Detailed information for compound 223844

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 392.43 | Formula: C17H20N4O5S
  • H donors: 2 H acceptors: 2 LogP: 1.95 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccccc1S(=O)(=O)Oc1cc(OC/C=N/N=C(N)N)cc(c1)C
  • InChi: 1S/C17H20N4O5S/c1-12-9-13(25-8-7-20-21-17(18)19)11-14(10-12)26-27(22,23)16-6-4-3-5-15(16)24-2/h3-7,9-11H,8H2,1-2H3,(H4,18,19,21)/b20-7+
  • InChiKey: QOLWOCSONNTNTB-IFRROFPPSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens coagulation factor II (thrombin) Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0254 1 1
Loa Loa (eye worm) hypothetical protein 0.0254 1 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0046 0.1411 0.1313
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0254 1 1
Schistosoma mansoni biogenic amine receptor 0.0254 1 1
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0254 1 1
Loa Loa (eye worm) TK/ROR protein kinase 0.0021 0.039 0.0279
Echinococcus granulosus tm gpcr rhodopsin 0.0254 1 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.0046 0.1411 0.1313
Brugia malayi hypothetical protein 0.0254 1 1
Echinococcus granulosus serotonin receptor 0.0254 1 1
Schistosoma mansoni immunophilin 0.0085 0.3017 0.2937
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0254 1 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.039 0.0279
Echinococcus multilocularis rhodopsin orphan GPCR 0.0254 1 1
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0254 1 1
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0254 1 1
Echinococcus granulosus alpha 1A adrenergic receptor 0.0254 1 1
Loa Loa (eye worm) hypothetical protein 0.0254 1 1
Echinococcus granulosus neuropeptide receptor 0.0254 1 1
Loa Loa (eye worm) hypothetical protein 0.0254 1 1
Loa Loa (eye worm) hypothetical protein 0.0254 1 1
Loa Loa (eye worm) hypothetical protein 0.0254 1 1
Onchocerca volvulus 0.0254 1 1
Loa Loa (eye worm) hypothetical protein 0.0031 0.0811 0.0705
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0254 1 1
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0084 0.2968 1
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP4 0.0073 0.2542 0.2456
Brugia malayi hypothetical protein 0.0254 1 1
Brugia malayi RE15519p 0.0254 1 1
Loa Loa (eye worm) neuropeptide F receptor 0.0254 1 1
Echinococcus multilocularis neuropeptide Y receptor 0.0254 1 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0254 1 1
Echinococcus multilocularis sex peptide receptor 0.0254 1 1
Echinococcus multilocularis orexin receptor type 2 0.0254 1 1
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0084 0.2968 1
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.0084 0.2968 0.5
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0254 1 1
Echinococcus multilocularis neuropeptides capa receptor 0.0254 1 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0254 1 1
Brugia malayi AKH receptor 0.0254 1 1
Loa Loa (eye worm) hypothetical protein 0.0254 1 1
Schistosoma mansoni opsin-like receptor 0.0254 1 1
Schistosoma mansoni neuropeptide receptor 0.0254 1 1
Brugia malayi follicle stimulating hormone receptor 0.0254 1 1
Onchocerca volvulus 0.0254 1 1
Loa Loa (eye worm) hypothetical protein 0.0254 1 1
Schistosoma mansoni biogenic amine receptor 0.0254 1 1
Loa Loa (eye worm) hypothetical protein 0.0254 1 1
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0254 1 1
Echinococcus granulosus fmrfamide receptor 0.0254 1 1
Loa Loa (eye worm) hypothetical protein 0.0046 0.1411 0.1313
Loa Loa (eye worm) hypothetical protein 0.0254 1 1
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0254 1 1
Brugia malayi Dopamine receptor protein 2 0.0254 1 1
Brugia malayi hypothetical protein 0.0254 1 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0254 1 1
