Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0038 | 0.0106 | 0.0272 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0032 | 0.001 | 0.0011 |
Echinococcus multilocularis | neutral alpha glucosidase AB | 0.0036 | 0.0071 | 0.0113 |
Brugia malayi | Phosphoglycerate kinase | 0.0084 | 0.0778 | 0.0816 |
Echinococcus granulosus | FTZ F1 alpha | 0.006 | 0.0422 | 0.0705 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0432 | 0.5857 | 1 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.006 | 0.0422 | 0.0765 |
Echinococcus multilocularis | dna polymerase kappa | 0.0038 | 0.0106 | 0.0179 |
Leishmania major | DNA polymerase kappa, putative,DNA polymerase IV, putative | 0.0038 | 0.0106 | 0.0272 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0141 | 0.1614 | 0.4125 |
Echinococcus multilocularis | retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha | 0.04 | 0.5396 | 1 |
Brugia malayi | hypothetical protein | 0.0438 | 0.595 | 0.6237 |
Entamoeba histolytica | phosphoglycerate kinase, putative | 0.0084 | 0.0778 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.006 | 0.0422 | 0.0433 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.006 | 0.0422 | 0.0705 |
Schistosoma mansoni | phosphoglycerate kinase | 0.0084 | 0.0778 | 0.1314 |
Trypanosoma brucei | DNA polymerase eta, putative | 0.0063 | 0.0474 | 0.1213 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.006 | 0.0422 | 0.0443 |
Schistosoma mansoni | thyroid hormone receptor | 0.006 | 0.0422 | 0.0705 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.0422 | 0.0433 |
Schistosoma mansoni | DNA polymerase eta | 0.0063 | 0.0474 | 0.0794 |
Giardia lamblia | Phosphoglycerate kinase | 0.0084 | 0.0778 | 1 |
Leishmania major | phosphoglycerate kinase B, cytosolic | 0.0084 | 0.0778 | 0.1989 |
Plasmodium falciparum | phosphoglycerate kinase | 0.0084 | 0.0778 | 0.5 |
Leishmania major | DNA polymerase eta, putative | 0.0037 | 0.009 | 0.023 |
Schistosoma mansoni | terminal deoxycytidyl transferase | 0.0038 | 0.0106 | 0.0165 |
Echinococcus multilocularis | FTZ F1 alpha | 0.006 | 0.0422 | 0.0765 |
Loa Loa (eye worm) | steroid hormone receptor | 0.006 | 0.0422 | 0.0433 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.0422 | 0.0433 |
Mycobacterium leprae | Probable phosphoglycerate kinase Pgk | 0.0084 | 0.0778 | 0.5 |
Toxoplasma gondii | phosphoglycerate kinase PGKII | 0.0084 | 0.0778 | 1 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.006 | 0.0422 | 0.0443 |
Trypanosoma brucei | DNA polymerase beta thumb, putative | 0.0042 | 0.0162 | 0.0415 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.006 | 0.0422 | 0.0705 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0063 | 0.0474 | 0.0497 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.006 | 0.0422 | 0.0705 |
Echinococcus granulosus | terminal deoxycytidyl transferase rev1 | 0.0038 | 0.0106 | 0.0165 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0038 | 0.0106 | 0.0272 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.006 | 0.0422 | 0.0443 |
Schistosoma mansoni | rab geranylgeranyl transferase alpha subunit | 0.0038 | 0.0106 | 0.0165 |
Trypanosoma cruzi | DNA polymerase beta thumb, putative | 0.0042 | 0.0162 | 0.0415 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.006 | 0.0422 | 0.0705 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.006 | 0.0422 | 0.0443 |
Toxoplasma gondii | ImpB/MucB/SamB family protein | 0.0037 | 0.009 | 0.0266 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.006 | 0.0422 | 0.0765 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.006 | 0.0422 | 0.0443 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.0422 | 0.0433 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.006 | 0.0422 | 0.0705 |
Leishmania major | DNA polymerase kappa, putative | 0.0038 | 0.0106 | 0.0272 |
Schistosoma mansoni | glutaminase | 0.027 | 0.3499 | 0.5967 |
Mycobacterium ulcerans | glutaminase | 0.027 | 0.3499 | 1 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.006 | 0.0422 | 0.0705 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0036 | 0.0071 | 0.0182 |
Toxoplasma gondii | hypothetical protein | 0.0048 | 0.0253 | 0.2566 |
Schistosoma mansoni | phosphoglycerate kinase | 0.0084 | 0.0778 | 0.1314 |
