Detailed information for compound 223797

Basic information

Technical information
  • TDR Targets ID: 223797
  • Name: methyl 2-(2,2-diphenylacetyl)-5-phenyl-3,4-di hydro-1H-isoquinoline-3-carboxylate
  • MW: 461.551 | Formula: C31H27NO3
  • H donors: 0 H acceptors: 2 LogP: 6.12 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: COC(=O)C1Cc2c(CN1C(=O)C(c1ccccc1)c1ccccc1)cccc2c1ccccc1
  • InChi: 1S/C31H27NO3/c1-35-31(34)28-20-27-25(18-11-19-26(27)22-12-5-2-6-13-22)21-32(28)30(33)29(23-14-7-3-8-15-23)24-16-9-4-10-17-24/h2-19,28-29H,20-21H2,1H3
  • InChiKey: PPQXGGXAGYPULW-UHFFFAOYSA-N  

Network

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Synonyms

  • 2-(1-oxo-2,2-diphenylethyl)-5-phenyl-3,4-dihydro-1H-isoquinoline-3-carboxylic acid methyl ester
  • methyl 2-(2,2-diphenylethanoyl)-5-phenyl-3,4-dihydro-1H-isoquinoline-3-carboxylate
  • 2-(2,2-diphenylacetyl)-5-phenyl-3,4-dihydro-1H-isoquinoline-3-carboxylic acid methyl ester
  • methyl 2-[2,2-di(phenyl)acetyl]-5-phenyl-3,4-dihydro-1H-isoquinoline-3-carboxylate
  • 2-[1-oxo-2,2-di(phenyl)ethyl]-5-phenyl-3,4-dihydro-1H-isoquinoline-3-carboxylic acid methyl ester
  • 2-[2,2-di(phenyl)acetyl]-5-phenyl-3,4-dihydro-1H-isoquinoline-3-carboxylic acid methyl ester
  • methyl 2-[2,2-di(phenyl)ethanoyl]-5-phenyl-3,4-dihydro-1H-isoquinoline-3-carboxylate

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Rattus norvegicus Angiotensin II receptor (AT-1) type-1 Starlite/ChEMBL References
Rattus norvegicus Angiotensin II type 2 (AT-2) receptor Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Echinococcus granulosus tm gpcr rhodopsin Angiotensin II receptor (AT-1) type-1   359 aa 300 aa 21.0 %
Echinococcus multilocularis neuropeptide receptor Angiotensin II type 2 (AT-2) receptor   363 aa 308 aa 21.4 %
Echinococcus granulosus neuropeptide receptor Angiotensin II type 2 (AT-2) receptor   363 aa 306 aa 22.2 %
Brugia malayi ORL1-like opioid receptor Angiotensin II receptor (AT-1) type-1   359 aa 314 aa 20.4 %
Echinococcus multilocularis G-protein coupled receptor, putative Angiotensin II receptor (AT-1) type-1   359 aa 307 aa 22.1 %
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor Angiotensin II receptor (AT-1) type-1   359 aa 350 aa 23.1 %
Schistosoma mansoni adenoreceptor Angiotensin II type 2 (AT-2) receptor   363 aa 328 aa 22.0 %
Schistosoma japonicum ko:K04209 neuropeptide Y receptor, invertebrate, putative Angiotensin II type 2 (AT-2) receptor   363 aa 310 aa 23.5 %
Brugia malayi putative neuropeptide receptor NPR1 Angiotensin II receptor (AT-1) type-1   359 aa 295 aa 27.1 %
Onchocerca volvulus E3 ubiquitin-protein ligase rpm-1 homolog Angiotensin II receptor (AT-1) type-1   359 aa 354 aa 20.6 %
Loa Loa (eye worm) neuropeptide F receptor Angiotensin II type 2 (AT-2) receptor   363 aa 356 aa 23.3 %
Echinococcus granulosus growth hormone secretagogue receptor type 1 Angiotensin II receptor (AT-1) type-1   359 aa 343 aa 23.0 %
Onchocerca volvulus Angiotensin II receptor (AT-1) type-1   359 aa 350 aa 24.0 %
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor Angiotensin II type 2 (AT-2) receptor   363 aa 398 aa 18.1 %
Echinococcus multilocularis thyrotropin releasing hormone receptor Angiotensin II type 2 (AT-2) receptor   363 aa 308 aa 21.8 %
Loa Loa (eye worm) hypothetical protein Angiotensin II receptor (AT-1) type-1   359 aa 329 aa 24.0 %
Echinococcus multilocularis allatostatin A receptor Angiotensin II type 2 (AT-2) receptor   363 aa 342 aa 24.6 %
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor Angiotensin II receptor (AT-1) type-1   359 aa 346 aa 18.2 %
Onchocerca volvulus Angiotensin II type 2 (AT-2) receptor   363 aa 305 aa 21.6 %
Onchocerca volvulus Angiotensin II receptor (AT-1) type-1   359 aa 314 aa 25.2 %
Echinococcus granulosus pyroglutamylated rfamide peptide receptor Angiotensin II type 2 (AT-2) receptor   363 aa 398 aa 18.3 %
Schistosoma mansoni opsin-like receptor Angiotensin II receptor (AT-1) type-1   359 aa 299 aa 25.8 %
Schistosoma japonicum ko:K04134 cholinergic receptor, invertebrate, putative Angiotensin II receptor (AT-1) type-1   359 aa 325 aa 20.9 %
Loa Loa (eye worm) hypothetical protein Angiotensin II receptor (AT-1) type-1   359 aa 308 aa 27.6 %
Schistosoma japonicum Rhodopsin, putative Angiotensin II type 2 (AT-2) receptor   363 aa 341 aa 22.0 %
Schistosoma mansoni peptide (allatostatin)-like receptor Angiotensin II type 2 (AT-2) receptor   363 aa 364 aa 20.9 %
Brugia malayi GnHR receptor homolog Angiotensin II receptor (AT-1) type-1   359 aa 357 aa 20.4 %
Onchocerca volvulus Angiotensin II receptor (AT-1) type-1   359 aa 386 aa 24.4 %
Onchocerca volvulus Angiotensin II type 2 (AT-2) receptor   363 aa 311 aa 23.8 %
Echinococcus granulosus allatostatin A receptor Angiotensin II type 2 (AT-2) receptor   363 aa 340 aa 24.1 %
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily Angiotensin II receptor (AT-1) type-1   359 aa 300 aa 21.0 %
Onchocerca volvulus Angiotensin II type 2 (AT-2) receptor   363 aa 306 aa 22.5 %
Onchocerca volvulus Angiotensin II receptor (AT-1) type-1   359 aa 355 aa 23.9 %
Onchocerca volvulus Angiotensin II receptor (AT-1) type-1   359 aa 309 aa 18.8 %
Echinococcus granulosus thyrotropin releasing hormone receptor Angiotensin II type 2 (AT-2) receptor   363 aa 308 aa 22.1 %

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0019 0.0088 0.0088
Loa Loa (eye worm) melatonin receptor type 1A 0.0009 0.002 0.002
Leishmania major nucleoside phosphorylase-like protein 0.0148 0.0923 1
Loa Loa (eye worm) hypothetical protein 0.0009 0.0021 0.0021
Loa Loa (eye worm) hypothetical protein 0.1168 0.7555 0.7555
Plasmodium vivax purine nucleoside phosphorylase, putative 0.0148 0.0923 1
Schistosoma mansoni acetylcholine receptor-related 0.0009 0.0021 0.0021
Schistosoma mansoni biogenic amine receptor 0.0009 0.002 0.002
