Detailed information for compound 223945

Basic information

Technical information
  • TDR Targets ID: 223945
  • Name: (2S)-1-[(2S)-2-[[(2S)-2-[[(2S)-2-acetamido-3- hydroxypropanoyl]amino]-4-hydroxy-4-oxobutano yl]amino]-6-aminohexyl]pyrrolidine-2-carboxyl ic acid
  • MW: 473.521 | Formula: C20H35N5O8
  • H donors: 7 H acceptors: 8 LogP: -7.09 Rotable bonds: 18
    Rule of 5 violations (Lipinski): 2
  • SMILES: NCCCC[C@@H](CN1CCC[C@H]1C(=O)O)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)C)CO)CC(=O)O
  • InChi: 1S/C20H35N5O8/c1-12(27)22-15(11-26)19(31)24-14(9-17(28)29)18(30)23-13(5-2-3-7-21)10-25-8-4-6-16(25)20(32)33/h13-16,26H,2-11,21H2,1H3,(H,22,27)(H,23,30)(H,24,31)(H,28,29)(H,32,33)/t13-,14-,15-,16-/m0/s1
  • InChiKey: SLEBTZVIISRYKI-VGWMRTNUSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (2S)-1-[(2S)-2-[[(2S)-2-[[(2S)-2-acetamido-3-hydroxy-propanoyl]amino]-4-hydroxy-4-oxo-butanoyl]amino]-6-amino-hexyl]pyrrolidine-2-carboxylic acid
  • (2S)-1-[(2S)-2-[[(2S)-2-[[(2S)-2-acetamido-3-hydroxy-1-oxopropyl]amino]-4-hydroxy-1,4-dioxobutyl]amino]-6-aminohexyl]-2-pyrrolidinecarboxylic acid
  • (2S)-1-[(2S)-2-[[(2S)-2-[[(2S)-2-acetamido-3-hydroxy-propanoyl]amino]-4-hydroxy-4-oxo-butanoyl]amino]-6-azanyl-hexyl]pyrrolidine-2-carboxylic acid
  • (2S)-1-[(2S)-2-[[(2S)-2-[[(2S)-2-acetamido-3-hydroxy-propanoyl]amino]-4-hydroxy-4-keto-butanoyl]amino]-6-amino-hexyl]proline

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis aldo/keto reductase, putative 0.0404 0.5219 0.9101
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 4 0.0006 0.0006 0.0005
Loa Loa (eye worm) hypothetical protein 0.0022 0.0213 0.0406
Loa Loa (eye worm) hypothetical protein 0.0006 0.0006 0.0009
Trichomonas vaginalis aldo-keto reductase, putative 0.0404 0.5219 0.9101
Loa Loa (eye worm) hypothetical protein 0.0022 0.0213 0.0406
Echinococcus granulosus ubiquitin specific peptidase 30 (C19 family) 0.0006 0.0006 0.0005
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0006 0.0006 0.0009
Loa Loa (eye worm) hypothetical protein 0.0022 0.0213 0.0406
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0404 0.5219 0.5218
Trypanosoma brucei aldo-keto reductase, putative 0.0404 0.5219 1
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0006 0.0006 0.0009
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0006 0.0006 0.0011
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0086 0.015
Echinococcus granulosus snurportin 1 0.0295 0.3791 0.379
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0046 0.0535 0.0534
Echinococcus multilocularis dnaJ subfamily B 0.0768 1 1
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0006 0.0011
Schistosoma mansoni ap endonuclease 0.0018 0.0162 0.016
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0018 0.0162 0.0307
Schistosoma mansoni nuclear lim interactor-interacting factor (nli-interacting factor) (nli-if) 0.0009 0.005 0.0048
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0015 0.0124 0.0122
Brugia malayi hypothetical protein 0.0022 0.0213 0.0406
Schistosoma mansoni peptidase 0.0007 0.0012 0.001
Onchocerca volvulus 0.0022 0.0213 0.0397
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0006 0.0006 0.0009
Echinococcus multilocularis ubiquitin specific protease 41 0.0039 0.0433 0.0431
Echinococcus granulosus GTP binding nuclear protein Ran 0.002 0.0192 0.0191
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0404 0.5219 0.5218
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0006 0.0006 0.0011
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0006 0.0006 0.0009
Mycobacterium ulcerans aldehyde dehydrogenase 0.0056 0.0659 0.0983
Mycobacterium ulcerans hypothetical protein 0.0117 0.1459 0.2565
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0006 0.0006 0.0011
Schistosoma mansoni ubiquitin-specific peptidase 48 (C19 family) 0.0006 0.0006 0.0005
Echinococcus multilocularis aldo keto reductase 0.0404 0.5219 0.5218
Echinococcus granulosus Carboxy terminal domain RNA polymerase II 0.0009 0.005 0.0048
Trypanosoma cruzi ubiquitin hydrolase, putative 0.0006 0.0006 0.0012
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0006 0.0011
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0006 0.0006 0.0011
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0033 0.0353 0.0665
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0006 0.0006 0.0011
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0046 0.0531 0.1015
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.002 0.0192 0.0365
Loa Loa (eye worm) hypothetical protein 0.0006 0.0006 0.0009
Schistosoma mansoni zinc finger protein 0.0022 0.0213 0.0212
Echinococcus multilocularis u4:u6.u5 tri snrnp associated protein 2 0.0006 0.0006 0.0005
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0006 0.0006 0.0011
Trichomonas vaginalis nuclear lim interactor-interacting factor, putative 0.0009 0.005 0.0087
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0006 0.0006 0.0011
Echinococcus multilocularis nuclear receptor nhr 48 0.0022 0.0213 0.0212
Plasmodium vivax NLI interacting factor-like phosphatase, putative 0.0009 0.005 0.0302
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0006 0.0006 0.0011
Schistosoma mansoni nuclear receptor 0.0022 0.0213 0.0212
Trypanosoma cruzi ubiquitin hydrolase, putative 0.0006 0.0006 0.0012
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0006 0.0006 0.0011
Echinococcus granulosus ubiquitin specific peptidase c family 0.0006 0.0006 0.0005
Schistosoma mansoni cpg binding protein 0.0057 0.0673 0.0672
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0039 0.0433 0.0431
Trichomonas vaginalis ubiquitin specific protease, putative 0.0006 0.0006 0.0011
Brugia malayi exodeoxyribonuclease III family protein 0.0018 0.0162 0.0307
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0006 0.0006 0.0011
Trypanosoma brucei cysteine peptidase, Clan CA, family C19, putative 0.0006 0.0006 0.0012
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0039 0.0433 0.0431
Brugia malayi CXXC zinc finger family protein 0.0054 0.0633 0.121
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0015 0.0124 0.0122
Trypanosoma cruzi ubiquitin hydrolase, putative 0.0006 0.0006 0.0012
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0404 0.5219 0.5218
Trypanosoma cruzi cysteine peptidase, Clan CA, family C19, putative 0.0006 0.0006 0.0012
Schistosoma mansoni ran 0.002 0.0192 0.0191
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0006 0.0006 0.0011
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0006 0.0006 0.0011
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0006 0.0011
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0022 0.0213 0.0212
Loa Loa (eye worm) ubiquitin carboxyl-terminal hydrolase 0.0006 0.0006 0.0009
Loa Loa (eye worm) ubiquitin carboxyl-terminal hydrolase 46 0.0006 0.0006 0.0009
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0022 0.0219 0.0382
Echinococcus granulosus aldo keto reductase 0.0404 0.5219 0.5218
Schistosoma mansoni aldo-keto reductase 0.0404 0.5219 0.5218
Trypanosoma cruzi ubiquitin hydrolase, putative 0.0006 0.0006 0.0012
Echinococcus granulosus tar DNA binding protein 0.0061 0.0721 0.072
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0006 0.0006 0.0011
Plasmodium vivax NLI interacting factor-like phosphatase, putative 0.0009 0.005 0.0302
Trypanosoma brucei aldo/keto reductase, putative 0.0117 0.1459 0.2795
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0162 0.0282
Onchocerca volvulus 0.0404 0.5219 1
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0039 0.0433 0.083
Loa Loa (eye worm) hypothetical protein 0.0009 0.0049 0.009
