TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 440.441 | Formula: C21H28O10
H donors: 3 H acceptors: 6 LogP: -0.08 Rotable bonds: 2
Rule of 5 violations (Lipinski): 1
SMILES: COC1OC(=O)[C@@H](C21[C@@H]([C@H](C1[C@@]32C[C@H]2[C@](C3C(=O)O1)(O)[C@@H](C(=O)O2)C)O)C(C)(C)C)O
InChi: 1S/C21H28O10/c1-7-14(24)29-8-6-19-11(21(7,8)27)15(25)30-13(19)9(22)10(18(2,3)4)20(19)12(23)16(26)31-17(20)28-5/h7-13,17,22-23,27H,6H2,1-5H3/t7-,8+,9-,10+,11?,12+,13?,17?,19-,20?,21-/m1/s1
InChiKey: LLVUAPFYWJRBDS-YOTUTOPNSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Mus musculus	platelet-activating factor receptor	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	aldo keto reductase	0.0129	0.0476	0.0476
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0129	0.0476	0.0476
Loa Loa (eye worm)	hypothetical protein	0.0079	0.0248	0.0248
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0079	0.0248	0.0248
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0053	0.0053
Leishmania major	prostaglandin f2-alpha synthase/D-arabinose dehydrogenase	0.0129	0.0476	0.0426
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.1034	0.4683	1
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0079	0.0248	0.0248
Trypanosoma cruzi	aldo/keto reductase, putative	0.0129	0.0476	0.0426
Echinococcus multilocularis	nuclear receptor subfamily 4 group A	0.0037	0.0053	0.0053
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0079	0.0248	0.0248
Schistosoma mansoni	carbonic anhydrase-related	0.1085	0.4921	0.4921
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0079	0.0248	0.0248
Echinococcus granulosus	thyroid hormone receptor alpha	0.0037	0.0053	0.0053
Loa Loa (eye worm)	glutamate-cysteine ligase modifier subunit	0.0037	0.0052	0.0052
Brugia malayi	ecdysone receptor	0.0037	0.0053	0.0053
Loa Loa (eye worm)	hypothetical protein	0.1085	0.4921	0.4921
Brugia malayi	nuclear receptor subfamily 1, group D, member 1, putative	0.0037	0.0053	0.0053
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.0042	0.0074	0.0074
Schistosoma mansoni	aldo-keto reductase	0.0129	0.0476	0.0476
Schistosoma mansoni	carbonic anhydrase II (carbonate dehydratase II)	0.2178	1	1
Brugia malayi	nuclear hormone receptor family member nhr-6	0.0037	0.0053	0.0053
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0053	0.0053
Brugia malayi	photoreceptor-specific nuclear receptor	0.0079	0.0248	0.0248
Brugia malayi	Nuclear hormone receptor-like 1	0.0079	0.0248	0.0248
Leishmania major	aldo-keto reductase-like protein	0.0129	0.0476	0.0426
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0079	0.0248	0.0248
Brugia malayi	nuclear receptor NHR-88	0.0037	0.0053	0.0053
Schistosoma mansoni	nuclear receptor nhr-48	0.0037	0.0053	0.0053
Schistosoma mansoni	coup transcription factor	0.0079	0.0248	0.0248
Brugia malayi	Eukaryotic-type carbonic anhydrase family protein	0.1085	0.4921	0.4921
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0079	0.0248	0.0248
Brugia malayi	Carbonic anhydrase like protein 2 precursor	0.1085	0.4921	0.4921
Brugia malayi	oxidoreductase, aldo/keto reductase family protein	0.0129	0.0476	0.0476
Schistosoma mansoni	aldo-keto reductase	0.0129	0.0476	0.0476
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0079	0.0248	0.0248
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0079	0.0248	0.0248
Brugia malayi	hypothetical protein	0.0037	0.0053	0.0053
Trichomonas vaginalis	aldo-keto reductase, putative	0.0129	0.0476	1
Trichomonas vaginalis	aldo-keto reductase, putative	0.0129	0.0476	1
Trypanosoma brucei	aldo-keto reductase, putative	0.0129	0.0476	0.0426
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0129	0.0476	0.0476
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0074	0.0074
Trypanosoma cruzi	carbonic anhydrase-like protein, putative	0.2178	1	1
Onchocerca volvulus		0.0037	0.0053	0.0114
Trichomonas vaginalis	aldo-keto reductase, putative	0.0129	0.0476	1
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0079	0.0248	0.0248
Loa Loa (eye worm)	hypothetical protein	0.0079	0.0248	0.0248
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0079	0.0248	0.0248
Schistosoma mansoni	hypothetical protein	0.1085	0.4921	0.4921
Brugia malayi	Carbonic anhydrase like protein 2 precursor	0.1085	0.4921	0.4921
Echinococcus granulosus	carbonic anhydrase II	0.2178	1	1
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0079	0.0248	0.0248
Trichomonas vaginalis	aldo-keto reductase, putative	0.0129	0.0476	1
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0074	0.0074
Brugia malayi	nuclear hormone receptor	0.0079	0.0248	0.0248