Loa Loa (eye worm) hypothetical protein 0.0009 0.002 0.002
Mycobacterium ulcerans bifunctional Mta/Sah nucleosidase Mtn 0.0148 0.0923 0.0923
Loa Loa (eye worm) hypothetical protein 0.0009 0.002 0.002
Schistosoma mansoni cpg binding protein 0.0017 0.0073 0.0073
Loa Loa (eye worm) CXXC zinc finger family protein 0.0017 0.0073 0.0073
Echinococcus granulosus sex peptide receptor 0.0009 0.002 0.002
Giardia lamblia UPL-1 0.0148 0.0923 0.2009
Brugia malayi Tachykinin-like peptides receptor 99D 0.0009 0.002 0.002
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0019 0.0088 0.0088
Wolbachia endosymbiont of Brugia malayi UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.0878 0.5669 1
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0009 0.002 0.002
Schistosoma mansoni opsin-like receptor 0.0009 0.002 0.002
Trypanosoma cruzi methylthioadenosine phosphorylase, putative 0.0148 0.0923 1
Echinococcus granulosus purine nucleoside phosphorylase 0.0713 0.4594 0.4594
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.0087 0.0624
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0019 0.0088 0.0088
Loa Loa (eye worm) hypothetical protein 0.0009 0.002 0.002
Echinococcus granulosus glycine receptor subunit beta 0.0019 0.0088 0.0088
Trypanosoma cruzi nucleoside phosphorylase, putative 0.0148 0.0923 1
Brugia malayi Serotonin receptor 0.0009 0.002 0.002
Echinococcus granulosus methylthioadenosine phosphorylase 0.0148 0.0923 0.0923
Mycobacterium leprae probable 3-phosphoshikimate 1-carboxyvinyl transferase AroA (5-ENOLPYRUVYLSHIKIMATE-3-PHOSPHATE SYNTHASE) (EPSP SYNTHASE) (EPSPS 0.1438 0.9306 0.9235
Onchocerca volvulus Neuropeptide F receptor homolog 0.0009 0.002 0.0041
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0009 0.002 0.002
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0019 0.0088 0.0088
Echinococcus multilocularis sex peptide receptor 0.0009 0.002 0.002
Echinococcus granulosus tachykinin peptides receptor 99D 0.0009 0.002 0.002
Loa Loa (eye worm) hypothetical protein 0.1142 0.7381 0.7381
Loa Loa (eye worm) hypothetical protein 0.0019 0.0088 0.0088
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0019 0.0088 0.0088
Onchocerca volvulus 0.0009 0.002 0.0041
Schistosoma mansoni nAChR subunit 0.0009 0.0021 0.0021
Schistosoma mansoni adenoreceptor 0.0009 0.002 0.002
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0009 0.0021 0.0021
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.001 0.0031 0.0031
Chlamydia trachomatis AMP nucleosidase 0.0148 0.0923 0.0992
Loa Loa (eye worm) hypothetical protein 0.1168 0.7555 0.7555
Trichomonas vaginalis purine nucleoside phosphorylase, putative 0.0148 0.0923 0.2009
Giardia lamblia 5-methylthioadenosine nucleosidase, S-adenosylhomocysteine nucleosidase 0.0148 0.0923 0.2009
Echinococcus granulosus dro:myosuppressin receptor 0.0009 0.002 0.002
Onchocerca volvulus 0.0019 0.0088 0.0179
Schistosoma mansoni nAChR subunit 0.0019 0.0088 0.0088
Echinococcus multilocularis nAChR subunit 0.001 0.0031 0.0031
Brugia malayi CXXC zinc finger family protein 0.0017 0.0073 0.0073
Echinococcus multilocularis rhodopsin orphan GPCR 0.0009 0.002 0.002
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0087 0.0939
Brugia malayi follicle stimulating hormone receptor 0.0009 0.002 0.002
Loa Loa (eye worm) hypothetical protein 0.0009 0.002 0.002
Loa Loa (eye worm) hypothetical protein 0.001 0.0031 0.0031
Mycobacterium tuberculosis Conserved hypothetical protein 0.0148 0.0923 0.0923
Echinococcus granulosus serotonin receptor 0.0009 0.002 0.002
Loa Loa (eye worm) hypothetical protein 0.0009 0.0021 0.0021
Schistosoma mansoni opsin-like receptor 0.0009 0.002 0.002
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0019 0.0088 0.0088
Entamoeba histolytica hypothetical protein 0.0148 0.0923 1
Echinococcus multilocularis dro:myosuppressin receptor 0.0009 0.002 0.002
Loa Loa (eye worm) hypothetical protein 0.1168 0.7555 0.7555
Mycobacterium leprae probable zinc metalloprotease 0.1545 1 1
Loa Loa (eye worm) hypothetical protein 0.0009 0.002 0.002
Loa Loa (eye worm) neuropeptide F receptor 0.0009 0.002 0.002
Mycobacterium ulcerans zinc metalloprotease 0.1545 1 1
Echinococcus granulosus g protein coupled receptor 0.0009 0.002 0.002
Loa Loa (eye worm) hypothetical protein 0.0009 0.002 0.002
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.0087 0.0153
Schistosoma mansoni neurotransmitter gated ion channel 0.0009 0.0021 0.0021
Echinococcus multilocularis purine nucleoside phosphorylase 0.0565 0.3636 0.3636
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0009 0.002 0.002
Loa Loa (eye worm) hypothetical protein 0.0009 0.0021 0.0021
Echinococcus multilocularis neuropeptide Y receptor 0.0009 0.002 0.002
Onchocerca volvulus 0.0765 0.4936 1
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0009 0.002 0.002
Brugia malayi Cation transporter family protein 0.0019 0.0088 0.0088
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0009 0.002 0.002
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0009 0.002 0.002
Brugia malayi excitatory GABA receptor EXP-1A 0.0019 0.0088 0.0088
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0019 0.0088 0.0088
Echinococcus granulosus tm gpcr rhodopsin 0.0009 0.002 0.002
Loa Loa (eye worm) G-protein coupled receptor 0.0009 0.002 0.002
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0009 0.002 0.002
Onchocerca volvulus 0.0009 0.002 0.0041
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0019 0.0088 0.0088
Loa Loa (eye worm) ACC-1 protein 0.0019 0.0088 0.0088
Schistosoma mansoni neuropeptide F-like receptor 0.0009 0.002 0.002
Loa Loa (eye worm) hypothetical protein 0.001 0.0031 0.0031
Echinococcus multilocularis purine nucleoside phosphorylase 0.0713 0.4594 0.4594
Loa Loa (eye worm) hypothetical protein 0.0009 0.002 0.002
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0009 0.002 0.002