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 4 0.0006 0.0006 0.0005
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0018 0.0162 0.016
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0046 0.0535 0.1023
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0006 0.0011
Entamoeba histolytica aldose reductase, putative 0.0404 0.5219 0.91
Loa Loa (eye worm) glutamate-cysteine ligase modifier subunit 0.0117 0.1459 0.2793
Trichomonas vaginalis Harbinger-1_Harbinger/PIFA2 transposable element protein 0.0006 0.0006 0.0011
Trypanosoma cruzi ubiquitin hydrolase, putative 0.0006 0.0006 0.0012
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0046 0.0535 0.0534
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 14 0.0006 0.0006 0.0005
Entamoeba histolytica alcohol dehydrogenase, putative 0.0117 0.1459 0.2536
Brugia malayi hypothetical protein 0.0226 0.2895 0.5545
Loa Loa (eye worm) hypothetical protein 0.0006 0.0006 0.0009
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0046 0.0535 0.0534
Brugia malayi Nuclear hormone receptor E75 0.0022 0.0213 0.0406
Loa Loa (eye worm) hypothetical protein 0.0006 0.0006 0.0009
Giardia lamblia Nuclear LIM interactor-interacting factor 1 0.0009 0.005 0.0084
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 36 0.0006 0.0006 0.0005
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0046 0.0535 0.1023
Echinococcus multilocularis ecdysone induced protein 78C 0.0046 0.0535 0.0534
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0006 0.0006 0.0011
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0006 0.0006 0.0012
Schistosoma mansoni nuclear receptor 0.0022 0.0213 0.0212
Toxoplasma gondii aldose reductase, putative 0.0404 0.5219 1
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 20 0.0006 0.0006 0.0005
Echinococcus multilocularis FTZ F1 alpha 0.0046 0.0535 0.0534
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0006 0.0006 0.0009
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0006 0.0011
Loa Loa (eye worm) hypothetical protein 0.0022 0.0213 0.0406
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0006 0.0006 0.0011
Trichomonas vaginalis bromodomain-containing protein, putative 0.0033 0.0353 0.0615
Brugia malayi latrophilin 2 splice variant baaae 0.0026 0.0267 0.0509
Brugia malayi photoreceptor-specific nuclear receptor 0.0046 0.0535 0.1023
Echinococcus granulosus 5'partial|Ubiquitin carboxyl terminal hydrolase 48 0.0006 0.0006 0.0005
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0006 0.0011
Loa Loa (eye worm) hypothetical protein 0.0046 0.0535 0.1023
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0006 0.0006 0.0012
Brugia malayi Protein-tyrosine phosphatase containing protein 0.009 0.111 0.2125
Giardia lamblia Aldose reductase 0.0404 0.5219 1
Schistosoma mansoni calpain-7 (C02 family) 0.0006 0.0006 0.0005
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0006 0.0006 0.0009
Trypanosoma brucei Mitochondrial import inner membrane translocase subunit TIM50 0.0009 0.005 0.0096
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0006 0.0006 0.0011
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0018 0.0162 0.031
Loa Loa (eye worm) hypothetical protein 0.0226 0.2895 0.5545
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0006 0.0006 0.0012
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0006 0.0006 0.0011
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0085 0.1046 0.2005
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0404 0.5219 0.5218
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0022 0.0213 0.0212
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0006 0.0006 0.0011
Loa Loa (eye worm) hypothetical protein 0.0404 0.5219 1
Brugia malayi F/Y-rich N-terminus family protein 0.0016 0.0142 0.0269
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.009 0.111 0.1109
Schistosoma mansoni ubiquitin-specific peptidase 9X (C19 family) 0.0006 0.0006 0.0005
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0006 0.0011
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0022 0.0213 0.0212
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0018 0.0162 0.031
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0404 0.5219 0.9101
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0404 0.5219 0.5218
Schistosoma mansoni ubiquitin-specific peptidase 44 (C19 family) 0.0006 0.0006 0.0005
Schistosoma mansoni hypothetical protein 0.0046 0.0531 0.053
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0006 0.0006 0.0011
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 0.0006 0.0006 0.0005
Schistosoma mansoni retinoic acid receptor RXR 0.0046 0.0535 0.0534
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0006 0.0006 0.0011
Entamoeba histolytica aldose reductase, putative 0.0404 0.5219 0.91
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 7 0.0006 0.0006 0.0005
Brugia malayi nuclear receptor NHR-67 0.0022 0.0213 0.0406
Loa Loa (eye worm) hypothetical protein 0.0046 0.0535 0.1023
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0015 0.0124 0.0238
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0006 0.0006 0.0011
Schistosoma mansoni aldehyde dehydrogenase 0.0056 0.0659 0.0657
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0006 0.0006 0.0011
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.009 0.1103 0.2112
Plasmodium vivax oxidoreductase, aldo/keto reductase domain containing protein 0.0117 0.1459 1
Trichomonas vaginalis dullard protein, putative 0.0009 0.005 0.0087
Loa Loa (eye worm) hypothetical protein 0.0039 0.0433 0.0827
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0006 0.0006 0.0011
Loa Loa (eye worm) hypothetical protein 0.0022 0.0213 0.0406
Echinococcus granulosus mixed lineage leukemia protein mll 0.0013 0.0101 0.01
Trypanosoma cruzi hypothetical protein, conserved 0.0009 0.005 0.0096
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0025 0.0248 0.0246
Onchocerca volvulus 0.0404 0.5219 1
Schistosoma mansoni nuclear lim interactor-interacting factor (nli-interacting factor) (nli-if) 0.0009 0.005 0.0048
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0404 0.5219 0.5218
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0012 0.0086 0.015
Brugia malayi Nuclear hormone receptor E75 0.0022 0.0213 0.0406
Loa Loa (eye worm) hypothetical protein 0.0022 0.0213 0.0406
Loa Loa (eye worm) oxidoreductase 0.0404 0.5219 1
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0033 0.0353 0.2386
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0025 0.0248 0.0246
Leishmania major importin beta-1 subunit, putative 0.0022 0.0219 0.0409
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0006 0.0011
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0006 0.0006 0.0011
Echinococcus multilocularis expressed protein 0.0006 0.0006 0.0005
Plasmodium vivax aldehyde reductase, putative 0.0117 0.1459 1
Loa Loa (eye worm) ubiquitin carboxyl-terminal hydrolase 0.0006 0.0006 0.0009
Echinococcus granulosus u4:u6.u5 tri snrnp associated protein 2 0.0006 0.0006 0.0005
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0012 0.0084 0.0082
Loa Loa (eye worm) hypothetical protein 0.0012 0.0084 0.0157
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0006 0.0006 0.0011
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0288 0.0551
Schistosoma mansoni ubiquitin-specific peptidase 10 (C19 family) 0.0006 0.0006 0.0005
Onchocerca volvulus Bile acid receptor homolog 0.0046 0.0535 0.1015
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0721 0.072
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0404 0.5219 1
