Detailed information for compound 223643

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 448.468 | Formula: C25H24N2O6
  • H donors: 1 H acceptors: 5 LogP: 1.44 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOC(=O)CCc1c2ccccc2nc2c1Cn1c2cc2c(c1=O)COC(=O)[C@]2(O)CC
  • InChi: 1S/C25H24N2O6/c1-3-25(31)18-11-20-22-16(12-27(20)23(29)17(18)13-33-24(25)30)14(9-10-21(28)32-4-2)15-7-5-6-8-19(15)26-22/h5-8,11,31H,3-4,9-10,12-13H2,1-2H3/t25-/m0/s1
  • InChiKey: PLSMRQXVNAASRW-VWLOTQADSA-N  

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0054 0.1128 0.1506
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0029 0.0396 0.0396
Plasmodium vivax ataxin-2 like protein, putative 0.0029 0.0401 0.0735
Brugia malayi exodeoxyribonuclease III family protein 0.0018 0.0085 0.0114
Plasmodium vivax orotate phosphoribosyltransferase, putative 0.0049 0.0985 0.209
Trypanosoma brucei ribonuclease H1 0.0023 0.0221 0.0461
Brugia malayi RNA recognition motif domain containing protein 0.0066 0.1465 0.1956
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0069 0.1559 0.1559
Trypanosoma cruzi AMP deaminase, putative 0.0054 0.1131 0.3212
Schistosoma mansoni phosphoglucomutase 0.0023 0.0221 0.0221
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0041 0.0756 0.1009
Entamoeba histolytica glyceraldehyde-3-phosphate dehydrogenase, putative 0.0132 0.3375 0.7641
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0029 0.0396 0.0396
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.0041 0.0739 0.2026
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0042 0.0761 0.0761
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0022 0.019 0.019
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0132 0.3375 0.5359
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0041 0.0756 0.1009
Schistosoma mansoni intermediate filament proteins 0.0054 0.1128 0.1128
Loa Loa (eye worm) TAR-binding protein 0.0066 0.1465 0.1956
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.0132 0.3375 1
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0041 0.0756 0.0756
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0041 0.0756 0.1009
Loa Loa (eye worm) bromodomain containing protein 0.002 0.0149 0.0198
Plasmodium vivax adenosine/AMP deaminase, putative 0.0054 0.1131 0.2429
Schistosoma mansoni lamin 0.0054 0.1128 0.1128
Brugia malayi Glyceraldehyde 3-phosphate dehydrogenase 0.0132 0.3375 0.4506
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0041 0.0756 0.0756
Loa Loa (eye worm) intermediate filament protein 0.0054 0.1128 0.1506
Trypanosoma cruzi cytidine deaminase-like protein 0.0104 0.2574 0.7577
Mycobacterium ulcerans adenosine deaminase 0.0167 0.439 1
Trypanosoma brucei hypothetical protein, conserved 0.0025 0.0278 0.0632
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0026 0.0312 0.0312
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0041 0.0756 0.1009
Echinococcus multilocularis geminin 0.0361 1 1
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.0132 0.3375 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0041 0.0756 0.1009
Brugia malayi hypothetical protein 0.0029 0.0401 0.0536
Echinococcus multilocularis nuclear receptor nhr 48 0.002 0.0122 0.0122
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0396 0.0396
Echinococcus multilocularis Polycystic kidney disease protein 0.0019 0.0119 0.0119
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0041 0.0756 0.0756
Trypanosoma cruzi PAB1-binding protein , putative 0.0029 0.0401 0.1006
Trichomonas vaginalis DNA helicase recq, putative 0.0041 0.0749 0.1082
Schistosoma mansoni thyroid hormone receptor 0.0172 0.455 0.455
Leishmania major hypothetical protein, conserved 0.0054 0.1131 0.2457
Wolbachia endosymbiont of Brugia malayi orotate phosphoribosyltransferase 0.0049 0.0985 0.2735
Echinococcus multilocularis solute carrier family 28 0.0333 0.9208 0.9208
Echinococcus multilocularis glyceraldehyde 3 phosphate dehydrogenase 0.0132 0.3375 0.3375
Leishmania major PIF1 helicase-like protein, putative,DNA repair and recombination protein, mitochondrial precursor, putative 0.0056 0.1186 0.2585
Brugia malayi RNase H family protein 0.0023 0.0221 0.0296
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0053 0.1091 0.2366
Leishmania major glyceraldehyde 3-phosphate dehydrogenase, glycosomal 0.0132 0.3375 0.765
Schistosoma mansoni cellular tumor antigen P53 0.0048 0.0948 0.0948
Echinococcus granulosus bloom syndrome protein 0.0041 0.0749 0.0749
Loa Loa (eye worm) hypothetical protein 0.002 0.0122 0.0163
Schistosoma mansoni ap endonuclease 0.0018 0.0085 0.0085
Echinococcus multilocularis sodium:nucleoside cotransporter 2 0.0217 0.5851 0.5851
Onchocerca volvulus 0.0104 0.2574 0.4136
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0054 0.1128 0.1506
Echinococcus granulosus tumor protein p63 0.0328 0.9067 0.9067
Loa Loa (eye worm) nuclear hormone receptor 0.002 0.0122 0.0163
Brugia malayi hypothetical protein 0.002 0.0122 0.0163
Trypanosoma cruzi AMP deaminase, putative 0.0054 0.1131 0.3212
Schistosoma mansoni steroid hormone receptor ad4bp 0.0041 0.0756 0.0756
