Detailed information for compound 223643

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 448.468 | Formula: C25H24N2O6
  • H donors: 1 H acceptors: 5 LogP: 1.44 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOC(=O)CCc1c2ccccc2nc2c1Cn1c2cc2c(c1=O)COC(=O)[C@]2(O)CC
  • InChi: 1S/C25H24N2O6/c1-3-25(31)18-11-20-22-16(12-27(20)23(29)17(18)13-33-24(25)30)14(9-10-21(28)32-4-2)15-7-5-6-8-19(15)26-22/h5-8,11,31H,3-4,9-10,12-13H2,1-2H3/t25-/m0/s1
  • InChiKey: PLSMRQXVNAASRW-VWLOTQADSA-N  

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Echinococcus multilocularis thyroid hormone receptor alpha 0.0172 0.455 0.455
Brugia malayi cytidine deaminase, identical 0.0104 0.2574 0.3437
Mycobacterium tuberculosis Probable orotidine 5'-phosphate decarboxylase PyrF (OMP decarboxylase) (ompdecase) 0.0049 0.0985 0.209
Schistosoma mansoni phosphoglucomutase 0.0023 0.0221 0.0221
Brugia malayi nuclear receptor RXR 0.0022 0.019 0.0253
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0041 0.0756 0.0756
Toxoplasma gondii glyceraldehyde-3-phosphate dehydrogenase GAPDH1 0.0132 0.3375 0.7641
Loa Loa (eye worm) hypothetical protein 0.002 0.0122 0.0163
Loa Loa (eye worm) nuclear hormone receptor 0.002 0.0122 0.0163
Schistosoma mansoni nuclear receptor nhr-48 0.002 0.0122 0.0122
Loa Loa (eye worm) hypothetical protein 0.002 0.0122 0.0163
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0022 0.019 0.019
Brugia malayi ecdysteroid receptor 0.0041 0.0756 0.1009
Schistosoma mansoni lipoxygenase 0.0019 0.0119 0.0119
Brugia malayi RNase H family protein 0.0023 0.0221 0.0296
Treponema pallidum ribonuclease H (rnhA) 0.0023 0.0221 0.0316
Plasmodium falciparum orotidine 5'-phosphate decarboxylase 0.0112 0.2799 0.6303
Echinococcus multilocularis glyceraldehyde 3 phosphate dehydrogenase 0.0132 0.3375 0.3375
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0041 0.0756 0.0756
Loa Loa (eye worm) hypothetical protein 0.0086 0.2058 0.2748
Brugia malayi bZIP transcription factor family protein 0.0097 0.2373 0.3169
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0041 0.0756 0.1009
Echinococcus granulosus Na+ dependent nucleoside transporter 0.0333 0.9208 0.9208
Echinococcus granulosus RUN 0.0019 0.0119 0.0119
Loa Loa (eye worm) hypothetical protein 0.0029 0.0396 0.0529
Loa Loa (eye worm) TAR-binding protein 0.0066 0.1465 0.1956
Brugia malayi photoreceptor-specific nuclear receptor 0.0041 0.0756 0.1009
Schistosoma mansoni phosphoglucomutase 0.0023 0.0221 0.0221
Onchocerca volvulus 0.0054 0.1128 0.1812
Loa Loa (eye worm) hypothetical protein 0.0041 0.0756 0.1009
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0069 0.1559 0.1559
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0041 0.0756 0.1009
Giardia lamblia Cytidine deaminase 0.0104 0.2574 0.7565
Entamoeba histolytica AMP deaminase, putative 0.0054 0.1131 0.2429
Trypanosoma cruzi orotidine-5-phosphate decarboxylase/orotate phosphoribosyltransferase, putative 0.0112 0.2799 0.8257
Schistosoma mansoni hypothetical protein 0.0361 1 1
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0029 0.0396 0.0396
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0132 0.3375 0.5359
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0018 0.0085 0.0049
Echinococcus granulosus Nuclear hormone receptor HR96 0.002 0.0122 0.0122
Brugia malayi MAP kinase sur-1 0.0053 0.1091 0.1457
Loa Loa (eye worm) intermediate filament protein 0.0054 0.1128 0.1506
Trichomonas vaginalis conserved hypothetical protein 0.0056 0.1186 0.1793
Schistosoma mansoni zinc finger protein 0.0023 0.0213 0.0213
Mycobacterium ulcerans adenosine deaminase 0.0167 0.439 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0396 0.0396
Trypanosoma cruzi AMP deaminase, putative 0.0054 0.1131 0.3212
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0132 0.3375 0.5359
Plasmodium falciparum ataxin-2 like protein, putative 0.0029 0.0401 0.0735
Trichomonas vaginalis CMGC family protein kinase 0.0053 0.1091 0.1639
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.0132 0.3375 1
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0041 0.0756 0.0756
Schistosoma mansoni ap endonuclease 0.0018 0.0085 0.0085
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0041 0.0756 0.0756
Schistosoma mansoni loxhd1 0.0019 0.0119 0.0119
Loa Loa (eye worm) hypothetical protein 0.002 0.0122 0.0163
Loa Loa (eye worm) hypothetical protein 0.0029 0.0401 0.0536
Onchocerca volvulus 0.023 0.6223 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0041 0.0756 0.1009
Entamoeba histolytica glyceraldehyde-3-phosphate dehydrogenase, putative 0.0132 0.3375 0.7641
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0054 0.1133 0.1133
Echinococcus granulosus lipoxygenase domain containing protein 0.0019 0.0119 0.0119
Brugia malayi nuclear hormone receptor family member nhr-6 0.002 0.0122 0.0163
Onchocerca volvulus 0.0048 0.0948 0.1523
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.002 0.0122 0.0122
Echinococcus granulosus FTZ F1 alpha 0.0041 0.0756 0.0756
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0041 0.0756 0.0756