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0162 0.1071
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0046 0.0535 0.1023
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0295 0.3791 0.7262
Echinococcus multilocularis GTP binding nuclear protein Ran 0.002 0.0192 0.0191
Echinococcus granulosus FTZ F1 alpha 0.0046 0.0535 0.0534
Echinococcus multilocularis aldo keto reductase 0.0404 0.5219 0.5218
Toxoplasma gondii isocitrate dehydrogenase 0.0015 0.0124 0.0226
Echinococcus multilocularis muscleblind protein 0.0264 0.3393 0.3392
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0111 0.1378 0.1377
Schistosoma mansoni ubiquitin-specific peptidase 16 (C19 family) 0.0006 0.0006 0.0005
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0006 0.0006 0.0012
Brugia malayi nuclear hormone receptor family member odr-7 0.0022 0.0213 0.0406
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0086 0.015
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.009 0.1103 0.1102
Loa Loa (eye worm) oxidoreductase 0.0404 0.5219 1
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0039 0.0433 0.0745
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0085 0.1046 0.2005
Echinococcus multilocularis Ubiquitin carboxyl terminal hydrolase 48 0.0006 0.0006 0.0005
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0046 0.0535 0.0534
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0018 0.0162 0.0074
Trichomonas vaginalis pps1 dual specificty phosphatase, putative 0.0443 0.5734 1
Loa Loa (eye worm) hypothetical protein 0.0046 0.0535 0.1023
Plasmodium falciparum zinc finger protein, putative 0.0006 0.0009 0.002
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0006 0.0006 0.0011
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 7 0.0006 0.0006 0.0005
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 22 0.0006 0.0006 0.0005
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0721 0.072
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0404 0.5219 0.9101
Entamoeba histolytica NLI interacting factor-like phosphatase domain-containing protein 0.0009 0.005 0.0077
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0006 0.0006 0.0011
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0006 0.0006 0.0011
Onchocerca volvulus 0.0022 0.0213 0.0397
Schistosoma mansoni survival motor neuron protein 0.0046 0.0531 0.053
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.009 0.1103 0.1102
Echinococcus multilocularis ubiquitin specific peptidase (c family) ubiquitin terminal hydrolase 0.0006 0.0006 0.0005
Onchocerca volvulus 0.0404 0.5219 1
Schistosoma mansoni ubiquitin carboxyl-terminal hydrolase of the cysteine proteinase fold 0.0006 0.0006 0.0005
Loa Loa (eye worm) hypothetical protein 0.0025 0.0248 0.0472
Loa Loa (eye worm) oxidoreductase 0.0404 0.5219 1
Trichomonas vaginalis alcohol dehydrogenase, putative 0.0117 0.1459 0.2544
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0006 0.0006 0.0011
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0046 0.0535 0.1023
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0015 0.0124 0.0122
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0046 0.0535 0.0534
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0006 0.0006 0.0009
Schistosoma mansoni thyroid hormone receptor 0.0046 0.0535 0.0534
Trichomonas vaginalis aldo-keto reductase, putative 0.0404 0.5219 0.9101
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0006 0.0006 0.0011
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 24 0.0006 0.0006 0.0005
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0006 0.0006 0.0011
Brugia malayi nuclear receptor RXR 0.0025 0.0248 0.0472
Trichomonas vaginalis ubiquitin specific protease, putative 0.0006 0.0006 0.0011
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0006 0.0006 0.0011
Loa Loa (eye worm) hypothetical protein 0.0009 0.005 0.0093
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0006 0.0006 0.0011
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0046 0.0535 0.1023
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0018 0.0162 0.0299
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.002 0.0192 0.128
Plasmodium falciparum importin beta, putative 0.0028 0.0288 0.1938
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0025 0.0248 0.0246
Brugia malayi orphan nuclear receptor NR2E1 0.0022 0.0213 0.0406
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0006 0.0006 0.0012
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0006 0.0006 0.0012
Leishmania major aldo/keto reductase, putative,aldo/keto reductase family-like protein 0.0117 0.1459 0.2787
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0006 0.0006 0.0009
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0046 0.0535 0.0534
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0404 0.5219 0.5218
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0033 0.0353 0.0665
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0046 0.0535 0.1023
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 16 0.0006 0.0006 0.0005
Trichomonas vaginalis ran, putative 0.002 0.0192 0.0335
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.002 0.0192 0.0357
Brugia malayi steroid hormone receptor 0.0046 0.0535 0.1023
Echinococcus multilocularis aldehyde reductase 0.0287 0.3686 0.3685
Trypanosoma brucei prostaglandin f synthase 0.0404 0.5219 1
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0006 0.0006 0.0011
Trichomonas vaginalis aldo-keto reductase, putative 0.0404 0.5219 0.9101
Trichomonas vaginalis importin beta-1, putative 0.0022 0.0219 0.0382
Trichomonas vaginalis ubiquitin specific protease, putative 0.0006 0.0006 0.0011
Leishmania major aldehyde reductase, putative,oxidoreductase, putative 0.0404 0.5219 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0046 0.0535 0.1023
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0006 0.0006 0.0011
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0056 0.0659 0.1252
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.009 0.111 0.1109
Echinococcus multilocularis aldo keto reductase 0.0404 0.5219 0.5218
Echinococcus granulosus ubiquitin specific protease 41 0.0039 0.0433 0.0431
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0086 0.015
Echinococcus granulosus aldehyde reductase 0.0287 0.3686 0.3685
Schistosoma mansoni ran 0.002 0.0192 0.0191
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0046 0.0535 0.0534
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0006 0.0006 0.0009
Echinococcus multilocularis Carboxy terminal domain RNA polymerase II 0.0009 0.005 0.0048
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 4 0.0006 0.0006 0.0005
Onchocerca volvulus 0.0404 0.5219 1
Schistosoma mansoni hypothetical protein 0.0026 0.0267 0.0266
Trichomonas vaginalis helicase, putative 0.0012 0.0086 0.015
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0039 0.0433 0.0431
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 7 0.0006 0.0006 0.0005
Loa Loa (eye worm) nuclear receptor NHR-67 0.0022 0.0213 0.0406
Schistosoma mansoni ubiquitin-specific peptidase 30 (C19 family) 0.0006 0.0006 0.0005
Trichomonas vaginalis aldo-keto reductase, putative 0.0404 0.5219 0.9101
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0006 0.0006 0.0011
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0015 0.0124 0.0811
Echinococcus multilocularis dual specificity 0.0085 0.1046 0.1045
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 20 0.0006 0.0006 0.0005
Schistosoma mansoni ap endonuclease 0.0018 0.0162 0.016
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0006 0.0006 0.0011