Schistosoma mansoni	carbonic anhydrase-related	0.1085	0.4921	0.4921
Onchocerca volvulus		0.0037	0.0052	0.0111
Brugia malayi	Putative carbonic anhydrase 5 precursor	0.2178	1	1
Echinococcus granulosus	FTZ F1 alpha	0.0079	0.0248	0.0248
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0079	0.0248	0.0248
Mycobacterium tuberculosis	Probable oxidoreductase	0.0129	0.0476	1
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0079	0.0248	0.0248
Onchocerca volvulus	Protein ultraspiracle homolog	0.0079	0.0248	0.053
Trichomonas vaginalis	dihydrodiol dehydrogenase, putative	0.0129	0.0476	1
Schistosoma mansoni	RAR-like nuclear receptor	0.0079	0.0248	0.0248
Brugia malayi	ecdysteroid receptor	0.0079	0.0248	0.0248
Onchocerca volvulus		0.0079	0.0248	0.053
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0079	0.0248	0.0248
Loa Loa (eye worm)	hypothetical protein	0.0079	0.0248	0.0248
Brugia malayi	oxidoreductase, aldo/keto reductase family protein	0.0129	0.0476	0.0476
Loa Loa (eye worm)	eukaryotic-type carbonic anhydrase	0.1085	0.4921	0.4921
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0129	0.0476	0.0476
Loa Loa (eye worm)	oxidoreductase	0.0129	0.0476	0.0476
Echinococcus multilocularis	nuclear receptor nhr 48	0.0037	0.0053	0.0053
Loa Loa (eye worm)	oxidoreductase	0.0129	0.0476	0.0476
Loa Loa (eye worm)	hypothetical protein	0.0079	0.0248	0.0248
Loa Loa (eye worm)	oxidoreductase	0.0129	0.0476	0.0476
Plasmodium vivax	aldehyde reductase, putative	0.0037	0.0052	0.5
Leishmania major	prostaglandin f synthase, putative	0.0129	0.0476	0.0426
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0037	0.0053	0.0053
Loa Loa (eye worm)	nuclear receptor nhr-7B	0.0992	0.4488	0.4488
Echinococcus multilocularis	aldehyde reductase	0.0091	0.0303	0.0303
Schistosoma mansoni	carbonic anhydrase-related	0.1085	0.4921	0.4921
Brugia malayi	tailless protein	0.0037	0.0053	0.0053
Entamoeba histolytica	aldose reductase, putative	0.0129	0.0476	1
Mycobacterium leprae	Conserved hypothetical protein	0.0091	0.0303	0.5922
Brugia malayi	Eukaryotic-type carbonic anhydrase family protein	0.1085	0.4921	0.4921
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.0037	0.0053	0.0114
Trichomonas vaginalis	dihydrodiol dehydrogenase, putative	0.0129	0.0476	1
Schistosoma mansoni	potassium channel beta	0.0037	0.0052	0.0052
Schistosoma mansoni	carbonic anhydrase II (carbonate dehydratase II)	0.2178	1	1
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0129	0.0476	0.0476
Onchocerca volvulus		0.0129	0.0476	0.1017
Trichomonas vaginalis	aldo-keto reductase, putative	0.0129	0.0476	1
Loa Loa (eye worm)	nuclear receptor NHR-67	0.0037	0.0053	0.0053
Brugia malayi	NADH-dependent xylose reductase	0.0037	0.0052	0.0052
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0129	0.0476	0.0476
Brugia malayi	hypothetical protein	0.0042	0.0074	0.0074
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0053	0.0053
Loa Loa (eye worm)	oxidoreductase	0.0129	0.0476	0.0476
Trichomonas vaginalis	aldo-keto reductase, putative	0.0129	0.0476	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0079	0.0248	0.0248
Brugia malayi	nuclear hormone receptor	0.0992	0.4488	0.4488
Schistosoma mansoni	nuclear receptor	0.0037	0.0053	0.0053
Trichomonas vaginalis	aldo-keto reductase, putative	0.0129	0.0476	1
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0053	0.0053
Echinococcus multilocularis	retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha	0.0481	0.2112	0.2112
Echinococcus multilocularis	ecdysone induced protein 78C	0.0079	0.0248	0.0248
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0079	0.0248	0.0248
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0129	0.0476	0.0476
Brugia malayi	nuclear receptor NHR-67	0.0037	0.0053	0.0053
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0079	0.0248	0.0248
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0129	0.0476	0.0476
Loa Loa (eye worm)	hypothetical protein	0.0079	0.0248	0.0248
Schistosoma mansoni	thyroid hormone receptor	0.0079	0.0248	0.0248
Trichomonas vaginalis	aldo/keto reductase, putative	0.0129	0.0476	1
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0053	0.0053
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0079	0.0248	0.0248
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0079	0.0248	0.0248
Brugia malayi	Steroid receptor seven-up type 2	0.0079	0.0248	0.0248
Trichomonas vaginalis	aldo-keto reductase, putative	0.0129	0.0476	1
Echinococcus multilocularis	carbonic anhydrase	0.1085	0.4921	0.4921