Echinococcus granulosus fetal alzheimer antigen falz 0.0026 0.0312 0.0312
Leishmania major glyceraldehyde 3-phosphate dehydrogenase, glycosomal 0.0132 0.3375 0.765
Trichomonas vaginalis DNA helicase recq1, putative 0.0041 0.0749 0.1082
Mycobacterium leprae PROBABLE OROTATE PHOSPHORIBOSYLTRANSFERASE PYRE (OPRT) (OPRTASE) 0.0049 0.0985 0.0313
Brugia malayi Nuclear hormone receptor-like 1 0.0041 0.0756 0.1009
Brugia malayi conserved hypotetical protein 0.002 0.0122 0.0163
Trypanosoma brucei glyceraldehyde 3-phosphate dehydrogenase, cytosolic 0.0132 0.3375 1
Trypanosoma cruzi cytidine deaminase-like protein 0.0104 0.2574 0.7577
Echinococcus granulosus jun protein 0.0097 0.2373 0.2373
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0041 0.0756 0.0756
Brugia malayi RNA recognition motif domain containing protein 0.0066 0.1465 0.1956
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0041 0.0756 0.1009
Plasmodium falciparum LCCL domain-containing protein 0.0019 0.0119 0.0079
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.002 0.0122 0.0122
Schistosoma mansoni tar DNA-binding protein 0.0066 0.1465 0.1465
Giardia lamblia Rrm3p helicase 0.0056 0.1186 0.3346
Trichomonas vaginalis CMGC family protein kinase 0.0053 0.1091 0.1639
Loa Loa (eye worm) hypothetical protein 0.0054 0.1128 0.1506
Trypanosoma brucei glyceraldehyde-3-phosphate dehydrogenase, putative 0.0086 0.2056 0.601
Brugia malayi nuclear hormone receptor 0.0041 0.0756 0.1009
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0026 0.0312 0.0312
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.0132 0.3375 1
Echinococcus multilocularis RUN 0.0019 0.0119 0.0119
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0032 0.0469 0.0926
Treponema pallidum adenosine deaminase 0.0167 0.439 1
Schistosoma mansoni methyl-cpg binding protein mbd 0.002 0.0128 0.0128
Schistosoma mansoni cellular tumor antigen P53 0.0048 0.0948 0.0948
Echinococcus multilocularis Nuclear hormone receptor HR96 0.002 0.0122 0.0122
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0029 0.0396 0.0396
Mycobacterium tuberculosis Probable cytidine deaminase Cdd (cytidine aminohydrolase) (cytidine nucleoside deaminase) 0.0104 0.2574 0.5781
Brugia malayi Nuclear hormone receptor E75 0.002 0.0122 0.0163
Echinococcus granulosus concentrative Na nucleoside cotransporter 0.0333 0.9208 0.9208
Loa Loa (eye worm) hypothetical protein 0.0041 0.0756 0.1009
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.0041 0.0739 0.2026
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.002 0.0122 0.0196
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0132 0.3375 0.5359
Trypanosoma brucei ingi protein (ORF1) 0.0025 0.0278 0.0632
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0365 0.0365
Brugia malayi Adenosine/AMP deaminase family protein 0.0167 0.439 0.5862
Brugia malayi Nuclear hormone receptor-like 1 0.0022 0.019 0.0253
Leishmania major hypothetical protein, conserved 0.0029 0.0401 0.0769
Toxoplasma gondii glyceraldehyde-3-phosphate dehydrogenase GAPDH2 0.0132 0.3375 0.7641
Wolbachia endosymbiont of Brugia malayi orotate phosphoribosyltransferase 0.0049 0.0985 0.2735
Trypanosoma brucei cytidine deaminase 0.0104 0.2574 0.7577
Schistosoma mansoni glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) 0.0132 0.3375 0.3375
Loa Loa (eye worm) hypothetical protein 0.0167 0.439 0.5862
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0132 0.3375 0.5359
Trypanosoma cruzi glyceraldehyde-3-phosphate dehydrogenase, putative 0.0086 0.2056 0.601
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0131 0.335 0.335
Loa Loa (eye worm) hypothetical protein 0.0027 0.0337 0.045
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0086 0.2058 0.3214
Trichomonas vaginalis set domain proteins, putative 0.023 0.6223 1
Toxoplasma gondii orotate phosphoribosyltransferase 0.0049 0.0985 0.209
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0041 0.0756 0.1009
Echinococcus multilocularis zinc finger protein 0.0023 0.0213 0.0213
Schistosoma mansoni retinoic acid receptor RXR 0.0041 0.0756 0.0756
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0041 0.0756 0.1009
Brugia malayi hypothetical protein 0.002 0.0122 0.0163
Schistosoma mansoni tar DNA-binding protein 0.0066 0.1465 0.1465
Loa Loa (eye worm) DR-78 0.002 0.0122 0.0163
Wolbachia endosymbiont of Brugia malayi glyceraldehyde-3-phosphate dehydrogenase, GapA 0.0132 0.3375 1
Echinococcus granulosus mitogen activated protein kinase 3 0.0053 0.1091 0.1091
Leishmania major AMP deaminase, putative 0.0054 0.1131 0.2457
Loa Loa (eye worm) hypothetical protein 0.0049 0.0987 0.1317
Echinococcus multilocularis AMP deaminase 2 0.0054 0.1131 0.1131
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0041 0.0756 0.0756
Plasmodium falciparum orotate phosphoribosyltransferase 0.0049 0.0985 0.209
Plasmodium falciparum glyceraldehyde-3-phosphate dehydrogenase 0.0132 0.3375 0.7641
Loa Loa (eye worm) hypothetical protein 0.0274 0.7489 1
Trypanosoma cruzi AMP deaminase, putative 0.0054 0.1131 0.3212
