Detailed information for compound 223695

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 438.557 | Formula: C30H30O3
  • H donors: 1 H acceptors: 1 LogP: 6.37 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCc1cc2cc(OCc3cccc(c3)C3(O)CCOCC3)ccc2c(c1)c1ccccc1
  • InChi: 1S/C30H30O3/c1-2-22-17-25-20-27(11-12-28(25)29(19-22)24-8-4-3-5-9-24)33-21-23-7-6-10-26(18-23)30(31)13-15-32-16-14-30/h3-12,17-20,31H,2,13-16,21H2,1H3
  • InChiKey: HFPITKHYGHMBJB-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens arachidonate 5-lipoxygenase Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum ko:K00461 arachidonate 5-lipoxygenase [EC1.13.11.34], putative Get druggable targets OG5_127482 All targets in OG5_127482
Schistosoma mansoni lipoxygenase Get druggable targets OG5_127482 All targets in OG5_127482
Schistosoma japonicum IPR001024,Lipoxygenase, LH2;IPR013819,Lipoxygenase, C-terminal,domain-containing Get druggable targets OG5_127482 All targets in OG5_127482
Schistosoma mansoni lipoxygenase Get druggable targets OG5_127482 All targets in OG5_127482
Echinococcus multilocularis arachidonate 5 lipoxygenase Get druggable targets OG5_127482 All targets in OG5_127482
Echinococcus granulosus arachidonate 5 lipoxygenase Get druggable targets OG5_127482 All targets in OG5_127482
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.005 0.0023 0.0048
Brugia malayi aryl hydrocarbon receptor AHR-1 0.004 0.0016 0.0016
Onchocerca volvulus Folate transporter 1 homolog 0.0107 0.0057 0.0847
Echinococcus granulosus folate receptor beta 0.0915 0.0547 0.0547
Brugia malayi Nuclear hormone receptor-like 1 0.0047 0.0021 0.0021
Trichomonas vaginalis peroxiredoxin, putative 0.0024 0.0006 0.0167
Brugia malayi Probable ClpP-like protease 0.0086 0.0044 0.0044
Giardia lamblia DINP protein human, muc B family 0.0044 0.0019 0.3285
Loa Loa (eye worm) multidrug resistance-associated protein 0.0022 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0014 0 0.0000059338
Toxoplasma gondii enoyl-acyl carrier reductase ENR 0.0031 0.0011 0.0023
Mycobacterium tuberculosis Probable 3-oxoacyl-[acyl-carrier protein] reductase FabG2 (3-ketoacyl-acyl carrier protein reductase) 0.0031 0.0011 0.0011
Echinococcus multilocularis caspase 3, apoptosis cysteine peptidase 0.0128 0.007 0.007
Echinococcus multilocularis follistatin 0.0021 0.0005 0.0004
Loa Loa (eye worm) hypothetical protein 0.0014 0 0.0000059338
Brugia malayi Thioredoxin reductase 0.0052 0.0024 0.0024
Giardia lamblia Multidrug resistance-associated protein 1 0.0028 0.0009 0.1533
Leishmania major hypothetical protein, conserved 0.0028 0.0009 0.0018
Loa Loa (eye worm) hypothetical protein 0.0028 0.0009 0.0008
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0025 0.0007 0.0007
Trypanosoma cruzi metacaspase, putative 0.0049 0.0021 0.0046
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0086 0.0044 0.0044
Echinococcus multilocularis dna polymerase eta 0.0065 0.0031 0.0031
Echinococcus granulosus ATP dependent DNA helicase Q5 0.002 0.0004 0.0004
Brugia malayi hypothetical protein 0.004 0.0016 0.0016
Echinococcus granulosus dihydrofolate reductase 1.6483 1 1
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0033 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.0487 0.0287 0.0287
Toxoplasma gondii NADPH-glutathione reductase 0.0018 0.0003 0.0005
Schistosoma mansoni multidrug resistance protein 0.0028 0.0009 0.0009
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0037 0.0014 0.0014
Onchocerca volvulus Protein ultraspiracle homolog 0.0047 0.0021 0.0304
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0031 0.0011 0.0011
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0068 0.0033 0.0033
Loa Loa (eye worm) hypothetical protein 0.0021 0.0005 0.0004
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0012 0.0012
Trypanosoma cruzi DNA polymerase kappa, putative 0.0066 0.0032 0.0069
Leishmania major DNA polymerase kappa, putative 0.0044 0.0019 0.004
Plasmodium vivax 3-oxoacyl-[acyl-carrier-protein] reductase, putative 0.0031 0.0011 0.0023
Trypanosoma cruzi transcription factor btf3, putative 0.0038 0.0015 0.0032
Trypanosoma brucei importin beta-1 subunit, putative 0.0032 0.0011 0.0023
Toxoplasma gondii isocitrate dehydrogenase 0.005 0.0023 0.0048
Plasmodium vivax dihydrofolate synthase/folylpolyglutamate synthase, putative 0.0422 0.0248 0.0538
Mycobacterium leprae Possible regulatory protein 0.0017 0.0002 0.0002
Mycobacterium ulcerans DNA polymerase IV 0.0066 0.0032 0.0032
Echinococcus granulosus importin subunit beta 1 0.0032 0.0011 0.0011
Treponema pallidum thioredoxin 0.0024 0.0006 0.0146
Plasmodium vivax apurinic/apyrimidinic endonuclease Apn1, putative 0.0084 0.0043 0.0093
Brugia malayi nuclear receptor NHR-88 0.0022 0.0005 0.0005
Echinococcus granulosus regulator of G protein signaling 3 0.0021 0.0005 0.0004
Brugia malayi hypothetical protein 0.0025 0.0007 0.0007
Plasmodium falciparum glutathione reductase 0.0018 0.0003 0.0005
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0015 0.0408
Leishmania major ATP-binding cassette protein subfamily C, member 2, putative 0.0028 0.0009 0.0019
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0022 0.0005 0.0077
Loa Loa (eye worm) hypothetical protein 0.0021 0.0005 0.0004
Echinococcus multilocularis regulator of G protein signaling 7 0.0021 0.0005 0.0004
Brugia malayi jmjC domain containing protein 0.0017 0.0002 0.0002
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0047 0.002 0.0043
Schistosoma mansoni tar DNA-binding protein 0.0139 0.0076 0.0076
Mycobacterium ulcerans short chain dehydrogenase 0.0031 0.0011 0.0011
Onchocerca volvulus 0.0021 0.0005 0.0064
Trypanosoma brucei DNA polymerase kappa, putative 0.0066 0.0032 0.0069
Loa Loa (eye worm) oxidoreductase 0.0014 0 0.0000059338
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0049 0.0021 0.0577
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0033 0.0012 0.0012
Plasmodium falciparum apurinic/apyrimidinic endonuclease Apn1, putative 0.0084 0.0043 0.0093
Trypanosoma brucei multidrug resistance-associated protein, putative 0.0028 0.0009 0.0019
Onchocerca volvulus 0.003 0.001 0.0144
Brugia malayi DNA-(Apurinic or apyrimidinic site) lyase 0.0084 0.0043 0.0043
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0017 0.0002 0.0004
Brugia malayi Regulator of G protein signaling domain containing protein 0.0021 0.0005 0.0005
Trichomonas vaginalis DNA helicase recq1, putative 0.005 0.0022 0.0594
Loa Loa (eye worm) hypothetical protein 0.0047 0.0021 0.002
Giardia lamblia Multidrug resistance-associated protein 1 0.0028 0.0009 0.1508
Entamoeba histolytica transcription factor BTF3, putative 0.0038 0.0015 0.2436
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0022 0.0005 0.0005
Brugia malayi hypothetical protein 0.0025 0.0007 0.0007
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0017 0.0002 0.0057
Schistosoma mansoni peptidase Clp (S14 family) 0.0086 0.0044 0.0044
Loa Loa (eye worm) oxidoreductase 0.0014 0 0.0000059338
Echinococcus granulosus folylpolyglutamate synthase, mitochondrial 0.0422 0.0248 0.0248
Echinococcus granulosus follistatin 0.0021 0.0005 0.0004
Brugia malayi PXA domain containing protein 0.0021 0.0005 0.0005
Trichomonas vaginalis DNA helicase recq, putative 0.0027 0.0008 0.021
Plasmodium falciparum thioredoxin reductase 0.0018 0.0003 0.0005
Loa Loa (eye worm) hypothetical protein 0.0107 0.0057 0.0056
Onchocerca volvulus 0.0047 0.0021 0.0304
Echinococcus multilocularis caspase 2 0.0094 0.0049 0.0049
Trichomonas vaginalis conserved hypothetical protein 0.0049 0.0021 0.0577
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0021 0.0005 0.0005
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0065 0.0031 0.0031
Mycobacterium tuberculosis Probable thiol peroxidase Tpx 0.0024 0.0006 0.0006
Schistosoma mansoni lamin 0.003 0.001 0.001
Mycobacterium tuberculosis Probable endonuclease IV End (endodeoxyribonuclease IV) (apurinase) 0.0084 0.0043 0.0043
Mycobacterium leprae PROBABLE ENDONUCLEASE IV END (ENDODEOXYRIBONUCLEASE IV) (APURINASE) 0.0084 0.0043 0.0043
Leishmania major trypanothione reductase 0.0052 0.0024 0.005
Loa Loa (eye worm) hypothetical protein 0.0025 0.0007 0.0007
Toxoplasma gondii LsmAD domain-containing protein 0.0028 0.0009 0.0018
Loa Loa (eye worm) hypothetical protein 0.0014 0 0.0000059338
Schistosoma mansoni hypothetical protein 0.0053 0.0024 0.0024
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0021 0.0005 0.0675
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0005 0.012
Echinococcus granulosus tar DNA binding protein 0.0139 0.0076 0.0076
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0047 0.0021 0.0021
Echinococcus multilocularis beta adrenergic receptor kinase 0.0021 0.0005 0.0004
Toxoplasma gondii hypothetical protein 0.0225 0.0129 0.0278
Loa Loa (eye worm) hypothetical protein 0.0047 0.0021 0.002
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0018 0.0003 0.0005
Leishmania major basic transcription factor 3a, putative 0.0038 0.0015 0.0032
Schistosoma mansoni cpg binding protein 0.0033 0.0012 0.0012
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0037 0.0014 0.0014
Brugia malayi intermediate filament protein 0.003 0.001 0.001
Echinococcus granulosus dna polymerase eta 0.0065 0.0031 0.0031
Loa Loa (eye worm) hypothetical protein 0.0047 0.0021 0.002
Mycobacterium leprae 3-OXOACYL-[ACYL-CARRIER PROTEIN] REDUCTASE FABG1 (3-KETOACYL-ACYL CARRIER PROTEIN REDUCTASE) (MYCOLIC ACID BIOSYNTHESIS A PROTEI 0.0031 0.0011 0.0011
Brugia malayi orphan nuclear receptor NR2E1 0.0022 0.0005 0.0005
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0016 0.0002 0.0001
Loa Loa (eye worm) hypothetical protein 0.0022 0.0005 0.0005
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0086 0.0044 0.0042
Schistosoma mansoni hypothetical protein 0.0449 0.0265 0.0264
Plasmodium falciparum ataxin-2 like protein, putative 0.0028 0.0009 0.0018
Plasmodium falciparum V-type K+-independent H+-translocating inorganic pyrophosphatase 0.0369 0.0216 0.0468
Trypanosoma brucei unspecified product 0.0026 0.0008 0.0015
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.0021 0.0005 0.012
Echinococcus granulosus dnaJ subfamily B 0.0449 0.0265 0.0264
Trypanosoma brucei DNA polymerase kappa, putative 0.0066 0.0032 0.0069
Loa Loa (eye worm) hypothetical protein 0.0025 0.0007 0.0007
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0005 0.012
Loa Loa (eye worm) aryl Hydrocarbon receptor Associated protein family member 0.0058 0.0027 0.0027