Echinococcus granulosus cytidine deaminase 0.0104 0.2574 0.2574
Echinococcus multilocularis lipoxygenase domain containing protein 0.0019 0.0119 0.0119
Echinococcus multilocularis thyroid hormone receptor alpha 0.0172 0.455 0.455
Loa Loa (eye worm) hypothetical protein 0.0274 0.7489 1
Loa Loa (eye worm) hypothetical protein 0.0053 0.1099 0.1467
Wolbachia endosymbiont of Brugia malayi ribonuclease HI 0.0023 0.0221 0.0414
Onchocerca volvulus Protein ultraspiracle homolog 0.0041 0.0756 0.1214
Brugia malayi hypothetical protein 0.0022 0.019 0.0253
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0041 0.0756 0.0756
Loa Loa (eye worm) hypothetical protein 0.002 0.0122 0.0163
Brugia malayi nuclear hormone receptor family member nhr-6 0.002 0.0122 0.0163
Schistosoma mansoni rab6-interacting 0.0019 0.0119 0.0119
Echinococcus multilocularis lamin 0.0054 0.1128 0.1128
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0032 0.0469 0.1211
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.0097 0.2373 0.2373
Onchocerca volvulus 0.002 0.0122 0.0196
Toxoplasma gondii orotidine-5-phosphate decarboxylase/orotate phosphoribosyltransferase 0.0112 0.2799 0.6303
Echinococcus multilocularis glyceraldehyde 3 phosphate dehydrogenase 0.0132 0.3375 0.3375
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0041 0.0756 0.0756
Loa Loa (eye worm) hypothetical protein 0.002 0.0122 0.0163
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0049 0.0968 0.0968
Loa Loa (eye worm) hypothetical protein 0.0041 0.0756 0.1009
Brugia malayi RNase H family protein 0.0023 0.0221 0.0296
Loa Loa (eye worm) hypothetical protein 0.002 0.0122 0.0163
Trichomonas vaginalis cytidine deaminase, putative 0.0104 0.2574 0.4054
Echinococcus granulosus AMP deaminase 2 0.0054 0.1131 0.1131
Echinococcus multilocularis survival motor neuron protein 1 0.0274 0.7489 0.7489
Trypanosoma brucei AMP deaminase, putative 0.0054 0.1131 0.3212
Schistosoma mansoni methyl-cpg binding protein mbd 0.002 0.0128 0.0128
Loa Loa (eye worm) hypothetical protein 0.002 0.0122 0.0163
Leishmania major orotidine-5-phosphate decarboxylase/orotate phosphoribosyltransferase, putative,OMPDCase-OPRTase, putative 0.0112 0.2799 0.6316
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0032 0.0469 0.0926
Echinococcus granulosus glyceraldehyde 3 phosphate dehydrogenase 0.0086 0.2058 0.2058
Onchocerca volvulus 0.002 0.0122 0.0196
Loa Loa (eye worm) hypothetical protein 0.0048 0.0948 0.1266
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0066 0.1465 0.1956
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.002 0.0122 0.0122
Onchocerca volvulus Ribonuclease H1 homolog 0.0023 0.0221 0.0356
Loa Loa (eye worm) hypothetical protein 0.0082 0.1928 0.2575
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0041 0.0756 0.1009
Chlamydia trachomatis glyceraldehyde-3-phosphate dehydrogenase 0.0132 0.3375 0.5
Loa Loa (eye worm) hypothetical protein 0.0173 0.4567 0.6099
Plasmodium falciparum adenosine deaminase 0.0167 0.439 1
Trypanosoma cruzi glyceraldehyde-3-phosphate dehydrogenase, putative 0.0086 0.2056 0.601
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0132 0.3375 0.5359
Loa Loa (eye worm) hypothetical protein 0.0029 0.0396 0.0529
Brugia malayi nuclear receptor RXR 0.0022 0.019 0.0253
Schistosoma mansoni tar DNA-binding protein 0.0066 0.1465 0.1465
Plasmodium falciparum LCCL domain-containing protein 0.0019 0.0119 0.0079
Schistosoma mansoni loxhd1 0.0019 0.0119 0.0119
Trypanosoma brucei protein kinase, putative 0.0053 0.1091 0.3093
Toxoplasma gondii Adenosine/AMP deaminase domain-containing protein 0.0167 0.439 1
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0029 0.0398 0.0531
Mycobacterium tuberculosis Probable cytidine deaminase Cdd (cytidine aminohydrolase) (cytidine nucleoside deaminase) 0.0104 0.2574 0.5781
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0029 0.0396 0.0529
Giardia lamblia Glyceraldehyde 3-phosphate dehydrogenase 0.0132 0.3375 1
Schistosoma mansoni nuclear hormone receptor 0.0041 0.0756 0.0756
Onchocerca volvulus 0.0054 0.1128 0.1812
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.0132 0.3375 1
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.002 0.0122 0.0196
Trypanosoma cruzi glyceraldehyde-3-phosphate dehydrogenase, putative 0.0086 0.2056 0.601
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0041 0.0756 0.0756
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0053 0.1091 0.3093
Echinococcus granulosus glyceraldehyde 3 phosphate dehydrogenase 0.0132 0.3375 0.3375
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0029 0.0396 0.0723
Echinococcus granulosus Nuclear hormone receptor HR96 0.002 0.0122 0.0122
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0024 0.0248 0.0377
Leishmania major cytidine deaminase-like protein 0.0104 0.2574 0.5796
Onchocerca volvulus 0.0019 0.0119 0.0191
Schistosoma mansoni tar DNA-binding protein 0.0066 0.1465 0.1465
Schistosoma mansoni phosphoglucomutase 0.0023 0.0221 0.0221
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.002 0.0122 0.0122
