Detailed information for compound 22434

Basic information

Technical information
  • TDR Targets ID: 22434
  • Name: 2-(1H-benzimidazol-2-ylsulfinylmethyl)-N-meth ylaniline
  • MW: 285.364 | Formula: C15H15N3OS
  • H donors: 2 H acceptors: 2 LogP: 3.25 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: CNc1ccccc1C[S+](c1nc2c([nH]1)cccc2)[O-]
  • InChi: 1S/C15H15N3OS/c1-16-12-7-3-2-6-11(12)10-20(19)15-17-13-8-4-5-9-14(13)18-15/h2-9,16H,10H2,1H3,(H,17,18)
  • InChiKey: DKAJHHLUKNOBFB-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-(1H-benzimidazol-2-ylsulfinylmethyl)-N-methyl-aniline
  • [2-(1H-benzimidazol-2-ylsulfinylmethyl)phenyl]-methyl-amine

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens ATPase, H+/K+ exchanging, alpha polypeptide Starlite/ChEMBL References
Homo sapiens ATPase, H+/K+ exchanging, beta polypeptide Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Brugia malayi Sodium/potassium-transporting ATPase alpha chain, putative Get druggable targets OG5_127003 All targets in OG5_127003
Schistosoma japonicum Sodium/potassium-transporting ATPase subunit alpha, putative Get druggable targets OG5_127003 All targets in OG5_127003
Schistosoma japonicum ko:K01538 Na+/K+-exchanging ATPase [EC3.6.3.9], putative Get druggable targets OG5_127003 All targets in OG5_127003
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127003 All targets in OG5_127003
Candida albicans similar to Pichia farinosa Acu1p, putative P-type ATPase involved in high affinity uptake of potassium or sodium (CAF22247) Get druggable targets OG5_127003 All targets in OG5_127003
Schistosoma japonicum Sodium/potassium-transporting ATPase subunit alpha, putative Get druggable targets OG5_127003 All targets in OG5_127003
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127003 All targets in OG5_127003
Mycobacterium ulcerans metal cation transporter p-type ATPase a Get druggable targets OG5_127003 All targets in OG5_127003
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127003 All targets in OG5_127003
Onchocerca volvulus Get druggable targets OG5_127003 All targets in OG5_127003
Mycobacterium leprae PROBABLE CATION-TRANSPORTER ATPASE I CTPI Get druggable targets OG5_127003 All targets in OG5_127003
Brugia malayi Na,K-ATPase alpha subunit Get druggable targets OG5_127003 All targets in OG5_127003
Loa Loa (eye worm) sodium/potassium-transporting ATPase subunit alpha Get druggable targets OG5_127003 All targets in OG5_127003
Echinococcus multilocularis Na+:K+ ATPase alpha subunit Get druggable targets OG5_127003 All targets in OG5_127003
Candida albicans similar to Pichia farinosa Acu1p, putative P-type ATPase involved in high affinity uptake of potassium or sodium (CAF22247) Get druggable targets OG5_127003 All targets in OG5_127003
Schistosoma mansoni Na+/K+ transporting ATPase subunit alpha Get druggable targets OG5_127003 All targets in OG5_127003
Echinococcus granulosus Na:K ATPase alpha subunit Get druggable targets OG5_127003 All targets in OG5_127003
Schistosoma japonicum Sodium/potassium-transporting ATPase subunit alpha, putative Get druggable targets OG5_127003 All targets in OG5_127003
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127003 All targets in OG5_127003
Schistosoma japonicum Sodium/potassium-transporting ATPase subunit alpha, putative Get druggable targets OG5_127003 All targets in OG5_127003
Giardia lamblia Potassium-transporting ATPase alpha chain 1 Get druggable targets OG5_127003 All targets in OG5_127003
Schistosoma mansoni na+/k+ atpase alpha subunit Get druggable targets OG5_127003 All targets in OG5_127003
Schistosoma japonicum Sodium/potassium-transporting ATPase subunit alpha-1 precursor, putative Get druggable targets OG5_127003 All targets in OG5_127003
Loa Loa (eye worm) Na,K-ATPase alpha subunit Get druggable targets OG5_127003 All targets in OG5_127003
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Echinococcus granulosus sodium:potassium dependent atpase beta subunit ATPase, H+/K+ exchanging, beta polypeptide 291 aa 264 aa 28.0 %
Trypanosoma brucei vacuolar-type Ca2+-ATPase 2 ATPase, H+/K+ exchanging, alpha polypeptide 1035 aa 861 aa 26.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) sex muscle abnormal protein 5 0.0056 0.0171 0.0171
Brugia malayi G-protein coupled receptor 0.0033 0.0048 0.0031
Echinococcus granulosus alpha 1A adrenergic receptor 0.0033 0.0048 0.0042
Brugia malayi Protein kinase domain containing protein 0.0036 0.0064 0.0047
Schistosoma mansoni dreadlocks/dock 0.0027 0.0016 0.001
Entamoeba histolytica BAR/SH3 domain containing protein 0.0027 0.0016 0.001
Entamoeba histolytica hypothetical protein 0.0027 0.0016 0.001
Brugia malayi SH2 domain containing protein 0.0028 0.002 0.0004
Brugia malayi larval opioid receptor 0.0033 0.0048 0.0031
Entamoeba histolytica protein kinase, putative 0.0046 0.0117 0.0111
Echinococcus granulosus tensin C1 domain containing phosphatase 0.0028 0.002 0.0014
Schistosoma mansoni tensin 0.0028 0.002 0.0014
Loa Loa (eye worm) hypothetical protein 0.0028 0.002 0.002
Echinococcus multilocularis tyrosine protein kinase HCK 0.0226 0.1108 0.1102
Echinococcus multilocularis tensin 0.0028 0.002 0.0014
Echinococcus multilocularis neuropeptide receptor A26 0.0033 0.0048 0.0042
Echinococcus multilocularis SH2 motif 0.0028 0.002 0.0014
Entamoeba histolytica protein kinase domain containing protein 0.1844 1 1
Onchocerca volvulus 0.0028 0.002 0.0004
Onchocerca volvulus 0.0033 0.0048 0.0031
Echinococcus granulosus SH2 motif 0.0028 0.002 0.0014
Schistosoma mansoni neuropeptide receptor 0.0033 0.0048 0.0042
Loa Loa (eye worm) G-protein coupled receptor 0.0033 0.0048 0.0048
Echinococcus granulosus neuropeptide s receptor 0.0033 0.0048 0.0042
Echinococcus multilocularis SH2 motif 0.0028 0.002 0.0014
Trichomonas vaginalis adenosylhomocysteinase, putative 0.0129 0.0577 0.0561
Echinococcus granulosus rhodopsin orphan GPCR 0.0033 0.0048 0.0042
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) 0.1844 1 1