Loa Loa (eye worm) hypothetical protein 0.0047 0.0021 0.002
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0118 0.0064 0.0064
Loa Loa (eye worm) hypothetical protein 0.0017 0.0002 0.0002
Plasmodium falciparum enoyl-acyl carrier reductase 0.0031 0.0011 0.0023
Trypanosoma brucei DNA polymerase kappa, putative 0.0044 0.0019 0.004
Mycobacterium ulcerans dihydrofolate reductase DfrA 1.6483 1 1
Brugia malayi exodeoxyribonuclease III family protein 0.0021 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0107 0.0057 0.0056
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0018 0.0003 0.0005
Echinococcus multilocularis Protein lozenge 0.0061 0.0029 0.0029
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0047 0.0021 0.0021
Echinococcus multilocularis survival motor neuron protein 1 0.026 0.015 0.0149
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0018 0.0003 0.0003
Loa Loa (eye worm) RNA binding protein 0.0139 0.0076 0.0076
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0021 0.0005 0.0009
Brugia malayi hypothetical protein 0.0022 0.0005 0.0005
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0021 0.0005 0.0004
Brugia malayi nuclear receptor RXR 0.0022 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0021 0.0005 0.0004
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0047 0.0021 0.0021
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0021 0.0005 0.0005
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0005 0.012
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.0021 0.0005 0.0009
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0022 0.0005 0.0005
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0003 0.0005
Echinococcus granulosus RUN 0.0045 0.002 0.0019
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0021 0.0005 0.0004
Schistosoma mansoni microtubule-associated protein tau 0.0758 0.0452 0.0452
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0018 0.0003 0.0003
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0033 0.0012 0.0012
Loa Loa (eye worm) DR-78 0.0022 0.0005 0.0005
Schistosoma mansoni caspase-7 (C14 family) 0.0094 0.0049 0.0049
Loa Loa (eye worm) hypothetical protein 0.0028 0.0009 0.0009
Brugia malayi hypothetical protein 0.0134 0.0073 0.0073
Schistosoma mansoni jumonji domain containing protein 0.0017 0.0002 0.0002
Brugia malayi ecdysone receptor 0.0022 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0058 0.0027 0.0027
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0017 0.0002 0.0057
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0018 0.0003 0.0005
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0066 0.0032 0.0871
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.003 0.001 0.0287
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0056 0.0026 0.0026
Trichomonas vaginalis glutaminase, putative 0.0298 0.0173 0.4726
Schistosoma mansoni hypothetical protein 0.0164 0.0092 0.0091
Loa Loa (eye worm) hypothetical protein 0.0022 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0022 0.0005 0.0005
Trypanosoma cruzi PAB1-binding protein , putative 0.0028 0.0009 0.0018
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0021 0.0005 0.0004
Echinococcus granulosus caspase 0.0128 0.007 0.007
Echinococcus granulosus thioredoxin glutathione reductase 0.0052 0.0024 0.0023
Trypanosoma cruzi vacuolar-type proton translocating pyrophosphatase 1 0.0369 0.0216 0.0468
Plasmodium falciparum glutathione reductase 0.0052 0.0024 0.005
Brugia malayi hypothetical protein 0.0616 0.0366 0.0366
Loa Loa (eye worm) acetyltransferase 0.0159 0.0089 0.0088
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0065 0.0031 0.0031
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.002 0.0004 0.0004
Brugia malayi folate-like transporter 3 0.0107 0.0057 0.0057
Entamoeba histolytica hypothetical protein 0.0115 0.0062 1
Loa Loa (eye worm) reduced folate carrier family protein 0.0107 0.0057 0.0056
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0018 0.0003 0.0005
Mycobacterium ulcerans short chain dehydrogenase 0.0031 0.0011 0.0011
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0017 0.0002 0.0005
Entamoeba histolytica 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0031 0.0011 0.1719
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0021 0.0005 0.0009
Loa Loa (eye worm) oxidoreductase 0.0014 0 0.0000059338
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.0021 0.0005 0.0009
Loa Loa (eye worm) hypothetical protein 0.0107 0.0057 0.0056
Loa Loa (eye worm) hypothetical protein 0.0021 0.0005 0.0004
Trichomonas vaginalis ap endonuclease, putative 0.0021 0.0005 0.0113
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.003 0.001 0.0021
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0113 0.006 0.006
Schistosoma mansoni thyroid hormone receptor 0.0047 0.0021 0.002
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0017 0.0002 0.0004
Trypanosoma cruzi multidrug resistance protein E, putative 0.0028 0.0009 0.0019
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0018 0.0003 0.0003
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0073 0.0036 0.0036
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0021 0.0005 0.0004
Echinococcus granulosus beta-adrenergic receptor kinase 0.0021 0.0005 0.0004
Schistosoma mansoni intermediate filament proteins 0.003 0.001 0.001
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0031 0.0011 0.0011
Trypanosoma cruzi DNA polymerase eta, putative 0.0065 0.0031 0.0068
Schistosoma mansoni hypothetical protein 0.0045 0.0019 0.0019
Onchocerca volvulus 0.0045 0.002 0.0289
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0017 0.0002 0.0002
Onchocerca volvulus Folate transporter 1 homolog 0.0107 0.0057 0.0847
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0047 0.0021 0.002
Mycobacterium tuberculosis Conserved hypothetical protein 0.0037 0.0014 0.0014
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0018 0.0003 0.0005
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0049 0.0021 0.0577
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0047 0.0021 0.002
Giardia lamblia Histone acetyltransferase GCN5 0.0043 0.0018 0.3132
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0021 0.0005 0.0004
Plasmodium falciparum LCCL domain-containing protein 0.0045 0.002 0.0042
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0019 0.0003 0.0006
Mycobacterium ulcerans short chain dehydrogenase 0.0031 0.0011 0.0011
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0086 0.0044 0.0095
Brugia malayi Hypothetical 29.7 kDa protein C05D11.5 in chromosome III 0.0022 0.0005 0.0005
Trypanosoma brucei unspecified product 0.0026 0.0008 0.0015
Loa Loa (eye worm) hypothetical protein 0.0017 0.0002 0.0002
Schistosoma mansoni tar DNA-binding protein 0.0139 0.0076 0.0076
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0047 0.0021 0.002
Schistosoma mansoni lipoxygenase 0.0203 0.0115 0.0115
Onchocerca volvulus 0.0033 0.0012 0.0179
Echinococcus granulosus regulator of G protein signaling 7 0.0021 0.0005 0.0004
Schistosoma mansoni dihydropteridine reductase 0.0031 0.0011 0.0011
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.005 0.0023 0.0022
Onchocerca volvulus Protein cycle homolog 0.004 0.0016 0.0242
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0073 0.0036 0.0077
Loa Loa (eye worm) intermediate filament protein 0.003 0.001 0.001
Loa Loa (eye worm) oxidoreductase 0.0014 0 0.0000059338
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0021 0.0005 0.0005
Trypanosoma cruzi hypothetical protein 0.0022 0.0005 0.001
Toxoplasma gondii bifunctional protein FolC subfamily protein 0.0422 0.0248 0.0538
Loa Loa (eye worm) hypothetical protein 0.004 0.0016 0.0016
Schistosoma mansoni polycystin 1-related 0.0045 0.002 0.0019
Onchocerca volvulus 0.0022 0.0005 0.0077
Echinococcus multilocularis regulator of G protein signaling 0.0021 0.0005 0.0004
Schistosoma mansoni cpg binding protein 0.0033 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.0107 0.0057 0.0056
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.003 0.001 0.0021
Trypanosoma brucei multidrug resistance-associated protein, putative 0.0028 0.0009 0.0019
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.005 0.0023 0.0022
Echinococcus multilocularis caspase 3 0.008 0.004 0.004
Echinococcus granulosus nuclear receptor nhr 48 0.0022 0.0005 0.0005
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0017 0.0002 0.0002
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0044 0.0019 0.004
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0049 0.0021 0.0046
Loa Loa (eye worm) hypothetical protein 0.0022 0.0005 0.0005
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0021 0.0005 0.0009
Brugia malayi regulator of G-protein signaling rgs-7 0.0021 0.0005 0.0005
Trypanosoma brucei DNA polymerase kappa, putative 0.0066 0.0032 0.0069
Mycobacterium ulcerans short chain dehydrogenase 0.0045 0.0019 0.0019
Entamoeba histolytica hypothetical protein 0.0115 0.0062 1
Plasmodium vivax glutathione reductase, putative 0.0052 0.0024 0.005
Loa Loa (eye worm) hypothetical protein 0.0037 0.0015 0.0014
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0021 0.0005 0.0004
Onchocerca volvulus Bile acid receptor homolog 0.0047 0.0021 0.0304
Trichomonas vaginalis conserved hypothetical protein 0.0049 0.0021 0.0577
Loa Loa (eye worm) hypothetical protein 0.0014 0 0.0000059338
Loa Loa (eye worm) hypothetical protein 0.0031 0.0011 0.001
Echinococcus granulosus Nuclear hormone receptor HR96 0.0022 0.0005 0.0005
Schistosoma mansoni regulator of G protein signaling 0.0021 0.0005 0.0004
Loa Loa (eye worm) RGS-3 protein 0.0021 0.0005 0.0004
Echinococcus granulosus phd:f box containing protein 0.0017 0.0002 0.0002
Echinococcus multilocularis RUN 0.0045 0.002 0.0019
Plasmodium falciparum metacaspase 1 0.0049 0.0021 0.0046
Schistosoma mansoni dihydrofolate reductase 1.6483 1 1
Leishmania major hypothetical protein, conserved 0.0017 0.0002 0.0004
Loa Loa (eye worm) hypothetical protein 0.0031 0.0011 0.001
Leishmania major folylpolyglutamate synthetase 0.0422 0.0248 0.0538
Echinococcus multilocularis Solute carrier organic anion transporter family 0.0031 0.0011 0.001
Schistosoma mansoni nuclear hormone receptor 0.0022 0.0005 0.0005
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0045 0.0019 0.0019
Loa Loa (eye worm) hypothetical protein 0.0021 0.0005 0.0004
