-phosphate acyltransferase, putative | 0.03 | 0.9333 | 0.5 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0058 | 0.1211 | 0.1261 |
Brugia malayi | Acyltransferase family protein | 0.03 | 0.9333 | 1 |
Echinococcus multilocularis | homeobox | 0.0287 | 0.892 | 0.9557 |
Chlamydia trachomatis | glycerol-3-phosphate acyltransferase | 0.03 | 0.9333 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | 1-acyl-sn-glycerol-3-phosphate acyltransferase | 0.03 | 0.9333 | 0.5 |
Schistosoma mansoni | 1-acyl-sn-glycerol-3-phosphate o-acyltransferase | 0.03 | 0.9333 | 0.9333 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.005 | 0.0968 | 0.0999 |
Brugia malayi | PHD-finger family protein | 0.0027 | 0.0197 | 0.008 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.005 | 0.0968 | 0.0968 |
Brugia malayi | Cytochrome P450 family protein | 0.0058 | 0.1211 | 0.1181 |
Trichomonas vaginalis | chromobox protein, putative | 0.0077 | 0.1853 | 1 |
Schistosoma mansoni | sex comb on midleg homolog | 0.0053 | 0.104 | 0.104 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.005 | 0.0968 | 0.0917 |
Brugia malayi | mbt repeat family protein | 0.0053 | 0.104 | 0.0995 |
Toxoplasma gondii | acyltransferase domain-containing protein | 0.03 | 0.9333 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.03 | 0.9333 | 1 |
Onchocerca volvulus | 0.0053 | 0.104 | 1 | |
Echinococcus multilocularis | chromobox protein 1 | 0.0077 | 0.1853 | 0.1985 |
Echinococcus multilocularis | 1 acyl sn glycerol 3 phosphate acyltransferase | 0.03 | 0.9333 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.0783 | 0.08 |
Echinococcus multilocularis | Phospholipid glycerol acyltransferase | 0.03 | 0.9333 | 1 |
Treponema pallidum | lysophosphatidic acid acyltransferase | 0.03 | 0.9333 | 0.5 |
Trichomonas vaginalis | chromobox protein, putative | 0.0046 | 0.083 | 0.3419 |
Echinococcus granulosus | SAM and MBT domain containing protein | 0.0053 | 0.104 | 0.1114 |
Onchocerca volvulus | Heterochromatin protein 1 homolog | 0.0046 | 0.083 | 0.6675 |
Echinococcus multilocularis | SAM and MBT domain containing protein | 0.0053 | 0.104 | 0.1114 |
Echinococcus granulosus | suppression of tumorigenicity 18 protein | 0.006 | 0.1284 | 0.1376 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0066 | 0.1484 | 0.159 |
Echinococcus granulosus | Msx-like | 0.0287 | 0.892 | 0.9557 |
Echinococcus granulosus | chromobox protein 1 | 0.0077 | 0.1853 | 0.1985 |
Mycobacterium ulcerans | 1-acylglycerol-3-phosphate O-acyltransferase | 0.03 | 0.9333 | 1 |
Echinococcus multilocularis | 1 acyl sn glycerol 3 phosphate acyltransferase | 0.03 | 0.9333 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0078 | 0.1892 | 0.1993 |
Echinococcus multilocularis | chromobox protein 1 | 0.0077 | 0.1853 | 0.1985 |
Echinococcus granulosus | 1 acyl sn glycerol 3 phosphate acyltransferase | 0.03 | 0.9333 | 1 |
Mycobacterium tuberculosis | 1-acylglycerol-3-phosphate O-acyltransferase | 0.03 | 0.9333 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0287 | 0.892 | 0.9555 |
Trichomonas vaginalis | chromobox protein, putative | 0.0046 | 0.083 | 0.3419 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Cleavage (functional) | = 0 % | Percent DNA cleavage induced by administering the compound (1.0 uM) within 12 hr to form RfIII DNA was determined by using phiX174 bacteriophage DNA | ChEMBL. | 11738560 |
Cleavage (functional) | = 11 % | Percent DNA cleavage induced by administering the compound (1.0 uM) within 12 hr to form RfI DNA was determined by using phiX174 bacteriophage DNA | ChEMBL. | 11738560 |
Cleavage (functional) | = 89 % | Percent DNA cleavage induced by administering the compound (1.0 uM) within 12 hr to form RfII DNA was determined by using phiX174 bacteriophage DNA | ChEMBL. | 11738560 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.