Echinococcus multilocularis mitogen activated protein kinase 0.0053 0.1091 0.1091
Echinococcus granulosus zinc finger protein 0.0023 0.0213 0.0213
Giardia lamblia Ribonuclease H 0.0023 0.0221 0.0414
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0054 0.1133 0.1133
Echinococcus multilocularis AMP deaminase 2 0.0054 0.1131 0.1131
Trypanosoma brucei AMP deaminase, putative 0.0054 0.1131 0.3212
Plasmodium falciparum orotidine 5'-phosphate decarboxylase 0.0112 0.2799 0.6303
Loa Loa (eye worm) hypothetical protein 0.0027 0.0337 0.045
Trichomonas vaginalis ribonuclease H1, putative 0.0023 0.0221 0.0222
Loa Loa (eye worm) hypothetical protein 0.0086 0.2058 0.2748
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0086 0.2058 0.3214
Loa Loa (eye worm) hypothetical protein 0.0041 0.0756 0.1009
Echinococcus granulosus jun protein 0.0097 0.2373 0.2373
Echinococcus granulosus mitogen activated protein kinase 0.0053 0.1091 0.1091
Echinococcus multilocularis lamin dm0 0.0054 0.1128 0.1128
Loa Loa (eye worm) DR-78 0.002 0.0122 0.0163
Echinococcus granulosus nuclear receptor nhr 48 0.002 0.0122 0.0122
Brugia malayi Nuclear hormone receptor E75 0.002 0.0122 0.0163
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.0132 0.3375 1
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0053 0.1091 0.3093
Loa Loa (eye worm) nuclear receptor NHR-67 0.002 0.0122 0.0163
Brugia malayi Pre-SET motif family protein 0.0202 0.5414 0.7229
Schistosoma mansoni phosphoglucomutase 0.0023 0.0221 0.0221
Schistosoma mansoni RAR-like nuclear receptor 0.0041 0.0756 0.0756
Toxoplasma gondii glyceraldehyde-3-phosphate dehydrogenase GAPDH2 0.0132 0.3375 0.7641
Schistosoma mansoni DNA helicase recq5 0.0029 0.0396 0.0396
Toxoplasma gondii orotate phosphoribosyltransferase 0.0049 0.0985 0.209
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0029 0.0396 0.0396
Schistosoma mansoni zinc finger protein 0.002 0.0122 0.0122
Toxoplasma gondii AMP deaminase 0.0054 0.1131 0.2429
Trypanosoma cruzi AMP deaminase, putative 0.0054 0.1131 0.3212
Loa Loa (eye worm) hypothetical protein 0.0022 0.019 0.0253
Giardia lamblia Glyceraldehyde 3-phosphate dehydrogenase 0.0086 0.2056 0.599
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0029 0.0396 0.0529
Schistosoma mansoni jun-related protein 0.0079 0.1845 0.1845
Entamoeba histolytica glyceraldehyde-3-phosphate dehydrogenase, putative 0.0132 0.3375 0.7641
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain, putative 0.0041 0.0739 0.2026
Schistosoma mansoni tar DNA-binding protein 0.0066 0.1465 0.1465
Schistosoma mansoni coup transcription factor 0.0041 0.0756 0.0756
Echinococcus granulosus uridine 5' monophosphate synthase 0.0112 0.2799 0.2799
Brugia malayi Adenosine/AMP deaminase family protein 0.0167 0.439 0.5862
Leishmania major glyceraldehyde 3-phosphate dehydrogenase, glycosomal 0.0132 0.3375 0.765
Echinococcus multilocularis ecdysone induced protein 78C 0.0041 0.0756 0.0756
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.0041 0.0739 0.2026
Schistosoma mansoni zinc finger protein 0.0023 0.0213 0.0213
Trypanosoma brucei adenosine monophosphate deaminase, putative 0.0054 0.1131 0.3212
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0041 0.0756 0.0756
Giardia lamblia Sgs1 DNA helicase, putative 0.0029 0.0396 0.0946
Echinococcus multilocularis uridine 5' monophosphate synthase 0.0112 0.2799 0.2799
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0122 0.0122
Trypanosoma brucei PAB1-binding protein , putative 0.0029 0.0401 0.1006
Loa Loa (eye worm) hypothetical protein 0.0022 0.019 0.0253
Mycobacterium leprae Probable orotidine 5'-phosphate decarboxylase PyrF (OMP decarboxylase) (OMPDCase) (OMPdecase) 0.0112 0.2799 0.5472
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.0041 0.0739 0.2026
Onchocerca volvulus Adenosine deaminase homolog 0.0167 0.439 0.7055
Loa Loa (eye worm) hypothetical protein 0.0113 0.2815 0.3759
Loa Loa (eye worm) glyceraldehyde-3-phosphate dehydrogenase 0.0091 0.2192 0.2926
Brugia malayi Bromodomain containing protein 0.0044 0.0841 0.1123
Loa Loa (eye worm) MH2 domain-containing protein 0.0138 0.3561 0.4755
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0053 0.1091 0.2337
Schistosoma mansoni hypothetical protein 0.0361 1 1
Schistosoma mansoni hypothetical protein 0.0086 0.2051 0.2051
Loa Loa (eye worm) hypothetical protein 0.0022 0.019 0.0253
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.002 0.0122 0.0122
Brugia malayi adenosine monophosphate deaminase 0.0054 0.1131 0.151
Trichomonas vaginalis DNA helicase recq1, putative 0.0041 0.0749 0.1082
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0069 0.1559 0.1559
Entamoeba histolytica hypothetical protein, conserved 0.0056 0.1186 0.2557
Onchocerca volvulus 0.0041 0.0756 0.1214
Echinococcus granulosus RUN 0.0019 0.0119 0.0119
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0022 0.019 0.019
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.002 0.0122 0.0122
Echinococcus granulosus lipoxygenase domain containing protein 0.0019 0.0119 0.0119