Wolbachia endosymbiont of Brugia malayi enoyl-ACP reductase 0.0031 0.0011 0.2405
Schistosoma mansoni z-protein (S1r protein) 0.0021 0.0005 0.0004
Brugia malayi hypothetical protein 0.0045 0.002 0.002
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0132 0.0072 0.0072
Echinococcus multilocularis Alpha N acetylgalactosaminidase 0.0113 0.006 0.006
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0047 0.0021 0.002
Trypanosoma brucei metacaspase MCA3 0.0049 0.0021 0.0046
Brugia malayi sodium-independent organic anion transporter family protein 0.0031 0.0011 0.0011
Trypanosoma brucei beta-ketoacyl-ACP reductase 0.0031 0.0011 0.0023
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0073 0.0036 0.0077
Mycobacterium tuberculosis Probable oxidoreductase 0.0132 0.0072 0.0072
Brugia malayi hypothetical protein 0.0487 0.0287 0.0287
Loa Loa (eye worm) hypothetical protein 0.0014 0 0.0000059338
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0047 0.0021 0.0021
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0025 0.0007 0.0007
Schistosoma mansoni phd/f-box containing protein 0.0017 0.0002 0.0002
Brugia malayi hypothetical protein 0.0045 0.002 0.002
Wolbachia endosymbiont of Brugia malayi Short-chain alcohol dehydrogenase family enzyme 0.0031 0.0011 0.2405
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0017 0.0002 0.0004
Mycobacterium ulcerans hypothetical protein 0.0022 0.0005 0.0005
Brugia malayi ecdysteroid receptor 0.0047 0.0021 0.0021
Brugia malayi sodium-independent organic anion transporter family protein 0.0031 0.0011 0.0011
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0055 0.0025 0.0025
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0021 0.0005 0.0004
Schistosoma mansoni hypothetical protein 0.0338 0.0197 0.0197
Loa Loa (eye worm) hypothetical protein 0.0021 0.0005 0.0004
Echinococcus granulosus 3 oxoacyl acyl carrier protein reductase 0.0031 0.0011 0.0011
Mycobacterium ulcerans enoyl-(acyl carrier protein) reductase 0.0031 0.0011 0.0011
Mycobacterium ulcerans epimerase 0.0022 0.0005 0.0005
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0073 0.0036 0.0036
Echinococcus multilocularis lipoxygenase domain containing protein 0.0045 0.002 0.0019
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0039 0.0016 0.0034
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.005 0.0023 0.0048
Entamoeba histolytica hypothetical protein 0.0021 0.0005 0.0715
Loa Loa (eye worm) glutathione reductase 0.0052 0.0024 0.0023
Entamoeba histolytica acetyltransferase, GNAT family 0.0043 0.0018 0.2884
Leishmania major dihydrofolate reductase-thymidylate synthase 0.7598 0.4606 1
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0032 0.0012 0.185
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0021 0.0005 0.0004
Brugia malayi thymidylate synthase 0.111 0.0666 0.0666
Brugia malayi PXA domain containing protein 0.0021 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0022 0.0005 0.0005
Trypanosoma cruzi transcription factor btf3, putative 0.0038 0.0015 0.0032
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0017 0.0002 0.0004
Schistosoma mansoni hypothetical protein 0.0371 0.0217 0.0217
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0022 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0022 0.0005 0.0005
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0075 0.0038 0.0037
Trypanosoma brucei DNA polymerase kappa, putative 0.0033 0.0012 0.0025
Plasmodium vivax SET domain protein, putative 0.0033 0.0012 0.0026
Trichomonas vaginalis ap endonuclease, putative 0.0021 0.0005 0.0113
Schistosoma mansoni rab6-interacting 0.0045 0.002 0.0019
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0338 0.0197 0.0197
Loa Loa (eye worm) hypothetical protein 0.0021 0.0005 0.0004
Loa Loa (eye worm) hypothetical protein 0.0031 0.0011 0.001
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0047 0.0021 0.002
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.005 0.0023 0.0048
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0021 0.0005 0.0004
Brugia malayi jmjC domain containing protein 0.0017 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0164 0.0092 0.0091
Schistosoma mansoni caspase-3 (C14 family) 0.0128 0.007 0.007
Onchocerca volvulus 0.0107 0.0057 0.0847
Echinococcus granulosus lipoxygenase domain containing protein 0.0045 0.002 0.0019
Trichomonas vaginalis dihydrofolate synthase/folylpolyglutamate synthase, putative 0.0422 0.0248 0.6776
Loa Loa (eye worm) jmjC domain-containing protein 0.0017 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0022 0.0005 0.0005
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0047 0.0021 0.002
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.003 0.001 0.001
Plasmodium falciparum metacaspase-like protein 0.0049 0.0021 0.0046
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0075 0.0038 0.0037
Toxoplasma gondii Alpha-galactosidase 0.0016 0.0002 0.0003
Schistosoma mansoni nuclear receptor 0.0022 0.0005 0.0005
Giardia lamblia Hypothetical protein 0.0107 0.0057 1
Echinococcus granulosus multidrug resistance associated protein 4 0.0022 0.0005 0.0005
Schistosoma mansoni terminal deoxycytidyl transferase 0.0037 0.0014 0.0014
Echinococcus granulosus cpg binding protein 0.0033 0.0012 0.0012
Leishmania major oxidoreductase-like protein 0.0045 0.0019 0.0041
Onchocerca volvulus 0.0058 0.0027 0.04
Echinococcus multilocularis Aryl hydrocarbon receptor nuclear 0.0017 0.0002 0.0002
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0018 0.0003 0.0003
Leishmania major p-glycoprotein e 0.0028 0.0009 0.0019
Trypanosoma cruzi metacaspase, putative 0.0049 0.0021 0.0046
Loa Loa (eye worm) hypothetical protein 0.0031 0.0011 0.001
Trichomonas vaginalis conserved hypothetical protein 0.0616 0.0366 1
Toxoplasma gondii isocitrate dehydrogenase 0.005 0.0023 0.0048
Loa Loa (eye worm) thioredoxin reductase 0.0052 0.0024 0.0023
Loa Loa (eye worm) runx1 0.0061 0.0029 0.0029
Loa Loa (eye worm) hypothetical protein 0.0014 0 0.0000059338
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0018 0.0003 0.0005
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0047 0.0021 0.0021
Echinococcus granulosus caspase 8 0.0049 0.0021 0.0021
Onchocerca volvulus 0.0045 0.0019 0.0285
Echinococcus granulosus ecdysone induced protein 78C 0.0047 0.0021 0.002
Schistosoma mansoni hypothetical protein 0.0017 0.0002 0.0002
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.005 0.0023 0.0022
Brugia malayi glutaminase DH11.1 0.0298 0.0173 0.0173
Plasmodium falciparum 1-cys peroxiredoxin 0.0093 0.0049 0.0105
Loa Loa (eye worm) hypothetical protein 0.0047 0.0021 0.002
Loa Loa (eye worm) hypothetical protein 0.0022 0.0005 0.0005
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.002 0.0004 0.0009
Mycobacterium tuberculosis NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase) 0.0031 0.0011 0.0011
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0002 0.0057
Loa Loa (eye worm) ABC transporter transmembrane region family protein 0.0028 0.0009 0.0009
Plasmodium falciparum dihydrofolate synthase/folylpolyglutamate synthase 0.0422 0.0248 0.0538
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.005 0.0023 0.0022
Onchocerca volvulus Putative folylpolyglutamate synthase 0.0422 0.0248 0.3725
Mycobacterium tuberculosis Possible 20-beta-hydroxysteroid dehydrogenase FabG3 (cortisone reductase) ((R)-20-hydroxysteroid dehydrogenase) 0.0031 0.0011 0.0011
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.005 0.0023 0.0048
Mycobacterium leprae PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) 0.111 0.0666 0.0665
Leishmania major importin beta-1 subunit, putative 0.0026 0.0008 0.0016
Trypanosoma cruzi DNA polymerase eta, putative 0.0039 0.0016 0.0034
Mycobacterium tuberculosis Probable conserved lipoprotein DsbF 0.0024 0.0006 0.0006
Onchocerca volvulus 0.0031 0.0011 0.0153
Plasmodium vivax metacaspase 1, putative 0.0049 0.0021 0.0046
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0025 0.0007 0.0007
Echinococcus multilocularis multidrug resistance associated protein 7 0.0028 0.0009 0.0009
Entamoeba histolytica multidrug resistance protein, putative 0.0028 0.0009 0.1411
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0037 0.0014 0.0014
Loa Loa (eye worm) hypothetical protein 0.0031 0.0011 0.001
Echinococcus multilocularis apoptotic protease activating factor 1 0.0045 0.0019 0.0019
Brugia malayi hypothetical protein 0.0031 0.0011 0.0011
Loa Loa (eye worm) jmjC domain-containing protein 0.0017 0.0002 0.0002
Trichomonas vaginalis conserved hypothetical protein 0.0049 0.0021 0.0577
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0028 0.0009 0.0019
Giardia lamblia MRP-like ABC transporter 0.0028 0.0009 0.1533
Loa Loa (eye worm) hypothetical protein 0.0014 0 0.0000059338
Brugia malayi ABC transporter transmembrane region family protein 0.0028 0.0009 0.0009
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0017 0.0002 0.0005
Mycobacterium leprae POSSIBLE OXIDOREDUCTASE 0.0031 0.0011 0.0011
Echinococcus multilocularis thymidylate synthase 0.111 0.0666 0.0665
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0018 0.0003 0.0005
Leishmania major metacaspase, putative 0.0049 0.0021 0.0046
Echinococcus granulosus JmjC domain containing protein 4 0.0017 0.0002 0.0002
Echinococcus granulosus expressed protein 0.041 0.0241 0.0241
Echinococcus granulosus bloom syndrome protein 0.005 0.0022 0.0022
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0017 0.0002 0.0002
Schistosoma mansoni ap endonuclease 0.0021 0.0005 0.0004
Schistosoma mansoni regulator of G protein signaling 0.0021 0.0005 0.0004
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0003 0.0005
Schistosoma mansoni coup transcription factor 0.0047 0.0021 0.002
Mycobacterium ulcerans 3-oxoacyl-ACP reductase 0.0031 0.0011 0.0011
Schistosoma mansoni hypothetical protein 0.0017 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0025 0.0007 0.0007
Loa Loa (eye worm) nuclear hormone receptor 0.0022 0.0005 0.0005
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0031 0.0011 0.0011
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0047 0.002 0.0043
Loa Loa (eye worm) hypothetical protein 0.0014 0 0.0000059338
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0159 0.0089 0.0088
Brugia malayi hypothetical protein 0.0031 0.0011 0.0011
Chlamydia trachomatis enoyl-acyl-carrier protein reductase 0.0031 0.0011 0.0008
Echinococcus granulosus muscleblind protein 0.0164 0.0092 0.0091