Schistosoma mansoni suppressor of cytokine signaling 0.0028 0.002 0.0014
Schistosoma mansoni protein tyrosine phosphatase n11 (shp2) 0.0028 0.002 0.0014
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0046 0.0117 0.0111
Loa Loa (eye worm) hypothetical protein 0.0033 0.0048 0.0048
Schistosoma mansoni hypothetical protein 0.0033 0.0048 0.0042
Brugia malayi protein-tyrosine kinase 0.0254 0.1263 0.1248
Trypanosoma cruzi paraflagellar rod protein 5, putative 0.0027 0.0016 0.001
Brugia malayi neuropeptide F receptor 0.0033 0.0048 0.0031
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0033 0.0048 0.0042
Loa Loa (eye worm) hypothetical protein 0.0028 0.002 0.002
Brugia malayi hypothetical protein 0.0033 0.0048 0.0031
Brugia malayi SRC-1 0.0282 0.1413 0.1399
Loa Loa (eye worm) hypothetical protein 0.0033 0.0048 0.0048
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0033 0.0048 0.0042
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0254 0.1263 0.1257
Loa Loa (eye worm) protein-tyrosine kinase 0.0027 0.0016 0.0016
Schistosoma mansoni tensin 0.0028 0.002 0.0014
Schistosoma mansoni tensin-related 0.0028 0.002 0.0014
Schistosoma mansoni sorbin 0.0027 0.0016 0.001
Entamoeba histolytica hypothetical protein 0.0027 0.0016 0.001
Giardia lamblia Kinase, CMGC GSK 0.1844 1 1
Echinococcus granulosus suppressor of cytokine signaling 7 0.0028 0.002 0.0014
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0033 0.0048 0.0031
Schistosoma mansoni adapter molecule crk 0.0056 0.0171 0.0165
Echinococcus granulosus tyrosine protein kinase Fyn 0.0282 0.1413 0.1408
Loa Loa (eye worm) hypothetical protein 0.0033 0.0048 0.0048
Brugia malayi G-protein coupled receptor 0.0033 0.0048 0.0031
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0282 0.1413 0.1408
Echinococcus multilocularis rhodopsin orphan GPCR 0.0033 0.0048 0.0042
Onchocerca volvulus 0.0033 0.0048 0.0031
Schistosoma mansoni sodium/potassium-dependent atpase beta subunit 0.0077 0.0288 0.0282
Echinococcus multilocularis suppressor of cytokine signaling 7 0.0028 0.002 0.0014
Echinococcus granulosus rhodopsin orphan GPCR 0.0033 0.0048 0.0042
Loa Loa (eye worm) hypothetical protein 0.0033 0.0048 0.0048
Echinococcus multilocularis 0.0028 0.002 0.0014
Loa Loa (eye worm) hypothetical protein 0.004 0.0083 0.0083
Echinococcus granulosus NCK adaptor protein 0.0056 0.0171 0.0165
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0028 0.002 0.0014
Schistosoma mansoni formin binding protein and related proteins 0.0027 0.0016 0.001
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0033 0.0048 0.0042
Brugia malayi hypothetical protein 0.0033 0.0048 0.0031
Loa Loa (eye worm) hypothetical protein 0.0055 0.0166 0.0166
Loa Loa (eye worm) hypothetical protein 0.0033 0.0048 0.0048
Onchocerca volvulus 0.0033 0.0048 0.0031
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0033 0.0048 0.0042
Echinococcus granulosus Na:K ATPase alpha subunit 0.004 0.0083 0.0077
Mycobacterium ulcerans acyl-CoA synthetase 0.0073 0.0268 0.0384
Loa Loa (eye worm) hypothetical protein 0.0077 0.0288 0.0288
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0033 0.0048 0.0042
Schistosoma mansoni adenoreceptor 0.0033 0.0048 0.0042
Loa Loa (eye worm) hypothetical protein 0.0027 0.0016 0.0016
Echinococcus granulosus neuropeptide FF receptor 2 0.0033 0.0048 0.0042
Loa Loa (eye worm) neuropeptide F receptor 0.0033 0.0048 0.0048
Schistosoma mansoni growth factor receptor-bound protein 0.0056 0.0171 0.0165
Loa Loa (eye worm) hypothetical protein 0.0033 0.0048 0.0048
Loa Loa (eye worm) hypothetical protein 0.0033 0.0048 0.0048
Echinococcus multilocularis rhodopsin orphan GPCR 0.0033 0.0048 0.0042
Brugia malayi Dopamine receptor 0.0033 0.0048 0.0031
Onchocerca volvulus 0.0036 0.0064 0.0047
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0282 0.1413 0.1408
Trypanosoma cruzi hypothetical protein, conserved 0.0027 0.0016 0.001
Entamoeba histolytica hypothetical protein, conserved 0.0027 0.0016 0.001
Schistosoma mansoni signal transducing adapter molecule (stam) 0.0027 0.0016 0.001
Schistosoma mansoni hypothetical protein 0.0033 0.0048 0.0042
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0033 0.0048 0.0031
Brugia malayi Dopamine receptor protein 2 0.0033 0.0048 0.0031
Loa Loa (eye worm) TYRA-2 protein 0.0033 0.0048 0.0048
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0064 0.0214 0.0209
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0036 0.0064 0.0058
Echinococcus granulosus tyrosine protein kinase Srms 0.0036 0.0064 0.0058
Loa Loa (eye worm) hypothetical protein 0.0055 0.0166 0.0166
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0036 0.0064 0.0058
Echinococcus multilocularis rhodopsin orphan GPCR 0.0033 0.0048 0.0042
Echinococcus granulosus rhodopsin orphan GPCR 0.0033 0.0048 0.0042
Onchocerca volvulus 0.0038 0.0075 0.0059
Toxoplasma gondii adenosylhomocysteinase, putative 0.0129 0.0577 0.0571
Onchocerca volvulus 0.0033 0.0048 0.0031
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0073 0.0268 0.4202
Echinococcus granulosus tyrosine protein kinase Src64B 0.0282 0.1413 0.1408
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0282 0.1413 0.1408
Leishmania major 4-coumarate:coa ligase-like protein 0.0073 0.0268 0.0263
Entamoeba histolytica acyl-coA synthetase, putative 0.0073 0.0268 0.0263
Echinococcus granulosus rhodopsin orphan GPCR 0.0033 0.0048 0.0042
Schistosoma mansoni biogenic amine receptor 0.0033 0.0048 0.0042
Schistosoma mansoni adenosylhomocysteinase 0.008 0.0306 0.03
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0033 0.0048 0.0048
Onchocerca volvulus 0.0033 0.0048 0.0031
Echinococcus multilocularis g protein coupled receptor 0.0033 0.0048 0.0042
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0033 0.0048 0.0042
Echinococcus multilocularis rhodopsin orphan GPCR 0.0033 0.0048 0.0042
Loa Loa (eye worm) SRC-1 0.0282 0.1413 0.1413
Mycobacterium ulcerans acyl-CoA synthetase 0.0073 0.0268 0.0384
Entamoeba histolytica hypothetical protein 0.0027 0.0016 0.001