Brugia malayi hypothetical protein 0.0019 0.0119 0.0159
Echinococcus multilocularis glyceraldehyde 3 phosphate dehydrogenase 0.0086 0.2058 0.2058
Mycobacterium tuberculosis Probable adenosine deaminase Add (adenosine aminohydrolase) 0.0167 0.439 1
Plasmodium falciparum AMP deaminase, putative 0.0054 0.1131 0.2429
Loa Loa (eye worm) hypothetical protein 0.0041 0.0756 0.1009
Schistosoma mansoni hypothetical protein 0.0024 0.0248 0.0248
Echinococcus granulosus ecdysone induced protein 78C 0.0041 0.0756 0.0756
Entamoeba histolytica adenosine deaminase, putative 0.0167 0.439 1
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0053 0.1091 0.2366
Echinococcus granulosus thyroid hormone receptor alpha 0.002 0.0122 0.0122
Schistosoma mansoni retinoic acid receptor RXR 0.0041 0.0756 0.0756
Trypanosoma cruzi PAB1-binding protein , putative 0.0029 0.0401 0.1006
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.002 0.0122 0.0163
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0041 0.0756 0.1009
Onchocerca volvulus AMP deaminase 2 homolog 0.0054 0.1131 0.1817
Onchocerca volvulus Bile acid receptor homolog 0.0041 0.0756 0.1214
Plasmodium vivax glyceraldehyde-3-phosphate dehydrogenase, putative 0.0132 0.3375 0.7641
Schistosoma mansoni nuclear receptor 0.002 0.0122 0.0122
Schistosoma mansoni nuclear receptor nhr-48 0.002 0.0122 0.0122
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0018 0.0085 0.0085
Toxoplasma gondii Adenosine/AMP deaminase domain-containing protein 0.0167 0.439 1
Loa Loa (eye worm) hypothetical protein 0.0113 0.2815 0.3759
Echinococcus multilocularis lipoxygenase domain containing protein 0.0019 0.0119 0.0119
Loa Loa (eye worm) hypothetical protein 0.002 0.0122 0.0163
Trypanosoma brucei glyceraldehyde 3-phosphate dehydrogenase, glycosomal 0.0132 0.3375 1
Plasmodium vivax adenosine deaminase, putative 0.0167 0.439 1
Loa Loa (eye worm) hypothetical protein 0.0054 0.1131 0.151
Brugia malayi nuclear receptor RXR 0.002 0.0122 0.0163
Brugia malayi Bloom's syndrome protein homolog 0.0041 0.0749 0.1
Schistosoma mansoni tar DNA-binding protein 0.0066 0.1465 0.1465
Echinococcus granulosus Na+ dependent nucleoside transporter 0.0333 0.9208 0.9208
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0026 0.0314 0.0314
Onchocerca volvulus 0.0104 0.2574 0.4136
Schistosoma mansoni lamin 0.0054 0.1128 0.1128
Brugia malayi Pre-SET motif family protein 0.0029 0.0396 0.0529
Trypanosoma cruzi cytidine deaminase-like protein, putative 0.0104 0.2574 0.7577
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0045 0.0873 0.1283
Onchocerca volvulus 0.0048 0.0948 0.1523
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0053 0.1091 0.3093
Plasmodium vivax SET domain protein, putative 0.0029 0.0396 0.0722
Schistosoma mansoni glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) 0.0132 0.3375 0.3375
Giardia lamblia Rrm3p helicase 0.0056 0.1186 0.3346
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.002 0.0122 0.0196
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0041 0.0756 0.1009
Loa Loa (eye worm) hypothetical protein 0.0167 0.439 0.5862
Schistosoma mansoni serine/threonine protein kinase 0.0053 0.1091 0.1091
Echinococcus multilocularis musashi 0.0054 0.1128 0.1128
Echinococcus granulosus solute carrier family 28 0.0333 0.9208 0.9208
Brugia malayi nuclear hormone receptor 0.002 0.0122 0.0163
Trypanosoma brucei retrotransposon hot spot protein 4 (RHS4), interrupted 0.0025 0.0278 0.0632
Echinococcus granulosus fetal alzheimer antigen falz 0.0026 0.0312 0.0312
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0132 0.3375 0.5359
Schistosoma mansoni adenosine deaminase-related 0.0167 0.439 0.439
Treponema pallidum adenosine deaminase 0.0167 0.439 1
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0041 0.0756 0.0756
Schistosoma mansoni thyroid hormone receptor 0.0172 0.455 0.455
Trypanosoma brucei glyceraldehyde 3-phosphate dehydrogenase, glycosomal 0.0132 0.3375 1
Schistosoma mansoni DNA helicase recq1 0.0029 0.0396 0.0396
Echinococcus multilocularis zinc finger protein 0.0023 0.0213 0.0213
Wolbachia endosymbiont of Brugia malayi glyceraldehyde-3-phosphate dehydrogenase, GapA 0.0132 0.3375 1
Loa Loa (eye worm) hypothetical protein 0.0025 0.0286 0.0381
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0041 0.0756 0.1009
Leishmania major AMP deaminase, putative,amp deaminase-like protein 0.0054 0.1131 0.2457
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0202 0.5414 0.7229
Loa Loa (eye worm) hypothetical protein 0.002 0.0122 0.0163
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0018 0.0085 0.0049
Plasmodium falciparum ataxin-2 like protein, putative 0.0029 0.0401 0.0735
Echinococcus granulosus adenosine deaminase 0.0167 0.439 0.439
Plasmodium falciparum orotate phosphoribosyltransferase 0.0049 0.0985 0.209
Echinococcus multilocularis ribonuclease H1 0.0023 0.0221 0.0221
Loa Loa (eye worm) hypothetical protein 0.0026 0.0314 0.042
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0029 0.0396 0.0723