Loa Loa (eye worm) hypothetical protein 0.0264 0.3393 0.65
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0006 0.0006 0.0011
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 7 0.0006 0.0006 0.0005
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0006 0.0006 0.0009
Mycobacterium ulcerans aldehyde dehydrogenase 0.0056 0.0659 0.0983
Loa Loa (eye worm) ubiquitin carboxyl-terminal hydrolase 0.0006 0.0006 0.0009
Loa Loa (eye worm) hypothetical protein 0.0006 0.0006 0.0009
Trichomonas vaginalis aldo-keto reductase, putative 0.0404 0.5219 0.9101
Entamoeba histolytica dual specificity protein phosphatase, putative 0.0443 0.5734 1
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0006 0.0006 0.0011
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0404 0.5219 0.9101
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0404 0.5219 1
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0006 0.0006 0.0011
Schistosoma mansoni cpg binding protein 0.0057 0.0673 0.0672
Leishmania major prostaglandin f2-alpha synthase/D-arabinose dehydrogenase 0.0404 0.5219 1
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0006 0.0006 0.0011
Brugia malayi Protein kinase domain containing protein 0.0085 0.1046 0.2002
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0404 0.5219 0.5218
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0006 0.0006 0.0011
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0015 0.0124 0.0122
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0006 0.0006 0.0011
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0006 0.0006 0.0011
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0012 0.0084 0.0157
Trypanosoma brucei CMGC/DYRK protein kinase, putative 0.0085 0.1046 0.2005
Trypanosoma cruzi aldo/keto reductase, putative 0.0404 0.5219 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0012 0.0086 0.015
Entamoeba histolytica hypothetical protein 0.0085 0.1046 0.1816
Echinococcus multilocularis GPCR, family 2 0.0012 0.0084 0.0082
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0006 0.0006 0.0011
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0012 0.0084 0.0082
Brugia malayi RNA, U transporter 1 0.0078 0.0955 0.1828
Schistosoma mansoni microtubule-associated protein tau 0.0661 0.859 0.859
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0012 0.0086 0.015
Brugia malayi hypothetical protein 0.0025 0.0248 0.0472
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0022 0.0213 0.0212
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0006 0.0006 0.0012
Mycobacterium leprae Conserved hypothetical protein 0.0287 0.3686 0.5922
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0008 0.0027 0.0026
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0039 0.0433 0.0819
Brugia malayi TAR-binding protein 0.0061 0.0721 0.1379
Echinococcus granulosus Nuclear hormone receptor HR96 0.0022 0.0213 0.0212
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0006 0.0011
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0006 0.0006 0.0011
Echinococcus multilocularis voltage gated potassium channel subunit 0.0117 0.1459 0.1458
Entamoeba histolytica aldose reductase, putative 0.0404 0.5219 0.91
Echinococcus granulosus aldo keto reductase 0.0404 0.5219 0.5218
Trichomonas vaginalis aldo-keto reductase, putative 0.0404 0.5219 0.9101
Loa Loa (eye worm) hypothetical protein 0.0046 0.0535 0.1023
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0006 0.0006 0.0009
Trypanosoma cruzi ubiquitin hydrolase, putative 0.0006 0.0006 0.0012
Entamoeba histolytica Ran family GTPase 0.002 0.0192 0.0325
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0046 0.0535 0.0534
Brugia malayi conserved hypotetical protein 0.0022 0.0213 0.0406
Echinococcus multilocularis aldo keto reductase 0.0404 0.5219 0.5218
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0022 0.0213 0.0212
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0006 0.0006 0.0012
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0114 0.1426 0.1425
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0017 0.0145 0.0143
Toxoplasma gondii aldo-keto reductase 0.0117 0.1459 0.2787
Trypanosoma cruzi cysteine peptidase, Clan CA, family C19, putative 0.0006 0.0006 0.0012
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0721 0.072
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0404 0.5219 0.5218
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0013 0.0101 0.01
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 47 0.0006 0.0006 0.0005
Brugia malayi NADH-dependent xylose reductase 0.0117 0.1459 0.2793
Schistosoma mansoni ubiquitin-specific peptidase 46 (C19 family) 0.0006 0.0006 0.0005
Brugia malayi ubiquitin specific protease 14 0.0006 0.0006 0.0009
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0721 0.072
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0046 0.0535 0.1023
Echinococcus granulosus nuclear receptor nhr 48 0.0022 0.0213 0.0212
Trichomonas vaginalis aldo-keto reductase, putative 0.0404 0.5219 0.9101
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0012 0.0086 0.015
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0012 0.0086 0.015
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0046 0.0535 0.1023
Schistosoma mansoni coup transcription factor 0.0046 0.0535 0.0534
Loa Loa (eye worm) ubiquitin carboxyl-terminal hydrolase 0.0006 0.0006 0.0009
Toxoplasma gondii HEAT repeat-containing protein 0.0028 0.0288 0.054
Onchocerca volvulus Protein ultraspiracle homolog 0.0046 0.0535 0.1015
Loa Loa (eye worm) ubiquitin carboxyl-terminal hydrolase 0.0006 0.0006 0.0009
Schistosoma mansoni hypothetical protein 0.0768 1 1
Echinococcus granulosus aldo keto reductase family 1, member B4 0.0117 0.1459 0.1458
Schistosoma mansoni cpg binding protein 0.0054 0.0633 0.0632
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0046 0.0535 0.1023
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 24 0.0006 0.0006 0.0005
Loa Loa (eye worm) hypothetical protein 0.0025 0.0248 0.0472
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0022 0.0213 0.0212
Echinococcus granulosus histone acetyltransferase KAT2B 0.0108 0.1337 0.1336
Onchocerca volvulus 0.0046 0.0535 0.1015
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0006 0.0006 0.0011
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0433 0.0755
Loa Loa (eye worm) TAR-binding protein 0.0061 0.0721 0.1379
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0006 0.0006 0.0011
Entamoeba histolytica acetyltransferase, GNAT family 0.003 0.0317 0.0543
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0006 0.0006 0.0011
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0039 0.0433 0.0431
Brugia malayi Nuclear hormone receptor-like 1 0.0025 0.0248 0.0472
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 14 0.0006 0.0006 0.0005
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0006 0.0006 0.0011
Brugia malayi nuclear receptor NHR-88 0.0046 0.0535 0.1023
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0039 0.0433 0.0431
Schistosoma mansoni ubiquitin-specific peptidase 14 (C19 family) 0.0006 0.0006 0.0005
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0006 0.0006 0.0009
Trichomonas vaginalis conserved hypothetical protein 0.0117 0.1459 0.2544
Schistosoma mansoni ubiquitin-specific peptidase 5 (C19 family) 0.0006 0.0006 0.0005
Entamoeba histolytica alcohol dehydrogenase, putative 0.0117 0.1459 0.2536
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0012 0.0086 0.015
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0018 0.0162 0.031
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0006 0.0006 0.0011