Loa Loa (eye worm) hypothetical protein 0.0028 0.002 0.002
Brugia malayi AMP-binding enzyme family protein 0.0073 0.0268 0.0253
Loa Loa (eye worm) hypothetical protein 0.0033 0.0048 0.0048
Echinococcus granulosus g protein coupled receptor 0.0033 0.0048 0.0042
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0033 0.0048 0.0042
Schistosoma mansoni na+/k+ atpase alpha subunit 0.004 0.0083 0.0077
Entamoeba histolytica SH2 domain containing protein 0.0028 0.002 0.0014
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0033 0.0048 0.0042
Schistosoma mansoni suppressor of cytokine signaling 0.0028 0.002 0.0014
Schistosoma mansoni shc transforming protein 0.0028 0.002 0.0014
Loa Loa (eye worm) hypothetical protein 0.0033 0.0048 0.0048
Leishmania major S-adenosylhomocysteine hydrolase 0.0129 0.0577 0.0571
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0033 0.0048 0.0042
Echinococcus multilocularis SH2 domain containing protein 7 0.0028 0.002 0.0014
Schistosoma mansoni biogenic amine (5HT) receptor 0.0033 0.0048 0.0042
Loa Loa (eye worm) TK/FER protein kinase 0.0036 0.0064 0.0064
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0073 0.0268 0.0384
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0033 0.0048 0.0042
Echinococcus granulosus c src tyrosine kinase 0.0064 0.0214 0.0209
Onchocerca volvulus 0.0028 0.002 0.0004
Schistosoma mansoni opsin-like receptor 0.0033 0.0048 0.0042
Echinococcus multilocularis fmrfamide receptor 0.0033 0.0048 0.0042
Loa Loa (eye worm) hypothetical protein 0.0028 0.002 0.002
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0033 0.0048 0.0031
Trypanosoma brucei protein kinase, putative 0.1844 1 1
Loa Loa (eye worm) hypothetical protein 0.0027 0.0016 0.0016
Schistosoma mansoni tyrosine-protein kinase zap-70 0.0028 0.002 0.0014
Echinococcus multilocularis SH2 domain containing adapter protein F 0.0028 0.002 0.0014
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0028 0.002 0.002
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0073 0.0268 0.4202
Echinococcus multilocularis neuropeptide receptor 0.0033 0.0048 0.0042
Echinococcus multilocularis neuropeptide FF receptor 2 0.0033 0.0048 0.0042
Schistosoma mansoni sh3-containing grb2-like protein 1 (endophilin II) 0.0027 0.0016 0.001
Brugia malayi neuropeptide F receptor 0.0033 0.0048 0.0031
Loa Loa (eye worm) hypothetical protein 0.0033 0.0048 0.0048
Loa Loa (eye worm) hypothetical protein 0.0027 0.0016 0.0016
Echinococcus granulosus protein kinase shaggy 0.1844 1 1
Echinococcus granulosus tyrosine kinase 0.0036 0.0064 0.0058
Onchocerca volvulus 0.0036 0.0064 0.0047
Loa Loa (eye worm) hypothetical protein 0.0033 0.0048 0.0048
Echinococcus granulosus peptide allatostatin:somatostatin 0.0033 0.0048 0.0042
Loa Loa (eye worm) hypothetical protein 0.0036 0.0064 0.0064
Brugia malayi tRNA modification GTPase TrmE family protein 0.0028 0.002 0.0004
Brugia malayi Protein kinase domain containing protein 0.0036 0.0064 0.0047
Onchocerca volvulus Suppressor of cytokine signaling 7 homolog 0.0028 0.002 0.0004
Echinococcus multilocularis growth factor receptor bound protein 2 0.0056 0.0171 0.0165
Echinococcus multilocularis somatostatin receptor 0.0033 0.0048 0.0042
Echinococcus multilocularis g protein coupled receptor 0.0033 0.0048 0.0042
Echinococcus granulosus g-protein coupled receptor 0.0033 0.0048 0.0042
Onchocerca volvulus 0.0033 0.0048 0.0031
Loa Loa (eye worm) hypothetical protein 0.0033 0.0048 0.0048
Echinococcus granulosus tyrosine protein kinase HCK 0.0226 0.1108 0.1102
Brugia malayi hypothetical protein 0.0028 0.002 0.0004
Schistosoma mansoni amine GPCR 0.0033 0.0048 0.0042
Loa Loa (eye worm) hypothetical protein 0.0031 0.0034 0.0034
Brugia malayi SH2 domain containing protein 0.0028 0.002 0.0004
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0033 0.0048 0.0048
Schistosoma mansoni cell polarity protein 0.0027 0.0016 0.001
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.0077 0.0288 0.0282
Plasmodium vivax glycogen synthase kinase 3, putative 0.1844 1 1
Echinococcus granulosus tm gpcr rhodopsin 0.0033 0.0048 0.0042
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0064 0.0214 0.0209
Echinococcus granulosus nostrin 0.0027 0.0016 0.001
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0033 0.0048 0.0042
Echinococcus granulosus tyrosine protein kinase Fyn 0.0282 0.1413 0.1408
Echinococcus granulosus rho guanine nucleotide exchange factor 7 0.0027 0.0016 0.001
Schistosoma mansoni neuropeptide F-like receptor 0.0033 0.0048 0.0042
Trypanosoma brucei conserved protein 0.0027 0.0016 0.001
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0033 0.0048 0.0042
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0033 0.0048 0.0042
Brugia malayi Melatonin receptor type 1A 0.0033 0.0048 0.0031
Loa Loa (eye worm) hypothetical protein 0.0033 0.0048 0.0048
Echinococcus granulosus tyrosine protein kinase Lyn 0.0299 0.1511 0.1506
Echinococcus multilocularis N chimaerin 0.0028 0.002 0.0014
Loa Loa (eye worm) hypothetical protein 0.0033 0.0048 0.0048
Brugia malayi Sex muscle abnormal protein 5 0.0056 0.0171 0.0155
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0033 0.0048 0.0048
Schistosoma mansoni myosin xvIII 0.0033 0.0048 0.0042
Schistosoma mansoni tyrosine kinase 0.0036 0.0064 0.0058
Echinococcus granulosus nervana 2 0.0077 0.0288 0.0282
Echinococcus multilocularis epidermal growth factor receptor kinase 0.0027 0.0016 0.001
Echinococcus granulosus N chimaerin 0.0028 0.002 0.0014
Echinococcus multilocularis glycogen synthase kinase 3 beta 0.1844 1 1
Schistosoma mansoni biogenic amine receptor 0.0033 0.0048 0.0042
Loa Loa (eye worm) hypothetical protein 0.0056 0.0171 0.0171
Echinococcus granulosus growth factor receptor bound protein 2 0.0056 0.0171 0.0165
Schistosoma mansoni neuropeptide receptor 0.0033 0.0048 0.0042
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0028 0.002 0.0014
Schistosoma mansoni amine GPCR 0.0033 0.0048 0.0042
Echinococcus multilocularis sex peptide receptor 0.0033 0.0048 0.0042