Plasmodium vivax multidomain scavenger receptor, putative 0.0019 0.0119 0.0079
Brugia malayi MAP kinase sur-1 0.0053 0.1091 0.1457
Echinococcus granulosus survival motor neuron protein 1 0.0274 0.7489 0.7489
Toxoplasma gondii glyceraldehyde-3-phosphate dehydrogenase GAPDH1 0.0132 0.3375 0.7641
Brugia malayi orotate phosphoribosyltransferase family protein 0.0112 0.2799 0.3737
Loa Loa (eye worm) hypothetical protein 0.0113 0.2815 0.3759
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.0132 0.3375 1
Schistosoma mansoni survival motor neuron protein 0.0056 0.1174 0.1174
Trypanosoma cruzi adenosine monophosphate deaminase-like protein, putative 0.0054 0.1131 0.3212
Brugia malayi nuclear hormone receptor 0.0041 0.0756 0.1009
Loa Loa (eye worm) hypothetical protein 0.0041 0.0756 0.1009
Loa Loa (eye worm) glyceraldehyde 3-phosphate dehydrogenase 0.0086 0.2058 0.2748
Schistosoma mansoni hypothetical protein 0.0131 0.335 0.335
Loa Loa (eye worm) hypothetical protein 0.0022 0.019 0.0253
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0041 0.0756 0.1009
Schistosoma mansoni hypothetical protein 0.0056 0.1186 0.1186
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0041 0.0756 0.0756
Trichomonas vaginalis CMGC family protein kinase 0.0053 0.1091 0.1639
Brugia malayi TAR-binding protein 0.0066 0.1465 0.1956
Loa Loa (eye worm) glyceraldehyde 3-phosphate dehydrogenase 0.0086 0.2058 0.2748
Mycobacterium tuberculosis Probable orotidine 5'-phosphate decarboxylase PyrF (OMP decarboxylase) (ompdecase) 0.0049 0.0985 0.209
Loa Loa (eye worm) hypothetical protein 0.0047 0.0923 0.1232
Echinococcus multilocularis FTZ F1 alpha 0.0041 0.0756 0.0756
Brugia malayi hypothetical protein 0.0076 0.1768 0.2361
Entamoeba histolytica glyceraldehyde-3-phosphate dehydrogenase, putative 0.0132 0.3375 0.7641
Echinococcus granulosus FTZ F1 alpha 0.0041 0.0756 0.0756
Loa Loa (eye worm) hypothetical protein 0.0041 0.0756 0.1009
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0041 0.0756 0.1009
Schistosoma mansoni glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) 0.0132 0.3375 0.3375
Brugia malayi orphan nuclear receptor NR2E1 0.002 0.0122 0.0163
Trypanosoma brucei ingi protein (ORF1) 0.0025 0.0278 0.0632
Entamoeba histolytica recQ family helicase, putative 0.0032 0.0469 0.0892
Echinococcus granulosus Nuclear hormone receptor HR96 0.002 0.0122 0.0122
Echinococcus multilocularis muscleblind protein 1 0.0173 0.4567 0.4567
Echinococcus granulosus lamin dm0 0.0054 0.1128 0.1128
Mycobacterium ulcerans glyceraldehyde 3-phosphate dehydrogenase Gap 0.0132 0.3375 0.7641
Brugia malayi cytidine deaminase, identical 0.0104 0.2574 0.3437
Entamoeba histolytica AMP deaminase, putative 0.0054 0.1131 0.2429
Brugia malayi tailless protein 0.002 0.0122 0.0163
Plasmodium falciparum glyceraldehyde-3-phosphate dehydrogenase 0.0132 0.3375 0.7641
Brugia malayi nuclear receptor NHR-67 0.002 0.0122 0.0163
Schistosoma mansoni nuclear receptor 0.002 0.0122 0.0122
Brugia malayi hypothetical protein 0.0019 0.0102 0.0136
Toxoplasma gondii LsmAD domain-containing protein 0.0029 0.0401 0.0735
Echinococcus multilocularis methyl CpG binding domain protein 2 0.002 0.0128 0.0128
Mycobacterium leprae PROBABLE CYTIDINE DEAMINASE CDD (CYTIDINE AMINOHYDROLASE) (CYTIDINE NUCLEOSIDE DEAMINASE) 0.0104 0.2574 0.4833
Plasmodium falciparum ataxin-2 like protein, putative 0.0029 0.0401 0.0735
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0131 0.335 0.335
Trypanosoma cruzi DNA repair and recombination helicase protein PIF7, putative 0.0056 0.1186 0.3379
Loa Loa (eye worm) hypothetical protein 0.002 0.0122 0.0163
Trypanosoma cruzi AMP deaminase 2, putative 0.0054 0.1131 0.3212
Schistosoma mansoni rab6-interacting 0.0019 0.0119 0.0119
Schistosoma mansoni hypothetical protein 0.0018 0.0069 0.0069
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0041 0.0756 0.0756
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0041 0.0756 0.0756
Schistosoma mansoni bromodomain containing protein 0.0073 0.1679 0.1679
Schistosoma mansoni methyl-cpg binding protein mbd 0.002 0.0128 0.0128
Trypanosoma brucei DNA repair and recombination helicase protein PIF6 0.0056 0.1186 0.3379
Trypanosoma cruzi AMP deaminase, putative 0.0054 0.1131 0.3212
Loa Loa (eye worm) hypothetical protein 0.0029 0.0401 0.0536
Schistosoma mansoni adenosine deaminase 0.0167 0.439 0.439
Schistosoma mansoni hypothetical protein 0.0361 1 1
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0132 0.3375 0.5359
Mycobacterium tuberculosis Probable orotate phosphoribosyltransferase PyrE (OPRT) (oprtase) 0.0049 0.0985 0.209
Loa Loa (eye worm) hypothetical protein 0.002 0.0122 0.0163
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0029 0.0396 0.0529
Echinococcus multilocularis cytidine deaminase 0.0104 0.2574 0.2574
Echinococcus granulosus glyceraldehyde 3 phosphate dehydrogenase 0.0132 0.3375 0.3375
Brugia malayi hypothetical protein 0.0019 0.0119 0.0159
Trypanosoma brucei RNA helicase, putative 0.0086 0.2051 0.5997
Onchocerca volvulus 0.0019 0.0119 0.0191
Brugia malayi photoreceptor-specific nuclear receptor 0.0041 0.0756 0.1009