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0404 0.5219 0.5218
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0033 0.0353 0.0615
Brugia malayi nuclear hormone receptor 0.0046 0.0535 0.1023
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0006 0.0006 0.0011
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0006 0.0006 0.0011
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0006 0.0006 0.0011
Leishmania major GTP-binding protein, putative 0.002 0.0192 0.0357
Schistosoma mansoni hypothetical protein 0.0012 0.0084 0.0082
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.009 0.1103 0.1102
Onchocerca volvulus 0.0054 0.0633 0.1203
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0006 0.0006 0.0011
Echinococcus multilocularis cpg binding protein 0.0057 0.0673 0.0672
Schistosoma mansoni myst-related protein 0.0006 0.0009 0.0008
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0006 0.0006 0.0011
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0006 0.0011
Schistosoma mansoni RAR-like nuclear receptor 0.0046 0.0535 0.0534
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0404 0.5219 0.5218
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0013 0.0101 0.01
Brugia malayi tailless protein 0.0022 0.0213 0.0406
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0038 0.0425 0.0812
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0006 0.0006 0.0011
Entamoeba histolytica hypothetical protein 0.0006 0.0009 0.0005
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0404 0.5219 0.5218
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0015 0.0124 0.0122
Loa Loa (eye worm) hypothetical protein 0.0006 0.0006 0.0009
Loa Loa (eye worm) hypothetical protein 0.0026 0.0267 0.0509
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 12 0.0006 0.0006 0.0005
Brugia malayi acetyltransferase, GNAT family protein 0.0111 0.1378 0.2638
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.002 0.0192 0.0368
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0404 0.5219 0.5218
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0006 0.0006 0.0012
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0039 0.0433 0.0431
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0006 0.0006 0.0009
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 36 0.0006 0.0006 0.0005
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0015 0.0124 0.0238
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0086 0.015
Echinococcus multilocularis survival motor neuron protein 1 0.0226 0.2895 0.2894
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0006 0.0006 0.0011
Echinococcus granulosus ecdysone induced protein 78C 0.0046 0.0535 0.0534
Loa Loa (eye worm) hypothetical protein 0.0025 0.0248 0.0472
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0046 0.0535 0.0534
Loa Loa (eye worm) hypothetical protein 0.0046 0.0535 0.1023
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.009 0.111 0.1109
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0046 0.0535 0.1023
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0086 0.015
Leishmania major prostaglandin f synthase, putative 0.0404 0.5219 1
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0022 0.0219 0.0382
Loa Loa (eye worm) hypothetical protein 0.0025 0.0248 0.0472
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0006 0.0006 0.0011
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.009 0.1103 0.2112
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.002 0.0192 0.128
Echinococcus granulosus histone acetyltransferase KAT2B 0.0033 0.0353 0.0351
Loa Loa (eye worm) RNA binding protein 0.0061 0.0721 0.1379
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0006 0.0006 0.0009
Brugia malayi Carboxy-terminal domain RNA polymerase II polypeptide A smallphosphatase 1 0.0009 0.005 0.0093
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0013 0.0101 0.01
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0006 0.0006 0.0011
Plasmodium vivax importin-beta 2, putative 0.0028 0.0288 0.1938
Trichomonas vaginalis aldo-keto reductase, putative 0.0404 0.5219 0.9101
Trypanosoma cruzi ubiquitin hydrolase, putative 0.0006 0.0006 0.0012
Schistosoma mansoni nuclear hormone receptor 0.0022 0.0213 0.0212
Echinococcus multilocularis snurportin 1 0.0295 0.3791 0.379
Trypanosoma cruzi ubiquitin hydrolase, putative 0.0006 0.0006 0.0012
Loa Loa (eye worm) hypothetical protein 0.0025 0.0248 0.0472
Loa Loa (eye worm) protein-tyrosine phosphatase 0.009 0.111 0.2125
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.009 0.1103 0.1102
Trichomonas vaginalis aldo/keto reductase, putative 0.0404 0.5219 0.9101
Trypanosoma cruzi ubiquitin hydrolase, putative 0.0006 0.0006 0.0012
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0046 0.0535 0.1023
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0046 0.0535 0.1023
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0046 0.0535 0.1015
Brugia malayi ecdysteroid receptor 0.0046 0.0535 0.1023
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0404 0.5219 1
Echinococcus granulosus muscleblind protein 0.0264 0.3393 0.3392
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0022 0.0213 0.0406
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0006 0.0006 0.0011
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0046 0.0535 0.0534
Trichomonas vaginalis aldo-keto reductase, putative 0.0404 0.5219 0.9101
Toxoplasma gondii exonuclease III APE 0.0018 0.0162 0.0299
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0404 0.5219 0.5218
Trichomonas vaginalis hypothetical protein 0.0007 0.0012 0.002
Plasmodium falciparum NLI interacting factor-like phosphatase, putative 0.0009 0.005 0.0302
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0012 0.0086 0.015
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0006 0.0006 0.0011
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0006 0.0006 0.0011
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0018 0.0162 0.0272
Brugia malayi hypothetical protein 0.0006 0.0006 0.0009
Brugia malayi nuclear hormone receptor 0.0022 0.0213 0.0406
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0018 0.0162 0.5
Echinococcus multilocularis thyroid hormone receptor alpha 0.0046 0.0535 0.0534
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0006 0.0006 0.0011
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0111 0.1378 0.1377
Schistosoma mansoni family C19 unassigned peptidase (C19 family) 0.0006 0.0006 0.0005
Brugia malayi Muscleblind-like protein 0.0264 0.3393 0.65
Echinococcus multilocularis importin subunit beta 1 0.0028 0.0288 0.0286
Loa Loa (eye worm) hypothetical protein 0.0022 0.0213 0.0406
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0006 0.0011
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0006 0.0006 0.0011
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0006 0.0011
Trypanosoma brucei ISWI complex protein 0.0006 0.0000014753 0.0000028267
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0404 0.5219 0.5218
Trichomonas vaginalis Harbinger-1_Harbinger/PIFA2 transposable element protein 0.0006 0.0006 0.0011
Mycobacterium ulcerans aldehyde dehydrogenase 0.0056 0.0659 0.0983
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 4 0.0006 0.0006 0.0005
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0056 0.0659 0.0657
Loa Loa (eye worm) hypothetical protein 0.0006 0.0006 0.0009
Loa Loa (eye worm) hypothetical protein 0.0006 0.0006 0.0009
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0015 0.0124 0.0122
Entamoeba histolytica protein kinase, putative 0.0085 0.1046 0.1816
Loa Loa (eye worm) hypothetical protein 0.0046 0.0535 0.1023