Echinococcus granulosus neuropeptide receptor A26 0.0033 0.0048 0.0042
Brugia malayi Protein kinase domain containing protein 0.0036 0.0064 0.0047
Echinococcus granulosus g protein coupled receptor 0.0033 0.0048 0.0042
Brugia malayi Variant SH3 domain containing protein 0.0056 0.0171 0.0155
Echinococcus granulosus nervana 2 0.0077 0.0288 0.0282
Mycobacterium ulcerans S-adenosyl-L-homocysteine hydrolase 0.0129 0.0577 0.0996
Loa Loa (eye worm) hypothetical protein 0.0033 0.0048 0.0048
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0282 0.1413 0.1408
Brugia malayi hypothetical protein 0.0033 0.0048 0.0031
Loa Loa (eye worm) hypothetical protein 0.0033 0.0048 0.0048
Echinococcus multilocularis rhodopsin orphan GPCR 0.0033 0.0048 0.0042
Loa Loa (eye worm) hypothetical protein 0.0033 0.0048 0.0048
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0033 0.0048 0.0042
Entamoeba histolytica hypothetical protein 0.0027 0.0016 0.001
Echinococcus granulosus tyrosine kinase 0.0254 0.1263 0.1257
Echinococcus granulosus neuropeptide receptor 0.0033 0.0048 0.0042
Schistosoma mansoni GTPase activating protein 0.0028 0.002 0.0014
Schistosoma mansoni tensin 0.0028 0.002 0.0014
Schistosoma mansoni hypothetical protein 0.0033 0.0048 0.0042
Loa Loa (eye worm) TK protein kinase 0.0226 0.1108 0.1108
Echinococcus granulosus neuropeptides capa receptor 0.0033 0.0048 0.0042
Loa Loa (eye worm) hypothetical protein 0.0028 0.002 0.002
Brugia malayi G protein-coupled receptor 0.0033 0.0048 0.0031
Schistosoma mansoni tyrosine kinase 0.0064 0.0214 0.0209
Echinococcus granulosus breast cancer anti estrogen resistance protein 0.0027 0.0016 0.001
Onchocerca volvulus 0.0033 0.0048 0.0031
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.0077 0.0288 0.0282
Loa Loa (eye worm) hypothetical protein 0.0033 0.0048 0.0048
Echinococcus granulosus tm gpcr rhodopsin 0.0033 0.0048 0.0042
Brugia malayi putative neuropeptide receptor 0.0033 0.0048 0.0031
Schistosoma mansoni development and differentiation-enhancing factor ddef 0.0027 0.0016 0.001
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0033 0.0048 0.0042
Echinococcus granulosus sex peptide receptor 0.0033 0.0048 0.0042
Onchocerca volvulus 0.0045 0.0113 0.0097
Loa Loa (eye worm) hypothetical protein 0.0033 0.0048 0.0048
Onchocerca volvulus 0.0036 0.0064 0.0047
Loa Loa (eye worm) hypothetical protein 0.0027 0.0016 0.0016
Loa Loa (eye worm) TK/FER protein kinase 0.0036 0.0064 0.0064
Schistosoma mansoni apoptosis stimulating of P53 0.0027 0.0016 0.001
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0282 0.1413 0.1408
Onchocerca volvulus 0.0036 0.0064 0.0047
Schistosoma mansoni tyrosine kinase 0.0282 0.1413 0.1408
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0033 0.0048 0.0042
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.0077 0.0288 0.0282
Onchocerca volvulus Neuropeptide F receptor homolog 0.0033 0.0048 0.0031
Brugia malayi RhoGAP domain containing protein 0.0028 0.002 0.0004
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0056 0.0171 0.0171
Echinococcus granulosus slit robo rho gtpase activating protein 1 0.0027 0.0016 0.001
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0033 0.0048 0.0031
Schistosoma mansoni serine/threonine protein kinase 0.0035 0.006 0.0054
Echinococcus granulosus hypothetical protein 0.0028 0.002 0.0014
Brugia malayi SH2 domain containing protein 0.0028 0.002 0.0004
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0246 0.1219 0.1214
Loa Loa (eye worm) hypothetical protein 0.0028 0.002 0.002
Brugia malayi SH2 domain containing protein 0.0028 0.002 0.0004
Loa Loa (eye worm) hypothetical protein 0.0033 0.0048 0.0048
Schistosoma mansoni vav2 0.0028 0.002 0.0014
Loa Loa (eye worm) SH2 domain-containing protein 0.0028 0.002 0.002
Loa Loa (eye worm) hypothetical protein 0.0033 0.0048 0.0048
Schistosoma mansoni sorting nexin 0.0027 0.0016 0.001
Onchocerca volvulus 0.0033 0.0048 0.0031
Entamoeba histolytica protein kinase, putative 0.0226 0.1108 0.1102
Brugia malayi hypothetical protein 0.0033 0.0048 0.0031
Echinococcus granulosus Spectrin alpha actinin 0.0027 0.0016 0.001
Echinococcus multilocularis protein kinase shaggy 0.1844 1 1
Echinococcus granulosus tyrosine protein kinase Fps85D 0.0036 0.0064 0.0058
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0027 0.0016 0.0016
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0055 0.0166 0.5
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0282 0.1413 0.1408
Brugia malayi Variant SH3 domain containing protein 0.0028 0.002 0.0004
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0033 0.0048 0.0048
Brugia malayi SH2 domain containing protein 0.0028 0.002 0.0004
Brugia malayi Serotonin receptor 0.0033 0.0048 0.0031
Loa Loa (eye worm) sodium/potassium-transporting ATPase subunit alpha 0.0034 0.0053 0.0053
Trypanosoma brucei S-adenosylhomocysteine hydrolase, putative 0.0129 0.0577 0.0571
Loa Loa (eye worm) hypothetical protein 0.0033 0.0048 0.0048
Schistosoma mansoni C-fyn 0.0027 0.0016 0.001
Echinococcus multilocularis SHC transforming protein 3 0.0028 0.002 0.0014
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0073 0.0268 0.0384
Loa Loa (eye worm) cytokine inducible SH2-containing protein 5 0.0028 0.002 0.002
Schistosoma mansoni neuropeptide f receptor 76f 0.0033 0.0048 0.0042
Brugia malayi hypothetical protein 0.0033 0.0048 0.0031
Loa Loa (eye worm) melatonin receptor type 1A 0.0033 0.0048 0.0048
Brugia malayi hypothetical protein 0.0033 0.0048 0.0031
Entamoeba histolytica hypothetical protein 0.0027 0.0016 0.001
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0064 0.0214 0.0209
Schistosoma mansoni tyrosine kinase 0.0064 0.0214 0.0209
Echinococcus granulosus neuropeptide Y receptor 0.0033 0.0048 0.0042
Echinococcus multilocularis endophilin A3 0.0027 0.0016 0.001
Onchocerca volvulus 0.0033 0.0048 0.0031
Onchocerca volvulus 0.0077 0.0288 0.0272
Loa Loa (eye worm) hypothetical protein 0.0033 0.0048 0.0048