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0054 0.1133 0.1133
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0041 0.0756 0.1009
Trichomonas vaginalis CMGC family protein kinase 0.0053 0.1091 0.1639
Loa Loa (eye worm) hypothetical protein 0.0049 0.0968 0.1293
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0041 0.0756 0.0756
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.0132 0.3375 1
Schistosoma mansoni nuclear hormone receptor 0.002 0.0122 0.0122
Loa Loa (eye worm) hypothetical protein 0.0019 0.0119 0.0159
Onchocerca volvulus 0.0056 0.1174 0.1886
Trypanosoma brucei DNA repair and recombination helicase protein PIF7 0.0056 0.1186 0.3379
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0365 0.0365
Brugia malayi Doublecortin family protein 0.0019 0.0119 0.0159
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0041 0.0756 0.1009
Loa Loa (eye worm) orotate phosphoribosyltransferase 0.0112 0.2799 0.3737
Plasmodium vivax orotidine 5'-phosphate decarboxylase, putative 0.0112 0.2799 0.6303
Schistosoma mansoni hypothetical protein 0.0079 0.1845 0.1845
Loa Loa (eye worm) hypothetical protein 0.0049 0.0987 0.1317
Loa Loa (eye worm) hypothetical protein 0.0041 0.0756 0.1009
Schistosoma mansoni lipoxygenase 0.0019 0.0119 0.0119
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0029 0.0396 0.0396
Loa Loa (eye worm) AMP deaminase 0.0054 0.1131 0.151
Schistosoma mansoni blooms syndrome DNA helicase 0.0026 0.0321 0.0321
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0032 0.0469 0.1211
Brugia malayi glyceraldehyde 3-phosphate dehydrogenase 0.0041 0.0739 0.0987
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0026 0.0312 0.0312
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.0132 0.3375 1
Brugia malayi Nuclear hormone receptor-like 1 0.0022 0.019 0.0253
Giardia lamblia Kinase, CMGC MAPK 0.0053 0.1091 0.3059
Leishmania major AMP deaminase, putative,adenosine monophosphate deaminase-like protein 0.0054 0.1131 0.2457
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0041 0.0756 0.0756
Echinococcus granulosus Polycystic kidney disease protein 0.0019 0.0119 0.0119
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0041 0.0756 0.1009
Echinococcus granulosus lamin 0.0054 0.1128 0.1128
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0041 0.0756 0.1009
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0041 0.0756 0.0756
Brugia malayi ecdysone receptor 0.002 0.0122 0.0163
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0039 0.0676 0.1373
Trypanosoma brucei AMP deaminase, putative 0.0054 0.1131 0.3212
Loa Loa (eye worm) hypothetical protein 0.0173 0.4567 0.6099
Mycobacterium leprae PROBABLE OROTATE PHOSPHORIBOSYLTRANSFERASE PYRE (OPRT) (OPRTASE) 0.0049 0.0985 0.0313
Mycobacterium leprae Probable adenosine deaminase Add (ADENOSINE AMINOHYDROLASE) 0.0167 0.439 1
Echinococcus granulosus concentrative Na nucleoside cotransporter 0.0333 0.9208 0.9208
Echinococcus granulosus ribonuclease H1 0.0023 0.0221 0.0221
Trypanosoma cruzi AMP deaminase, putative 0.0054 0.1131 0.3212
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0018 0.0085 0.0114
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0018 0.0085 0.0049
Trypanosoma cruzi orotidine-5-phosphate decarboxylase/orotate phosphoribosyltransferase, putative 0.0112 0.2799 0.8257
Loa Loa (eye worm) hypothetical protein 0.0025 0.0286 0.0381
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0029 0.0396 0.0396
Loa Loa (eye worm) glyceraldehyde-3-phosphate dehydrogenase 0.0091 0.2192 0.2926
Trichomonas vaginalis set domain proteins, putative 0.023 0.6223 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0041 0.0756 0.1009
Loa Loa (eye worm) RNA binding protein 0.0066 0.1465 0.1956
Loa Loa (eye worm) hypothetical protein 0.0095 0.2296 0.3066
Loa Loa (eye worm) hypothetical protein 0.002 0.0122 0.0163
Trypanosoma brucei cytidine deaminase 0.0104 0.2574 0.7577
Loa Loa (eye worm) hypothetical protein 0.0044 0.0843 0.1126
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0042 0.0761 0.0761
Trypanosoma cruzi ribonuclease H1, putative 0.0023 0.0221 0.0461
Brugia malayi nuclear receptor NHR-88 0.002 0.0122 0.0163
Entamoeba histolytica adenosine deaminase, putative 0.0167 0.439 1
Brugia malayi intermediate filament protein 0.0054 0.1128 0.1506
Echinococcus granulosus methyl CpG binding domain protein 2 0.002 0.0128 0.0128
Brugia malayi steroid hormone receptor 0.0041 0.0756 0.1009
Leishmania major AMP deaminase, putative 0.0054 0.1131 0.2457
Brugia malayi cytoplasmic intermediate filament protein 0.0029 0.0398 0.0531
Onchocerca volvulus 0.023 0.6223 1
Giardia lamblia Cytidine deaminase 0.0104 0.2574 0.7565
Schistosoma mansoni nuclear hormone receptor 0.002 0.0122 0.0122
Brugia malayi bZIP transcription factor family protein 0.0097 0.2373 0.3169
Leishmania major hypothetical protein, conserved 0.0029 0.0401 0.0769
Schistosoma mansoni lipoxygenase 0.0054 0.1133 0.1133
Trypanosoma cruzi DNA repair and recombination helicase protein PIF7, putative 0.0056 0.1186 0.3379