Schistosoma mansoni neuropeptide F-like receptor 0.0254 1 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0254 1 1
Schistosoma mansoni biogenic amine receptor 0.0254 1 1
Brugia malayi sulfakinin receptor protein 0.0254 1 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0254 1 1
Mycobacterium ulcerans FK-506 binding protein, peptidyl-prolyl cis-trans isomerase 0.0084 0.2968 0.5
Giardia lamblia 70 kDa peptidylprolyl isomerase, putative 0.0084 0.2968 0.5
Echinococcus granulosus neuropeptide Y receptor 0.0254 1 1
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0254 1 1
Schistosoma mansoni hypothetical protein 0.0031 0.0811 0.0705
Schistosoma mansoni neuropeptide receptor 0.0254 1 1
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0254 1 1
Brugia malayi neuropeptide F receptor 0.0254 1 1
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0254 1 1
Brugia malayi G protein-coupled receptor 0.0254 1 1
Loa Loa (eye worm) hypothetical protein 0.0254 1 1
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-12, BmFKBP-12 0.0084 0.2968 0.2887
Echinococcus granulosus 7TM GPCR rhodopsin 0.0254 1 1
Loa Loa (eye worm) neuropeptide F receptor 0.0254 1 1
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, FKBP-type, putative 0.0085 0.3017 0.5
Echinococcus granulosus tissue type plasminogen activator 0.0021 0.039 0.0279
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0015 0.0114 0.0076
Loa Loa (eye worm) hypothetical protein 0.0254 1 1
Onchocerca volvulus 0.0021 0.039 0.039
Echinococcus multilocularis g protein coupled receptor 0.0254 1 1
Echinococcus granulosus g protein coupled receptor 0.0254 1 1
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0015 0.0114 0.0076
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-59, BmFKBP59 0.0084 0.298 0.2899
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0254 1 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0254 1 1
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase, putative 0.0084 0.2968 0.5
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0254 1 1
Schistosoma mansoni neuropeptide receptor 0.0254 1 1
Loa Loa (eye worm) hypothetical protein 0.0254 1 1
Onchocerca volvulus 0.0254 1 1
Giardia lamblia FKBP-type peptidyl-prolyl cis-trans isomerase 0.0084 0.2968 0.5
Echinococcus multilocularis rhodopsin orphan GPCR 0.0254 1 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0254 1 1
Trypanosoma cruzi FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0084 0.2968 1
Loa Loa (eye worm) hypothetical protein 0.0254 1 1
Loa Loa (eye worm) TYRA-2 protein 0.0254 1 1
Echinococcus granulosus g protein coupled receptor 0.0254 1 1
Echinococcus multilocularis g protein coupled receptor 0.0254 1 1
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0254 1 1
Brugia malayi G protein-coupled receptor F59B2.13 0.0254 1 1
Loa Loa (eye worm) hypothetical protein 0.0254 1 1
Schistosoma mansoni immunophilin 0.0085 0.3017 0.2937
Onchocerca volvulus 0.0254 1 1
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP1A 0.0084 0.2968 0.2887
Brugia malayi hypothetical protein 0.0254 1 1
Loa Loa (eye worm) hypothetical protein 0.0254 1 1
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0254 1 1
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0254 1 1
Onchocerca volvulus 0.0254 1 1
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.0084 0.2968 0.5
Echinococcus multilocularis tissue type plasminogen activator 0.0021 0.039 0.0354
Schistosoma mansoni opsin-like receptor 0.0254 1 1
Schistosoma mansoni immunophilin FK506 binding protein FKBP12 0.0084 0.2968 0.2887
Echinococcus granulosus tm gpcr rhodopsin 0.0254 1 1
Loa Loa (eye worm) hypothetical protein 0.0254 1 1