Entamoeba histolytica hypothetical protein 0.0022 0.0219 0.0372
Loa Loa (eye worm) hypothetical protein 0.0022 0.0213 0.0406
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0006 0.0011
Echinococcus granulosus aldo keto reductase 0.0404 0.5219 0.5218
Trypanosoma cruzi ubiquitin hydrolase, putative 0.0006 0.0006 0.0012
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 23 0.0006 0.0006 0.0005
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0046 0.0535 0.0534
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.009 0.1103 0.1102
Trypanosoma cruzi Peptidase C19, ubiquitin carboxyl-terminal hydrolase, putative 0.0006 0.0006 0.0012
Echinococcus granulosus survival motor neuron protein 1 0.0226 0.2895 0.2894
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 0.0006 0.0006 0.0005
Loa Loa (eye worm) hypothetical protein 0.0022 0.0213 0.0406
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0162 0.1071
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0056 0.0659 0.0657
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0404 0.5219 0.5218
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0039 0.0433 0.0755
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0006 0.0006 0.0011
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0006 0.0006 0.0012
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0006 0.0006 0.0011
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0006 0.0006 0.0011
Brugia malayi hypothetical protein 0.0022 0.0213 0.0406
Giardia lamblia Aldose reductase 0.0404 0.5219 1
Schistosoma mansoni nuclear hormone receptor 0.0046 0.0535 0.0534
Trypanosoma cruzi ubiquitin hydrolase, putative 0.0006 0.0006 0.0012
Loa Loa (eye worm) ubiquitin carboxyl-terminal hydrolase 0.0006 0.0006 0.0009
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0006 0.0006 0.0012
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0046 0.0535 0.1023
Trypanosoma cruzi ubiquitin hydrolase, putative 0.0006 0.0006 0.0012
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0006 0.0006 0.0011
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0006 0.0011
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0086 0.015
Loa Loa (eye worm) hypothetical protein 0.0006 0.0006 0.0009
Loa Loa (eye worm) hypothetical protein 0.0006 0.0006 0.0009
Mycobacterium tuberculosis Conserved protein 0.0117 0.1459 0.262
Brugia malayi Nuclear hormone receptor-like 1 0.0046 0.0535 0.1023
Onchocerca volvulus 0.0404 0.5219 1
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0006 0.0011
Schistosoma mansoni calpain-7 (C02 family) 0.0006 0.0006 0.0005
Brugia malayi Calcitonin receptor-like protein seb-1 0.0038 0.0425 0.0812
Schistosoma mansoni thyroid hormone receptor 0.0046 0.0535 0.0534
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0022 0.0213 0.0212
Schistosoma mansoni pol-related 0.0404 0.5219 0.5218
Schistosoma mansoni ubiquitin-specific peptidase 9X (C19 family) 0.0006 0.0006 0.0005
Toxoplasma gondii aldehyde dehydrogenase 0.0056 0.0659 0.1252
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.0085 0.1046 0.1995
Echinococcus multilocularis microtubule associated protein 2 0.0661 0.859 0.859
Echinococcus multilocularis 0.0009 0.005 0.0048
Treponema pallidum exodeoxyribonuclease (exoA) 0.0018 0.0162 0.5
Plasmodium falciparum aldehyde reductase, putative 0.0117 0.1459 1
Loa Loa (eye worm) acetyltransferase 0.0111 0.1378 0.2638
Echinococcus multilocularis ubiquitin specific peptidase 42 (C19 family) 0.0006 0.0006 0.0005
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0006 0.0006 0.0012
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 47 0.0006 0.0006 0.0005
Schistosoma mansoni importin beta-1 0.0028 0.0288 0.0286
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0006 0.0006 0.0011
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0046 0.0535 0.1023
Loa Loa (eye worm) hypothetical protein 0.0022 0.0213 0.0406
Brugia malayi nuclear receptor RXR 0.0022 0.0213 0.0406
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0025 0.0248 0.0246
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0046 0.0535 0.1023
Loa Loa (eye worm) hypothetical protein 0.0264 0.3393 0.65
Schistosoma mansoni ubiquitin-specific peptidase 22 (C19 family) 0.0006 0.0006 0.0005
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0039 0.0433 0.0827
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0006 0.0006 0.0011
Plasmodium falciparum histone acetyltransferase GCN5 0.003 0.0317 0.2141
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0006 0.0006 0.0011
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0046 0.0535 0.1023
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0006 0.0006 0.0011
Loa Loa (eye worm) hypothetical protein 0.0006 0.0006 0.0009
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0006 0.0006 0.0011
Toxoplasma gondii aldo/keto reductase family oxidoreductase 0.0117 0.1459 0.2787
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.002 0.0192 0.0368
Trichomonas vaginalis aldo-keto reductase, putative 0.0117 0.1459 0.2544
Loa Loa (eye worm) hypothetical protein 0.0046 0.0535 0.1023
Trichomonas vaginalis aldo-keto reductase, putative 0.0404 0.5219 0.9101
Trypanosoma cruzi ubiquitin hydrolase, putative 0.0006 0.0006 0.0012
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0006 0.0006 0.0012
Brugia malayi Steroid receptor seven-up type 2 0.0046 0.0535 0.1023
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0006 0.0006 0.0012
Trypanosoma cruzi Peptidase C19, ubiquitin carboxyl-terminal hydrolase, putative 0.0006 0.0006 0.0012
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0006 0.0006 0.0011
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0006 0.0006 0.0011
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0288 0.0551
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0006 0.0006 0.0011
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0006 0.0006 0.0011
Echinococcus granulosus dual specificity 0.0085 0.1046 0.1045
Brugia malayi ubiquitin carboxyl-terminal hydrolase 46 0.0006 0.0006 0.0009
Trichomonas vaginalis dullard protein, putative 0.0009 0.005 0.0087
Schistosoma mansoni ubiquitin-specific peptidase 7 (C19 family) 0.0006 0.0006 0.0005
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0006 0.0006 0.0011
Entamoeba histolytica protein kinase, putative 0.0085 0.1046 0.1816
Echinococcus granulosus thyroid hormone receptor alpha 0.0022 0.0213 0.0212
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 5 0.0006 0.0006 0.0005
Brugia malayi RNA binding protein 0.0061 0.0721 0.1379
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0006 0.0006 0.0011
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0006 0.0006 0.0012
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0006 0.0006 0.0011
Trypanosoma cruzi ubiquitin hydrolase, putative 0.0006 0.0006 0.0012
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 4 0.0006 0.0006 0.0005
Schistosoma mansoni protein tyrosine phosphatase n11 (shp2) 0.009 0.111 0.1109
Trichomonas vaginalis Harbinger-1_Harbinger/PIFA2 transposable element protein 0.0006 0.0006 0.0011
Loa Loa (eye worm) hypothetical protein 0.0022 0.0213 0.0406
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0046 0.0535 0.1023
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0025 0.0248 0.0472
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0012 0.0084 0.0082
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0404 0.5219 0.5218
Schistosoma mansoni nuclear receptor nhr-48 0.0022 0.0213 0.0212
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0007 0.0012 0.002
Leishmania major hypothetical protein, conserved 0.0009 0.005 0.0084