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0087 0.0939
Schistosoma mansoni purine nucleoside phosphorylase 0.0713 0.4594 0.4594
Schistosoma mansoni amine GPCR 0.0009 0.002 0.002
Echinococcus multilocularis serotonin receptor 0.0009 0.002 0.002
Loa Loa (eye worm) hypothetical protein 0.0019 0.0088 0.0088
Onchocerca volvulus 0.0019 0.0088 0.0179
Schistosoma mansoni cpg binding protein 0.0018 0.0079 0.0079
Loa Loa (eye worm) acetylcholine receptor protein 0.0009 0.0021 0.0021
Mycobacterium leprae Probable purine nucleoside phosphorylase DeoD (INOSINE PHOSPHORYLASE) (PNP) 0.0713 0.4594 0.4045
Onchocerca volvulus 0.0019 0.0088 0.0179
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0009 0.002 0.002
Brugia malayi Neuronal acetylcholine receptor protein, alpha-2 chain precursor 0.0009 0.0021 0.0021
Brugia malayi ORL1-like opioid receptor 0.0009 0.002 0.002
Echinococcus granulosus allatostatin A receptor 0.0009 0.002 0.002
Giardia lamblia 5-methylthioadenosine nucleosidase, S-adenosylhomocysteine nucleosidase 0.0148 0.0923 0.2009
Schistosoma mansoni alpha-1 adrenergic receptor 0.0009 0.002 0.002
Schistosoma mansoni nAChR subunit 0.0009 0.0021 0.0021
Onchocerca volvulus 0.0009 0.002 0.0041
Echinococcus multilocularis rhodopsin orphan GPCR 0.0009 0.002 0.002
Schistosoma mansoni amine GPCR 0.0009 0.002 0.002
Echinococcus granulosus glycine receptor subunit alpha 1 0.0019 0.0088 0.0088
Chlamydia trachomatis dehyroquinate synthase 0.056 0.36 0.3869
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0019 0.0088 0.0088
Loa Loa (eye worm) hypothetical protein 0.0019 0.0088 0.0088
Echinococcus granulosus neuropeptides capa receptor 0.0009 0.002 0.002
Trichomonas vaginalis conserved hypothetical protein 0.0148 0.0923 0.2009
Loa Loa (eye worm) hypothetical protein 0.0765 0.4936 0.4936
Trypanosoma brucei methylthioadenosine phosphorylase, putative 0.0148 0.0923 1
Entamoeba histolytica purine nucleoside phosphorylase, putative 0.0148 0.0923 1
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0009 0.002 0.002
Echinococcus granulosus purine nucleoside phosphorylase 0.0713 0.4594 0.4594
Schistosoma mansoni neuropeptide receptor 0.0009 0.002 0.002
Loa Loa (eye worm) hypothetical protein 0.0009 0.002 0.002
Mycobacterium ulcerans purine nucleoside phosphorylase 0.0713 0.4594 0.4594
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0087 0.0189
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0019 0.0088 0.0088
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0019 0.0088 0.0088
Echinococcus multilocularis uridine phosphorylase 1 0.0148 0.0923 0.0923
Loa Loa (eye worm) hypothetical protein 0.001 0.0031 0.0031
Loa Loa (eye worm) hypothetical protein 0.0009 0.002 0.002
Schistosoma mansoni opsin-like receptor 0.0009 0.002 0.002
Echinococcus granulosus tm gpcr rhodopsin 0.0009 0.002 0.002
Treponema pallidum hypothetical protein 0.0023 0.0113 0.0048
Onchocerca volvulus 0.0009 0.002 0.0041
Chlamydia trachomatis phosphoshikimate 1-carboxyl vinyltransferase 0.1438 0.9306 1
Loa Loa (eye worm) hypothetical protein 0.0009 0.0021 0.0021
Schistosoma mansoni nAChR subunit 0.0019 0.0088 0.0088
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0019 0.0088 0.0088
Trichomonas vaginalis xanthine dehydrogenase, putative 0.0172 0.108 0.235
Loa Loa (eye worm) hypothetical protein 0.0009 0.002 0.002
Schistosoma mansoni biogenic amine (5HT) receptor 0.0009 0.002 0.002
Brugia malayi hypothetical protein 0.0009 0.002 0.002
Echinococcus multilocularis dnaJ subfamily B 0.0239 0.1518 0.1518
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0009 0.0021 0.0021
Loa Loa (eye worm) hypothetical protein 0.0009 0.002 0.002
Echinococcus granulosus G protein coupled receptor 139 0.0009 0.002 0.002
Mycobacterium tuberculosis Probable carbon monoxyde dehydrogenase (medium chain) 0.0058 0.0341 0.0341
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0009 0.002 0.002
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0019 0.0088 0.0088
Loa Loa (eye worm) hypothetical protein 0.0009 0.0021 0.0021
Schistosoma mansoni neuropeptide receptor 0.0009 0.002 0.002
Brugia malayi G-protein coupled receptor 0.0009 0.002 0.002
Echinococcus granulosus peptide allatostatin:somatostatin 0.0009 0.002 0.002
Brugia malayi uridine phosphorylase family protein 0.0148 0.0923 0.0923
Toxoplasma gondii Purine nucleoside phosphorylase 0.0148 0.0923 0.0923
Echinococcus granulosus neuropeptide receptor 0.0009 0.002 0.002
Schistosoma mansoni uridine phosphorylase 0.0148 0.0923 0.0923
Loa Loa (eye worm) TYRA-2 protein 0.0009 0.002 0.002
Schistosoma mansoni uridine phosphorylase 0.0148 0.0923 0.0923
Echinococcus multilocularis neuropeptide receptor 0.0009 0.002 0.002
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0009 0.002 0.002
Echinococcus granulosus rhodopsin orphan GPCR 0.0009 0.002 0.002
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0019 0.0088 0.0088
Echinococcus granulosus cpg binding protein 0.0018 0.0079 0.0079
Loa Loa (eye worm) hypothetical protein 0.0019 0.0088 0.0088
Schistosoma mansoni nAChR subunit 0.0019 0.0088 0.0088
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0009 0.002 0.002
Brugia malayi Serotonin receptor 0.0009 0.002 0.002
Onchocerca volvulus Putative nachr subunit 0.0019 0.0088 0.0179
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0087 0.0087
Echinococcus multilocularis purine nucleoside phosphorylase 0.0713 0.4594 0.4594
Onchocerca volvulus 0.0009 0.002 0.0041
Echinococcus multilocularis G-protein coupled receptor, putative 0.0009 0.002 0.002
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0009 0.002 0.002
Echinococcus granulosus inosine guanosine and xanthosine phosphorylase 0.0565 0.3636 0.3636
Schistosoma mansoni biogenic amine receptor 0.0009 0.002 0.002
Loa Loa (eye worm) hypothetical protein 0.0009 0.002 0.002