Brugia malayi G-protein coupled receptor 0.0254 1 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0254 1 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0254 1 1
Loa Loa (eye worm) hypothetical protein 0.0254 1 1
Schistosoma mansoni neuropeptide f receptor 76f 0.0254 1 1
Echinococcus multilocularis neuropeptide receptor A26 0.0254 1 1
Loa Loa (eye worm) hypothetical protein 0.0254 1 1
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0254 1 1
Echinococcus multilocularis neuropeptide receptor 0.0254 1 1
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0254 1 1
Onchocerca volvulus 0.0254 1 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0254 1 1
Loa Loa (eye worm) hypothetical protein 0.0254 1 1
Echinococcus granulosus sex peptide receptor 0.0254 1 1
Echinococcus multilocularis serotonin receptor 0.0254 1 1
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0254 1 1
Schistosoma mansoni myosin xvIII 0.0254 1 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0254 1 1
Loa Loa (eye worm) FKBP-type peptidyl-prolyl cis-trans isomerase-12 0.0084 0.2968 0.2887
Brugia malayi Protein kinase domain containing protein 0.0021 0.039 0.0279
Schistosoma mansoni amine GPCR 0.0254 1 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0254 1 1
Brugia malayi Melatonin receptor type 1A 0.0254 1 1
Trichomonas vaginalis fk506-binding protein, putative 0.0084 0.2968 0.5
Echinococcus granulosus neuropeptide s receptor 0.0254 1 1
Loa Loa (eye worm) hypothetical protein 0.0254 1 1
Loa Loa (eye worm) hypothetical protein 0.0254 1 1
Echinococcus multilocularis neuropeptide receptor 0.0254 1 1
Onchocerca volvulus 0.0254 1 1
Echinococcus granulosus g protein coupled receptor 0.0254 1 1
Echinococcus multilocularis peptidyl prolyl cis trans isomerase FKBP4 0.0073 0.2542 0.2514
Brugia malayi hypothetical protein 0.0254 1 1
Echinococcus multilocularis GPCR, family 2 0.0015 0.0114 0.0076
Echinococcus granulosus neuropeptide receptor A26 0.0254 1 1
Loa Loa (eye worm) hypothetical protein 0.0254 1 1
Echinococcus multilocularis peptidyl prolyl cis trans isomerase FKBP4 0.0085 0.3017 0.2991
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, FKBP-type , putative 0.0085 0.3017 0.5
Echinococcus granulosus neuropeptides capa receptor 0.0254 1 1
Echinococcus granulosus neuropeptide Y receptor 0.0254 1 1
Loa Loa (eye worm) G-protein coupled receptor 0.0254 1 1
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0254 1 1
Trypanosoma cruzi FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0084 0.2968 1
Schistosoma mansoni immunophilin 0.0073 0.2542 0.2456
Echinococcus granulosus biogenic amine 5HT receptor 0.0254 1 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0254 1 1
Schistosoma mansoni amine GPCR 0.0254 1 1
Schistosoma mansoni amine GPCR 0.0254 1 1
Leishmania major peptidylprolyl isomerase-like protein 0.0084 0.2968 1
Brugia malayi putative neuropeptide receptor 0.0254 1 1
Loa Loa (eye worm) hypothetical protein 0.0073 0.2504 0.2418
Brugia malayi Tachykinin-like peptides receptor 99D 0.0254 1 1
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0254 1 1
Brugia malayi Serotonin receptor 0.0254 1 1
Loa Loa (eye worm) hypothetical protein 0.0254 1 1
Onchocerca volvulus 0.0254 1 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0254 1 1
Echinococcus multilocularis allatostatin A receptor 0.0254 1 1
Brugia malayi larval opioid receptor 0.0254 1 1
Brugia malayi hypothetical protein 0.0254 1 1
Loa Loa (eye worm) hypothetical protein 0.0254 1 1
Echinococcus granulosus neuropeptides capa receptor 0.0254 1 1
Echinococcus multilocularis fk506 binding protein 0.0084 0.2968 0.2942
Echinococcus granulosus tachykinin peptides receptor 99D 0.0254 1 1
Toxoplasma gondii kringle domain-containing protein 0.0021 0.039 0.5