Trypanosoma brucei ingi protein (ORF1) 0.0025 0.0278 0.0632
Schistosoma mansoni glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) 0.0132 0.3375 0.3375
Schistosoma mansoni jun-related protein 0.0079 0.1845 0.1845
Schistosoma mansoni phosphoglucomutase 0.0023 0.0221 0.0221
Trichomonas vaginalis DNA helicase recq, putative 0.0041 0.0749 0.1082
Mycobacterium tuberculosis Probable orotate phosphoribosyltransferase PyrE (OPRT) (oprtase) 0.0049 0.0985 0.209
Loa Loa (eye worm) hypothetical protein 0.0025 0.0286 0.0381
Brugia malayi Nuclear hormone receptor E75 0.002 0.0122 0.0163
Giardia lamblia Ribonuclease H 0.0023 0.0221 0.0414
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain, putative 0.0041 0.0739 0.2026
Schistosoma mansoni tar DNA-binding protein 0.0066 0.1465 0.1465
Brugia malayi Bromodomain containing protein 0.0044 0.0841 0.1123
Leishmania major glyceraldehyde-3-phosphate dehydrogenase-like protein 0.0086 0.2056 0.4597
Loa Loa (eye worm) hypothetical protein 0.0022 0.019 0.0253
Loa Loa (eye worm) hypothetical protein 0.002 0.0122 0.0163
Loa Loa (eye worm) hypothetical protein 0.002 0.0122 0.0163
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0041 0.0756 0.1009
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0041 0.0756 0.1009
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0018 0.0085 0.0085
Trypanosoma brucei unspecified product 0.0025 0.0278 0.0632
Giardia lamblia Sgs1 DNA helicase, putative 0.0029 0.0396 0.0946
Trichomonas vaginalis cytidine deaminase, putative 0.0104 0.2574 0.4054
Wolbachia endosymbiont of Brugia malayi ribonuclease HI 0.0023 0.0221 0.0414
Echinococcus granulosus lamin dm0 0.0054 0.1128 0.1128
Onchocerca volvulus 0.0019 0.0119 0.0191
Schistosoma mansoni lamin 0.0054 0.1128 0.1128
Loa Loa (eye worm) hypothetical protein 0.0095 0.2296 0.3066
Schistosoma mansoni hypothetical protein 0.0024 0.0248 0.0248
Echinococcus granulosus cytidine deaminase 0.0104 0.2574 0.2574
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0053 0.1091 0.3093
Brugia malayi hypothetical protein 0.0076 0.1768 0.2361
Trypanosoma brucei DNA repair and recombination helicase protein PIF6 0.0056 0.1186 0.3379
Onchocerca volvulus 0.0104 0.2574 0.4136
Leishmania major PIF1 helicase-like protein, putative,DNA repair and recombination protein, mitochondrial precursor, putative 0.0056 0.1186 0.2585
Loa Loa (eye worm) hypothetical protein 0.0041 0.0756 0.1009
Echinococcus multilocularis sodium:nucleoside cotransporter 2 0.0217 0.5851 0.5851
Brugia malayi Steroid receptor seven-up type 2 0.0041 0.0756 0.1009
Loa Loa (eye worm) hypothetical protein 0.0019 0.0119 0.0159
Loa Loa (eye worm) MH2 domain-containing protein 0.0138 0.3561 0.4755
Trypanosoma brucei orotidine-5-phosphate decarboxylase/orotate phosphoribosyltransferase, putative 0.0112 0.2799 0.8257
Onchocerca volvulus Protein ultraspiracle homolog 0.0041 0.0756 0.1214
Trypanosoma cruzi AMP deaminase 2, putative 0.0054 0.1131 0.3212
Schistosoma mansoni hypothetical protein 0.0056 0.1174 0.1174
Schistosoma mansoni nuclear hormone receptor 0.002 0.0122 0.0122
Echinococcus granulosus adenosine deaminase 0.0167 0.439 0.439
Echinococcus granulosus glyceraldehyde 3 phosphate dehydrogenase 0.0086 0.2058 0.2058
Echinococcus multilocularis lipoxygenase domain containing protein 0.0019 0.0119 0.0119
Mycobacterium ulcerans orotate phosphoribosyltransferase 0.0049 0.0985 0.209
Trypanosoma brucei adenosine monophosphate deaminase, putative 0.0054 0.1131 0.3212
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0042 0.0761 0.0761
Schistosoma mansoni nuclear hormone receptor 0.0041 0.0756 0.0756
Schistosoma mansoni DNA helicase recq5 0.0029 0.0396 0.0396
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.0132 0.3375 1
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0024 0.0264 0.0415
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0041 0.0756 0.1009
Loa Loa (eye worm) hypothetical protein 0.0173 0.4567 0.6099
Brugia malayi MH2 domain containing protein 0.0138 0.3561 0.4755
Plasmodium falciparum adenosine deaminase 0.0167 0.439 1
Brugia malayi adenosine monophosphate deaminase 0.0054 0.1131 0.151
Echinococcus granulosus methyl CpG binding domain protein 2 0.002 0.0128 0.0128
Echinococcus granulosus zinc finger protein 0.0023 0.0213 0.0213
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0024 0.0248 0.0377
Trichomonas vaginalis adenosine deaminase, putative 0.0167 0.439 0.7014
Brugia malayi RNase H family protein 0.0023 0.0221 0.0296
Entamoeba histolytica cytidine deaminase, putative 0.0104 0.2574 0.5781
Brugia malayi TAR-binding protein 0.0066 0.1465 0.1956
Echinococcus multilocularis cytidine deaminase 0.0104 0.2574 0.2574
Trypanosoma cruzi orotidine-5-phosphate decarboxylase/orotate phosphoribosyltransferase, putative 0.0112 0.2799 0.8257
Echinococcus granulosus Polycystic kidney disease protein 0.0019 0.0119 0.0119
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0053 0.1091 0.3093
Onchocerca volvulus 0.0041 0.0756 0.1214
Echinococcus multilocularis tumor protein p63 0.0328 0.9067 0.9067