Loa Loa (eye worm) hypothetical protein 0.0033 0.0048 0.0048
Echinococcus granulosus intersectin 2 0.0027 0.0016 0.001
Schistosoma mansoni biogenic amine (5HT) receptor 0.0033 0.0048 0.0042
Loa Loa (eye worm) TK protein kinase 0.0254 0.1263 0.1263
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0033 0.0048 0.0042
Echinococcus multilocularis nostrin 0.0027 0.0016 0.001
Echinococcus granulosus neuropeptide receptor 0.0033 0.0048 0.0042
Loa Loa (eye worm) hypothetical protein 0.0073 0.0268 0.0268
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0073 0.0268 0.0238
Echinococcus multilocularis neuropeptide s receptor 0.0033 0.0048 0.0042
Onchocerca volvulus 0.0033 0.0048 0.0031
Loa Loa (eye worm) hypothetical protein 0.0055 0.0166 0.0166
Schistosoma mansoni dynamin-associated protein 0.0027 0.0016 0.001
Schistosoma mansoni hypothetical protein 0.0027 0.0016 0.001
Trypanosoma cruzi hypothetical protein, conserved 0.0027 0.0016 0.001
Echinococcus multilocularis dro:myosuppressin receptor 0.0033 0.0048 0.0042
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0028 0.002 0.0014
Brugia malayi ORL1-like opioid receptor 0.0033 0.0048 0.0031
Echinococcus multilocularis suppressor of cytokine signaling 7 0.0028 0.002 0.0014
Schistosoma mansoni neuropeptide receptor 0.0033 0.0048 0.0042
Onchocerca volvulus 0.1844 1 1
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.0077 0.0288 0.0282
Echinococcus multilocularis intersectin 2 0.0027 0.0016 0.001
Loa Loa (eye worm) hypothetical protein 0.0027 0.0016 0.0016
Brugia malayi Tyrosine-protein kinase abl-1 0.0064 0.0214 0.0199
Onchocerca volvulus 0.0036 0.0064 0.0047
Echinococcus granulosus sodium:potassium transporting ATPase subunit 0.0077 0.0288 0.0282
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0033 0.0048 0.0042
Echinococcus granulosus allatostatin A receptor 0.0033 0.0048 0.0042
Loa Loa (eye worm) hypothetical protein 0.0033 0.0048 0.0048
Loa Loa (eye worm) G-protein coupled receptor 0.0033 0.0048 0.0048
Loa Loa (eye worm) thyroid receptor interactor 0.0027 0.0016 0.0016
Echinococcus multilocularis fch and double sh3 domains protein 2 0.0027 0.0016 0.001
Trypanosoma cruzi glycogen synthase kinase 3, putative 0.1844 1 1
Echinococcus granulosus somatostatin receptor 0.0033 0.0048 0.0042
Loa Loa (eye worm) TK/FER protein kinase 0.0036 0.0064 0.0064
Echinococcus granulosus arf GAP with SH3 domain ANK repeat and PH 0.0027 0.0016 0.001
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0254 0.1263 0.1257
Schistosoma mansoni proto-oncogene tyrosine-protein kinase abl1 0.0056 0.0171 0.0165
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0055 0.0166 0.0033
Loa Loa (eye worm) hypothetical protein 0.0033 0.0048 0.0048
Echinococcus granulosus nervana 2 0.0077 0.0288 0.0282
Loa Loa (eye worm) hypothetical protein 0.0027 0.0016 0.0016
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0033 0.0048 0.0042
Loa Loa (eye worm) SH2 domain-containing protein 0.0028 0.002 0.002
Echinococcus multilocularis NCK adaptor protein 0.0056 0.0171 0.0165
Schistosoma mansoni slit-robo rho gtpase activating protein 0.0027 0.0016 0.001
Brugia malayi sulfakinin receptor protein 0.0033 0.0048 0.0031
Loa Loa (eye worm) TK/FER protein kinase 0.0036 0.0064 0.0064
Loa Loa (eye worm) TK/FER protein kinase 0.0036 0.0064 0.0064
Schistosoma mansoni tensin-related 0.0028 0.002 0.0014
Echinococcus granulosus expressed conserved protein 0.0028 0.002 0.0014
Echinococcus granulosus adenosylhomocysteinase 0.0129 0.0577 0.0571
Schistosoma mansoni amine GPCR 0.0033 0.0048 0.0042
Schistosoma mansoni tyrosine kinase 0.0282 0.1413 0.1408
Entamoeba histolytica hypothetical protein 0.0027 0.0016 0.001
Loa Loa (eye worm) STAT protein 0.0028 0.002 0.002
Brugia malayi Sodium/potassium-transporting ATPase alpha chain, putative 0.0034 0.0053 0.0036
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0033 0.0048 0.0042
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0073 0.0268 0.0384
Echinococcus multilocularis tyrosine protein kinase Srms 0.0254 0.1263 0.1257
Loa Loa (eye worm) TK/FER protein kinase 0.0036 0.0064 0.0064
Echinococcus granulosus 7tm_1 domain containing protein 0.0033 0.0048 0.0042
Brugia malayi follicle stimulating hormone receptor 0.0033 0.0048 0.0031
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0033 0.0048 0.0042
Onchocerca volvulus 0.0073 0.0268 0.0253
Loa Loa (eye worm) hypothetical protein 0.0027 0.0016 0.0016
Echinococcus multilocularis Spectrin alpha actinin 0.0027 0.0016 0.001
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0033 0.0048 0.0042
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0033 0.0048 0.0042
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0028 0.002 0.002
Echinococcus granulosus biogenic amine 5HT receptor 0.0033 0.0048 0.0042
Echinococcus granulosus G protein coupled receptor 139 0.0033 0.0048 0.0042
Brugia malayi SH2 domain containing protein 0.0028 0.002 0.0004
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0033 0.0048 0.0048
Echinococcus multilocularis nervana 2 0.0077 0.0288 0.0282
Schistosoma mansoni sodium / potassium ATPase beta chain 0.0077 0.0288 0.0282
Echinococcus multilocularis fmrfamide receptor 0.0033 0.0048 0.0042
Onchocerca volvulus 0.0033 0.0048 0.0031
Echinococcus granulosus tyrosine protein kinase Fyn 0.0282 0.1413 0.1408
Trypanosoma cruzi S-adenosylhomocysteine hydrolase, putative 0.0129 0.0577 0.0571
Echinococcus granulosus orexin receptor type 2 0.0033 0.0048 0.0042
Echinococcus granulosus rhodopsin orphan GPCR 0.0033 0.0048 0.0042
Echinococcus multilocularis tyrosine protein kinase shark 0.0036 0.0064 0.0058
Echinococcus multilocularis hematopoietic lineage cell specific protein 0.0027 0.0016 0.001
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0033 0.0048 0.0042
Echinococcus multilocularis sodium:potassium transporting ATPase subunit 0.0077 0.0288 0.0282
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0033 0.0048 0.0042
Entamoeba histolytica hypothetical protein, conserved 0.0027 0.0016 0.001