Leishmania major pentamidine resistance protein 1 0.0028 0.0009 0.0019
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0021 0.0005 0.0009
Loa Loa (eye worm) hypothetical protein 0.0045 0.002 0.0019
Plasmodium falciparum 3-oxoacyl-[acyl-carrier-protein] reductase 0.0031 0.0011 0.0023
Brugia malayi FolC bifunctional protein 0.0422 0.0248 0.0248
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0018 0.0003 0.0005
Echinococcus granulosus axis inhibition protein axin 0.0021 0.0005 0.0004
Echinococcus multilocularis regulator of G protein signaling 7 0.0021 0.0005 0.0004
Toxoplasma gondii transporter, major facilitator family protein 0.0031 0.0011 0.0022
Mycobacterium tuberculosis Probable oxidoreductase 0.0045 0.0019 0.0019
Mycobacterium tuberculosis Probable thymidylate synthase ThyA (ts) (TSASE) 0.111 0.0666 0.0665
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0017 0.0002 0.0057
Leishmania major ATP-binding cassette protein subfamily C, member 6, putative 0.0028 0.0009 0.0019
Loa Loa (eye worm) hypothetical protein 0.003 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.0031 0.0011 0.001
Schistosoma mansoni cpg binding protein 0.0032 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.0029 0.001 0.0009
Loa Loa (eye worm) hypothetical protein 0.0021 0.0005 0.0004
Brugia malayi cytoplasmic intermediate filament protein 0.0016 0.0002 0.0002
Echinococcus multilocularis lamin dm0 0.003 0.001 0.001
Mycobacterium ulcerans oxidoreductase 0.0031 0.0011 0.0011
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.002 0.0004 0.0004
Trichomonas vaginalis rotamase, putative 0.0032 0.0012 0.031
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0047 0.0021 0.002
Brugia malayi conserved hypotetical protein 0.0022 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0041 0.0017 0.0016
Echinococcus multilocularis multidrug resistance associated protein 1 0.0028 0.0009 0.0009
Trypanosoma cruzi Vacuolar proton pyrophosphatase 1, putative 0.0369 0.0216 0.0468
Trypanosoma brucei DNA polymerase kappa, putative 0.0066 0.0032 0.0069
Toxoplasma gondii V-type H(+)-translocating pyrophosphatase VP1 0.0369 0.0216 0.0468
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0022 0.0005 0.0077
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0025 0.0007 0.0007
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0021 0.0005 0.0009
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0021 0.0005 0.0004
Plasmodium vivax hypothetical protein, conserved 0.0049 0.0021 0.0046
Onchocerca volvulus 0.0045 0.0019 0.0287
Echinococcus multilocularis axis inhibition protein axin 0.0021 0.0005 0.0004
Loa Loa (eye worm) hypothetical protein 0.0054 0.0025 0.0025
Mycobacterium leprae DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) 1.6483 1 1
Trypanosoma brucei p-glycoprotein 0.0028 0.0009 0.0019
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0047 0.0021 0.002
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.0021 0.0005 0.0009
Loa Loa (eye worm) glutaminase 0.0298 0.0173 0.0173
Echinococcus granulosus histone lysine methyltransferase setb 0.0033 0.0012 0.0012
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0049 0.0021 0.0577
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0073 0.0036 0.0036
Trypanosoma cruzi metacaspase, putative 0.0049 0.0021 0.0046
Loa Loa (eye worm) nuclear receptor NHR-67 0.0022 0.0005 0.0005
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0086 0.0044 0.1681
Trypanosoma brucei DNA polymerase kappa, putative 0.0066 0.0032 0.0069
Schistosoma mansoni aryl hydrocarbon receptor 0.0017 0.0002 0.0002
Echinococcus granulosus Alpha N acetylgalactosaminidase 0.0113 0.006 0.006
Onchocerca volvulus Putative organic anion transporter 0.0031 0.0011 0.0153
Loa Loa (eye worm) hypothetical protein 0.0164 0.0092 0.0091
Schistosoma mansoni hypothetical protein 0.0037 0.0015 0.0014
Brugia malayi Muscleblind-like protein 0.0164 0.0092 0.0092
Loa Loa (eye worm) isocitrate dehydrogenase 0.005 0.0023 0.0022
Echinococcus granulosus GPCR family 2 0.0017 0.0002 0.0002
Leishmania major pteridine reductase 1 0.0739 0.0441 0.0956
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0047 0.0021 0.0021
Entamoeba histolytica ATP-binding cassette protein, putative 0.0028 0.0009 0.1411
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0047 0.0021 0.002
Plasmodium falciparum ataxin-2 like protein, putative 0.0028 0.0009 0.0018
Echinococcus granulosus caspase 3 0.008 0.004 0.004
Entamoeba histolytica ATP-binding cassette protein, putative 0.0028 0.0009 0.1411
Brugia malayi Importin beta-1 subunit 0.0032 0.0011 0.0011
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0073 0.0036 0.0036
Mycobacterium ulcerans DNA polymerase IV 0.0066 0.0032 0.0032
Onchocerca volvulus 0.0031 0.0011 0.0153
Loa Loa (eye worm) hypothetical protein 0.0107 0.0057 0.0056
Schistosoma mansoni cellular tumor antigen P53 0.0054 0.0025 0.0025
Echinococcus multilocularis muscleblind protein 0.0164 0.0092 0.0091
Loa Loa (eye worm) agrin synaptic family protein 0.0021 0.0005 0.0004
Schistosoma mansoni single-minded 0.0017 0.0002 0.0002
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0047 0.0021 0.0021
Loa Loa (eye worm) dihydrofolate reductase 1.6483 1 1
Echinococcus multilocularis JmjC domain containing protein 4 0.0017 0.0002 0.0002
Trypanosoma cruzi PAB1-binding protein , putative 0.0028 0.0009 0.0018
Schistosoma mansoni hypothetical protein 0.0115 0.0062 0.0061
Trichomonas vaginalis guanylate cyclase, putative 0.0017 0.0002 0.0057
Echinococcus granulosus caspase 3 apoptosis cysteine peptidase 0.0128 0.007 0.007
Loa Loa (eye worm) CXXC zinc finger family protein 0.0032 0.0011 0.0011
Echinococcus granulosus survival motor neuron protein 1 0.026 0.015 0.0149
Loa Loa (eye worm) latrophilin receptor protein 2 0.0017 0.0002 0.0002
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0047 0.0021 0.002
Echinococcus multilocularis multidrug resistance associated protein 4 0.0022 0.0005 0.0005
Schistosoma mansoni glutaminase 0.0298 0.0173 0.0173
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0049 0.0021 0.0577
Schistosoma mansoni steroid hormone receptor ad4bp 0.0047 0.0021 0.002
Entamoeba histolytica Acid sphingomyelinase-like phosphodiesterase, putative 0.0091 0.0047 0.7626
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0026 0.0008 0.0196
Schistosoma mansoni regulator of G protein signaling 0.0021 0.0005 0.0004
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0018 0.0003 0.0005
Entamoeba histolytica hypothetical protein 0.0028 0.0009 0.1411
Loa Loa (eye worm) hypothetical protein 0.0022 0.0005 0.0005
Leishmania major 3-oxoacyl-ACP reductase, putative 0.0031 0.0011 0.0023
Echinococcus multilocularis folate receptor beta 0.0915 0.0547 0.0547
Toxoplasma gondii exonuclease III APE 0.0021 0.0005 0.0009
Plasmodium vivax peroxiredoxin, putative 0.0093 0.0049 0.0105
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0073 0.0036 0.0036
Echinococcus multilocularis dnaJ subfamily B 0.0449 0.0265 0.0264
Brugia malayi multidrug resistance related protein 1 0.0028 0.0009 0.0009
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0086 0.0044 0.0095
Onchocerca volvulus 0.0022 0.0005 0.0077
Echinococcus granulosus transcription factor btf3 0.0038 0.0015 0.0015
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0118 0.0064 0.0064
Schistosoma mansoni regulator of G protein signaling 0.0021 0.0005 0.0004
Plasmodium falciparum thioredoxin reductase 0.0052 0.0024 0.005
Trichomonas vaginalis adenylate cyclase, putative 0.0017 0.0002 0.0057
Plasmodium vivax V-type H(+)-translocating pyrophosphatase, putative 0.0369 0.0216 0.0468
Echinococcus multilocularis tumor protein p63 0.0371 0.0217 0.0217
Echinococcus multilocularis isocitrate dehydrogenase 0.005 0.0023 0.0022
Schistosoma mansoni hypothetical protein 0.0017 0.0002 0.0002
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0022 0.0005 0.0005
Trichomonas vaginalis set domain proteins, putative 0.0261 0.015 0.4102
Plasmodium vivax enoyl-acyl carrier protein reductase 0.0031 0.0011 0.0023
Loa Loa (eye worm) hypothetical protein 0.0017 0.0002 0.0002
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0021 0.0005 0.0009
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.0017 0.0002 0.0005
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0047 0.0021 0.0021
Trichomonas vaginalis conserved hypothetical protein 0.0049 0.0021 0.0577
Schistosoma mansoni rotamase 0.0033 0.0012 0.0012
Echinococcus granulosus histone acetyltransferase KAT2B 0.0155 0.0086 0.0086
Schistosoma mansoni multidrug resistance protein 0.0028 0.0009 0.0009
Trichomonas vaginalis guanylate cyclase, putative 0.0017 0.0002 0.0057
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0047 0.002 0.0043
Brugia malayi hypothetical protein 0.0018 0.0003 0.0003
Echinococcus multilocularis phd:f box containing protein 0.0017 0.0002 0.0002
Entamoeba histolytica hypothetical protein 0.0021 0.0005 0.0715
Schistosoma mansoni zinc finger protein 0.0022 0.0005 0.0005
Brugia malayi polk-prov protein 0.0041 0.0017 0.0017
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0018 0.0003 0.0576
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0022 0.0005 0.0005
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.002 0.0004 0.0004
Mycobacterium ulcerans folylpolyglutamate synthase protein FolC 0.0422 0.0248 0.0248
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0021 0.0005 0.0005
Schistosoma mansoni rab6-interacting 0.0045 0.002 0.0019
Onchocerca volvulus 0.0031 0.0011 0.0153
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0086 0.0044 0.0044
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0049 0.0021 0.0577
Trypanosoma brucei oxidoreductase-like protein 0.0045 0.0019 0.0041
Brugia malayi ImpB/MucB/SamB family protein 0.0065 0.0031 0.0031
Mycobacterium ulcerans glutaminase 0.0298 0.0173 0.0173
Onchocerca volvulus Folate transporter 1 homolog 0.0107 0.0057 0.0847
Loa Loa (eye worm) hypothetical protein 0.0348 0.0204 0.0203
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0229 0.0131 0.0131
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0018 0.0003 0.0005
Loa Loa (eye worm) hypothetical protein 0.0021 0.0005 0.0004
Loa Loa (eye worm) helix-loop-helix DNA-binding domain-containing protein 0.004 0.0016 0.0016
Mycobacterium leprae PROBABLE FOLYLPOLYGLUTAMATE SYNTHASE PROTEIN FOLC (FOLYLPOLY-GAMMA-GLUTAMATE SYNTHETASE) (FPGS) 0.0422 0.0248 0.0248
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.005 0.0023 0.0048