Echinococcus granulosus neuropeptide s receptor 0.0009 0.002 0.002
Loa Loa (eye worm) hypothetical protein 0.1168 0.7555 0.7555
Echinococcus granulosus rhodopsin orphan GPCR 0.0009 0.002 0.002
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.0087 0.0189
Echinococcus multilocularis purine nucleoside phosphorylase 0.0713 0.4594 0.4594
Loa Loa (eye worm) hypothetical protein 0.0009 0.002 0.002
Mycobacterium ulcerans 3-phosphoshikimate 1-carboxyvinyltransferase 0.1438 0.9306 0.9306
Echinococcus multilocularis glycine receptor subunit beta 0.0019 0.0088 0.0088
Loa Loa (eye worm) hypothetical protein 0.0009 0.0021 0.0021
Onchocerca volvulus 0.0009 0.0021 0.0043
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0009 0.002 0.002
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0009 0.002 0.002
Echinococcus granulosus glycine receptor subunit beta 0.0019 0.0088 0.0088
Schistosoma mansoni endothelin-converting enzyme-like 1 (damage-induced neuronal endopeptidase) 0.0376 0.2409 0.2409
Treponema pallidum pfs protein (pfs) 0.0148 0.0923 0.1498
Loa Loa (eye worm) S-methyl-5'-thioadenosine phosphorylase MTAP 0.0148 0.0923 0.0923
Giardia lamblia Purine nucleoside phosphorylase lateral transfer candidate 0.0713 0.4594 1
Toxoplasma gondii phosphorylase family protein 0.0148 0.0923 0.0923
Trichomonas vaginalis aldehyde oxidase, putative 0.0172 0.108 0.235
Loa Loa (eye worm) G-protein coupled receptor 0.0009 0.002 0.002
Loa Loa (eye worm) neuronal acetylcholine receptor protein 0.0009 0.0021 0.0021
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0087 0.0087
Echinococcus granulosus nAChR subunit 0.0019 0.0088 0.0088
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0019 0.0088 0.0088
Schistosoma mansoni biogenic amine receptor 0.0009 0.002 0.002
Onchocerca volvulus 0.0009 0.002 0.0041
Mycobacterium tuberculosis Probable bifunctional MTA/SAH nucleosidase Mtn: 5'-methylthioadenosine nucleosidase (methylthioadenosine methylthioribohydrolase 0.0148 0.0923 0.0923
Mycobacterium ulcerans hypothetical protein 0.0028 0.0146 0.0146
Schistosoma mansoni nAChR subunit 0.0019 0.0088 0.0088
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0009 0.002 0.002
Loa Loa (eye worm) hypothetical protein 0.0009 0.002 0.002
Mycobacterium ulcerans carbon monoxyde dehydrogenase large chain CoxL 0.0051 0.0295 0.0295
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0009 0.002 0.002
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0019 0.0088 0.0088
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0087 0.0087
Brugia malayi hypothetical protein 0.0009 0.0021 0.0021
Loa Loa (eye worm) hypothetical protein 0.0565 0.3636 0.3636
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0009 0.002 0.002
Loa Loa (eye worm) hypothetical protein 0.0009 0.002 0.002
Echinococcus multilocularis somatostatin receptor 0.0009 0.002 0.002
Schistosoma mansoni 3-dehydroquinate synthase 0.056 0.36 0.36
Echinococcus granulosus neuropeptide FF receptor 2 0.0009 0.002 0.002
Schistosoma mansoni neuropeptide f receptor 76f 0.0009 0.002 0.002
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0376 0.2409 0.2409
Loa Loa (eye worm) hypothetical protein 0.1142 0.7381 0.7381
Loa Loa (eye worm) hypothetical protein 0.0019 0.0088 0.0088
Brugia malayi hypothetical protein 0.0009 0.002 0.002
Echinococcus granulosus neuropeptide Y receptor 0.0009 0.002 0.002
Echinococcus multilocularis allatostatin A receptor 0.0009 0.002 0.002
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0009 0.002 0.002
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0019 0.0088 0.0088
Echinococcus granulosus somatostatin receptor 0.0009 0.002 0.002
Trichomonas vaginalis purine nucleoside phosphorylase, putative 0.0148 0.0923 0.2009
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0009 0.002 0.002
Loa Loa (eye worm) hypothetical protein 0.0009 0.002 0.002
Brugia malayi hypothetical protein 0.0009 0.002 0.002
Loa Loa (eye worm) hypothetical protein 0.0009 0.002 0.002
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0376 0.2409 0.2409
Echinococcus multilocularis neuropeptide receptor 0.0009 0.002 0.002
Schistosoma mansoni methylthioadenosine phosphorylase 0.0148 0.0923 0.0923
Brugia malayi putative neuropeptide receptor 0.0009 0.002 0.002
Loa Loa (eye worm) hypothetical protein 0.0009 0.002 0.002
Onchocerca volvulus 0.0019 0.0088 0.0179
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0019 0.0088 0.0088
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0009 0.0021 0.0021
Trichomonas vaginalis xanthine dehydrogenase, putative 0.0172 0.108 0.235
Brugia malayi hypothetical protein 0.0009 0.002 0.002
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0036 0.0195 0.0195
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0009 0.002 0.002
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0009 0.002 0.002
Loa Loa (eye worm) hypothetical protein 0.0009 0.002 0.002
Loa Loa (eye worm) hypothetical protein 0.0009 0.002 0.002
Echinococcus granulosus purine nucleoside phosphorylase 0.0713 0.4594 0.4594
Onchocerca volvulus 0.0009 0.002 0.0041
Loa Loa (eye worm) hypothetical protein 0.0019 0.0088 0.0088
Onchocerca volvulus 0.0019 0.0088 0.0179
Treponema pallidum purine nucleoside phosphorylase (deoD) 0.0148 0.0923 0.1498
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0019 0.0088 0.0088
Loa Loa (eye worm) hypothetical protein 0.0009 0.0021 0.0021
Brugia malayi hypothetical protein 0.0009 0.002 0.002
Brugia malayi peptidase family M13 containing protein 0.0376 0.2409 0.2409
Echinococcus multilocularis endothelin converting enzyme 1 0.1545 1 1
Loa Loa (eye worm) hypothetical protein 0.0009 0.002 0.002
Echinococcus granulosus rhodopsin orphan GPCR 0.0009 0.002 0.002
Trypanosoma cruzi nucleoside phosphorylase, putative 0.0148 0.0923 1
Echinococcus granulosus purine nucleoside phosphorylase 0.0713 0.4594 0.4594
