Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (binding) | = 35 % | Percentage inhibition was measured on human placenta dipeptidylpeptidase 4 after 2 min incubation | ChEMBL. | 7966157 |
Inhibition (binding) | = 35 % | Percentage inhibition was measured on human placenta dipeptidylpeptidase 4 after 2 min incubation | ChEMBL. | 7966157 |
Inhibition (binding) | = 88 % | Percentage inhibition of the compound was measured on human placenta dipeptidylpeptidase 4 after 30 min | ChEMBL. | 7966157 |
Inhibition (binding) | = 88 % | Percentage inhibition of the compound was measured on human placenta dipeptidylpeptidase 4 after 30 min | ChEMBL. | 7966157 |
K obs / 1 (binding) | = 4.2 M-1 s-1 | The second order inhibition rate constant was measured against human placenta dipeptidylpeptidase 4 | ChEMBL. | 7966157 |
K obs / 1 (binding) | = 4.2 M-1 s-1 | The second order inhibition rate constant was measured against human placenta dipeptidylpeptidase 4 | ChEMBL. | 7966157 |
T1/2 (ADMET) | > 48 hr | Half life for the spontaneous hydrolysis in buffer was measured | ChEMBL. | 7966157 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.