Trichomonas vaginalis glutathione reductase, putative 0.0018 0.0003 0.0069
Trypanosoma brucei DNA polymerase IV, putative 0.0066 0.0032 0.0069
Entamoeba histolytica hypothetical protein 0.0115 0.0062 1
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0047 0.0021 0.002
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0018 0.0003 0.0003
Trypanosoma brucei pteridine reductase 1 0.0725 0.0432 0.0938
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0012 0.0012
Trypanosoma cruzi importin beta-1 subunit, putative 0.0026 0.0008 0.0016
Loa Loa (eye worm) hypothetical protein 0.0107 0.0057 0.0056
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0022 0.0005 0.0005
Brugia malayi CXXC zinc finger family protein 0.0032 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.0107 0.0057 0.0056
Schistosoma mansoni loxhd1 0.0045 0.002 0.0019
Onchocerca volvulus 0.0107 0.0057 0.0847
Mycobacterium tuberculosis Probable dehydrogenase 0.0118 0.0064 0.0064
Schistosoma mansoni nuclear receptor 0.0022 0.0005 0.0005
Brugia malayi RNA recognition motif domain containing protein 0.0139 0.0076 0.0076
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0018 0.0003 0.0005
Loa Loa (eye worm) oxidoreductase 0.0014 0 0.0000059338
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0017 0.0002 0.0004
Mycobacterium leprae conserved hypothetical protein 0.0022 0.0005 0.0005
Trichomonas vaginalis adenylate cyclase, type VII, putative 0.0017 0.0002 0.0057
Schistosoma mansoni serine/threonine protein kinase 0.0021 0.0005 0.0004
Echinococcus granulosus folylpolyglutamate synthase mitochondrial 0.0422 0.0248 0.0248
Brugia malayi Helix-loop-helix DNA-binding domain containing protein 0.004 0.0016 0.0016
Loa Loa (eye worm) hypothetical protein 0.0014 0 0.0000059338
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0015 0.0408
Brugia malayi jmjC domain containing protein 0.0066 0.0032 0.0032
Onchocerca volvulus Putative organic anion transporter 0.0031 0.0011 0.0153
Toxoplasma gondii histone lysine methyltransferase SET1 0.0065 0.0031 0.0067
Loa Loa (eye worm) hypothetical protein 0.0031 0.0011 0.001
Mycobacterium ulcerans short chain dehydrogenase 0.0031 0.0011 0.0011
Loa Loa (eye worm) dehydrogenase 0.0014 0 0.0000059338
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0031 0.0011 0.0011
Echinococcus multilocularis Regulator of G protein signaling 20 0.0021 0.0005 0.0004
Loa Loa (eye worm) hypothetical protein 0.026 0.015 0.0149
Brugia malayi hypothetical protein 0.0058 0.0027 0.0027
Schistosoma mansoni ap endonuclease 0.0021 0.0005 0.0004
Mycobacterium tuberculosis Soluble secreted antigen Mpt53 precursor 0.0024 0.0006 0.0006
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0052 0.0024 0.0023
Mycobacterium tuberculosis Possible oxidoreductase 0.0031 0.0011 0.0011
Brugia malayi nuclear hormone receptor 0.0022 0.0005 0.0005
Brugia malayi isocitrate dehydrogenase 0.005 0.0023 0.0023
Toxoplasma gondii endonuclease IV APN 0.0084 0.0043 0.0093
Trypanosoma brucei Metacaspase-4 0.0049 0.0021 0.0046
Schistosoma mansoni hypothetical protein 0.0057 0.0026 0.0026
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0012 0.0323
Loa Loa (eye worm) oxidoreductase 0.0014 0 0.0000059338
Loa Loa (eye worm) TAR-binding protein 0.0139 0.0076 0.0076
Echinococcus multilocularis transcription factor btf3 0.0038 0.0015 0.0015
Brugia malayi latrophilin 2 splice variant baaae 0.0037 0.0015 0.0015
Mycobacterium tuberculosis Probable reductase 0.0118 0.0064 0.0064
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0012 0.0012
Echinococcus multilocularis regulator of G protein signaling 3 0.0021 0.0005 0.0004
Loa Loa (eye worm) retinol dehydrogenase 12 0.0031 0.0011 0.0011
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0031 0.0011 0.0011
Echinococcus granulosus peptidase Clp S14 family 0.0056 0.0026 0.0026
Entamoeba histolytica hypothetical protein 0.0026 0.0008 0.1174
Plasmodium falciparum histone acetyltransferase GCN5 0.0043 0.0018 0.0038
Echinococcus granulosus Major facilitator superfamily general substrate transporter 0.0164 0.0092 0.0091
Loa Loa (eye worm) hypothetical protein 0.0022 0.0005 0.0005
Mycobacterium tuberculosis Probable folylpolyglutamate synthase protein FolC (folylpoly-gamma-glutamate synthetase) (FPGS) 0.0422 0.0248 0.0248
Plasmodium falciparum JmjC domain-containing protein, putative 0.0017 0.0002 0.0004
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0026 0.0008 0.0196
Schistosoma mansoni retinoic acid receptor RXR 0.0155 0.0086 0.0086
Entamoeba histolytica ABC transporter, putative 0.0028 0.0009 0.1411
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0017 0.0002 0.0005
Loa Loa (eye worm) short chain dehydrogenase/reductase family oxidoreductase 0.0014 0 0.0000059338
Schistosoma mansoni DNA helicase recq1 0.002 0.0004 0.0004
Echinococcus granulosus agrin 0.0021 0.0005 0.0004
Mycobacterium ulcerans thiol peroxidase 0.0024 0.0006 0.0006
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0016 0.0002 0.0001
Schistosoma mansoni aryl hydrocarbon receptor nuclear translocator homolog (darnt) 0.004 0.0016 0.0016
Toxoplasma gondii 3-ketoacyl-(acyl-carrier-protein) reductase 0.0031 0.0011 0.0023
Echinococcus multilocularis GPCR, family 2 0.0017 0.0002 0.0002
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0132 0.0072 0.0072
Loa Loa (eye worm) kazal-type serine protease inhibitor domain-containing protein 0.0021 0.0005 0.0004
Schistosoma mansoni lamin 0.003 0.001 0.001
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0017 0.0002 0.0005
Onchocerca volvulus 0.111 0.0666 1
Brugia malayi Doublecortin family protein 0.0045 0.002 0.002
Trypanosoma brucei metacaspase MCA2 0.0049 0.0021 0.0046
Brugia malayi RNA, U transporter 1 0.009 0.0047 0.0047
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0073 0.0036 0.0036
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0118 0.0064 0.0064
Trypanosoma brucei DNA polymerase kappa, putative 0.0066 0.0032 0.0069
Leishmania major dehydrogenase/oxidoreductase-like protein 0.0031 0.0011 0.0023
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0003 0.0005
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase 0.7598 0.4606 1
Loa Loa (eye worm) hypothetical protein 0.0014 0 0.0000059338
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0047 0.0021 0.002
Trypanosoma brucei DNA polymerase eta, putative 0.0065 0.0031 0.0068
Brugia malayi Nuclear hormone receptor E75 0.0022 0.0005 0.0005
Trypanosoma cruzi MFS transporter, putative 0.0031 0.0011 0.0022
Brugia malayi Calcitonin receptor-like protein seb-1 0.0055 0.0025 0.0025
Mycobacterium tuberculosis Hypothetical protein 0.0616 0.0366 0.0366
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0018 0.0003 0.0003
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0086 0.0044 0.0044
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0019 0.0004 0.0003
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0017 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0075 0.0038 0.0037
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.005 0.0023 0.0048
Entamoeba histolytica hypothetical protein 0.0021 0.0005 0.0715
Brugia malayi hypothetical protein 0.026 0.015 0.015
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0021 0.0005 0.0733
Brugia malayi hypothetical protein 0.0021 0.0005 0.0005
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0031 0.0011 0.0011
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0018 0.0003 0.0005
Trypanosoma brucei DNA polymerase IV, putative 0.0066 0.0032 0.0069
Leishmania major ATP-binding cassette protein subfamily C, member 1, putative 0.0028 0.0009 0.0019
Echinococcus granulosus lipoxygenase domain containing protein 0.0045 0.002 0.0019
Schistosoma mansoni lipoxygenase 0.0121 0.0066 0.0065
Onchocerca volvulus 0.0054 0.0025 0.0369
Loa Loa (eye worm) glutaminase 2 0.0298 0.0173 0.0173
Plasmodium vivax thioredoxin reductase, putative 0.0052 0.0024 0.005
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0132 0.0072 0.0072
Brugia malayi hypothetical protein 0.0028 0.0009 0.0009
Echinococcus granulosus intermediate filament protein 0.003 0.001 0.001
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0056 0.0026 0.0026
Toxoplasma gondii peptidylprolyl isomerase 0.0032 0.0012 0.0025
Entamoeba histolytica ATP-binding cassette protein, putative 0.0028 0.0009 0.1411
Plasmodium falciparum basic transcription factor 3b, putative 0.0038 0.0015 0.0032
Trypanosoma brucei metacaspase 5, putative 0.0049 0.0021 0.0046
Leishmania major ABC-thiol transporter 0.0028 0.0009 0.0019
Brugia malayi Pre-SET motif family protein 0.0033 0.0012 0.0012
Brugia malayi Bloom's syndrome protein homolog 0.005 0.0022 0.0022
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0073 0.0036 0.0077
Brugia malayi Nuclear hormone receptor E75 0.0022 0.0005 0.0005
Toxoplasma gondii short chain dehydrogenase family protein, putative 0.0031 0.0011 0.0023
Loa Loa (eye worm) hypothetical protein 0.0022 0.0005 0.0005
Brugia malayi nuclear receptor NHR-88 0.0047 0.0021 0.0021
Schistosoma mansoni folylpolyglutamate synthase 0.0422 0.0248 0.0248
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0047 0.0021 0.0021
Schistosoma mansoni agrin 0.0021 0.0005 0.0004
Giardia lamblia ABC transporter, putative 0.0028 0.0009 0.1533
Loa Loa (eye worm) hypothetical protein 0.0047 0.0021 0.002
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0044 0.0018 0.0039
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0037 0.0014 0.0014
Onchocerca volvulus 0.0107 0.0057 0.0847
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0017 0.0002 0.0005
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0031 0.0011 0.0011
Schistosoma mansoni subfamily C14A unassigned peptidase (C14 family) 0.0049 0.0021 0.0021
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0002 0.0057
Loa Loa (eye worm) hypothetical protein 0.0022 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0086 0.0044 0.0044
Brugia malayi nuclear hormone receptor 0.0047 0.0021 0.0021
Echinococcus multilocularis lamin 0.003 0.001 0.001
Toxoplasma gondii protease inhibitor PI2 0.0021 0.0005 0.0009
Onchocerca volvulus 0.0031 0.0011 0.0153
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0018 0.0003 0.0005
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0086 0.0044 0.0042
Echinococcus multilocularis expressed protein 0.0021 0.0005 0.0004
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0049 0.0021 0.0046