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0032 0.0469 0.1211
Brugia malayi hypothetical protein 0.0019 0.0119 0.0159
Schistosoma mansoni zinc finger protein 0.002 0.0122 0.0122
Onchocerca volvulus Adenosine deaminase homolog 0.0167 0.439 0.7055
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.0097 0.2373 0.2373
Brugia malayi Nuclear hormone receptor-like 1 0.0022 0.019 0.0253
Loa Loa (eye worm) hypothetical protein 0.0048 0.0948 0.1266
Loa Loa (eye worm) RecQ helicase 0.0041 0.0749 0.1
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0041 0.0756 0.0756
Echinococcus multilocularis geminin 0.0361 1 1
Brugia malayi PHD-finger family protein 0.0029 0.0392 0.0523
Loa Loa (eye worm) glyceraldehyde-3-phosphate dehydrogenase 0.0091 0.2192 0.2926
Loa Loa (eye worm) hypothetical protein 0.002 0.0122 0.0163
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0041 0.0756 0.1009
Schistosoma mansoni lamin 0.0054 0.1128 0.1128
Loa Loa (eye worm) hypothetical protein 0.0173 0.4567 0.6099
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.002 0.0122 0.0122
Schistosoma mansoni rab6-interacting 0.0019 0.0119 0.0119
Plasmodium vivax orotate phosphoribosyltransferase, putative 0.0049 0.0985 0.209
Onchocerca volvulus 0.0104 0.2574 0.4136
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0053 0.1091 0.1457
Loa Loa (eye worm) AMP deaminase 0.0054 0.1131 0.151
Schistosoma mansoni DNA helicase recq1 0.0029 0.0396 0.0396
Trypanosoma brucei AMP deaminase, putative 0.0054 0.1131 0.3212
Leishmania major ribonuclease H1, putative 0.0023 0.0221 0.0352
Brugia malayi RNase H family protein 0.0023 0.0221 0.0296
Brugia malayi nuclear receptor NHR-67 0.002 0.0122 0.0163
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0029 0.0396 0.0529
Schistosoma mansoni hypothetical protein 0.0361 1 1
Onchocerca volvulus 0.0019 0.0119 0.0191
Loa Loa (eye worm) nuclear receptor NHR-67 0.002 0.0122 0.0163
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0049 0.0968 0.0968
Echinococcus granulosus glyceraldehyde 3 phosphate dehydrogenase 0.0132 0.3375 0.3375
Echinococcus multilocularis ribonuclease H1 0.0023 0.0221 0.0221
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.002 0.0122 0.0122
Schistosoma mansoni nuclear receptor 0.002 0.0122 0.0122
Brugia malayi ecdysone receptor 0.002 0.0122 0.0163
Brugia malayi nuclear receptor NHR-88 0.0041 0.0756 0.1009
Trypanosoma cruzi ribonuclease H1, putative 0.0023 0.0221 0.0461
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.002 0.0122 0.0122
Brugia malayi Glyceraldehyde 3-phosphate dehydrogenase 0.0045 0.0873 0.1165
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0053 0.1091 0.3093
Loa Loa (eye worm) glyceraldehyde 3-phosphate dehydrogenase 0.0086 0.2058 0.2748
Mycobacterium leprae Probable orotidine 5'-phosphate decarboxylase PyrF (OMP decarboxylase) (OMPDCase) (OMPdecase) 0.0112 0.2799 0.5472
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.0041 0.0739 0.2026
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.002 0.0122 0.0163
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0029 0.0396 0.0722
Trichomonas vaginalis DNA helicase recq, putative 0.0032 0.0469 0.0626
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0041 0.0756 0.0756
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0029 0.0396 0.0723
Loa Loa (eye worm) hypothetical protein 0.002 0.0122 0.0163
Schistosoma mansoni tar DNA-binding protein 0.0066 0.1465 0.1465
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0045 0.0873 0.1283
Schistosoma mansoni survival motor neuron protein 0.0056 0.1174 0.1174
Schistosoma mansoni zinc finger protein 0.0018 0.0069 0.0069
Echinococcus multilocularis survival motor neuron protein 1 0.0274 0.7489 0.7489
Schistosoma mansoni glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) 0.0132 0.3375 0.3375
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0039 0.0676 0.1373
Entamoeba histolytica DNA repair and recombination protein, putative 0.0056 0.1186 0.2557
Plasmodium vivax multidomain scavenger receptor, putative 0.0019 0.0119 0.0079
Trichomonas vaginalis CMGC family protein kinase 0.0053 0.1091 0.1639
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0041 0.0756 0.1009
Echinococcus granulosus ribonuclease H1 0.0023 0.0221 0.0221
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0122 0.0122
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0041 0.0756 0.0756
Onchocerca volvulus Bile acid receptor homolog 0.0041 0.0756 0.1214
Schistosoma mansoni hypothetical protein 0.0056 0.1186 0.1186
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0018 0.0085 0.0037
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0041 0.0756 0.1009
Schistosoma mansoni rab6-interacting 0.0019 0.0119 0.0119
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0041 0.0756 0.1009
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0041 0.0756 0.0756
Trypanosoma cruzi DNA repair and recombination helicase protein PIF7, putative 0.0056 0.1186 0.3379
Trypanosoma cruzi orotidine-5-phosphate decarboxylase/orotate phosphoribosyltransferase, putative 0.0112 0.2799 0.8257