Echinococcus multilocularis | dna polymerase eta | 0.0063 | 0.0474 | 0.0862 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0038 | 0.0106 | 0.0272 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0032 | 0.001 | 0.0011 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0038 | 0.0106 | 0.0272 |
Mycobacterium ulcerans | phosphoglycerate kinase | 0.0084 | 0.0778 | 0.1981 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.006 | 0.0422 | 0.0433 |
Echinococcus multilocularis | terminal deoxycytidyl transferase rev1 | 0.0038 | 0.0106 | 0.0179 |
Trichomonas vaginalis | DNA polymerase eta, putative | 0.0038 | 0.0106 | 0.0103 |
Brugia malayi | nuclear hormone receptor | 0.0684 | 0.9538 | 1 |
Leishmania major | phosphoglycerate kinase C, glycosomal | 0.0084 | 0.0778 | 0.1989 |
Echinococcus granulosus | lysosomal alpha glucosidase | 0.0161 | 0.1903 | 0.3237 |
Onchocerca volvulus | 0.0438 | 0.595 | 0.5771 | |
Trypanosoma brucei | phosphoglycerate kinase | 0.0084 | 0.0778 | 0.1989 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0036 | 0.0071 | 0.0182 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.006 | 0.0422 | 0.0705 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0432 | 0.5857 | 1 |
Toxoplasma gondii | phosphoglycerate kinase PGKI | 0.0084 | 0.0778 | 1 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0063 | 0.0474 | 0.1213 |
Schistosoma mansoni | coup transcription factor | 0.006 | 0.0422 | 0.0705 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0299 | 0.3913 | 1 |
Schistosoma mansoni | lozenge | 0.0055 | 0.0352 | 0.0584 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0038 | 0.0106 | 0.0272 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0161 | 0.1903 | 0.3515 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.006 | 0.0422 | 0.0705 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.0422 | 0.0433 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.006 | 0.0422 | 0.0443 |
Treponema pallidum | phosphoglycerate kinase | 0.0084 | 0.0778 | 0.5 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.006 | 0.0422 | 0.0705 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0038 | 0.0106 | 0.0272 |
Trypanosoma cruzi | phosphoglycerate kinase, putative | 0.0084 | 0.0778 | 0.1989 |
Mycobacterium ulcerans | hypothetical protein | 0.0157 | 0.1848 | 0.5132 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0161 | 0.1903 | 0.1995 |
Trypanosoma brucei | unspecified product | 0.0038 | 0.0106 | 0.0272 |
Leishmania major | DNA polymerase eta, putative | 0.0063 | 0.0474 | 0.1213 |
Loa Loa (eye worm) | hypothetical protein | 0.0063 | 0.0474 | 0.0487 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.006 | 0.0422 | 0.0705 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0051 | 0.0297 | 0.0758 |
Echinococcus multilocularis | Protein lozenge | 0.0055 | 0.0352 | 0.0634 |
Loa Loa (eye worm) | runx1 | 0.0055 | 0.0352 | 0.0358 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.006 | 0.0422 | 0.0765 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0038 | 0.0106 | 0.0272 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0038 | 0.0106 | 0.0272 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.006 | 0.0422 | 0.0443 |
Echinococcus granulosus | phosphoglycerate kinase 1 | 0.0084 | 0.0778 | 0.1314 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0037 | 0.009 | 0.023 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.006 | 0.0422 | 0.0443 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.006 | 0.0422 | 0.0765 |
Schistosoma mansoni | alpha glucosidase | 0.0036 | 0.0071 | 0.0104 |
Trypanosoma brucei | glucosidase, putative | 0.0036 | 0.0071 | 0.0182 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0157 | 0.1848 | 1 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.006 | 0.0422 | 0.0705 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.006 | 0.0422 | 0.0433 |
Loa Loa (eye worm) | glutaminase 2 | 0.027 | 0.3499 | 0.3662 |
Loa Loa (eye worm) | hypothetical protein | 0.0084 | 0.0778 | 0.0806 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.006 | 0.0422 | 0.0765 |
Loa Loa (eye worm) | nuclear receptor nhr-7B | 0.0684 | 0.9538 | 1 |