Echinococcus multilocularis aryl hydrocarbon receptor 0.0058 0.0027 0.0027
Entamoeba histolytica deoxycytidyl transferase, putative 0.0037 0.0014 0.2306
Schistosoma mansoni DNA helicase recq5 0.002 0.0004 0.0004
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0047 0.0021 0.0021
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0021 0.0005 0.0004
Echinococcus granulosus FTZ F1 alpha 0.0047 0.0021 0.002
Echinococcus granulosus expressed protein 0.0033 0.0012 0.0012
Onchocerca volvulus Putative organic anion transporter 0.0031 0.0011 0.0153
Echinococcus multilocularis agrin 0.0021 0.0005 0.0004
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0073 0.0036 0.0036
Trypanosoma cruzi DNA polymerase kappa, putative 0.0066 0.0032 0.0069
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0203 0.0115 0.0115
Mycobacterium ulcerans endonuclease IV 0.0084 0.0043 0.0043
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0155 0.0086 0.0086
Brugia malayi small heat shock protein 0.0634 0.0377 0.0377
Brugia malayi TAR-binding protein 0.0139 0.0076 0.0076
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0031 0.0011 0.0011
Schistosoma mansoni transcription factor btf3 0.0038 0.0015 0.0015
Treponema pallidum exodeoxyribonuclease (exoA) 0.0021 0.0005 0.0066
Toxoplasma gondii thioredoxin reductase 0.0052 0.0024 0.005
Echinococcus granulosus microtubule associated protein 2 0.0758 0.0452 0.0452
Brugia malayi Intermediate filament tail domain containing protein 0.003 0.001 0.001
Echinococcus multilocularis nuclear receptor nhr 48 0.0022 0.0005 0.0005
Trypanosoma cruzi DNA polymerase kappa, putative 0.0066 0.0032 0.0069
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0017 0.0002 0.0002
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0022 0.0005 0.0005
Schistosoma mansoni tar DNA-binding protein 0.0139 0.0076 0.0076
Echinococcus multilocularis expressed protein 0.041 0.0241 0.0241
Echinococcus multilocularis Glycoside hydrolase, family 27 0.0113 0.006 0.006
Loa Loa (eye worm) RecQ helicase 0.005 0.0022 0.0022
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0047 0.0021 0.002
Echinococcus granulosus histone acetyltransferase KAT2B 0.0047 0.002 0.002
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0047 0.0021 0.002
Trypanosoma brucei unspecified product 0.0059 0.0028 0.006
Toxoplasma gondii 2,4-dienoyl CoA reductase 2, peroxisomal family protein 0.0045 0.0019 0.0041
Brugia malayi hypothetical protein 0.0021 0.0005 0.0005
Plasmodium vivax JmjC domain containing protein 0.0017 0.0002 0.0004
Loa Loa (eye worm) hypothetical protein 0.0045 0.002 0.0019
Loa Loa (eye worm) hypothetical protein 0.0065 0.0031 0.0031
Schistosoma mansoni RAR-like nuclear receptor 0.0047 0.0021 0.002
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0027 0.0008 0.0017
Mycobacterium ulcerans short chain dehydrogenase 0.0031 0.0011 0.0011
Echinococcus multilocularis folylpolyglutamate synthase, mitochondrial 0.0422 0.0248 0.0248
Mycobacterium leprae POSSIBLE MEMBRANE-ANCHORED THIOREDOXIN-LIKE PROTEIN (THIOL-DISULFIDE INTERCHANGE RELATED PROTEIN) 0.0024 0.0006 0.0006
Chlamydia trachomatis oxoacy-ACP reductase 0.0031 0.0011 0.0008
Echinococcus multilocularis cpg binding protein 0.0033 0.0012 0.0012
Brugia malayi sodium-independent organic anion transporter family protein 0.0031 0.0011 0.0011
Schistosoma mansoni serine/threonine protein kinase 0.0021 0.0005 0.0004
Loa Loa (eye worm) thymidylate synthase 0.111 0.0666 0.0665
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0049 0.0021 0.0046
Loa Loa (eye worm) hypothetical protein 0.004 0.0016 0.0016
Schistosoma mansoni tar DNA-binding protein 0.0139 0.0076 0.0076
Giardia lamblia NADH oxidase lateral transfer candidate 0.0018 0.0003 0.0447
Mycobacterium ulcerans short chain dehydrogenase 0.0031 0.0011 0.0011
Loa Loa (eye worm) oxidoreductase 0.0031 0.0011 0.0011
Echinococcus granulosus dna polymerase kappa 0.0066 0.0032 0.0032
Trypanosoma cruzi multidrug resistance-associated protein, putative 0.0028 0.0009 0.0019
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0047 0.0021 0.002
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0025 0.0007 0.0007
Echinococcus multilocularis FTZ F1 alpha 0.0047 0.0021 0.002
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0003 0.0005
Echinococcus granulosus thymidylate synthase 0.111 0.0666 0.0665
Leishmania major ATP-binding cassette protein subfamily C, member 5, putative 0.0028 0.0009 0.0019
Trypanosoma cruzi metacaspase 5, putative 0.0049 0.0021 0.0046
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0044 0.0019 0.0019
Mycobacterium ulcerans thymidylate synthase 0.111 0.0666 0.0665
Echinococcus multilocularis ecdysone induced protein 78C 0.0047 0.0021 0.002
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0047 0.0021 0.002
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0047 0.0021 0.002
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0005 0.012
Onchocerca volvulus 0.0053 0.0024 0.0357
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0031 0.0011 0.0011
Schistosoma mansoni multidrug resistance protein 0.0028 0.0009 0.0009
Brugia malayi prostaglandin transporter 0.0031 0.0011 0.0011
Trypanosoma brucei DNA polymerase kappa, putative 0.0033 0.0012 0.0025
Brugia malayi nuclear hormone receptor family member nhr-6 0.0022 0.0005 0.0005
Schistosoma mansoni caspase-7 (C14 family) 0.0128 0.007 0.007
Echinococcus granulosus apoptotic protease activating factor 1 0.0045 0.0019 0.0019
Entamoeba histolytica hypothetical protein 0.0115 0.0062 1
Brugia malayi beta-NAC-like protein 0.0038 0.0015 0.0015
Mycobacterium leprae NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE) 0.0031 0.0011 0.0011
Trypanosoma brucei isocitrate dehydrogenase, putative 0.005 0.0023 0.0048
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0045 0.0019 0.0019
Loa Loa (eye worm) hypothetical protein 0.0031 0.0011 0.0011
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0015 0.0408
Schistosoma mansoni nuclear receptor nhr-48 0.0022 0.0005 0.0005
Brugia malayi nuclear hormone receptor family member odr-7 0.0022 0.0005 0.0005
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0031 0.0011 0.0011
Brugia malayi Isocitrate dehydrogenase 0.005 0.0023 0.0023
Trypanosoma cruzi folylpolyglutamate synthase, putative 0.0422 0.0248 0.0538
Echinococcus multilocularis organic anion transporting polypeptide 30B 0.0031 0.0011 0.001
Leishmania major protein kinase, putative 0.0017 0.0002 0.0005
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0073 0.0036 0.0077
Echinococcus multilocularis dihydrofolate reductase 1.6483 1 1
Echinococcus granulosus Solute carrier organic anion transporter family 0.0031 0.0011 0.001
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0018 0.0003 0.0003
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0018 0.0003 0.0003
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0047 0.0021 0.0021
Treponema pallidum folylpolyglutamate synthetase (folC) 0.0422 0.0248 1
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0033 0.0012 0.0012
Schistosoma mansoni hypothetical protein 0.0045 0.002 0.0019
Trypanosoma brucei DNA polymerase kappa, putative 0.0033 0.0012 0.0025
Trichomonas vaginalis bromodomain-containing protein, putative 0.0047 0.002 0.0547
Echinococcus granulosus organic anion transporting polypeptide 30B 0.0031 0.0011 0.001
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0021 0.0005 0.0945
Echinococcus granulosus lysine specific demethylase 5A 0.0066 0.0032 0.0032
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0031 0.0011 0.0011
Brugia malayi mucosa associated lymphoid tissue lymphoma translocation protein 1 0.0049 0.0021 0.0021
Echinococcus multilocularis microtubule associated protein 2 0.0758 0.0452 0.0452
Loa Loa (eye worm) jmjC domain-containing protein 0.0017 0.0002 0.0002
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0032 0.0012 0.0025
Echinococcus granulosus Aryl hydrocarbon receptor nuclear 0.0017 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0021 0.0005 0.0004
Echinococcus granulosus thyroid hormone receptor alpha 0.0022 0.0005 0.0005
Onchocerca volvulus 0.0032 0.0011 0.0161
Mycobacterium ulcerans 20-beta-hydroxysteroid dehydrogenase FabG3 0.0031 0.0011 0.0011
Loa Loa (eye worm) steroid hormone receptor 0.0047 0.0021 0.002
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0031 0.0011 0.0011
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0113 0.006 0.006
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0073 0.0036 0.0036
Entamoeba histolytica recQ family helicase, putative 0.0027 0.0008 0.1257
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0047 0.0021 0.002
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0115 0.0062 0.0061
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase, putative 0.0616 0.0366 0.0794
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.005 0.0023 0.0022
Echinococcus multilocularis jumonji domain containing 1A 0.0017 0.0002 0.0002
Echinococcus multilocularis thyroid hormone receptor alpha 0.0047 0.0021 0.002
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0073 0.0036 0.0036
Echinococcus granulosus lamin 0.003 0.001 0.001
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0053 0.0024 0.0024
Brugia malayi follicle stimulating hormone receptor 0.0257 0.0148 0.0148
Giardia lamblia Multidrug resistance-associated protein 1 0.0028 0.0009 0.1533
Loa Loa (eye worm) hypothetical protein 0.0084 0.0043 0.0043
Trichomonas vaginalis peroxiredoxin, putative 0.0024 0.0006 0.0167
Echinococcus multilocularis importin subunit beta 1 0.0032 0.0011 0.0011
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0073 0.0036 0.0077
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0049 0.0021 0.0577
Toxoplasma gondii HEAT repeat-containing protein 0.0032 0.0011 0.0023
Brugia malayi nuclear receptor RXR 0.0025 0.0007 0.0007
Echinococcus multilocularis lysine specific demethylase 5A 0.0065 0.0031 0.0031
Echinococcus multilocularis 3 oxoacyl acyl carrier protein reductase 0.0031 0.0011 0.0011
Echinococcus multilocularis thioredoxin glutathione reductase 0.0052 0.0024 0.0023
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0073 0.0036 0.0036
Loa Loa (eye worm) hypothetical protein 0.004 0.0016 0.0016
Loa Loa (eye worm) sodium-independent organic anion transporter 0.0031 0.0011 0.001
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0017 0.0002 0.0005
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0019 0.0004 0.0003