Schistosoma mansoni methyl-cpg binding protein mbd 0.002 0.0128 0.0128
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0041 0.0756 0.1214
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0041 0.0756 0.1009
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0041 0.0756 0.0756
Trypanosoma cruzi adenosine monophosphate deaminase, putative 0.0054 0.1131 0.3212
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0041 0.0756 0.0756
Entamoeba histolytica hypothetical protein, conserved 0.0056 0.1186 0.2557
Loa Loa (eye worm) hypothetical protein 0.0022 0.019 0.0253
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.0041 0.0739 0.2026
Loa Loa (eye worm) hypothetical protein 0.0054 0.1131 0.151
Brugia malayi Pre-SET motif family protein 0.0029 0.0396 0.0529
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0018 0.0085 0.0049
Loa Loa (eye worm) hypothetical protein 0.002 0.0122 0.0163
Loa Loa (eye worm) hypothetical protein 0.0113 0.2815 0.3759
Loa Loa (eye worm) PHD-finger family protein 0.0024 0.0248 0.0331
Onchocerca volvulus 0.002 0.0122 0.0196
Loa Loa (eye worm) hypothetical protein 0.0022 0.019 0.0253
Brugia malayi Bromodomain containing protein 0.0087 0.2072 0.2767
Brugia malayi hypothetical protein 0.0029 0.0401 0.0536
Giardia lamblia Kinase, CMGC MAPK 0.0053 0.1091 0.3059
Loa Loa (eye worm) hypothetical protein 0.0041 0.0756 0.1009
Echinococcus multilocularis lamin dm0 0.0054 0.1128 0.1128
Onchocerca volvulus 0.0054 0.1131 0.1817
Trypanosoma brucei retrotransposon hot spot protein 4 (RHS4), interrupted 0.0025 0.0278 0.0632
Schistosoma mansoni orotidine 5'-phosphate decarboxylase 0.0112 0.2799 0.2799
Schistosoma mansoni hypothetical protein 0.0086 0.2051 0.2051
Brugia malayi cytoplasmic intermediate filament protein 0.0029 0.0398 0.0531
Echinococcus multilocularis mitogen activated protein kinase 3 0.0053 0.1091 0.1091
Loa Loa (eye worm) hypothetical protein 0.002 0.0122 0.0163
Toxoplasma gondii AMP deaminase 0.0054 0.1131 0.2429
Echinococcus granulosus histone lysine methyltransferase setb 0.0049 0.0968 0.0968
Schistosoma mansoni serine/threonine protein kinase 0.0053 0.1091 0.1091
Echinococcus granulosus lipoxygenase domain containing protein 0.0019 0.0119 0.0119
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0032 0.0469 0.1211
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0029 0.0396 0.0529
Echinococcus granulosus uridine 5' monophosphate synthase 0.0112 0.2799 0.2799
Loa Loa (eye worm) hypothetical protein 0.0022 0.019 0.0253
Onchocerca volvulus AMP deaminase 2 homolog 0.0054 0.1131 0.1817
Plasmodium vivax glyceraldehyde-3-phosphate dehydrogenase, putative 0.0132 0.3375 0.7641
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0069 0.1559 0.1559
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0018 0.0085 0.0049
Toxoplasma gondii orotidine-5-phosphate decarboxylase/orotate phosphoribosyltransferase 0.0112 0.2799 0.6303
Loa Loa (eye worm) hypothetical protein 0.002 0.0122 0.0163
Loa Loa (eye worm) steroid hormone receptor 0.0041 0.0756 0.1009
Trypanosoma brucei AMP deaminase, putative 0.0054 0.1131 0.3212
Entamoeba histolytica AMP deaminase, putative 0.0054 0.1131 0.2429
Schistosoma mansoni nuclear receptor 0.002 0.0122 0.0122
Schistosoma mansoni polycystin 1-related 0.0019 0.0119 0.0119
Loa Loa (eye worm) hypothetical protein 0.0082 0.1928 0.2575
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0022 0.019 0.019
Echinococcus granulosus mitogen activated protein kinase 0.0053 0.1091 0.1091
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0022 0.019 0.019
Leishmania major adenine aminohydrolase 0.0167 0.439 1
Brugia malayi RNA binding protein 0.0066 0.1465 0.1956
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0049 0.0968 0.0968
Chlamydia trachomatis glyceraldehyde-3-phosphate dehydrogenase 0.0132 0.3375 0.5
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0041 0.0756 0.1009
Echinococcus granulosus thyroid hormone receptor alpha 0.002 0.0122 0.0122
Echinococcus multilocularis glyceraldehyde 3 phosphate dehydrogenase 0.0086 0.2058 0.2058
Trypanosoma brucei DNA repair and recombination helicase protein PIF7 0.0056 0.1186 0.3379
Trypanosoma cruzi AMP deaminase, putative 0.0054 0.1131 0.3212
Loa Loa (eye worm) hypothetical protein 0.0026 0.0314 0.042
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0018 0.0085 0.0085
Loa Loa (eye worm) hypothetical protein 0.0041 0.0756 0.1009
Schistosoma mansoni nuclear hormone receptor 0.002 0.0122 0.0122
Mycobacterium ulcerans cytidine deaminase 0.0104 0.2574 0.5781
Loa Loa (eye worm) hypothetical protein 0.0113 0.2815 0.3759
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0041 0.0756 0.1009
Toxoplasma gondii ribonuclease HI protein 0.0023 0.0221 0.0316
Echinococcus multilocularis jun protein 0.0097 0.2373 0.2373
Schistosoma mansoni bromodomain containing protein 0.0073 0.1679 0.1679
Echinococcus multilocularis muscleblind protein 0.0173 0.4567 0.4567
Trypanosoma brucei hypothetical protein, conserved 0.0025 0.0278 0.0632
Echinococcus granulosus AMP deaminase 2 0.0054 0.1131 0.1131