Brugia malayi | steroid hormone receptor | 0.006 | 0.0422 | 0.0443 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0042 | 0.0162 | 0.0415 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.006 | 0.0422 | 0.0443 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.006 | 0.0422 | 0.0443 |
Trichomonas vaginalis | phosphoglycerate kinase, putative | 0.0084 | 0.0778 | 0.2063 |
Brugia malayi | hypothetical protein | 0.0032 | 0.001 | 0.0011 |
Brugia malayi | ecdysteroid receptor | 0.006 | 0.0422 | 0.0443 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.0422 | 0.0433 |
Loa Loa (eye worm) | glutaminase | 0.027 | 0.3499 | 0.3662 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.0422 | 0.0433 |
Brugia malayi | nuclear receptor NHR-88 | 0.006 | 0.0422 | 0.0443 |
Echinococcus granulosus | dna polymerase kappa | 0.0038 | 0.0106 | 0.0165 |
Schistosoma mansoni | alpha-glucosidase | 0.0139 | 0.1575 | 0.2677 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.006 | 0.0422 | 0.0443 |
Chlamydia trachomatis | phosphoglycerate kinase | 0.0084 | 0.0778 | 0.5 |
Echinococcus granulosus | neutral alpha glucosidase AB | 0.0036 | 0.0071 | 0.0104 |
Schistosoma mansoni | alpha-glucosidase | 0.0139 | 0.1575 | 0.2677 |
Trichomonas vaginalis | DNA polymerase IV / kappa, putative | 0.0038 | 0.0106 | 0.0103 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0038 | 0.0106 | 0.0272 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0038 | 0.0106 | 0.0272 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.0422 | 0.0433 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.006 | 0.0422 | 0.0705 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.006 | 0.0422 | 0.0443 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.006 | 0.0422 | 0.0433 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.006 | 0.0422 | 0.0705 |
Loa Loa (eye worm) | hypothetical protein | 0.0438 | 0.595 | 0.6233 |
Trypanosoma cruzi | DNA polymerase beta thumb, putative | 0.0042 | 0.0162 | 0.0415 |
Trypanosoma brucei | phosphoglycerate kinase | 0.0084 | 0.0778 | 0.1989 |
Wolbachia endosymbiont of Brugia malayi | phosphoglycerate kinase | 0.0084 | 0.0778 | 0.5 |
Leishmania major | mitochondrial DNA polymerase beta | 0.0299 | 0.3913 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0038 | 0.0106 | 0.0272 |
Brugia malayi | nuclear receptor RXR | 0.0032 | 0.001 | 0.0011 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0038 | 0.0106 | 0.0272 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.006 | 0.0422 | 0.0443 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.006 | 0.0422 | 0.0433 |
Trypanosoma brucei | mitochondrial DNA polymerase beta-PAK | 0.0141 | 0.1614 | 0.4125 |
Trypanosoma brucei | mitochondrial DNA polymerase beta | 0.0299 | 0.3913 | 1 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0161 | 0.1903 | 0.1987 |
Entamoeba histolytica | deoxycytidyl transferase, putative | 0.0038 | 0.0106 | 0.0499 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0161 | 0.1903 | 0.3515 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0038 | 0.0106 | 0.0272 |
Leishmania major | alpha glucosidase II subunit, putative | 0.0036 | 0.0071 | 0.0182 |
Schistosoma mansoni | thyroid hormone receptor | 0.006 | 0.0422 | 0.0705 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0038 | 0.0106 | 0.0272 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.006 | 0.0422 | 0.0705 |
Loa Loa (eye worm) | ImpB/MucB/SamB family protein | 0.0038 | 0.0106 | 0.0101 |
Loa Loa (eye worm) | hypothetical protein | 0.0656 | 0.9126 | 0.9567 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.006 | 0.0422 | 0.0765 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.006 | 0.0422 | 0.0705 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.006 | 0.0422 | 0.0765 |
Trypanosoma cruzi | phosphoglycerate kinase, putative | 0.0084 | 0.0778 | 0.1989 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0036 | 0.0071 | 0.0064 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0038 | 0.0106 | 0.0272 |
Trichomonas vaginalis | glutaminase, putative | 0.027 | 0.3499 | 1 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0038 | 0.0106 | 0.0112 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0036 | 0.0071 | 0.0074 |
Brugia malayi | hypothetical protein | 0.0032 | 0.001 | 0.0011 |