Loa Loa (eye worm) hypothetical protein 0.0009 0.002 0.002
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0019 0.0088 0.0088
Loa Loa (eye worm) hypothetical protein 0.0009 0.0021 0.0021
Onchocerca volvulus 0.0019 0.0088 0.0179
Loa Loa (eye worm) hypothetical protein 0.0009 0.002 0.002
Loa Loa (eye worm) hypothetical protein 0.0009 0.0021 0.0021
Loa Loa (eye worm) hypothetical protein 0.0009 0.0021 0.0021
Schistosoma mansoni purine nucleoside phosphorylase 0.0713 0.4594 0.4594
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0019 0.0088 0.0088
Echinococcus granulosus glycine receptor subunit alpha 1 0.0019 0.0088 0.0088
Onchocerca volvulus 0.0009 0.002 0.0041
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0019 0.0088 0.0088
Trichomonas vaginalis purine nucleoside phosphorylase, putative 0.0148 0.0923 0.2009
Entamoeba histolytica purine nucleoside phosphorylase, putative 0.0148 0.0923 1
Loa Loa (eye worm) hypothetical protein 0.0009 0.002 0.002
Loa Loa (eye worm) hypothetical protein 0.0009 0.002 0.002
Loa Loa (eye worm) hypothetical protein 0.0019 0.0088 0.0088
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0009 0.002 0.002
Schistosoma mansoni nAChR subunit 0.0019 0.0088 0.0088
Loa Loa (eye worm) hypothetical protein 0.0009 0.002 0.002
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0009 0.002 0.002
Mycobacterium ulcerans aerobic-type carbon monoxide dehydrogenase subunit CoxM_2 0.0058 0.0341 0.0341
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0009 0.002 0.002
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0376 0.2409 0.2409
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0009 0.0021 0.0021
Onchocerca volvulus 0.0009 0.002 0.0041
Echinococcus multilocularis serotonin receptor 0.0009 0.002 0.002
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0009 0.002 0.002
Schistosoma mansoni amine GPCR 0.0009 0.002 0.002
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0087 0.0087
Onchocerca volvulus 0.0009 0.0021 0.0043
Loa Loa (eye worm) hypothetical protein 0.0009 0.002 0.002
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0009 0.002 0.002
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0019 0.0088 0.0088
Schistosoma mansoni nAChR subunit 0.0019 0.0088 0.0088
Loa Loa (eye worm) hypothetical protein 0.0019 0.0088 0.0088
Echinococcus multilocularis rhodopsin orphan GPCR 0.0009 0.002 0.002
Brugia malayi G protein-coupled receptor F59B2.13 0.0009 0.002 0.002
Echinococcus granulosus 7TM GPCR rhodopsin 0.0009 0.002 0.002
Loa Loa (eye worm) hypothetical protein 0.0009 0.002 0.002
Loa Loa (eye worm) hypothetical protein 0.0009 0.002 0.002
Echinococcus granulosus g protein coupled receptor 0.0009 0.002 0.002
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0779 0.5028 0.5028
Loa Loa (eye worm) hypothetical protein 0.1545 1 1
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0087 0.0087
Loa Loa (eye worm) hypothetical protein 0.1142 0.7381 0.7381
Echinococcus granulosus g protein coupled receptor 0.0009 0.002 0.002
Loa Loa (eye worm) hypothetical protein 0.0019 0.0088 0.0088
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0009 0.002 0.002
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0009 0.002 0.002
Loa Loa (eye worm) hypothetical protein 0.0009 0.002 0.002
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0009 0.002 0.002
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0087 0.0939
Brugia malayi hypothetical protein 0.0009 0.002 0.002
Echinococcus granulosus g-protein coupled receptor 0.0009 0.002 0.002
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0009 0.002 0.002
Toxoplasma gondii histone lysine methyltransferase SET1 0.0032 0.0171 0.0171
Loa Loa (eye worm) hypothetical protein 0.0009 0.002 0.002
Treponema pallidum uridine phosphorylase (udp) 0.0148 0.0923 0.1498
Mycobacterium ulcerans 5'-methylthioadenosine phosphorylase 0.0148 0.0923 0.0923
Loa Loa (eye worm) hypothetical protein 0.0019 0.0088 0.0088
Loa Loa (eye worm) ACC-1 protein 0.0019 0.0088 0.0088
Loa Loa (eye worm) hypothetical protein 0.0019 0.0088 0.0088
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0009 0.002 0.002
Mycobacterium tuberculosis Hypothetical protein 0.0148 0.0923 0.0923
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.001 0.0031 0.0031
Mycobacterium tuberculosis Probable carbon monoxyde dehydrogenase (large chain) 0.0081 0.049 0.049
Trypanosoma cruzi nucleoside phosphorylase, putative 0.0148 0.0923 1
Schistosoma mansoni amine GPCR 0.0009 0.002 0.002
Onchocerca volvulus 0.0009 0.002 0.0041
Brugia malayi G-protein coupled receptor 0.0009 0.002 0.002
Brugia malayi Dopamine receptor 0.0009 0.002 0.002
Echinococcus granulosus biogenic amine 5HT receptor 0.0009 0.002 0.002
Loa Loa (eye worm) hypothetical protein 0.0009 0.002 0.002
Loa Loa (eye worm) hypothetical protein 0.0019 0.0088 0.0088
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0019 0.0088 0.0088
Echinococcus multilocularis rhodopsin orphan GPCR 0.0009 0.002 0.002
Schistosoma mansoni histamine h1 receptor 0.0009 0.002 0.002
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0009 0.002 0.002
Loa Loa (eye worm) hypothetical protein 0.1168 0.7555 0.7555
Echinococcus granulosus neuropeptide Y receptor 0.0009 0.002 0.002
Echinococcus multilocularis purine nucleoside phosphorylase 0.0713 0.4594 0.4594
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0019 0.0088 0.0088
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0009 0.002 0.002
Echinococcus granulosus hypothetical protein 0.0009 0.002 0.002
Brugia malayi Dopamine receptor protein 2 0.0009 0.002 0.002
Onchocerca volvulus 0.0009 0.002 0.0041
Toxoplasma gondii exonuclease III APE 0.0019 0.0087 0.0087
Echinococcus multilocularis g protein coupled receptor 0.0009 0.002 0.002
Mycobacterium tuberculosis 3-phosphoshikimate 1-carboxyvinyltransferase AroA (5-enolpyruvylshikimate-3-phosphate synthase) (EPSP synthase) (EPSPS) 0.056 0.36 0.36