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0254 1 1
Echinococcus granulosus dro:myosuppressin receptor 0.0254 1 1
Schistosoma mansoni hypothetical protein 0.0254 1 1
Brugia malayi ORL1-like opioid receptor 0.0254 1 1
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0254 1 1
Echinococcus multilocularis serotonin receptor 0.0254 1 1
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0254 1 1
Brugia malayi G-protein coupled receptor 0.0254 1 1
Echinococcus granulosus biogenic amine 5HT receptor 0.0254 1 1
Loa Loa (eye worm) hypothetical protein 0.0254 1 1
Loa Loa (eye worm) hypothetical protein 0.0254 1 1
Schistosoma mansoni histamine h1 receptor 0.0254 1 1
Echinococcus granulosus tm gpcr rhodopsin 0.0254 1 1
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0254 1 1
Echinococcus granulosus orexin receptor type 2 0.0254 1 1
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0254 1 1
Loa Loa (eye worm) melatonin receptor type 1A 0.0254 1 1
Schistosoma mansoni opsin-like receptor 0.0254 1 1
Trichomonas vaginalis immunophilin, putative 0.0084 0.2968 0.5
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0254 1 1
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0254 1 1
Brugia malayi putative neuropeptide receptor NPR1 0.0254 1 1
Loa Loa (eye worm) G-protein coupled receptor 0.0254 1 1
Plasmodium falciparum peptidyl-prolyl cis-trans isomerase FKBP35 0.0084 0.2968 1
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0254 1 1
Onchocerca volvulus 0.0254 1 1
Loa Loa (eye worm) hypothetical protein 0.0254 1 1
Onchocerca volvulus 0.0254 1 1
Schistosoma mansoni biogenic amine (5HT) receptor 0.0254 1 1
Echinococcus granulosus 7tm_1 domain containing protein 0.0254 1 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0254 1 1
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0254 1 1
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0254 1 1
Brugia malayi hypothetical protein 0.0254 1 1
Schistosoma mansoni neuropeptide F-like receptor 0.0254 1 1
Echinococcus granulosus peptide allatostatin:somatostatin 0.0254 1 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0254 1 1
Loa Loa (eye worm) hypothetical protein 0.0254 1 1
Loa Loa (eye worm) hypothetical protein 0.0254 1 1
Brugia malayi hypothetical protein 0.0254 1 1
Loa Loa (eye worm) hypothetical protein 0.0254 1 1
Echinococcus multilocularis neuropeptide s receptor 0.0254 1 1
Trypanosoma brucei FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0084 0.2968 0.5
Loa Loa (eye worm) hypothetical protein 0.0254 1 1
Loa Loa (eye worm) hypothetical protein 0.0254 1 1
Onchocerca volvulus 0.0254 1 1
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0254 1 1
Loa Loa (eye worm) hypothetical protein 0.0254 1 1
Schistosoma mansoni hypothetical protein 0.0021 0.039 0.0279
Schistosoma mansoni alpha-1 adrenergic receptor 0.0254 1 1
Onchocerca volvulus 0.0254 1 1
Onchocerca volvulus 0.0254 1 1
Brugia malayi Dopamine receptor 0.0254 1 1
Loa Loa (eye worm) hypothetical protein 0.0254 1 1
Loa Loa (eye worm) hypothetical protein 0.0254 1 1
Echinococcus multilocularis G-protein coupled receptor, putative 0.0254 1 1
Plasmodium vivax 70 kDa peptidylprolyl isomerase, putative 0.0084 0.2968 1
Loa Loa (eye worm) hypothetical protein 0.0254 1 1
Brugia malayi Dopamine receptor protein 1 0.0254 1 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0046 0.1411 0.1313
Treponema pallidum peptidyl-prolyl cis-trans isomerase, FKBP-type, 22 kDa (fklB) 0.0084 0.2968 0.5
Echinococcus granulosus rhodopsin orphan GPCR 0.0254 1 1
Leishmania major fk506-binding protein 1-like protein 0.0084 0.2968 1
Onchocerca volvulus 0.0254 1 1
Echinococcus multilocularis dro:myosuppressin receptor 0.0254 1 1
Echinococcus granulosus neuropeptide FF receptor 2 0.0254 1 1