Trichomonas vaginalis peroxiredoxin, putative 0.0024 0.0006 0.0167
Brugia malayi Steroid receptor seven-up type 2 0.0047 0.0021 0.0021
Onchocerca volvulus Cell death protein 3 homolog 0.0094 0.0049 0.073
Schistosoma mansoni bifunctional dihydrofolate reductase-thymidylate synthase 0.111 0.0666 0.0665
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0131 0.0071 0.0071
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0047 0.0021 0.002
Onchocerca volvulus Putative hydroxypyruvate isomerase 0.0022 0.0005 0.0076
Mycobacterium ulcerans short chain dehydrogenase 0.0031 0.0011 0.0011
Echinococcus granulosus axis inhibition protein axin 0.0021 0.0005 0.0004
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0031 0.0011 0.0011
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0005 0.012
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0115 0.0062 0.0061
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0032 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.0487 0.0287 0.0287
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0049 0.0021 0.0577
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.002 0.0004 0.0009
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0118 0.0064 0.0064
Brugia malayi Pre-SET motif family protein 0.0229 0.0131 0.0131
Echinococcus granulosus ATP dependent DNA helicase Q1 0.002 0.0004 0.0004
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0022 0.0005 0.0005
Brugia malayi photoreceptor-specific nuclear receptor 0.0047 0.0021 0.0021
Plasmodium vivax multidomain scavenger receptor, putative 0.0045 0.002 0.0042
Loa Loa (eye worm) hypothetical protein 0.0028 0.0009 0.0009
Leishmania major dehydrogenase/oxidoreductase-like protein 0.0031 0.0011 0.0023
Echinococcus granulosus tumor protein p63 0.0371 0.0217 0.0217
Giardia lamblia Sgs1 DNA helicase, putative 0.002 0.0004 0.0716
Loa Loa (eye worm) hypothetical protein 0.0045 0.0019 0.0019
Trypanosoma brucei trypanothione reductase 0.0052 0.0024 0.005
Brugia malayi A-kinase anchor protein 10, precursor 0.0021 0.0005 0.0005
Schistosoma mansoni jumonji domain containing protein 0.0065 0.0031 0.0031
Onchocerca volvulus 0.0031 0.0011 0.0153
Echinococcus granulosus transcription factor Dp 1 0.0042 0.0017 0.0017
Brugia malayi secreted modular calcium-binding protein 1 0.0021 0.0005 0.0005
Entamoeba histolytica Acid sphingomyelinase-like phosphodiesterase, putative 0.0091 0.0047 0.7626
Toxoplasma gondii NAC domain-containing protein 0.0038 0.0015 0.0032
Trypanosoma cruzi beta-ketoacyl-ACP reductase 0.0031 0.0011 0.0023
Trichomonas vaginalis importin beta-1, putative 0.0026 0.0008 0.0196
Leishmania major biopterin transporter, putative;with=GeneDB:LinJ35_V3.5120 0.0487 0.0288 0.0624
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0086 0.0044 0.0044
Loa Loa (eye worm) hypothetical protein 0.0047 0.0021 0.002
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0003 0.0005
Trypanosoma brucei PAB1-binding protein , putative 0.0028 0.0009 0.0018
Loa Loa (eye worm) hypothetical protein 0.0014 0 0.0000059338
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0018 0.0003 0.0005
Echinococcus multilocularis musashi 0.003 0.001 0.001
Schistosoma mansoni axis inhibition protein axin 0.0021 0.0005 0.0004
Schistosoma mansoni survival motor neuron protein 0.0053 0.0024 0.0024
Echinococcus multilocularis muscleblind protein 1 0.0164 0.0092 0.0091
Brugia malayi nuclear receptor NHR-67 0.0022 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.004 0.0016 0.0016
Trypanosoma cruzi oxidoreductase-like protein, putative 0.0045 0.0019 0.0041
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0018 0.0003 0.0005
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0002 0.0057
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0047 0.0021 0.0021
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0031 0.0011 0.0011
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0033 0.0012 0.0026
Echinococcus granulosus lysine specific demethylase 6a 0.0017 0.0002 0.0002
Echinococcus multilocularis lipoxygenase domain containing protein 0.0045 0.002 0.0019
Brugia malayi Dihydrofolate reductase 1.6483 1 1
Plasmodium vivax basic transcription factor 3b, putative 0.0038 0.0015 0.0032
Loa Loa (eye worm) oxidoreductase 0.0014 0 0.0000059338
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0027 0.0008 0.0017
Leishmania major vacuolar-type proton translocating pyrophosphatase 1, putative 0.0369 0.0216 0.0468
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0003 0.0005
Trichomonas vaginalis DNA helicase recq, putative 0.005 0.0022 0.0594
Brugia malayi SPARC precursor 0.0021 0.0005 0.0005
Echinococcus granulosus regulator of G protein signaling 3 0.0021 0.0005 0.0004
Mycobacterium ulcerans 3-alpha-hydroxysteroid dehydrogenase 0.0045 0.0019 0.0019
Mycobacterium ulcerans short chain dehydrogenase 0.0031 0.0011 0.0011
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.005 0.0023 0.0022
Brugia malayi hypothetical protein 0.004 0.0016 0.0016
Toxoplasma gondii hypothetical protein 0.003 0.001 0.0021
Schistosoma mansoni lozenge 0.0061 0.0029 0.0029
Trichomonas vaginalis conserved hypothetical protein 0.0049 0.0021 0.0577
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0086 0.0044 0.0044
Trichomonas vaginalis mercuric reductase, putative 0.0018 0.0003 0.0069
Loa Loa (eye worm) hypothetical protein 0.0017 0.0002 0.0002
Brugia malayi Cell death protein 3 precursor 0.0094 0.0049 0.0049
Echinococcus granulosus multidrug resistance associated protein 7 0.0028 0.0009 0.0009
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0021 0.0005 0.0004
Echinococcus multilocularis Polycystic kidney disease protein 0.0045 0.002 0.0019
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0159 0.0089 0.0088
Schistosoma mansoni organic anion transporter 0.0031 0.0011 0.001
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0049 0.0021 0.0577
Schistosoma mansoni DNA polymerase eta 0.0065 0.0031 0.0031
Schistosoma mansoni hypothetical protein 0.0371 0.0217 0.0217
Schistosoma mansoni follistatin 0.0021 0.0005 0.0004
Loa Loa (eye worm) hypothetical protein 0.0022 0.0005 0.0005
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.003 0.001 0.001
Trypanosoma cruzi multidrug resistance-associated protein, putative 0.0028 0.0009 0.0019
Schistosoma mansoni blooms syndrome DNA helicase 0.0039 0.0016 0.0015
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0027 0.0008 0.0017
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0017 0.0035
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase 0.7598 0.4606 1
Onchocerca volvulus 0.003 0.001 0.0144
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0049 0.0021 0.0577
Loa Loa (eye worm) hypothetical protein 0.0094 0.0049 0.0049
Loa Loa (eye worm) hypothetical protein 0.0032 0.0011 0.0011
Schistosoma mansoni jumonji/arid domain-containing protein 0.0066 0.0032 0.0032
Loa Loa (eye worm) hypothetical protein 0.0107 0.0057 0.0056
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0018 0.0003 0.0576
Echinococcus multilocularis dna polymerase kappa 0.0066 0.0032 0.0032
Trypanosoma cruzi beta-ketoacyl-ACP reductase 0.0031 0.0011 0.0023
Mycobacterium ulcerans sugar phosphate isomerases/epimerases 0.0022 0.0005 0.0005
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0022 0.0005 0.0005
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0086 0.0044 0.0095
Brugia malayi ImpB/MucB/SamB family protein 0.0037 0.0014 0.0014
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.009 0.0047 0.0046
Trypanosoma brucei transcription factor BTF3, putative 0.0038 0.0015 0.0032
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0257 0.0148 0.0148
Trichomonas vaginalis rotamase, putative 0.0033 0.0012 0.0323
Echinococcus granulosus snurportin 1 0.0338 0.0197 0.0197
Mycobacterium ulcerans short chain dehydrogenase 0.0031 0.0011 0.0011
Trypanosoma cruzi DNA polymerase kappa, putative 0.0066 0.0032 0.0069
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0047 0.0021 0.0021
Echinococcus granulosus Nuclear hormone receptor HR96 0.0022 0.0005 0.0005
Trypanosoma brucei DNA polymerase kappa, putative 0.0066 0.0032 0.0069
Echinococcus granulosus Polycystic kidney disease protein 0.0045 0.002 0.0019
Trypanosoma brucei Pyrophosphate-energized vacuolar membrane proton pump 2, putative 0.0369 0.0216 0.0468
Schistosoma mansoni nuclear hormone receptor 0.0047 0.0021 0.002
Loa Loa (eye worm) hypothetical protein 0.0151 0.0083 0.0083
Brugia malayi PAS domain containing protein 0.0017 0.0002 0.0002
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0113 0.006 0.006
Loa Loa (eye worm) hypothetical protein 0.0028 0.0009 0.0009
Mycobacterium tuberculosis Conserved hypothetical protein 0.0022 0.0005 0.0005
Schistosoma mansoni thyroid hormone receptor 0.0047 0.0021 0.002
Trypanosoma brucei dihydrofolate reductase-thymidylate synthase 0.7598 0.4606 1
Echinococcus granulosus multidrug resistance associated protein 1 0.0028 0.0009 0.0009
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0031 0.0011 0.0011
Brugia malayi hypothetical protein 0.0115 0.0062 0.0062
Plasmodium falciparum V-type H(+)-translocating pyrophosphatase, putative 0.0369 0.0216 0.0468
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0047 0.0021 0.002
Brugia malayi Latrophilin receptor protein 2 0.0017 0.0002 0.0002
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0118 0.0064 0.0064
Trypanosoma cruzi folylpolyglutamate synthetase 0.0422 0.0248 0.0538
Chlamydia trachomatis dihydrofolate reductase 1.6483 1 1
Echinococcus multilocularis geminin 0.0371 0.0217 0.0217
Plasmodium vivax ataxin-2 like protein, putative 0.0028 0.0009 0.0018
Onchocerca volvulus 0.0107 0.0057 0.0847
Loa Loa (eye worm) hypothetical protein 0.0107 0.0057 0.0056
Mycobacterium ulcerans short chain dehydrogenase 0.0031 0.0011 0.0011
Toxoplasma gondii bifunctional dihydrofolate reductase-thymidylate synthase 0.7598 0.4606 1
Brugia malayi steroid hormone receptor 0.0047 0.0021 0.0021
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0022 0.0005 0.0005
Onchocerca volvulus 0.0261 0.015 0.2255
Schistosoma mansoni transcription factor LCR-F1 0.0115 0.0062 0.0061
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0033 0.0012 0.0025
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0086 0.0044 0.0095
Echinococcus multilocularis caspase 8 0.0049 0.0021 0.0021
Loa Loa (eye worm) hypothetical protein 0.0025 0.0007 0.0007
Loa Loa (eye worm) FolC protein 0.0422 0.0248 0.0248