Plasmodium vivax | phosphoglycerate kinase, putative | 0.0084 | 0.0778 | 0.5 |
Leishmania major | mitochondrial DNA polymerase beta-PAK, putative | 0.0141 | 0.1614 | 0.4125 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.006 | 0.0422 | 0.0443 |
Schistosoma mansoni | nuclear hormone receptor | 0.006 | 0.0422 | 0.0705 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0038 | 0.0106 | 0.0272 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.006 | 0.0422 | 0.0443 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.006 | 0.0422 | 0.0443 |
Mycobacterium tuberculosis | Probable phosphoglycerate kinase Pgk | 0.0084 | 0.0778 | 0.3859 |
Echinococcus granulosus | dna polymerase eta | 0.0063 | 0.0474 | 0.0794 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.006 | 0.0422 | 0.0433 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.006 | 0.0422 | 0.0433 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.0422 | 0.0433 |
Loa Loa (eye worm) | hypothetical protein | 0.0438 | 0.595 | 0.6233 |
Brugia malayi | glutaminase DH11.1 | 0.027 | 0.3499 | 0.3668 |
Echinococcus multilocularis | phosphoglycerate kinase 1 | 0.0084 | 0.0778 | 0.1426 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0038 | 0.0106 | 0.0272 |
Trichomonas vaginalis | phosphoglycerate kinase, putative | 0.0084 | 0.0778 | 0.2063 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.006 | 0.0422 | 0.0765 |
Onchocerca volvulus | 0.0093 | 0.091 | 0.051 | |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0299 | 0.3913 | 1 |
Brugia malayi | nuclear hormone receptor | 0.006 | 0.0422 | 0.0443 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | = 0.6 uM | Concentration that reduces the difference in reversal of DOX accumulation between MDA-435/LCC6 and MDA-435/LCC6MDRI cells by 50%. | ChEMBL. | 11784143 |
EC50 (functional) | = 0.7 uM | Effect on reversal of [3H]- VBL accumulation in MDA-435/LCC6(Pgp-negative) cells. | ChEMBL. | 11784143 |
EC50 (functional) | = 0.8 uM | Concentration that reduces difference in reversal of [3H]-VBL accumulation between MDA-435/LCC6 and MDA-435/LCC6MDRI cells by 50% | ChEMBL. | 11784143 |
EC50 (functional) | = 0.9 uM | Effect on reversal of DOX accumulation in MDA-435/LCC6(Pgp-negative) cells. | ChEMBL. | 11784143 |
IC50 (functional) | > 20 uM | Growth inhibitory activity on MDA-435/LCC6 (Pgp-positive) human breast cancer cells | ChEMBL. | 11784143 |
IC50 (functional) | > 20 uM | Growth inhibitory activity on MDA-435/LCC6MDRI (Pgp-negative) human breast cancer cells | ChEMBL. | 11784143 |
ND (functional) | 0 | To estimate the extent of resistance conferred by Pgp, the ratioof IC50 in MDA-435/LCC6MDR1 and MDA-435/LCC6 cells (relative resistance of Pgp-positive cells) was used; no data | ChEMBL. | 11784143 |
ND (functional) | 0 | Ability of compound to inhibit MDA-435/LCC6 cell growth relative to progesterone; Not determined | ChEMBL. | 11784143 |
ND (functional) | 0 | Ability of compound to inhibit MDA-435/LCC6MDR cell growth relative to progesterone; Not determined | ChEMBL. | 11784143 |
Ratio (functional) | > 22.2 | Ratio of effect of compound on DOX accumulation (antiPgp activity) to its intrinsic cellular toxicity | ChEMBL. | 11784143 |
Ratio (functional) | > 28.6 | Ratio of effect of compound on VBL accumulation (antiPgp activity) to its intrinsic cellular toxicity | ChEMBL. | 11784143 |
Relative potency (functional) | = 24.5 | Potency of the compound relative to progesterone in reducing the difference in reversing of [3H]-VBL accumulation between MDA-435/LCC6 and MDA-435/LCC6MDRI cells | ChEMBL. | 11784143 |
Relative potency (functional) | = 28.2 | Potency of the compound relative to progesterone in reversing of [3H]- VBL accumulation in MDA-435/LCC6(Pgp-negative) cells. | ChEMBL. | 11784143 |
Relative potency (functional) | = 37.2 | Potency of the compound relative to progesterone in reducing the difference in reversal of DOX accumulation between MDA-435/LCC6 and MDA-435/LCC6MDRI cells | ChEMBL. | 11784143 |
Relative potency (functional) | = 44.8 | Potency of the compound relative to progesterone in reversing of DOX accumulation in MDA-435/LCC6(Pgp-negative) cells. | ChEMBL. | 11784143 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.