Schistosoma mansoni glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) 0.0132 0.3375 0.3375
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.0097 0.2373 0.2373
Entamoeba histolytica DNA repair and recombination protein, putative 0.0056 0.1186 0.2557
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0029 0.0396 0.0722
Trypanosoma cruzi DNA repair and recombination helicase protein PIF6, putative 0.0056 0.1186 0.3379
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0056 0.1174 0.1568
Echinococcus granulosus muscleblind protein 0.0173 0.4567 0.4567
Brugia malayi ecdysteroid receptor 0.0041 0.0756 0.1009
Brugia malayi nuclear hormone receptor family member odr-7 0.002 0.0122 0.0163
Brugia malayi hypothetical protein 0.0022 0.019 0.0253
Leishmania major ribonuclease H1, putative 0.0023 0.0221 0.0352
Toxoplasma gondii cytidine and deoxycytidylate deaminase zinc-binding region domain-containing protein 0.0104 0.2574 0.5781
Brugia malayi Muscleblind-like protein 0.0173 0.4567 0.6099
Trypanosoma brucei orotidine-5-phosphate decarboxylase/orotate phosphoribosyltransferase, putative 0.0112 0.2799 0.8257
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0041 0.0756 0.1009
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0053 0.1091 0.3093
Trichomonas vaginalis conserved hypothetical protein 0.0056 0.1186 0.1793
Trichomonas vaginalis cytidine deaminase, putative 0.0104 0.2574 0.4054
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0041 0.0756 0.0756
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0086 0.2058 0.3214
Loa Loa (eye worm) hypothetical protein 0.0041 0.0756 0.1009
Loa Loa (eye worm) nuclear receptor nhr-7B 0.002 0.0122 0.0163
Echinococcus multilocularis Nuclear hormone receptor HR96 0.002 0.0122 0.0122
Trichomonas vaginalis CMGC family protein kinase 0.0053 0.1091 0.1639
Loa Loa (eye worm) hypothetical protein 0.0041 0.0756 0.1009
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain, putative 0.0041 0.0739 0.2026
Echinococcus multilocularis muscleblind protein 0.0173 0.4567 0.4567
Echinococcus multilocularis concentrative Na+ nucleoside cotransporter 0.0333 0.9208 0.9208
Schistosoma mansoni hypothetical protein 0.0019 0.0119 0.0119
Onchocerca volvulus 0.0029 0.0396 0.0636
Trypanosoma cruzi orotidine-5-phosphate decarboxylase/orotate phosphoribosyltransferase, putative 0.0112 0.2799 0.8257
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0053 0.1091 0.3093
Onchocerca volvulus 0.0054 0.1128 0.1812
Toxoplasma gondii ribonuclease HI protein 0.0023 0.0221 0.0316
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0041 0.0756 0.1009
Echinococcus multilocularis tumor protein p63 0.0328 0.9067 0.9067
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0041 0.0756 0.0756
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0041 0.0756 0.0756
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0041 0.0756 0.1009
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0041 0.0756 0.0756
Schistosoma mansoni glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) 0.0132 0.3375 0.3375
Onchocerca volvulus 0.0054 0.1131 0.1817
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0022 0.019 0.019
Trichomonas vaginalis DNA helicase recq, putative 0.0032 0.0469 0.0626
Echinococcus multilocularis ATP dependent DNA helicase PIF1 0.0056 0.1186 0.1186
Brugia malayi conserved hypotetical protein 0.002 0.0122 0.0163
Leishmania major adenine aminohydrolase 0.0167 0.439 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0049 0.0968 0.0968
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0026 0.0314 0.0314
Loa Loa (eye worm) hypothetical protein 0.0019 0.0119 0.0159
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0022 0.019 0.019
Schistosoma mansoni hypothetical protein 0.0056 0.1174 0.1174
Treponema pallidum glyceraldehyde 3-phosphate dehydrogenase (gap) 0.0132 0.3375 0.7641
Loa Loa (eye worm) steroid hormone receptor 0.0041 0.0756 0.1009
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0024 0.0264 0.0415
Brugia malayi Intermediate filament tail domain containing protein 0.0054 0.1128 0.1506
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0053 0.1091 0.1457
Entamoeba histolytica AMP deaminase, putative 0.0054 0.1131 0.2429
Trypanosoma brucei ingi protein (ORF1) 0.0025 0.0278 0.0632
Echinococcus multilocularis bloom syndrome protein 0.0041 0.0749 0.0749
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0132 0.3375 0.5359
Echinococcus granulosus intermediate filament protein 0.0054 0.1128 0.1128
Loa Loa (eye worm) hypothetical protein 0.002 0.0122 0.0163
Schistosoma mansoni ap endonuclease 0.0018 0.0085 0.0085
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0029 0.0396 0.0396
Wolbachia endosymbiont of Brugia malayi orotidine-5'-phosphate decarboxylase 0.0063 0.137 0.3904
Brugia malayi MH2 domain containing protein 0.0138 0.3561 0.4755
Brugia malayi Glyceraldehyde 3-phosphate dehydrogenase 0.0045 0.0873 0.1165
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0018 0.0085 0.0085
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0041 0.0756 0.0756