Brugia malayi RNA binding protein 0.0139 0.0076 0.0076
Trichomonas vaginalis hypothetical protein 0.0031 0.0011 0.0288
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.002 0.0004 0.0009
Loa Loa (eye worm) jmjC domain-containing protein 0.0066 0.0032 0.0032
Brugia malayi Reduced folate carrier family protein 0.0107 0.0057 0.0057
Brugia malayi regulator of G-protein signaling egl-10 0.0021 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0017 0.0002 0.0002
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0047 0.0021 0.0304
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0113 0.006 0.006
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0047 0.0021 0.002
Toxoplasma gondii melibiase subfamily protein 0.0113 0.006 0.013
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0047 0.0021 0.002
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0047 0.0021 0.002
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0891 0.0533 0.0532
Entamoeba histolytica hypothetical protein 0.0107 0.0057 0.9208
Echinococcus granulosus jumonji domain containing 1A 0.0017 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0047 0.0021 0.002
Loa Loa (eye worm) hypothetical protein 0.0634 0.0377 0.0377
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0021 0.0005 0.0004
Trypanosoma cruzi trypanothione reductase, putative 0.0018 0.0003 0.0005
Mycobacterium tuberculosis Possible oxidoreductase 0.0031 0.0011 0.0011
Echinococcus multilocularis transcription factor Dp 1 0.0042 0.0017 0.0017
Echinococcus granulosus regulator of G protein signaling 7 0.0021 0.0005 0.0004
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0005 0.012
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0047 0.0021 0.002
Trypanosoma cruzi metacaspase 5, putative 0.0049 0.0021 0.0046
Echinococcus granulosus geminin 0.0371 0.0217 0.0217
Mycobacterium tuberculosis Probable dehydrogenase/reductase 0.0031 0.0011 0.0011
Schistosoma mansoni tar DNA-binding protein 0.0139 0.0076 0.0076
Schistosoma mansoni importin beta-1 0.0032 0.0011 0.0011
Brugia malayi jmjC domain containing protein 0.0065 0.0031 0.0031
Brugia malayi acetyltransferase, GNAT family protein 0.0159 0.0089 0.0089
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0032 0.0012 0.0025
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0203 0.0115 0.0115
Trypanosoma cruzi trypanothione reductase, putative 0.0052 0.0024 0.005
Brugia malayi Nuclear hormone receptor-like 1 0.0025 0.0007 0.0007
Brugia malayi Regulator of G protein signaling domain containing protein 0.0021 0.0005 0.0005
Schistosoma mansoni nuclear hormone receptor 0.0022 0.0005 0.0005
Leishmania major DNA polymerase eta, putative 0.0065 0.0031 0.0068
Mycobacterium ulcerans short chain dehydrogenase 0.0031 0.0011 0.0011
Echinococcus multilocularis tar DNA binding protein 0.0139 0.0076 0.0076
Mycobacterium ulcerans 3-oxoacyl-ACP reductase 0.0031 0.0011 0.0011
Echinococcus granulosus aryl hydrocarbon receptor 0.0058 0.0027 0.0027
Loa Loa (eye worm) PXA domain-containing protein 0.0021 0.0005 0.0004
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.0021 0.0005 0.0009
Echinococcus multilocularis peptidase Clp (S14 family) 0.0056 0.0026 0.0026
Echinococcus granulosus lamin dm0 0.003 0.001 0.001
Trichomonas vaginalis alpha-galactosidase/alpha-N-acetylgalactosaminidase, putative 0.0075 0.0038 0.1016
Entamoeba histolytica hypothetical protein 0.0038 0.0015 0.2436
Trichomonas vaginalis conserved hypothetical protein 0.0049 0.0021 0.0577
Brugia malayi aryl hydrocarbon receptor nuclear translocator protein, putative 0.004 0.0016 0.0016
Brugia malayi Melibiase family protein 0.0075 0.0038 0.0038
Echinococcus granulosus caspase 2 0.0094 0.0049 0.0049
Mycobacterium tuberculosis Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) 1.6483 1 1
Echinococcus multilocularis lysine specific demethylase 6a 0.0017 0.0002 0.0002
Echinococcus multilocularis regulator of G protein signaling 3 0.0021 0.0005 0.0004
Plasmodium falciparum importin beta, putative 0.0032 0.0011 0.0023
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0032 0.0012 0.0025
Trypanosoma brucei DNA polymerase kappa, putative 0.0066 0.0032 0.0069
Trichomonas vaginalis DNA polymerase eta, putative 0.0066 0.0032 0.0871
Trypanosoma brucei folylpolyglutamate synthase, putative 0.0422 0.0248 0.0538
Toxoplasma gondii redoxin domain-containing protein 0.0093 0.0049 0.0105
Plasmodium vivax importin-beta 2, putative 0.0032 0.0011 0.0023
Trypanosoma brucei importin beta-1 subunit, putative 0.0032 0.0011 0.0023
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0139 0.0076 0.0076
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0047 0.0021 0.002
Loa Loa (eye worm) ATP-dependent DNA helicase 0.002 0.0004 0.0004
Plasmodium vivax bifunctional dihydrofolate reductase-thymidylate synthase, putative 0.7598 0.4606 1
Echinococcus multilocularis bloom syndrome protein 0.005 0.0022 0.0022
Schistosoma mansoni serine/threonine protein kinase 0.0021 0.0005 0.0004
Trypanosoma brucei DNA polymerase kappa, putative 0.0066 0.0032 0.0069
Trichomonas vaginalis soluble guanylate cyclase gcy, putative 0.0017 0.0002 0.0057
Schistosoma mansoni organic anion transporter 0.0031 0.0011 0.001
Schistosoma mansoni 3-oxoacyl-[ACP] reductase 0.0031 0.0011 0.0011
Brugia malayi glutathione reductase 0.0052 0.0024 0.0024
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0047 0.002 0.0547
Loa Loa (eye worm) hypothetical protein 0.002 0.0004 0.0004
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0021 0.0005 0.0005
Echinococcus multilocularis Major facilitator superfamily, general substrate transporter 0.0164 0.0092 0.0091
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0017 0.0002 0.0002
Brugia malayi jmjC domain containing protein 0.0017 0.0002 0.0002
Schistosoma mansoni phosphatidylserine receptor 0.0017 0.0002 0.0002
Schistosoma mansoni regulator of G protein signaling 0.0021 0.0005 0.0004
Leishmania major DNA polymerase eta, putative 0.0039 0.0016 0.0034
Brugia malayi tailless protein 0.0022 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0025 0.0007 0.0007
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0032 0.0012 0.0025
Onchocerca volvulus 0.0045 0.002 0.0289
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0017 0.0035
Loa Loa (eye worm) hypothetical protein 0.0107 0.0057 0.0056
Loa Loa (eye worm) hypothetical protein 0.0091 0.0047 0.0047
Trypanosoma cruzi metacaspase, putative 0.0049 0.0021 0.0046
Entamoeba histolytica ATP-binding cassette protein, putative 0.0028 0.0009 0.1411
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0034 0.0012 0.0026
Onchocerca volvulus 0.0487 0.0287 0.4314
Schistosoma mansoni multidrug resistance protein 0.0028 0.0009 0.0009
Echinococcus multilocularis folylpolyglutamate synthase, mitochondrial 0.0422 0.0248 0.0248
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0073 0.0036 0.0036
Leishmania major protein kinase, putative 0.0017 0.0002 0.0005
Loa Loa (eye worm) hypothetical protein 0.0022 0.0005 0.0005
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0073 0.0036 0.0036
Brugia malayi Nuclear hormone receptor-like 1 0.0025 0.0007 0.0007
Plasmodium vivax vacuolar-type H+ pumping pyrophosphatase, putative 0.0369 0.0216 0.0468
Onchocerca volvulus 0.0031 0.0011 0.0158
Loa Loa (eye worm) hypothetical protein 0.0033 0.0012 0.0012
Chlamydia trachomatis endonuclease IV 0.0084 0.0043 0.0041
Trypanosoma brucei DNA polymerase IV, putative 0.0059 0.0028 0.006
Echinococcus multilocularis snurportin 1 0.0338 0.0197 0.0197
Trypanosoma brucei multidrug resistance protein E 0.0028 0.0009 0.0019
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0086 0.0044 1
Loa Loa (eye worm) hypothetical protein 0.0049 0.0021 0.0021
Echinococcus granulosus Regulator of G protein signaling 20 0.0021 0.0005 0.0004
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0056 0.0026 0.0026
Schistosoma mansoni protein phosphatase 2C 0.0017 0.0002 0.0002
Brugia malayi jmjC domain containing protein 0.0017 0.0002 0.0002
Echinococcus multilocularis expressed protein 0.0033 0.0012 0.0012
Echinococcus multilocularis axis inhibition protein axin 0.0021 0.0005 0.0004
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.005 0.0023 0.0022
Loa Loa (eye worm) hypothetical protein 0.0055 0.0025 0.0025
Loa Loa (eye worm) ICD-1 protein 0.0038 0.0015 0.0015
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0073 0.0036 0.5819
Loa Loa (eye worm) doublecortin family protein 0.0045 0.002 0.0019
Loa Loa (eye worm) dehydrogenase 0.0014 0 0.0000059338
Trypanosoma brucei Pyrophosphate-energized vacuolar membrane proton pump 1 0.0369 0.0216 0.0468
Trypanosoma brucei metacaspase 0.0049 0.0021 0.0046
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0031 0.0011 0.0011
Loa Loa (eye worm) oxidoreductase 0.0014 0 0.0000059338
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.002 0.0004 0.0004
Brugia malayi hypothetical protein 0.0045 0.0019 0.0019
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0055 0.0025 0.0025
Schistosoma mansoni jumonji/arid domain-containing protein 0.0066 0.0032 0.0032
Brugia malayi hypothetical protein 0.0022 0.0005 0.0005
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0033 0.0012 0.0012
Schistosoma mansoni hypothetical protein 0.0017 0.0002 0.0002
Schistosoma mansoni axis inhibition protein axin 0.0021 0.0005 0.0004
Loa Loa (eye worm) oxidoreductase 0.0014 0 0.0000059338
Echinococcus multilocularis caspase 0.0128 0.007 0.007

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 10 nM Test inhibition of LTB4 production in human peripheral blood polymorphonuclear leukocytes (HPMN) ChEMBL. 8831761
IC50 (functional) = 10 nM Test inhibition of LTB4 production in human peripheral blood polymorphonuclear leukocytes (HPMN) ChEMBL. 8831761
IC50 (binding) = 760 nM Potency to inhibit oxidation of arachidonic acid by recombinant human 5-lipoxygenase ChEMBL. 8831761
IC50 (binding) = 760 nM Potency to inhibit oxidation of arachidonic acid by recombinant human 5-lipoxygenase ChEMBL. 8831761
IC50 (functional) > 1000 nM Compound was tested for the inhibition of LTB4 production in human whole blood (HWB) ChEMBL. 8831761
IC50 (functional) > 1000 nM Compound was tested for the inhibition of LTB4 production in human whole blood (HWB) ChEMBL. 8831761

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23 8831761

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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