Brugia malayi Bloom's syndrome protein homolog 0.0041 0.0749 0.1
Toxoplasma gondii Adenosine/AMP deaminase domain-containing protein 0.0167 0.439 1
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0053 0.1091 0.3093
Schistosoma mansoni hypothetical protein 0.0019 0.0119 0.0119
Leishmania major AMP deaminase, putative,amp deaminase-like protein 0.0054 0.1131 0.2457
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0131 0.335 0.335
Trypanosoma cruzi adenosine monophosphate deaminase-like protein, putative 0.0054 0.1131 0.3212
Loa Loa (eye worm) doublecortin family protein 0.0019 0.0119 0.0159
Trypanosoma cruzi PAB1-binding protein , putative 0.0029 0.0401 0.1006
Echinococcus multilocularis FTZ F1 alpha 0.0041 0.0756 0.0756
Wolbachia endosymbiont of Brugia malayi orotidine-5'-phosphate decarboxylase 0.0063 0.137 0.3904
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0029 0.0396 0.0396
Brugia malayi Intermediate filament tail domain containing protein 0.0054 0.1128 0.1506
Treponema pallidum glyceraldehyde 3-phosphate dehydrogenase (gap) 0.0132 0.3375 0.7641
Trypanosoma cruzi glyceraldehyde-3-phosphate dehydrogenase, putative 0.0086 0.2056 0.601
Brugia malayi glyceraldehyde 3-phosphate dehydrogenase 0.0041 0.0739 0.0987
Brugia malayi hypothetical protein 0.0022 0.019 0.0253
Schistosoma mansoni hypothetical protein 0.0079 0.1845 0.1845
Entamoeba histolytica glyceraldehyde-3-phosphate dehydrogenase, putative 0.0132 0.3375 0.7641
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0053 0.1091 0.2337
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0026 0.0314 0.0314
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0041 0.0756 0.1009
Echinococcus multilocularis glyceraldehyde 3 phosphate dehydrogenase 0.0132 0.3375 0.3375
Loa Loa (eye worm) glyceraldehyde 3-phosphate dehydrogenase 0.0086 0.2058 0.2748
Loa Loa (eye worm) hypothetical protein 0.0019 0.0119 0.0159
Trypanosoma cruzi PAB1-binding protein , putative 0.0029 0.0401 0.1006
Leishmania major hypothetical protein, conserved 0.0054 0.1131 0.2457
Schistosoma mansoni blooms syndrome DNA helicase 0.0026 0.0321 0.0321
Plasmodium vivax adenosine/AMP deaminase, putative 0.0054 0.1131 0.2429
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0053 0.1091 0.2366
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0022 0.019 0.0253
Loa Loa (eye worm) hypothetical protein 0.0113 0.2815 0.3759
Echinococcus multilocularis ATP dependent DNA helicase PIF1 0.0056 0.1186 0.1186
Trypanosoma brucei AMP deaminase, putative 0.0054 0.1131 0.3212
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0041 0.0756 0.1009
Loa Loa (eye worm) hypothetical protein 0.0049 0.0968 0.1293
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0041 0.0756 0.1009
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0029 0.0396 0.0396
Trypanosoma brucei protein kinase, putative 0.0053 0.1091 0.3093
Brugia malayi Doublecortin family protein 0.0019 0.0119 0.0159
Loa Loa (eye worm) hypothetical protein 0.0041 0.0756 0.1009
Entamoeba histolytica adenosine deaminase, putative 0.0167 0.439 1
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain, putative 0.0041 0.0739 0.2026
Trypanosoma cruzi AMP deaminase, putative 0.0054 0.1131 0.3212
Loa Loa (eye worm) hypothetical protein 0.002 0.0122 0.0163
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0066 0.1465 0.1956
Plasmodium vivax orotidine 5'-phosphate decarboxylase, putative 0.0112 0.2799 0.6303
Echinococcus granulosus solute carrier family 28 0.0333 0.9208 0.9208
Echinococcus multilocularis uridine 5' monophosphate synthase 0.0112 0.2799 0.2799
Schistosoma mansoni hypothetical protein 0.0131 0.335 0.335
Mycobacterium ulcerans glyceraldehyde 3-phosphate dehydrogenase Gap 0.0132 0.3375 0.7641
Echinococcus granulosus intermediate filament protein 0.0054 0.1128 0.1128
Trypanosoma cruzi cytidine deaminase-like protein, putative 0.0104 0.2574 0.7577
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.0097 0.2373 0.2373
Mycobacterium ulcerans orotidine 5'-phosphate decarboxylase 0.0112 0.2799 0.6303
Mycobacterium tuberculosis Probable glyceraldehyde 3-phosphate dehydrogenase Gap (GAPDH) 0.0046 0.0875 0.1834
Schistosoma mansoni thyroid hormone receptor 0.0172 0.455 0.455
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0122 0.0122
Brugia malayi Muscleblind-like protein 0.0173 0.4567 0.6099
Entamoeba histolytica adenosine deaminase, putative 0.0167 0.439 1
Echinococcus multilocularis bloom syndrome protein 0.0041 0.0749 0.0749
Trichomonas vaginalis adenosine deaminase, putative 0.0167 0.439 0.7014
Echinococcus multilocularis adenosine deaminase 0.0167 0.439 0.439
Leishmania major AMP deaminase, putative,adenosine monophosphate deaminase-like protein 0.0054 0.1131 0.2457
Echinococcus multilocularis musashi 0.0054 0.1128 0.1128
Echinococcus multilocularis tar DNA binding protein 0.0066 0.1465 0.1465
Loa Loa (eye worm) hypothetical protein 0.002 0.0122 0.0163
Brugia malayi Glyceraldehyde 3-phosphate dehydrogenase 0.0132 0.3375 0.4506
Loa Loa (eye worm) glyceraldehyde-3-phosphate dehydrogenase 0.0091 0.2192 0.2926