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0009 0.002 0.002
Loa Loa (eye worm) hypothetical protein 0.0019 0.0088 0.0088
Brugia malayi Cation transporter family protein 0.0019 0.0088 0.0088
Mycobacterium ulcerans carbon monoxyde dehydrogenase medium chain CoxM 0.0058 0.0341 0.0341
Echinococcus multilocularis fmrfamide receptor 0.0009 0.002 0.002
Mycobacterium ulcerans carbon monoxide dehydrogenase 0.0114 0.0703 0.0703
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.001 0.0031 0.0031
Loa Loa (eye worm) hypothetical protein 0.0009 0.002 0.002
Schistosoma mansoni family M13 non-peptidase homologue (M13 family) 0.0779 0.5028 0.5028
Entamoeba histolytica purine nucleoside phosphorylase, putative 0.0148 0.0923 1
Schistosoma mansoni hypothetical protein 0.0403 0.2583 0.2583
Loa Loa (eye worm) hypothetical protein 0.0009 0.002 0.002
Mycobacterium ulcerans carbon monoxyde dehydrogenase small chain CoxS 0.0033 0.0177 0.0177
Loa Loa (eye worm) hypothetical protein 0.001 0.0031 0.0031
Loa Loa (eye worm) zinc metallopeptidase 4 0.0376 0.2409 0.2409
Onchocerca volvulus 0.0009 0.002 0.0041
Brugia malayi hypothetical protein 0.0009 0.002 0.002
Trichomonas vaginalis conserved hypothetical protein 0.0148 0.0923 0.2009
Echinococcus multilocularis neuropeptides capa receptor 0.0009 0.002 0.002
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0019 0.0088 0.0088
Onchocerca volvulus 0.001 0.0031 0.0063
Schistosoma mansoni growth hormone secretagogue receptor 0.0009 0.002 0.002
Echinococcus granulosus uridine phosphorylase 1 0.0148 0.0923 0.0923
Loa Loa (eye worm) hypothetical protein 0.001 0.0031 0.0031
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0009 0.002 0.002
Echinococcus multilocularis purine nucleoside phosphorylase 0.0713 0.4594 0.4594
Schistosoma mansoni cpg binding protein 0.0018 0.0079 0.0079
Toxoplasma gondii phosphorylase family protein 0.0148 0.0923 0.0923
Trichomonas vaginalis purine nucleoside phosphorylase, putative 0.0148 0.0923 0.2009
Echinococcus granulosus purine nucleoside phosphorylase 0.0713 0.4594 0.4594
Brugia malayi G protein-coupled receptor 0.0009 0.002 0.002
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0009 0.002 0.002
Brugia malayi MTAP 0.0148 0.0923 0.0923
Toxoplasma gondii peptidase family M13 protein 0.1545 1 1
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0019 0.0088 0.0088
Onchocerca volvulus 0.001 0.0031 0.0063
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0009 0.002 0.002
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0019 0.0088 0.0088
Loa Loa (eye worm) hypothetical protein 0.0019 0.0088 0.0088
Mycobacterium tuberculosis Probable carbon monoxyde dehydrogenase (small chain) 0.0033 0.0177 0.0177
Brugia malayi hypothetical protein 0.0009 0.0021 0.0021
Schistosoma mansoni acetylcholine receptor subunit beta 0.0009 0.0021 0.0021
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0009 0.0021 0.0021
Echinococcus granulosus 7tm_1 domain containing protein 0.0009 0.002 0.002
Loa Loa (eye worm) hypothetical protein 0.001 0.0031 0.0031
Loa Loa (eye worm) hypothetical protein 0.0019 0.0088 0.0088
Echinococcus granulosus nAChR subunit 0.001 0.0031 0.0031
Leishmania major methylthioadenosine phosphorylase, putative 0.0148 0.0923 1
Brugia malayi purine nucleoside phosphorylase I, inosine and guanosine-specific family protein 0.0713 0.4594 0.4594
Loa Loa (eye worm) hypothetical protein 0.0009 0.002 0.002
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0009 0.002 0.002
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0019 0.0088 0.0088
Chlamydia trachomatis UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.0878 0.5669 0.6092
Echinococcus multilocularis neuropeptides capa receptor 0.0009 0.002 0.002
Brugia malayi hypothetical protein 0.0009 0.0021 0.0021
Echinococcus multilocularis rhodopsin orphan GPCR 0.0009 0.002 0.002
Echinococcus multilocularis g-protein coupled receptor 0.0009 0.002 0.002
Brugia malayi hypothetical protein 0.0009 0.002 0.002
Loa Loa (eye worm) hypothetical protein 0.001 0.0031 0.0031
Loa Loa (eye worm) hypothetical protein 0.0019 0.0088 0.0088
Echinococcus multilocularis gamma aminobutyric acid receptor subunit 0.0009 0.0021 0.0021
Schistosoma mansoni hypothetical protein 0.0009 0.002 0.002
Loa Loa (eye worm) uridine phosphorylase 0.0148 0.0923 0.0923
Echinococcus granulosus neuropeptides capa receptor 0.0009 0.002 0.002
Schistosoma mansoni Nep2 peptidase (M13 family) 0.0779 0.5028 0.5028
Loa Loa (eye worm) hypothetical protein 0.0009 0.0021 0.0021
Loa Loa (eye worm) hypothetical protein 0.0009 0.002 0.002
Brugia malayi hypothetical protein 0.0009 0.0021 0.0021
Schistosoma mansoni hypothetical protein 0.0403 0.2583 0.2583
Echinococcus granulosus dnaJ subfamily B 0.0239 0.1518 0.1518
Brugia malayi putative neuropeptide receptor NPR1 0.0009 0.002 0.002
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0009 0.002 0.002
Mycobacterium tuberculosis Probable zinc metalloprotease Zmp1 0.1545 1 1
Loa Loa (eye worm) hypothetical protein 0.0009 0.0021 0.0021
Treponema pallidum hypothetical protein 0.0028 0.0146 0.0105
Brugia malayi sulfakinin receptor protein 0.0009 0.002 0.002
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0019 0.0088 0.0088
Echinococcus granulosus purine nucleoside phosphorylase 0.0713 0.4594 0.4594
Echinococcus multilocularis nAChR subunit 0.0019 0.0088 0.0088
Echinococcus multilocularis cpg binding protein 0.0018 0.0079 0.0079
Schistosoma mansoni methylthioadenosine phosphorylase 0.0148 0.0923 0.0923
Echinococcus multilocularis G protein coupled receptor 139 0.0009 0.002 0.002
Echinococcus multilocularis methylthioadenosine phosphorylase 0.0148 0.0923 0.0923
Loa Loa (eye worm) hypothetical protein 0.0019 0.0088 0.0088
Echinococcus multilocularis neuropeptide receptor A26 0.0009 0.002 0.002