Schistosoma mansoni transmemberane protein 0.0077 0.0288 0.0282
Echinococcus multilocularis neuropeptide Y receptor 0.0033 0.0048 0.0042
Echinococcus multilocularis guanine nucleotide exchange factor VAV2 0.0028 0.002 0.0014
Schistosoma mansoni hypothetical protein 0.0028 0.002 0.0014
Echinococcus granulosus fmrfamide receptor 0.0033 0.0048 0.0042
Loa Loa (eye worm) hypothetical protein 0.0033 0.0048 0.0048
Brugia malayi Variant SH3 domain containing protein 0.0056 0.0171 0.0155
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.0077 0.0288 0.0282
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.0036 0.0064 0.0058
Schistosoma mansoni signal transduction protein lnk-related 0.0028 0.002 0.0014
Brugia malayi AKH receptor 0.0033 0.0048 0.0031
Schistosoma mansoni adenosylhomocysteinase 0.0129 0.0577 0.0571
Loa Loa (eye worm) hypothetical protein 0.0033 0.0048 0.0048
Schistosoma mansoni opsin-like receptor 0.0033 0.0048 0.0042
Trichomonas vaginalis adenosylhomocysteinase, putative 0.0129 0.0577 0.0561
Onchocerca volvulus 0.0028 0.002 0.0004
Echinococcus multilocularis nervana 2 0.0077 0.0288 0.0282
Echinococcus multilocularis slit robo rho gtpase activating protein 1 0.0027 0.0016 0.001
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0033 0.0048 0.0042
Schistosoma mansoni histamine h1 receptor 0.0033 0.0048 0.0042
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0055 0.0166 0.0182
Echinococcus granulosus epidermal growth factor receptor kinase 0.0027 0.0016 0.001
Echinococcus multilocularis phosphatidylinositol 3 kinase regulatory subunit 0.0028 0.002 0.0014
Mycobacterium ulcerans haloalkane dehalogenase 0.0955 0.5115 1
Loa Loa (eye worm) hypothetical protein 0.0055 0.0166 0.0166
Echinococcus multilocularis tensin 0.0028 0.002 0.0014
Loa Loa (eye worm) hypothetical protein 0.0055 0.0166 0.0166
Entamoeba histolytica adenosylhomocysteinase, putative 0.0129 0.0577 0.0571
Echinococcus multilocularis orexin receptor type 2 0.0033 0.0048 0.0042
Entamoeba histolytica protein kinase, putative 0.1844 1 1
Trichomonas vaginalis CMGC family protein kinase 0.1844 1 1
Loa Loa (eye worm) TK/FER protein kinase 0.0036 0.0064 0.0064
Echinococcus multilocularis adenosylhomocysteinase 0.0129 0.0577 0.0571
Entamoeba histolytica protein kinase domain containing protein 0.1844 1 1
Onchocerca volvulus 0.0036 0.0064 0.0047
Echinococcus granulosus tyrosine protein kinase Blk 0.0254 0.1263 0.1257
Echinococcus granulosus tyrosine protein kinase ABL1 0.0036 0.0064 0.0058
Echinococcus multilocularis G protein coupled receptor 139 0.0033 0.0048 0.0042
Echinococcus granulosus SH2 motif 0.0028 0.002 0.0014
Brugia malayi Tachykinin-like peptides receptor 99D 0.0033 0.0048 0.0031
Echinococcus multilocularis transfer RNA-Ala 0.0027 0.0016 0.001
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0033 0.0048 0.0042
Schistosoma mansoni sodium/potassium-dependent atpase beta subunit 0.0077 0.0288 0.0282
Echinococcus multilocularis signal transduction protein lnk realted 0.0028 0.002 0.0014
Echinococcus multilocularis Na+:K+ ATPase alpha subunit 0.004 0.0083 0.0077
Onchocerca volvulus 0.0028 0.002 0.0004
Onchocerca volvulus 0.0028 0.002 0.0004
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0033 0.0048 0.0042
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 0.1844 1 1
Brugia malayi Na,K-ATPase alpha subunit 0.004 0.0083 0.0066
Loa Loa (eye worm) hypothetical protein 0.0028 0.002 0.002
Loa Loa (eye worm) hypothetical protein 0.0033 0.0048 0.0048
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0033 0.0048 0.0042
Schistosoma mansoni hypothetical protein 0.0027 0.0016 0.001
Loa Loa (eye worm) hypothetical protein 0.0073 0.0268 0.0268
Trypanosoma cruzi S-adenosylhomocysteine hydrolase, putative 0.0129 0.0577 0.0571
Schistosoma mansoni adenosylhomocysteinase 0.008 0.0306 0.03
Loa Loa (eye worm) hypothetical protein 0.0033 0.0048 0.0048
Echinococcus multilocularis nervana 2 0.0077 0.0288 0.0282
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0073 0.0268 0.0238
Loa Loa (eye worm) guanylate kinase 0.0027 0.0016 0.0016
Echinococcus granulosus hypothetical protein 0.0033 0.0048 0.0042
Echinococcus multilocularis c src tyrosine kinase 0.0064 0.0214 0.0209
Entamoeba histolytica unconventional myosin IB 0.0027 0.0016 0.001
Brugia malayi hypothetical protein 0.0033 0.0048 0.0031
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0033 0.0048 0.0031
Loa Loa (eye worm) adenosylhomocysteinase 0.0129 0.0577 0.0577
Loa Loa (eye worm) hypothetical protein 0.0033 0.0048 0.0048
Echinococcus multilocularis neuropeptide receptor 0.0033 0.0048 0.0042
Brugia malayi Protein kinase domain containing protein 0.0036 0.0064 0.0047
Echinococcus multilocularis SH2 motif 0.0028 0.002 0.0014
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0033 0.0048 0.0042
Echinococcus multilocularis allatostatin A receptor 0.0033 0.0048 0.0042
Brugia malayi GnHR receptor homolog 0.0033 0.0048 0.0031
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0282 0.1413 0.1408
Echinococcus granulosus phosphatidylinositol 3 kinase regulatory subunit 0.0028 0.002 0.0014
Brugia malayi AMP-binding enzyme family protein 0.0073 0.0268 0.0253
Entamoeba histolytica hypothetical protein 0.0027 0.0016 0.001
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0282 0.1413 0.1408
Echinococcus granulosus neuropeptides capa receptor 0.0033 0.0048 0.0042
Loa Loa (eye worm) Na,K-ATPase alpha subunit 0.004 0.0083 0.0083
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0033 0.0048 0.0042
Loa Loa (eye worm) TK/FER protein kinase 0.0036 0.0064 0.0064
Loa Loa (eye worm) hypothetical protein 0.0033 0.0048 0.0048
Echinococcus multilocularis tyrosine protein kinase Abl 0.0064 0.0214 0.0209
Echinococcus multilocularis neuropeptides capa receptor 0.0033 0.0048 0.0042
Echinococcus granulosus neuropeptide Y receptor 0.0033 0.0048 0.0042
Echinococcus granulosus rhodopsin orphan GPCR 0.0033 0.0048 0.0042
Onchocerca volvulus 0.0033 0.0048 0.0031