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0086 0.015
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0086 0.015
Schistosoma mansoni aldo-keto reductase 0.0404 0.5219 0.5218
Trypanosoma cruzi cysteine peptidase, Clan CA, family C19, putative 0.0006 0.0006 0.0012
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0006 0.0006 0.0011
Trichomonas vaginalis aldo-keto reductase, putative 0.0404 0.5219 0.9101
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0404 0.5219 0.5218
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.002 0.0192 0.0368
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0022 0.0213 0.0212
Schistosoma mansoni hypothetical protein 0.0012 0.0084 0.0082
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0006 0.0006 0.0009
Onchocerca volvulus 0.0046 0.0531 0.1007
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0006 0.0006 0.0011
Loa Loa (eye worm) DR-78 0.0022 0.0213 0.0406
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0006 0.0006 0.0011
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0006 0.0006 0.0011
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0404 0.5219 0.5218
Brugia malayi nuclear hormone receptor family member nhr-6 0.0022 0.0213 0.0406
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0006 0.0006 0.0011
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0006 0.0006 0.0011
Loa Loa (eye worm) hypothetical protein 0.0022 0.0213 0.0406
Loa Loa (eye worm) steroid hormone receptor 0.0046 0.0535 0.1023
Schistosoma mansoni hypothetical protein 0.0006 0.0006 0.0005
Loa Loa (eye worm) hypothetical protein 0.0085 0.104 0.1991
Trichomonas vaginalis nuclear lim interactor-interacting factor, putative 0.0009 0.005 0.0087
Trichomonas vaginalis nuclear lim interactor-interacting factor, putative 0.0009 0.005 0.0087
Echinococcus granulosus CTD small phosphatase protein like 0.0009 0.005 0.0048
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 12 0.0006 0.0006 0.0005
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 16 0.0006 0.0006 0.0005
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0039 0.0433 0.0755
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0006 0.0006 0.0011
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0404 0.5219 1
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0006 0.0006 0.0011
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0015 0.0124 0.0811
Onchocerca volvulus 0.0404 0.5219 1
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0006 0.0006 0.0011
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0022 0.0213 0.0397
Echinococcus granulosus microtubule associated protein 2 0.0661 0.859 0.859
Brugia malayi nuclear receptor NHR-88 0.0022 0.0213 0.0406
Toxoplasma gondii Dullard family phosphatase domain-containing protein 0.0009 0.005 0.0084
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0006 0.0006 0.0011
Trypanosoma brucei Peptidase C19, ubiquitin carboxyl-terminal hydrolase, putative 0.0006 0.0006 0.0012
Trichomonas vaginalis dullard protein, putative 0.0009 0.005 0.0087
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0006 0.0006 0.0011
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0006 0.0006 0.0011
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0046 0.0535 0.0534
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0018 0.0162 0.0299
Schistosoma mansoni hypothetical protein 0.0012 0.0084 0.0082
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.002 0.0192 0.0357
Brugia malayi Latrophilin receptor protein 2 0.0012 0.0084 0.0157
Trypanosoma brucei Peptidase C19, ubiquitin carboxyl-terminal hydrolase, putative 0.0006 0.0006 0.0012
Echinococcus multilocularis muscleblind protein 1 0.0264 0.3393 0.3392
Brugia malayi Nuclear hormone receptor-like 1 0.0025 0.0248 0.0472
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0404 0.5219 0.5218
Trichomonas vaginalis aldo-keto reductase, putative 0.0404 0.5219 0.9101
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0046 0.0535 0.0534
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.009 0.111 0.1109
Brugia malayi ecdysone receptor 0.0022 0.0213 0.0406
Schistosoma mansoni serine/threonine protein kinase 0.0085 0.1046 0.1045
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0013 0.0101 0.01
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0006 0.0011
Brugia malayi isocitrate dehydrogenase 0.0015 0.0124 0.0235
Schistosoma mansoni ubiquitin-specific peptidase 42 (C19 family) 0.0006 0.0006 0.0005
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 4 0.0006 0.0006 0.0005
Loa Loa (eye worm) CMGC/DYRK/DYRK1 protein kinase 0.0085 0.1046 0.2002
Echinococcus granulosus Nuclear hormone receptor HR96 0.0022 0.0213 0.0212
Schistosoma mansoni hypothetical protein 0.0012 0.0084 0.0082
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0046 0.0535 0.0534
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0006 0.0006 0.0011
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.009 0.1103 0.1102
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 5 0.0006 0.0006 0.0005
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0086 0.015
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0006 0.0011
Echinococcus multilocularis tar DNA binding protein 0.0061 0.0721 0.072
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0006 0.0006 0.0011
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0046 0.0535 0.1023
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.009 0.1103 0.1102
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0006 0.0011
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0006 0.0006 0.0012
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0015 0.0124 0.0226
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0018 0.0162 0.016
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0039 0.0433 0.0819
Brugia malayi glutamate-cysteine ligase modifier subunit 0.0117 0.1459 0.2793
Schistosoma mansoni hypothetical protein 0.0295 0.3791 0.379
Loa Loa (eye worm) hypothetical protein 0.0028 0.0288 0.0548
Loa Loa (eye worm) ubiquitin specific peptidase 39 0.0006 0.0006 0.0009
Toxoplasma gondii histone lysine methyltransferase SET1 0.0105 0.1301 0.2485
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0046 0.0535 0.0534
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0006 0.0006 0.0011
Loa Loa (eye worm) CXXC zinc finger family protein 0.0054 0.0633 0.121
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0006 0.0006 0.0011
Brugia malayi Importin beta-1 subunit 0.0028 0.0288 0.0548
Loa Loa (eye worm) hypothetical protein 0.0006 0.0006 0.0009
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0022 0.0213 0.0397
Echinococcus granulosus importin subunit beta 1 0.0028 0.0288 0.0286
Schistosoma mansoni aldehyde dehydrogenase 0.0056 0.0659 0.0657
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0006 0.0006 0.0012
Schistosoma mansoni ubiquitin-specific peptidase 4 (C19 family) 0.0006 0.0006 0.0005
Trichomonas vaginalis aldo/keto reductase, putative 0.0404 0.5219 0.9101
Loa Loa (eye worm) ubiquitin carboxyl-terminal hydrolase 0.0006 0.0006 0.0009
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0162 0.0282
Schistosoma mansoni steroid hormone receptor ad4bp 0.0046 0.0535 0.0534
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0006 0.0006 0.0011
Schistosoma mansoni nuclear hormone receptor 0.0022 0.0213 0.0212
Loa Loa (eye worm) hypothetical protein 0.0022 0.0213 0.0406
Mycobacterium tuberculosis Probable oxidoreductase 0.0404 0.5219 1
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0006 0.0006 0.0011
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0721 0.072