Echinococcus granulosus rhodopsin orphan GPCR 0.0009 0.002 0.002
Echinococcus granulosus glycine receptor subunit alpha 1 0.0019 0.0088 0.0088
Schistosoma mansoni hypothetical protein 0.0403 0.2583 0.2583
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0009 0.002 0.002
Onchocerca volvulus 0.0009 0.002 0.0041
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0019 0.0088 0.0088
Echinococcus multilocularis purine nucleoside phosphorylase 0.0713 0.4594 0.4594
Echinococcus multilocularis fmrfamide receptor 0.0009 0.002 0.002
Brugia malayi hypothetical protein 0.0009 0.002 0.002
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0019 0.0088 0.0088
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0019 0.0088 0.0088
Schistosoma mansoni myosin xvIII 0.0009 0.002 0.002
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0009 0.002 0.002
Echinococcus granulosus tm gpcr rhodopsin 0.0009 0.002 0.002
Echinococcus granulosus endothelin converting enzyme 1 0.1545 1 1
Schistosoma mansoni neprilysin-2 (M13 family) 0.0779 0.5028 0.5028
Schistosoma mansoni hypothetical protein 0.0403 0.2583 0.2583
Onchocerca volvulus 0.0009 0.002 0.0041
Echinococcus multilocularis rhodopsin orphan GPCR 0.0009 0.002 0.002
Schistosoma mansoni hypothetical protein 0.0239 0.1518 0.1518
Treponema pallidum UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.0878 0.5669 1
Loa Loa (eye worm) hypothetical protein 0.0009 0.002 0.002
Echinococcus granulosus purine nucleoside phosphorylase 0.0713 0.4594 0.4594
Loa Loa (eye worm) hypothetical protein 0.0009 0.002 0.002
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0019 0.0088 0.0088
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0009 0.002 0.002
Onchocerca volvulus 0.0009 0.002 0.0041
Mycobacterium ulcerans carbon monoxyde dehydrogenase small chain CoxS 0.0033 0.0177 0.0177
Loa Loa (eye worm) LGC-31 protein 0.0019 0.0088 0.0088
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0009 0.002 0.002
Brugia malayi Cation transporter family protein 0.0019 0.0088 0.0088
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0019 0.0088 0.0088
Mycobacterium ulcerans 3-dehydroquinate synthase 0.056 0.36 0.36
Echinococcus granulosus gamma aminobutyric acid receptor subunit 0.0009 0.0021 0.0021
Loa Loa (eye worm) neuropeptide F receptor 0.0009 0.002 0.002
Schistosoma mansoni neuropeptide receptor 0.0009 0.002 0.002
Onchocerca volvulus 0.0017 0.0073 0.0148
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.001 0.0031 0.0031
Echinococcus multilocularis g protein coupled receptor 0.0009 0.002 0.002
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0087 0.0939
Trichomonas vaginalis purine nucleoside phosphorylase I, putative 0.0713 0.4594 1
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0019 0.0088 0.0088
Schistosoma mansoni nicotinic acetylcholine receptor alpha 0.001 0.0031 0.0031
Schistosoma mansoni hypothetical protein 0.0403 0.2583 0.2583
Brugia malayi hypothetical protein 0.0009 0.002 0.002
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0009 0.002 0.002
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0019 0.0088 0.0088
Onchocerca volvulus Purine nucleoside phosphorylase homolog 0.0713 0.4594 0.9308
Brugia malayi larval opioid receptor 0.0009 0.002 0.002
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0087 0.0939
Schistosoma mansoni neurotransmitter gated ion channel 0.001 0.0031 0.0031
Loa Loa (eye worm) hypothetical protein 0.0009 0.002 0.002
Echinococcus multilocularis neuropeptide s receptor 0.0009 0.002 0.002
Schistosoma mansoni hypothetical protein 0.0009 0.002 0.002
Entamoeba histolytica MTA/SAH nucleosidase, putative 0.0148 0.0923 1
Mycobacterium ulcerans UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.0878 0.5669 0.5669
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0019 0.0088 0.0088
Mycobacterium tuberculosis Probable purine nucleoside phosphorylase DeoD (inosine phosphorylase) (PNP) 0.0713 0.4594 0.4594
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.1545 1 1
Schistosoma mansoni neurotransmitter gated ion channel 0.0009 0.0021 0.0021
Echinococcus multilocularis orexin receptor type 2 0.0009 0.002 0.002
Echinococcus granulosus fmrfamide receptor 0.0009 0.002 0.002
Onchocerca volvulus 0.0009 0.0021 0.0043
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0009 0.002 0.0041
Echinococcus multilocularis rhodopsin orphan GPCR 0.0009 0.002 0.002
Loa Loa (eye worm) hypothetical protein 0.001 0.0031 0.0031
Echinococcus granulosus alpha 1A adrenergic receptor 0.0009 0.002 0.002
Echinococcus multilocularis neuropeptide FF receptor 2 0.0009 0.002 0.002
Echinococcus granulosus neuropeptide receptor A26 0.0009 0.002 0.002
Schistosoma mansoni ap endonuclease 0.0019 0.0087 0.0087
Loa Loa (eye worm) hypothetical protein 0.1545 1 1
Loa Loa (eye worm) peptidase family M13 containing protein 0.1142 0.7381 0.7381
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0087 0.0189
Loa Loa (eye worm) hypothetical protein 0.001 0.0031 0.0031
Schistosoma mansoni endothelin-converting enzyme-related 0.0376 0.2409 0.2409
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0019 0.0088 0.0088
Schistosoma mansoni hypothetical protein 0.0009 0.002 0.002
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0019 0.0088 0.0088
Schistosoma mansoni hypothetical protein 0.0403 0.2583 0.2583
Brugia malayi Dopamine receptor protein 1 0.0009 0.002 0.002
Onchocerca volvulus 0.0009 0.002 0.0041
Echinococcus multilocularis glycine receptor subunit beta 0.0019 0.0088 0.0088
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0019 0.0088 0.0088
Trichomonas vaginalis purine nucleoside phosphorylase, putative 0.0148 0.0923 0.2009
Loa Loa (eye worm) hypothetical protein 0.1168 0.7555 0.7555
Loa Loa (eye worm) hypothetical protein 0.0009 0.0021 0.0021
