Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0165 | 1 | 0.5 |
Onchocerca volvulus | Peroxidasin homolog | 0.0165 | 1 | 0.5 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0165 | 1 | 0.5 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0165 | 1 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.0165 | 1 | 0.5 |
Schistosoma mansoni | lipoxygenase | 0.0114 | 0.4039 | 0.4039 |
Loa Loa (eye worm) | hypothetical protein | 0.0165 | 1 | 0.5 |
Loa Loa (eye worm) | blistered cuticle protein 3 | 0.0165 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0165 | 1 | 0.5 |
Onchocerca volvulus | Chorion peroxidase homolog | 0.0165 | 1 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.0165 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0165 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0165 | 1 | 0.5 |
Onchocerca volvulus | Peroxidase homolog | 0.0165 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0165 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0165 | 1 | 0.5 |
Onchocerca volvulus | Peroxidasin homolog | 0.0165 | 1 | 0.5 |
Onchocerca volvulus | Dual oxidase homolog | 0.0165 | 1 | 0.5 |
Echinococcus multilocularis | peroxidasin | 0.0165 | 1 | 1 |
Onchocerca volvulus | Peroxidase homolog | 0.0165 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0165 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0165 | 1 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.0165 | 1 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.0165 | 1 | 0.5 |
Schistosoma mansoni | peroxidasin | 0.0165 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0165 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0165 | 1 | 0.5 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0165 | 1 | 0.5 |
Brugia malayi | Peroxidasin | 0.0165 | 1 | 0.5 |
Schistosoma mansoni | peroxidasin | 0.0165 | 1 | 1 |
Onchocerca volvulus | 0.0165 | 1 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0165 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0165 | 1 | 0.5 |
Onchocerca volvulus | 0.0165 | 1 | 0.5 | |
Onchocerca volvulus | 0.0165 | 1 | 0.5 | |
Brugia malayi | Blistered cuticle protein 3 | 0.0165 | 1 | 0.5 |
Echinococcus granulosus | peroxidasin | 0.0165 | 1 | 1 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0165 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0165 | 1 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.0165 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Feces (ADMET) | = 3.3 % | Compound was tested for % clearance through the feaces in jaundiced (TR-) Wistar rats | ChEMBL. | 9397181 |
Feces (ADMET) | = 29.2 % | Compound was tested for % clearance through the feaces in normal Wistar rats | ChEMBL. | 9397181 |
ID/organ (ADMET) | = 0.37 % | Ratio of biodistribution of the compound in kidney and blood in normal Wistar rats at 5 min after injecting the compound | ChEMBL. | 9397181 |
ID/organ (ADMET) | = 0.48 % | Ratio of biodistribution of the compound in kidney and blood in normal Wistar rats at 15 min after injecting the compound | ChEMBL. | 9397181 |
ID/organ (ADMET) | = 0.74 % | Ratio of biodistribution of the compound in kidney and blood in normal Wistar rats at 30 min after injecting the compound | ChEMBL. | 9397181 |
ID/organ (ADMET) | = 0.82 % | The biodistribution of the compound in liver in normal Wistar rats at 60 min | ChEMBL. | 9397181 |
ID/organ (ADMET) | = 0.86 % | The biodistribution of the compound in blood in normal Wistar rats at 60 min | ChEMBL. | 9397181 |
ID/organ (ADMET) | = 0.9 % | Ratio of biodistribution of the compound in liver and blood in normal Wistar rats at 30 min. after injecting the compound | ChEMBL. | 9397181 |
ID/organ (ADMET) | = 0.99 % | Ratio of biodistribution of the compound in liver and blood in normal Wistar rats at 60 min. after injecting the compound | ChEMBL. | 9397181 |
ID/organ (ADMET) | = 1.04 % | Ratio of biodistribution of the compound in liver and blood in normal Wistar rats at 5 min. after injecting the compound | ChEMBL. | 9397181 |
ID/organ (ADMET) | = 1.1 % | Kidney uptake in normal Wistar rats at 60 min | ChEMBL. | 9397181 |
ID/organ (ADMET) | = 1.1 % | Ratio of biodistribution of the compound in liver and blood in normal Wistar rats at 15 min. after injecting the compound | ChEMBL. | 9397181 |
ID/organ (ADMET) | = 1.3 % | Ratio of biodistribution of the compound in kidney and blood in normal Wistar rats at 60 min after injecting the compound | ChEMBL. | 9397181 |
ID/organ (ADMET) | = 1.96 % | Kidney uptake in normal Wistar rats at 30 min | ChEMBL. | 9397181 |
ID/organ (ADMET) | = 2.17 % | The biodistribution of the compound in bone in normal Wistar rats at 30 min | ChEMBL. | 9397181 |
ID/organ (ADMET) | = 2.37 % | The biodistribution of the compound in liver in normal Wistar rats at 30 min | ChEMBL. | 9397181 |
ID/organ (ADMET) | = 2.43 % | The biodistribution of the compound in bone in normal Wistar rats at 60 min | ChEMBL. | 9397181 |
ID/organ (ADMET) | = 2.66 % | The biodistribution of the compound in blood in normal Wistar rats at 30 min | ChEMBL. | 9397181 |
ID/organ (ADMET) | = 3.04 % | Kidney uptake in normal Wistar rats at 15 min | ChEMBL. | 9397181 |
ID/organ (ADMET) | = 3.76 % | The biodistribution of the compound in bone in normal Wistar rats at 15 min | ChEMBL. | 9397181 |
ID/organ (ADMET) | = 4.59 % | The biodistribution of the compound in bone in normal Wistar rats at 5 min | ChEMBL. | 9397181 |
ID/organ (ADMET) | = 4.74 % | Kidney uptake in normal Wistar rats at 5 min | ChEMBL. | 9397181 |
ID/organ (ADMET) | = 6.36 % | The biodistribution of the compound in blood in normal Wistar rats at 15 min | ChEMBL. | 9397181 |
ID/organ (ADMET) | = 6.84 % | The biodistribution of the compound in liver in normal Wistar rats at 15 min | ChEMBL. | 9397181 |
ID/organ (ADMET) | = 12.7 % | The biodistribution of the compound in blood in normal Wistar rats at 5 min | ChEMBL. | 9397181 |
ID/organ (ADMET) | = 13.2 % | The biodistribution of the compound in liver in normal Wistar rats at 5 min | ChEMBL. | 9397181 |
Urine (ADMET) | = 62 % | Compound was tested for % clearance through the urine in normal rat | ChEMBL. | 9397181 |
Urine (ADMET) | = 85 % | Compound was tested for % clearance through the urine in jaundiced (TR-) Wistar rats | ChEMBL. | 9397181 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.