Toxoplasma gondii oxidoreductase, aldo/keto reductase family protein 0.0117 0.1459 0.2787
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0006 0.0006 0.0011
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0015 0.0124 0.0238
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0017 0.0145 0.0143
Entamoeba histolytica protein kinase domain containing protein 0.0085 0.1046 0.1816
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0061 0.0721 0.1379
Echinococcus granulosus cpg binding protein 0.0057 0.0673 0.0672
Mycobacterium ulcerans oxidoreductase 0.0404 0.5219 1
Loa Loa (eye worm) hypothetical protein 0.0038 0.0425 0.0812
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0006 0.0006 0.0011
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0022 0.0213 0.0406
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0006 0.0006 0.0011
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 22 0.0006 0.0006 0.0005
Trichomonas vaginalis aldo-keto reductase, putative 0.0117 0.1459 0.2544
Plasmodium falciparum aldo-keto reductase, putative 0.0117 0.1459 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0046 0.0535 0.0534
Brugia malayi hypothetical protein 0.0025 0.0248 0.0472
Leishmania major aldo-keto reductase-like protein 0.0404 0.5219 1
Trypanosoma cruzi importin beta-1 subunit, putative 0.0022 0.0219 0.042
Loa Loa (eye worm) hypothetical protein 0.0046 0.0535 0.1023
Loa Loa (eye worm) oxidoreductase 0.0404 0.5219 1
Trypanosoma cruzi aldo/keto reductase, putative 0.0117 0.1459 0.2795
Loa Loa (eye worm) oxidoreductase 0.0404 0.5219 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0046 0.0535 0.1023
Schistosoma mansoni potassium channel beta 0.0117 0.1459 0.1458
Echinococcus granulosus hypothetical protein 0.0404 0.5219 0.5218
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0039 0.0433 0.083
Echinococcus granulosus Ubiquitin carboxyl terminal hydrolase 48 0.0006 0.0006 0.0005
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0006 0.0006 0.0011
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0006 0.0006 0.0011
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0012 0.002
Trichomonas vaginalis nuclear lim interactor-interacting factor, putative 0.0009 0.005 0.0087
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0006 0.0006 0.0011
Brugia malayi Isocitrate dehydrogenase 0.0015 0.0124 0.0235
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0038 0.0425 0.0812
Schistosoma mansoni hypothetical protein 0.0009 0.0049 0.0047
Loa Loa (eye worm) hypothetical protein 0.0085 0.104 0.1991
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0006 0.0006 0.0011
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0006 0.0006 0.0011
Loa Loa (eye worm) histone methyltransferase 0.0017 0.0145 0.0274
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0046 0.0535 0.0534
Loa Loa (eye worm) ubiquitin carboxyl-terminal hydrolase 0.0006 0.0006 0.0009
Loa Loa (eye worm) isocitrate dehydrogenase 0.0015 0.0124 0.0235
Brugia malayi RNA recognition motif domain containing protein 0.0061 0.0721 0.1379
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0012 0.0084 0.0082
Giardia lamblia Histone acetyltransferase GCN5 0.003 0.0317 0.0597
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0006 0.0011
Trypanosoma cruzi aldo-keto reductase 0.0404 0.5219 1
Schistosoma mansoni ubiquitin-specific peptidase 45 (C19 family) 0.0006 0.0006 0.0005
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0006 0.0006 0.0009
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0046 0.0535 0.0534
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0006 0.0006 0.0011
Trypanosoma cruzi ubiquitin hydrolase, putative 0.0006 0.0006 0.0012
Loa Loa (eye worm) nuclear hormone receptor 0.0022 0.0213 0.0406
Loa Loa (eye worm) latrophilin receptor protein 2 0.0012 0.0084 0.0157
Echinococcus multilocularis isocitrate dehydrogenase 0.0015 0.0124 0.0122
Trichomonas vaginalis aldo-keto reductase, putative 0.0117 0.1459 0.2544
Onchocerca volvulus 0.0117 0.1459 0.2787
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0015 0.0124 0.0238
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0006 0.0006 0.0011
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0039 0.0433 0.083
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0046 0.0535 0.0534
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0006 0.0006 0.0011
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0022 0.0213 0.0212
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.002 0.0192 0.0365
Echinococcus granulosus GPCR family 2 0.0012 0.0084 0.0082
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0006 0.0006 0.0011
Toxoplasma gondii isocitrate dehydrogenase 0.0015 0.0124 0.0226
Mycobacterium leprae PROBABLE OXIDOREDUCTASE 0.0404 0.5219 1
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0056 0.0659 0.105
Schistosoma mansoni family C19 non-peptidase homologue (C19 family) 0.0006 0.0006 0.0005
Schistosoma mansoni myst-related protein 0.0006 0.0009 0.0008
Trichomonas vaginalis Harbinger-1_Harbinger/PIFA2 transposable element protein 0.0006 0.0006 0.0011
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0012 0.0086 0.015
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0006 0.0006 0.0012
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0006 0.0006 0.0011
Schistosoma mansoni ubiquitin-specific peptidase 24 (C19 family) 0.0006 0.0006 0.0005
Echinococcus granulosus voltage gated potassium channel subunit 0.0117 0.1459 0.1458

Activities

Activity type Activity value Assay description Source Reference
Residual peptide (binding) = 47.3 % In vitro stability of compound (0.5 microM) to inhibit NAcSDKP hydrolysis by rabbit lung Angiotensin I converting enzyme after 30 minutes incubation ChEMBL. 9397177
Residual peptide (binding) = 47.3 % In vitro stability of compound (0.5 microM) to inhibit NAcSDKP hydrolysis by rabbit lung Angiotensin I converting enzyme after 30 minutes incubation ChEMBL. 9397177
Residual peptide (binding) = 48.8 % In vitro stability of compound (5 microM) to inhibit NAcSDKP hydrolysis by rabbit lung Angiotensin I converting enzyme after 30 minutes incubation ChEMBL. 9397177
Residual peptide (binding) = 48.8 % In vitro stability of compound (5 microM) to inhibit NAcSDKP hydrolysis by rabbit lung Angiotensin I converting enzyme after 30 minutes incubation ChEMBL. 9397177
Residual peptide (binding) = 50.3 % In vitro stability of compound (50 microM) to inhibit NAcSDKP hydrolysis by rabbit lung Angiotensin I converting enzyme after 30 minutes incubation ChEMBL. 9397177
Residual peptide (binding) = 50.3 % In vitro stability of compound (50 microM) to inhibit NAcSDKP hydrolysis by rabbit lung Angiotensin I converting enzyme after 30 minutes incubation ChEMBL. 9397177
Residual peptide (binding) = 99.4 % In vitro stability of compound toward enzymatic degradation by rabbit lung Angiotensin I converting enzyme after 24 h incubation ChEMBL. 9397177
Residual peptide (binding) = 99.4 % In vitro stability of compound toward enzymatic degradation by rabbit lung Angiotensin I converting enzyme after 24 h incubation ChEMBL. 9397177
Residual peptide (binding) = 99.7 % In vitro stability of compound toward enzymatic degradation by rabbit lung Angiotensin I converting enzyme after 30 minutes incubation ChEMBL. 9397177
Residual peptide (binding) = 99.7 % In vitro stability of compound toward enzymatic degradation by rabbit lung Angiotensin I converting enzyme after 30 minutes incubation ChEMBL. 9397177

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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