Loa Loa (eye worm) hypothetical protein 0.0009 0.002 0.002
Loa Loa (eye worm) hypothetical protein 0.1142 0.7381 0.7381
Entamoeba histolytica purine nucleoside phosphorylase, putative 0.0148 0.0923 1
Echinococcus multilocularis g protein coupled receptor 0.0009 0.002 0.002
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0087 0.0939
Brugia malayi Acetylcholine receptor protein, alpha-like chain 1 precursor 0.0009 0.0021 0.0021
Brugia malayi hypothetical protein 0.0009 0.0021 0.0021
Brugia malayi Hypothetical zinc metalloproteinase T16A9.4 0.1545 1 1
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0009 0.002 0.002
Echinococcus multilocularis rhodopsin orphan GPCR 0.0009 0.002 0.002
Loa Loa (eye worm) GABA receptor subunit 0.001 0.0031 0.0031
Schistosoma mansoni neuropeptide receptor 0.0009 0.002 0.002
Schistosoma mansoni neuropeptide F-like receptor 0.0009 0.002 0.002
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0019 0.0088 0.0088
Toxoplasma gondii shikimate dehydrogenase substrate binding domain-containing protein 0.1438 0.9306 0.9306
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0019 0.0088 0.0088
Loa Loa (eye worm) hypothetical protein 0.0009 0.0021 0.0021
Loa Loa (eye worm) hypothetical protein 0.0009 0.002 0.002
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0009 0.002 0.002
Schistosoma mansoni methylthioadenosine phosphorylase 0.0148 0.0923 0.0923
Brugia malayi RE15519p 0.0009 0.002 0.002
Echinococcus granulosus orexin receptor type 2 0.0009 0.002 0.002
Trypanosoma brucei uridine phosphorylase 0.0148 0.0923 1
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0009 0.002 0.002
Brugia malayi neuropeptide F receptor 0.0009 0.002 0.002
Loa Loa (eye worm) hypothetical protein 0.0009 0.002 0.002
Schistosoma mansoni neprilysin 0.0403 0.2583 0.2583
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.001 0.0031 0.0031
Echinococcus granulosus rhodopsin orphan GPCR 0.0009 0.002 0.002
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0087 0.0087
Loa Loa (eye worm) hypothetical protein 0.0019 0.0088 0.0088
Loa Loa (eye worm) hypothetical protein 0.0019 0.0088 0.0088
Brugia malayi GnHR receptor homolog 0.0009 0.002 0.002
Echinococcus granulosus biogenic amine 5HT receptor 0.0009 0.002 0.002
Loa Loa (eye worm) hypothetical protein 0.1545 1 1
Trichomonas vaginalis purine nucleoside phosphorylase, putative 0.0148 0.0923 0.2009
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0009 0.002 0.002
Trypanosoma cruzi methylthioadenosine phosphorylase, putative 0.0148 0.0923 1
Onchocerca volvulus 0.0009 0.002 0.0041
Entamoeba histolytica purine nucleoside phosphorylase, putative 0.0148 0.0923 1
Brugia malayi Melatonin receptor type 1A 0.0009 0.002 0.002
Loa Loa (eye worm) hypothetical protein 0.0009 0.002 0.002
Brugia malayi AKH receptor 0.0009 0.002 0.002
Schistosoma mansoni amine GPCR 0.0009 0.002 0.002
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0019 0.0088 0.0088
Treponema pallidum quinoline 2-oxidoreductase 0.0027 0.0141 0.0098
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0009 0.0021 0.0021
Echinococcus granulosus rhodopsin orphan GPCR 0.0009 0.002 0.002
Mycobacterium ulcerans carbon monoxyde dehydrogenase large chain CoxL 0.0081 0.049 0.049
Schistosoma mansoni hypothetical protein 0.0009 0.002 0.002
Echinococcus granulosus purine nucleoside phosphorylase 0.0713 0.4594 0.4594
Loa Loa (eye worm) peptidase family M13 containing protein 0.1142 0.7381 0.7381
Mycobacterium leprae 3-dehydroquinate synthase AroB 0.056 0.36 0.295
Echinococcus multilocularis neuropeptide Y receptor 0.0009 0.002 0.002
Schistosoma mansoni biogenic amine (5HT) receptor 0.0009 0.002 0.002
Echinococcus multilocularis nicotinic acetylcholine receptor subunit type 0.0009 0.0021 0.0021
Mycobacterium tuberculosis 3-dehydroquinate synthase AroB 0.056 0.36 0.36
Plasmodium falciparum purine nucleoside phosphorylase 0.0148 0.0923 1
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0009 0.002 0.002
Trichomonas vaginalis purine nucleoside phosphorylase, putative 0.0148 0.0923 0.2009
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0779 0.5028 0.5028
Schistosoma mansoni nAChR subunit 0.0019 0.0088 0.0088
Echinococcus granulosus rhodopsin orphan GPCR 0.0009 0.002 0.002
Loa Loa (eye worm) hypothetical protein 0.0009 0.002 0.002
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0019 0.0088 0.0088
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0019 0.0088 0.0088
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0009 0.002 0.002
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0009 0.0021 0.0021
Echinococcus granulosus neuropeptide receptor 0.0009 0.002 0.002
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0403 0.2583 0.2583
Loa Loa (eye worm) hypothetical protein 0.0009 0.002 0.002
Echinococcus multilocularis purine nucleoside phosphorylase 0.0565 0.3636 0.3636
Schistosoma mansoni ap endonuclease 0.0019 0.0087 0.0087
Loa Loa (eye worm) hypothetical protein 0.0009 0.0021 0.0021
Mycobacterium ulcerans aerobic-type carbon monoxide dehydrogenase subunit CoxL_2 0.0081 0.049 0.049
Brugia malayi neuropeptide F receptor 0.0009 0.002 0.002
Schistosoma mansoni family M13 non-peptidase homologue (M13 family) 0.0376 0.2409 0.2409

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 2 uM Binding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomes ChEMBL. 8258820
IC50 (binding) = 2 uM Binding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomes ChEMBL. 8258820
IC50 (binding) > 10 uM Binding affinity towards Angiotensin II receptor, type 1 in rat isolated adrenal cortical microsomes ChEMBL. 8258820
IC50 (binding) > 10 uM Binding affinity towards Angiotensin II receptor, type 1 in rat isolated adrenal cortical microsomes ChEMBL. 8258820

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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