Loa Loa (eye worm) hypothetical protein 0.0028 0.002 0.002
Leishmania major 4-coumarate:coa ligase-like protein 0.0073 0.0268 0.0263
Brugia malayi SH2 domain containing protein 0.0036 0.0064 0.0047
Plasmodium falciparum glycogen synthase kinase 3 0.1844 1 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0033 0.0048 0.0042
Loa Loa (eye worm) hypothetical protein 0.0028 0.002 0.002
Echinococcus multilocularis G-protein coupled receptor, putative 0.0033 0.0048 0.0042
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0033 0.0048 0.0042
Entamoeba histolytica acyl-CoA synthetase, putative 0.0073 0.0268 0.0263
Mycobacterium ulcerans hypothetical protein 0.0073 0.0268 0.0384
Loa Loa (eye worm) hypothetical protein 0.0027 0.0016 0.0016
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0282 0.1413 0.1408
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0033 0.0048 0.0042
Echinococcus granulosus biogenic amine 5HT receptor 0.0033 0.0048 0.0042
Echinococcus multilocularis serotonin receptor 0.0033 0.0048 0.0042
Echinococcus granulosus endophilin A3 0.0027 0.0016 0.001
Loa Loa (eye worm) protein kinase C and casein kinase substrate in neurons protein 2 0.0027 0.0016 0.0016
Loa Loa (eye worm) hypothetical protein 0.0033 0.0048 0.0048
Onchocerca volvulus 0.0033 0.0048 0.0031
Echinococcus multilocularis tyrosine protein kinase Blk 0.0254 0.1263 0.1257
Mycobacterium leprae putative S-adenosyl-L-homocysteine hydrolase SahH 0.0129 0.0577 1
Brugia malayi G protein-coupled receptor F59B2.13 0.0033 0.0048 0.0031
Loa Loa (eye worm) hypothetical protein 0.0028 0.002 0.002
Entamoeba histolytica hypothetical protein 0.0027 0.0016 0.001
Onchocerca volvulus 0.0033 0.0048 0.0031
Loa Loa (eye worm) CMGC/GSK protein kinase 0.1844 1 1
Schistosoma mansoni biogenic amine receptor 0.0033 0.0048 0.0042
Echinococcus granulosus src region 0.0027 0.0016 0.001
Schistosoma mansoni adenosylhomocysteinase 0.008 0.0306 0.03
Echinococcus multilocularis neuropeptide Y receptor 0.0033 0.0048 0.0042
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0033 0.0048 0.0031
Echinococcus granulosus SH2 domain containing protein 7 0.0028 0.002 0.0014
Schistosoma mansoni amine GPCR 0.0033 0.0048 0.0042
Echinococcus granulosus SHC transforming protein 3 0.0028 0.002 0.0014
Trypanosoma cruzi hypothetical protein, conserved 0.0027 0.0016 0.001
Echinococcus multilocularis g protein coupled receptor 0.0033 0.0048 0.0042
Echinococcus granulosus g protein coupled receptor 0.0033 0.0048 0.0042
Echinococcus granulosus glycogen synthase kinase 3 beta 0.1844 1 1
Schistosoma mansoni tyrosine kinase 0.0036 0.0064 0.0058
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.0077 0.0288 0.0282
Echinococcus multilocularis suppressor of cytokine signaling 6 0.0028 0.002 0.0014
Mycobacterium tuberculosis Possible haloalkane dehalogenase DhaA (1-chlorohexane halidohydrolase) 0.0955 0.5115 1
Leishmania major 4-coumarate:coa ligase-like protein 0.0073 0.0268 0.0263
Echinococcus granulosus tensin 0.0028 0.002 0.0014
Brugia malayi SH2 domain containing protein 0.0036 0.0064 0.0047
Brugia malayi Adenosylhomocysteinase 0.0129 0.0577 0.0561
Loa Loa (eye worm) hypothetical protein 0.0033 0.0048 0.0048
Echinococcus granulosus 7TM GPCR rhodopsin 0.0033 0.0048 0.0042
Brugia malayi SH2 domain containing protein 0.0028 0.002 0.0004
Onchocerca volvulus 0.0033 0.0048 0.0031
Brugia malayi hypothetical protein 0.0033 0.0048 0.0031
Loa Loa (eye worm) hypothetical protein 0.0028 0.002 0.002
Schistosoma mansoni SH2A 0.0028 0.002 0.0014
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0033 0.0048 0.0042
Loa Loa (eye worm) hypothetical protein 0.0033 0.0048 0.0048
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0028 0.002 0.0014
Echinococcus multilocularis g-protein coupled receptor 0.0033 0.0048 0.0042
Echinococcus multilocularis breast cancer anti estrogen resistance protein 0.0027 0.0016 0.001
Loa Loa (eye worm) hypothetical protein 0.0033 0.0048 0.0048
Echinococcus granulosus hematopoietic lineage cell specific protein 0.0027 0.0016 0.001
Brugia malayi Protein kinase domain containing protein 0.0036 0.0064 0.0047
Schistosoma mansoni amine GPCR 0.0033 0.0048 0.0042
Loa Loa (eye worm) hypothetical protein 0.0026 0.0011 0.0011
Echinococcus multilocularis serotonin receptor 0.0033 0.0048 0.0042
Loa Loa (eye worm) hypothetical protein 0.0033 0.0048 0.0048
Echinococcus granulosus tyrosine protein kinase shark 0.0036 0.0064 0.0058
Loa Loa (eye worm) hypothetical protein 0.0033 0.0048 0.0048
Loa Loa (eye worm) hypothetical protein 0.0028 0.002 0.002
Toxoplasma gondii S-Adenosyl homocysteine hydrolase 0.0129 0.0577 0.0571
Brugia malayi hypothetical protein 0.0033 0.0048 0.0031
Brugia malayi putative neuropeptide receptor NPR1 0.0033 0.0048 0.0031
Echinococcus granulosus tm gpcr rhodopsin 0.0033 0.0048 0.0042
Onchocerca volvulus 0.0028 0.002 0.0004
Loa Loa (eye worm) CMGC/GSK protein kinase 0.1844 1 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0073 0.0268 0.0384
Brugia malayi Variant SH3 domain containing protein 0.0028 0.002 0.0004
Loa Loa (eye worm) neuropeptide F receptor 0.0033 0.0048 0.0048
Schistosoma mansoni adenosylhomocysteinase 0.008 0.0306 0.03
Echinococcus granulosus guanine nucleotide exchange factor VAV2 0.0028 0.002 0.0014
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0033 0.0048 0.0042
Echinococcus granulosus expressed protein 0.0027 0.0016 0.001
Echinococcus granulosus tyrosine protein kinase Src42A 0.0246 0.1219 0.1214
Schistosoma mansoni Na+/K+ transporting ATPase subunit alpha 0.004 0.0083 0.0077
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0073 0.0268 0.0384
Loa Loa (eye worm) hypothetical protein 0.0027 0.0016 0.0016
Brugia malayi hypothetical protein 0.0036 0.0064 0.0047
Loa Loa (eye worm) hypothetical protein 0.0077 0.0288 0.0288
Loa Loa (eye worm) hypothetical protein 0.0028 0.002 0.002
Leishmania major hypothetical protein, conserved 0.0027 0.0016 0.001
Loa Loa (eye worm) hypothetical protein 0.0033 0.0048 0.0048