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0029 0.0396 0.0723
Trypanosoma brucei unspecified product 0.0025 0.0278 0.0632
Loa Loa (eye worm) hypothetical protein 0.0022 0.019 0.0253
Mycobacterium ulcerans cytidine deaminase 0.0104 0.2574 0.5781
Brugia malayi hypothetical protein 0.002 0.0122 0.0163
Echinococcus multilocularis Nuclear hormone receptor HR96 0.002 0.0122 0.0122
Echinococcus granulosus tar DNA binding protein 0.0066 0.1465 0.1465
Trypanosoma brucei glyceraldehyde 3-phosphate dehydrogenase, cytosolic 0.0132 0.3375 1
Leishmania major PIF1 helicase-like protein, putative,DNA repair and recombination protein, mitochondrial precursor, putative 0.0056 0.1186 0.2585
Brugia malayi Nuclear hormone receptor-like 1 0.0022 0.019 0.0253
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0022 0.019 0.0253
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0018 0.0085 0.0037
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.002 0.0122 0.0122
Echinococcus multilocularis adenosine deaminase 0.0167 0.439 0.439
Trypanosoma cruzi orotidine-5-phosphate decarboxylase/orotate phosphoribosyltransferase, putative 0.0112 0.2799 0.8257
Echinococcus multilocularis jun protein 0.0097 0.2373 0.2373
Mycobacterium ulcerans orotidine 5'-phosphate decarboxylase 0.0112 0.2799 0.6303
Trichomonas vaginalis adenosine deaminase, putative 0.0167 0.439 0.7014
Trypanosoma cruzi adenosine monophosphate deaminase, putative 0.0054 0.1131 0.3212
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0049 0.0968 0.0968
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0041 0.0756 0.1214
Trypanosoma brucei glyceraldehyde-3-phosphate dehydrogenase, putative 0.0086 0.2056 0.601
Echinococcus granulosus mitogen activated protein kinase 3 0.0053 0.1091 0.1091
Leishmania major adenosine monophosphate deaminase, putative,AMP deaminase, putative 0.0054 0.1131 0.2457
Trichomonas vaginalis adenosine deaminase, putative 0.0167 0.439 0.7014
Brugia malayi RNA binding protein 0.0066 0.1465 0.1956
Echinococcus granulosus lipoxygenase domain containing protein 0.0019 0.0119 0.0119
Brugia malayi RNase H family protein 0.0023 0.0221 0.0296
Loa Loa (eye worm) hypothetical protein 0.0113 0.2815 0.3759
Mycobacterium ulcerans orotate phosphoribosyltransferase 0.0049 0.0985 0.209
Trichomonas vaginalis CMGC family protein kinase 0.0053 0.1091 0.1639
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0018 0.0085 0.0049
Brugia malayi hypothetical protein 0.0274 0.7489 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0041 0.0756 0.1009
Loa Loa (eye worm) hypothetical protein 0.002 0.0122 0.0163
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0131 0.335 0.335
Loa Loa (eye worm) hypothetical protein 0.002 0.0122 0.0163
Treponema pallidum ribonuclease H (rnhA) 0.0023 0.0221 0.0316
Schistosoma mansoni zinc finger protein 0.0018 0.0069 0.0069
Echinococcus granulosus histone lysine methyltransferase setb 0.0049 0.0968 0.0968
Schistosoma mansoni polycystin 1-related 0.0019 0.0119 0.0119
Loa Loa (eye worm) PHD-finger family protein 0.0024 0.0248 0.0331
Loa Loa (eye worm) doublecortin family protein 0.0019 0.0119 0.0159
Onchocerca volvulus 0.0076 0.1768 0.2841
Brugia malayi Nuclear hormone receptor-like 1 0.0041 0.0756 0.1009
Brugia malayi Nuclear hormone receptor E75 0.002 0.0122 0.0163
Trypanosoma cruzi ribonuclease H1, putative 0.0023 0.0221 0.0461
Brugia malayi Bromodomain containing protein 0.0087 0.2072 0.2767
Leishmania major glyceraldehyde-3-phosphate dehydrogenase-like protein 0.0086 0.2056 0.4597
Echinococcus multilocularis RUN 0.0019 0.0119 0.0119
Entamoeba histolytica cytidine deaminase, putative 0.0104 0.2574 0.5781
Brugia malayi PHD-finger family protein 0.0029 0.0392 0.0523
Brugia malayi nuclear receptor NHR-88 0.0041 0.0756 0.1009
Schistosoma mansoni orotidine 5'-phosphate decarboxylase 0.0112 0.2799 0.2799
Mycobacterium tuberculosis Probable glyceraldehyde 3-phosphate dehydrogenase Gap (GAPDH) 0.0046 0.0875 0.1834
Echinococcus multilocularis tar DNA binding protein 0.0066 0.1465 0.1465
Brugia malayi Steroid receptor seven-up type 2 0.0041 0.0756 0.1009
Echinococcus multilocularis mitogen activated protein kinase 3 0.0053 0.1091 0.1091
Schistosoma mansoni AMP deaminase 0.0054 0.1131 0.1131
Loa Loa (eye worm) RecQ helicase 0.0041 0.0749 0.1
Loa Loa (eye worm) transcription factor SMAD2 0.0138 0.3561 0.4755
Schistosoma mansoni tar DNA-binding protein 0.0066 0.1465 0.1465
Echinococcus granulosus ATP dependent DNA helicase PIF1 0.0056 0.1186 0.1186
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0122 0.0122

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 0.06 uM In vitro cytotoxic activity against human non small cell lung carcinoma H460 cell line ChEMBL. 11052801
IC50 (functional) = 0.06 uM In vitro cytotoxic activity against human non small cell lung carcinoma H460 cell line ChEMBL. 11052801

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23 11052801

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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