Entamoeba histolytica recQ family helicase, putative 0.0032 0.0469 0.0892
Trypanosoma cruzi ribonuclease H1, putative 0.0023 0.0221 0.0461
Schistosoma mansoni lipoxygenase 0.0054 0.1133 0.1133
Echinococcus multilocularis lamin 0.0054 0.1128 0.1128
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0054 0.1128 0.1506
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0041 0.0756 0.0756
Echinococcus granulosus muscleblind protein 0.0173 0.4567 0.4567
Toxoplasma gondii LsmAD domain-containing protein 0.0029 0.0401 0.0735
Schistosoma mansoni RAR-like nuclear receptor 0.0041 0.0756 0.0756
Mycobacterium tuberculosis Probable adenosine deaminase Add (adenosine aminohydrolase) 0.0167 0.439 1
Echinococcus multilocularis lipoxygenase domain containing protein 0.0019 0.0119 0.0119
Brugia malayi orotate phosphoribosyltransferase family protein 0.0112 0.2799 0.3737
Trypanosoma cruzi AMP deaminase, putative 0.0054 0.1131 0.3212
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.0132 0.3375 1
Loa Loa (eye worm) hypothetical protein 0.0022 0.019 0.0253
Mycobacterium leprae Probable adenosine deaminase Add (ADENOSINE AMINOHYDROLASE) 0.0167 0.439 1
Echinococcus granulosus ATP dependent DNA helicase PIF1 0.0056 0.1186 0.1186
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0029 0.0396 0.0529
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0042 0.0761 0.0761
Loa Loa (eye worm) hypothetical protein 0.0041 0.0756 0.1009
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0029 0.0396 0.0396
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0049 0.0968 0.0968
Giardia lamblia Glyceraldehyde 3-phosphate dehydrogenase 0.0086 0.2056 0.599
Trypanosoma brucei PAB1-binding protein , putative 0.0029 0.0401 0.1006
Brugia malayi hypothetical protein 0.0019 0.0102 0.0136
Schistosoma mansoni coup transcription factor 0.0041 0.0756 0.0756
Mycobacterium leprae PROBABLE CYTIDINE DEAMINASE CDD (CYTIDINE AMINOHYDROLASE) (CYTIDINE NUCLEOSIDE DEAMINASE) 0.0104 0.2574 0.4833
Onchocerca volvulus 0.0076 0.1768 0.2841
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0041 0.0756 0.0756
Onchocerca volvulus 0.002 0.0122 0.0196
Trypanosoma brucei glyceraldehyde 3-phosphate dehydrogenase, glycosomal 0.0132 0.3375 1
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.0132 0.3375 1
Onchocerca volvulus 0.0029 0.0396 0.0636
Plasmodium vivax SET domain protein, putative 0.0029 0.0396 0.0722
Schistosoma mansoni steroid hormone receptor ad4bp 0.0041 0.0756 0.0756
Trypanosoma brucei glyceraldehyde 3-phosphate dehydrogenase, glycosomal 0.0132 0.3375 1
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0053 0.1091 0.2366
Brugia malayi hypothetical protein 0.0274 0.7489 1
Loa Loa (eye worm) hypothetical protein 0.0053 0.1099 0.1467
Echinococcus multilocularis mitogen activated protein kinase 0.0053 0.1091 0.1091
Plasmodium vivax adenosine deaminase, putative 0.0167 0.439 1
Loa Loa (eye worm) hypothetical protein 0.0044 0.0843 0.1126
Echinococcus multilocularis Polycystic kidney disease protein 0.0019 0.0119 0.0119
Echinococcus granulosus glyceraldehyde 3 phosphate dehydrogenase 0.0132 0.3375 0.3375
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0026 0.0312 0.0312
Brugia malayi hypothetical protein 0.002 0.0122 0.0163
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0041 0.0756 0.0756
Loa Loa (eye worm) hypothetical protein 0.0047 0.0923 0.1232
Schistosoma mansoni adenosine deaminase 0.0167 0.439 0.439
Echinococcus granulosus ecdysone induced protein 78C 0.0041 0.0756 0.0756
Echinococcus granulosus lamin 0.0054 0.1128 0.1128
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0202 0.5414 0.7229
Brugia malayi nuclear hormone receptor 0.002 0.0122 0.0163
Brugia malayi hypothetical protein 0.0019 0.0119 0.0159
Brugia malayi nuclear hormone receptor family member odr-7 0.002 0.0122 0.0163
Schistosoma mansoni tar DNA-binding protein 0.0066 0.1465 0.1465
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0029 0.0398 0.0531
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0086 0.2058 0.3214
Loa Loa (eye worm) transcription factor SMAD2 0.0138 0.3561 0.4755
Onchocerca volvulus 0.0054 0.1128 0.1812
Schistosoma mansoni adenosine deaminase-related 0.0167 0.439 0.439
Loa Loa (eye worm) bromodomain containing protein 0.002 0.0149 0.0198
Plasmodium vivax ataxin-2 like protein, putative 0.0029 0.0401 0.0735
Echinococcus granulosus Nuclear hormone receptor HR96 0.002 0.0122 0.0122
Schistosoma mansoni thyroid hormone receptor 0.0172 0.455 0.455
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0029 0.0396 0.0723
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0054 0.1133 0.1133
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.0132 0.3375 1
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0029 0.0396 0.0723
Loa Loa (eye worm) RNA binding protein 0.0066 0.1465 0.1956
Loa Loa (eye worm) nuclear receptor nhr-7B 0.002 0.0122 0.0163
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0041 0.0756 0.0756
Echinococcus multilocularis muscleblind protein 1 0.0173 0.4567 0.4567
