Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Cavia porcellus | Type-1 angiotensin II receptor | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | hypothetical protein | 0.0389 | 0.7006 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | enoyl-ACP reductase | 0.0389 | 0.7006 | 1 |
Brugia malayi | DNA topoisomerase I | 0.0091 | 0.09 | 1 |
Mycobacterium tuberculosis | NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase) | 0.0389 | 0.7006 | 1 |
Plasmodium falciparum | beta-hydroxyacyl-ACP dehydratase | 0.0229 | 0.3732 | 0.5327 |
Plasmodium vivax | beta-hydroxyacyl-ACP dehydratase precursor, putative | 0.0229 | 0.3732 | 0.5327 |
Plasmodium falciparum | topoisomerase I | 0.0091 | 0.09 | 0.1285 |
Wolbachia endosymbiont of Brugia malayi | (3R)-hydroxymyristoyl-ACP dehydratase | 0.0229 | 0.3732 | 0.5327 |
Onchocerca volvulus | 0.0047 | 0 | 0.5 | |
Chlamydia trachomatis | 3-hydroxyacyl-ACP dehydratase | 0.0229 | 0.3732 | 0.5327 |
Plasmodium falciparum | enoyl-acyl carrier reductase | 0.0389 | 0.7006 | 1 |
Trypanosoma brucei | DNA topoisomerase type IB small subunit | 0.0535 | 1 | 1 |
Toxoplasma gondii | beta-hydroxyacyl-acyl carrier protein dehydratase (FABZ) | 0.0229 | 0.3732 | 0.5327 |
Toxoplasma gondii | enoyl-acyl carrier reductase ENR | 0.0389 | 0.7006 | 1 |
Mycobacterium leprae | NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE) | 0.0389 | 0.7006 | 1 |
Mycobacterium ulcerans | enoyl-(acyl carrier protein) reductase | 0.0389 | 0.7006 | 1 |
Plasmodium vivax | enoyl-acyl carrier protein reductase | 0.0389 | 0.7006 | 1 |
Plasmodium vivax | topoisomerase I, putative | 0.0091 | 0.09 | 0.1285 |
Trypanosoma cruzi | DNA topoisomerase type IB small subunit, putative | 0.0535 | 1 | 1 |
Toxoplasma gondii | DNA topoisomerase I, putative | 0.0091 | 0.09 | 0.1285 |
Echinococcus granulosus | DNA topoisomerase 1 | 0.0091 | 0.09 | 1 |
Loa Loa (eye worm) | DNA topoisomerase I | 0.0091 | 0.09 | 1 |
Chlamydia trachomatis | enoyl-acyl-carrier protein reductase | 0.0389 | 0.7006 | 1 |
Echinococcus multilocularis | DNA topoisomerase 1 | 0.0091 | 0.09 | 1 |
Entamoeba histolytica | 3-oxoacyl-(acyl-carrier protein) reductase, putative | 0.0047 | 0 | 0.5 |
Schistosoma mansoni | DNA topoisomerase type I | 0.0091 | 0.09 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 4.6 uM | In vitro inhibition of the specific binding of [125I]-angiotensin II to a guinea pig adrenal membrane preparation | ChEMBL. | 1433210 |
IC50 (binding) | = 4.6 uM | In vitro inhibition of the specific binding of [125I]-angiotensin II to a guinea pig adrenal membrane preparation | ChEMBL. | 1433210 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.