Echinococcus multilocularis neuropeptide Y receptor 0.0254 1 1
Echinococcus granulosus hypothetical protein 0.0254 1 1
Echinococcus multilocularis g-protein coupled receptor 0.0254 1 1
Echinococcus granulosus G protein coupled receptor 139 0.0254 1 1
Loa Loa (eye worm) hypothetical protein 0.0254 1 1
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0254 1 1
Loa Loa (eye worm) hypothetical protein 0.0254 1 1
Echinococcus multilocularis G protein coupled receptor 139 0.0254 1 1
Loa Loa (eye worm) hypothetical protein 0.0254 1 1
Schistosoma mansoni growth hormone secretagogue receptor 0.0254 1 1
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0254 1 1
Loa Loa (eye worm) hypothetical protein 0.0254 1 1
Schistosoma mansoni neuropeptide receptor 0.0254 1 1
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0254 1 1
Loa Loa (eye worm) FKBP5 protein 0.0084 0.2968 0.2887
Brugia malayi GnHR receptor homolog 0.0254 1 1
Echinococcus granulosus somatostatin receptor 0.0254 1 1
Brugia malayi neuropeptide F receptor 0.0254 1 1
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0254 1 1
Brugia malayi Serotonin receptor 0.0254 1 1
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0254 1 1
Loa Loa (eye worm) hypothetical protein 0.0254 1 1
Schistosoma mansoni amine GPCR 0.0254 1 1
Echinococcus multilocularis neuropeptide FF receptor 2 0.0254 1 1
Echinococcus multilocularis g protein coupled receptor 0.0254 1 1
Brugia malayi latrophilin 2 splice variant baaae 0.0031 0.0811 0.0705
Echinococcus granulosus rhodopsin orphan GPCR 0.0254 1 1
Brugia malayi Kringle domain containing protein 0.0021 0.039 0.0279
Echinococcus multilocularis rhodopsin orphan GPCR 0.0254 1 1
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0254 1 1
Echinococcus granulosus allatostatin A receptor 0.0254 1 1
Loa Loa (eye worm) hypothetical protein 0.0254 1 1
Onchocerca volvulus Neuropeptide F receptor homolog 0.0254 1 1
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0254 1 1
Echinococcus multilocularis somatostatin receptor 0.0254 1 1
Schistosoma mansoni adenoreceptor 0.0254 1 1
Loa Loa (eye worm) hypothetical protein 0.0254 1 1
Schistosoma mansoni biogenic amine (5HT) receptor 0.0254 1 1
Echinococcus multilocularis neuropeptides capa receptor 0.0254 1 1
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0254 1 1
Loa Loa (eye worm) hypothetical protein 0.0254 1 1
Onchocerca volvulus 0.0254 1 1
Echinococcus multilocularis fmrfamide receptor 0.0254 1 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0254 1 1
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP4 0.0085 0.3017 0.2937
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0254 1 1
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0254 1 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0254 1 1
Echinococcus multilocularis fmrfamide receptor 0.0254 1 1
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0254 1 1
Onchocerca volvulus 0.0254 1 1
Echinococcus granulosus neuropeptide receptor 0.0254 1 1
Echinococcus granulosus g-protein coupled receptor 0.0254 1 1
Brugia malayi hypothetical protein 0.0254 1 1
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0254 1 1
Schistosoma mansoni hypothetical protein 0.0254 1 1
Schistosoma mansoni hypothetical protein 0.0254 1 1
Schistosoma mansoni amine GPCR 0.0254 1 1
Schistosoma mansoni hypothetical protein 0.0254 1 1
Onchocerca volvulus 0.0254 1 1

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) > 1000 nM Inhibitory constant against human alpha thrombin ChEMBL. 10636229
Ki (binding) > 1000 nM Inhibitory constant against human alpha thrombin ChEMBL. 10636229

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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