Brugia malayi exodeoxyribonuclease III family protein 0.0018 0.0085 0.0114
Echinococcus multilocularis methyl CpG binding domain protein 2 0.002 0.0128 0.0128
Loa Loa (eye worm) orotate phosphoribosyltransferase 0.0112 0.2799 0.3737
Plasmodium falciparum ataxin-2 like protein, putative 0.0029 0.0401 0.0735
Echinococcus granulosus tar DNA binding protein 0.0066 0.1465 0.1465
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.002 0.0122 0.0196
Loa Loa (eye worm) hypothetical protein 0.002 0.0122 0.0163
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.0132 0.3375 1
Toxoplasma gondii cytidine and deoxycytidylate deaminase zinc-binding region domain-containing protein 0.0104 0.2574 0.5781
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0041 0.0756 0.0756
Schistosoma mansoni intermediate filament proteins 0.0054 0.1128 0.1128
Brugia malayi Pre-SET motif family protein 0.0202 0.5414 0.7229
Trichomonas vaginalis cytidine deaminase, putative 0.0104 0.2574 0.4054
Brugia malayi tailless protein 0.002 0.0122 0.0163
Onchocerca volvulus 0.0056 0.1174 0.1886
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0056 0.1174 0.1568
Brugia malayi nuclear receptor NHR-88 0.002 0.0122 0.0163
Trypanosoma brucei ribonuclease H1 0.0023 0.0221 0.0461
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0041 0.0756 0.1009
Entamoeba histolytica glyceraldehyde-3-phosphate dehydrogenase, putative 0.0132 0.3375 0.7641
Echinococcus multilocularis concentrative Na+ nucleoside cotransporter 0.0333 0.9208 0.9208
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0018 0.0085 0.0114
Echinococcus granulosus bloom syndrome protein 0.0041 0.0749 0.0749
Onchocerca volvulus Ribonuclease H1 homolog 0.0023 0.0221 0.0356
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0041 0.0756 0.0756
Echinococcus multilocularis ecdysone induced protein 78C 0.0041 0.0756 0.0756
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0053 0.1091 0.3093
Loa Loa (eye worm) hypothetical protein 0.0041 0.0756 0.1009
Echinococcus granulosus tumor protein p63 0.0328 0.9067 0.9067
Echinococcus multilocularis nuclear receptor nhr 48 0.002 0.0122 0.0122
Leishmania major adenosine monophosphate deaminase, putative,AMP deaminase, putative 0.0054 0.1131 0.2457
Echinococcus multilocularis solute carrier family 28 0.0333 0.9208 0.9208
Trypanosoma brucei RNA helicase, putative 0.0086 0.2051 0.5997
Brugia malayi orphan nuclear receptor NR2E1 0.002 0.0122 0.0163
Leishmania major glyceraldehyde 3-phosphate dehydrogenase, glycosomal 0.0132 0.3375 0.765
Leishmania major PIF1 helicase-like protein, putative,DNA repair and recombination protein, mitochondrial precursor, putative 0.0056 0.1186 0.2585
Brugia malayi steroid hormone receptor 0.0041 0.0756 0.1009
Trypanosoma cruzi DNA repair and recombination helicase protein PIF6, putative 0.0056 0.1186 0.3379
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0132 0.3375 0.5359
Echinococcus granulosus survival motor neuron protein 1 0.0274 0.7489 0.7489
Schistosoma mansoni AMP deaminase 0.0054 0.1131 0.1131
Toxoplasma gondii Adenosine/AMP deaminase domain-containing protein 0.0167 0.439 1
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0022 0.019 0.019
Trypanosoma cruzi DNA repair and recombination helicase protein PIF7, putative 0.0056 0.1186 0.3379
Plasmodium falciparum AMP deaminase, putative 0.0054 0.1131 0.2429
Schistosoma mansoni glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) 0.0132 0.3375 0.3375
Echinococcus granulosus nuclear receptor nhr 48 0.002 0.0122 0.0122
Brugia malayi intermediate filament protein 0.0054 0.1128 0.1506
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0029 0.0396 0.0396
Echinococcus multilocularis Nuclear hormone receptor HR96 0.002 0.0122 0.0122
Schistosoma mansoni hypothetical protein 0.0018 0.0069 0.0069
Loa Loa (eye worm) hypothetical protein 0.0113 0.2815 0.3759
Trichomonas vaginalis ribonuclease H1, putative 0.0023 0.0221 0.0222
Giardia lamblia Glyceraldehyde 3-phosphate dehydrogenase 0.0132 0.3375 1
Leishmania major cytidine deaminase-like protein 0.0104 0.2574 0.5796
Loa Loa (eye worm) hypothetical protein 0.0025 0.0286 0.0381
Schistosoma mansoni ap endonuclease 0.0018 0.0085 0.0085
Trichomonas vaginalis CMGC family protein kinase 0.0053 0.1091 0.1639
Brugia malayi hypothetical protein 0.0022 0.019 0.0253
Brugia malayi nuclear receptor RXR 0.002 0.0122 0.0163
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0026 0.0314 0.0314
Leishmania major orotidine-5-phosphate decarboxylase/orotate phosphoribosyltransferase, putative,OMPDCase-OPRTase, putative 0.0112 0.2799 0.6316

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 0.06 uM In vitro cytotoxic activity against human non small cell lung carcinoma H460 cell line ChEMBL. 11052801
IC50 (functional) = 0.06 uM In vitro cytotoxic activity against human non small cell lung carcinoma H460 cell line ChEMBL. 11052801

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23 11052801

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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