Entamoeba histolytica acyl-CoA synthetase, putative 0.0073 0.0268 0.0263
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0033 0.0048 0.0042
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0033 0.0048 0.0042
Echinococcus multilocularis nervana 2 0.0077 0.0288 0.0282
Loa Loa (eye worm) hypothetical protein 0.0033 0.0048 0.0048
Loa Loa (eye worm) hypothetical protein 0.0033 0.0048 0.0048
Loa Loa (eye worm) hypothetical protein 0.0028 0.002 0.002
Loa Loa (eye worm) SH2 domain-containing protein 0.0028 0.002 0.002
Brugia malayi hypothetical protein 0.0033 0.0048 0.0031
Schistosoma mansoni hypothetical protein 0.0028 0.002 0.0014
Loa Loa (eye worm) hypothetical protein 0.0033 0.0048 0.0048
Schistosoma mansoni growth hormone secretagogue receptor 0.0033 0.0048 0.0042
Schistosoma mansoni neuropeptide F-like receptor 0.0033 0.0048 0.0042
Echinococcus multilocularis rhodopsin orphan GPCR 0.0033 0.0048 0.0042
Echinococcus granulosus serotonin receptor 0.0033 0.0048 0.0042
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0033 0.0048 0.0042
Schistosoma mansoni Dab2-interacting protein-like 0.0027 0.0016 0.001
Echinococcus granulosus nervana 2 0.0077 0.0288 0.0282
Loa Loa (eye worm) p53BP2 0.0027 0.0016 0.0016
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0028 0.002 0.0004
Echinococcus granulosus tachykinin peptides receptor 99D 0.0033 0.0048 0.0042
Echinococcus granulosus tyrosine protein kinase Src42A 0.0282 0.1413 0.1408
Echinococcus multilocularis arf GAP with SH3 domain, ANK repeat and PH 0.0027 0.0016 0.001
Trichomonas vaginalis CMGC family protein kinase 0.1844 1 1
Trichomonas vaginalis adenosylhomocysteinase, putative 0.0041 0.0089 0.0073
Brugia malayi cytokine inducible SH2-containing protein 5 0.0028 0.002 0.0004
Entamoeba histolytica BAR/SH3 domain containing protein 0.0027 0.0016 0.001
Schistosoma mansoni sodium/potassium-dependent atpase beta subunit 0.0077 0.0288 0.0282
Echinococcus multilocularis neuropeptides capa receptor 0.0033 0.0048 0.0042
Schistosoma mansoni eps8-related protein 0.0027 0.0016 0.001
Plasmodium falciparum acyl-CoA synthetase 0.0055 0.0166 0.0161
Entamoeba histolytica protein kinase, putative 0.0027 0.0016 0.001
Echinococcus multilocularis rhodopsin orphan GPCR 0.0033 0.0048 0.0042
Plasmodium vivax adenosylhomocysteinase(S-adenosyl-L-homocystein e hydrolase), putative 0.0129 0.0577 0.0417
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative 0.1844 1 1
Echinococcus granulosus signal transduction protein lnk realted 0.0028 0.002 0.0014
Giardia lamblia Kinase, CMGC GSK 0.1844 1 1
Echinococcus multilocularis tyrosine kinase 0.0036 0.0064 0.0058
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0033 0.0048 0.0042
Echinococcus granulosus dro:myosuppressin receptor 0.0033 0.0048 0.0042
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0033 0.0048 0.0042
Echinococcus granulosus fch and double sh3 domains protein 2 0.0027 0.0016 0.001
Schistosoma mansoni nck2/grb4 0.0056 0.0171 0.0165
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0028 0.002 0.0014
Loa Loa (eye worm) TK/ABL protein kinase 0.0036 0.0064 0.0064
Loa Loa (eye worm) hypothetical protein 0.0073 0.0268 0.0268
Schistosoma mansoni growth factor receptor-bound protein 0.0056 0.0171 0.0165
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0033 0.0048 0.0042
Brugia malayi Dopamine receptor protein 1 0.0033 0.0048 0.0031
Schistosoma mansoni opsin-like receptor 0.0033 0.0048 0.0042
Loa Loa (eye worm) TK/FER protein kinase 0.0036 0.0064 0.0064
Loa Loa (eye worm) RhoGAP domain-containing protein 0.0028 0.002 0.002
Echinococcus multilocularis rho guanine nucleotide exchange factor 7 0.0027 0.0016 0.001
Mycobacterium tuberculosis Probable adenosylhomocysteinase SahH (S-adenosyl-L-homocysteine hydrolase) (adohcyase) 0.0129 0.0577 0.086
Echinococcus granulosus SH2 domain containing adapter protein F 0.0028 0.002 0.0014
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0033 0.0048 0.0042
Brugia malayi STAT protein, DNA binding domain containing protein 0.0028 0.002 0.0004
Plasmodium falciparum adenosylhomocysteinase 0.0129 0.0577 0.0571
Onchocerca volvulus 0.0077 0.0288 0.0272
Echinococcus granulosus suppressor of cytokine signaling 6 0.0028 0.002 0.0014
Loa Loa (eye worm) hypothetical protein 0.0033 0.0048 0.0048
Onchocerca volvulus 0.0033 0.0048 0.0031
Echinococcus multilocularis rhodopsin orphan GPCR 0.0033 0.0048 0.0042
Brugia malayi Tensin 0.0028 0.002 0.0004
Brugia malayi AMP-binding enzyme family protein 0.0073 0.0268 0.0253
Schistosoma mansoni neuropeptide receptor 0.0033 0.0048 0.0042
Brugia malayi Serotonin receptor 0.0033 0.0048 0.0031
Loa Loa (eye worm) hypothetical protein 0.0033 0.0048 0.0048
Brugia malayi RE15519p 0.0033 0.0048 0.0031
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0028 0.002 0.0014
Onchocerca volvulus 0.0033 0.0048 0.0031
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0282 0.1413 0.1408
Loa Loa (eye worm) hypothetical protein 0.0033 0.0048 0.0048
Schistosoma mansoni run and tbc1 domain containing 0.0027 0.0016 0.001
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0282 0.1413 0.1408
Loa Loa (eye worm) TK/FER protein kinase 0.0036 0.0064 0.0064
Schistosoma mansoni alpha-1 adrenergic receptor 0.0033 0.0048 0.0042
Onchocerca volvulus Suppressor of cytokine signaling at 36E homolog 0.0028 0.002 0.0004
Echinococcus multilocularis expressed protein 0.0027 0.0016 0.001
Schistosoma mansoni hypothetical protein 0.0033 0.0048 0.0042

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 0.6 uM In vitro inhibitory activity against H+/K+ ATPase prepared from canine fundic mucosa ChEMBL. 2836591
IC50 (binding) = 0.6 uM In vitro inhibitory activity against H+/K+ ATPase prepared from canine fundic mucosa ChEMBL. 2836591
Inhibition (functional) = 21 % Inhibitory activity when administered intravenously in histamine-stimulated gastric fistula dog at 3 mg/kg,id ChEMBL. 2836591

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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