Brugia malayi	hypothetical protein	0.0037	0.0053	0.0053
Loa Loa (eye worm)	hypothetical protein	0.0079	0.0248	0.0248
Schistosoma mansoni	thyroid hormone receptor	0.0079	0.0248	0.0248
Echinococcus granulosus	aldo keto reductase	0.0129	0.0476	0.0476
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0079	0.0248	0.0248
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0074	0.0074
Toxoplasma gondii	hypothetical protein	0.1085	0.4921	1
Loa Loa (eye worm)	carbonic anhydrase 3	0.2178	1	1
Giardia lamblia	Aldose reductase	0.0129	0.0476	0.5
Echinococcus multilocularis	voltage gated potassium channel subunit	0.0037	0.0052	0.0052
Trichomonas vaginalis	aldo-keto reductase, putative	0.0129	0.0476	1
Loa Loa (eye worm)	eukaryotic-type carbonic anhydrase	0.2178	1	1
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0079	0.0248	0.0248
Brugia malayi	Nuclear hormone receptor E75	0.0037	0.0053	0.0053
Onchocerca volvulus		0.0129	0.0476	0.1017
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0079	0.0248	0.0248
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0053	0.0053
Loa Loa (eye worm)	hypothetical protein	0.0129	0.0476	0.0476
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.0042	0.0074	0.0074
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0037	0.0053	0.0053
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0129	0.0476	0.0476
Brugia malayi	oxidoreductase, aldo/keto reductase family protein	0.0129	0.0476	0.0476
Brugia malayi	nuclear hormone receptor family member odr-7	0.0037	0.0053	0.0053
Entamoeba histolytica	aldose reductase, putative	0.0129	0.0476	1
Schistosoma mansoni	carbonic anhydrase	0.1085	0.4921	0.4921
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0053	0.0053
Schistosoma mansoni	nuclear hormone receptor	0.0079	0.0248	0.0248
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0129	0.0476	0.0476
Brugia malayi	Nuclear hormone receptor-like 1	0.0042	0.0074	0.0074
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0079	0.0248	0.0248
Loa Loa (eye worm)	DR-78	0.0037	0.0053	0.0053
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0079	0.0248	0.0248
Schistosoma mansoni	pol-related	0.0129	0.0476	0.0476
Loa Loa (eye worm)	hypothetical protein	0.0079	0.0248	0.0248
Brugia malayi	hypothetical protein	0.0042	0.0074	0.0074
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.0037	0.0053	0.0114
Trichomonas vaginalis	aldo/keto reductase, putative	0.0129	0.0476	1
Schistosoma mansoni	nuclear receptor	0.0037	0.0053	0.0053
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0129	0.0476	0.0476
Mycobacterium ulcerans	oxidoreductase	0.0129	0.0476	1
Loa Loa (eye worm)	hypothetical protein	0.0954	0.4313	0.4313
Schistosoma mansoni	hepatocyte nuclear factor 4-alpha (hnf-4-alpha)	0.0037	0.0053	0.0053
Echinococcus granulosus	aldehyde reductase	0.0091	0.0303	0.0303
Brugia malayi	oxidoreductase, aldo/keto reductase family protein	0.0129	0.0476	0.0476
Toxoplasma gondii	aldose reductase, putative	0.0129	0.0476	0.0871
Echinococcus granulosus	aldo keto reductase	0.0129	0.0476	0.0476
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0037	0.0053	0.0053
Brugia malayi	glutamate-cysteine ligase modifier subunit	0.0037	0.0052	0.0052
Brugia malayi	nuclear receptor NHR-88	0.0079	0.0248	0.0248
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0523	0.2307	0.2307
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0079	0.0248	0.0248
Schistosoma mansoni	zinc finger protein	0.0037	0.0053	0.0053
Echinococcus granulosus	carbonic anhydrase	0.1085	0.4921	0.4921
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0079	0.0248	0.0248
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0079	0.0248	0.0248
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0053	0.0053
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0053	0.0053
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0079	0.0248	0.0248
Brugia malayi	Nuclear hormone receptor E75	0.0037	0.0053	0.0053
Schistosoma mansoni	nuclear hormone receptor superfamily protein-related	0.0037	0.0053	0.0053
Giardia lamblia	Aldose reductase	0.0129	0.0476	0.5
Brugia malayi	conserved hypotetical protein	0.0037	0.0053	0.0053
Onchocerca volvulus		0.0129	0.0476	0.1017
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0079	0.0248	0.0248
Loa Loa (eye worm)	oxidoreductase	0.0129	0.0476	0.0476
Echinococcus granulosus	nuclear receptor nhr 48	0.0037	0.0053	0.0053
Echinococcus granulosus	carbonic anhydrase	0.1085	0.4921	0.4921
Brugia malayi	nuclear receptor RXR	0.0042	0.0074	0.0074
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0129	0.0476	0.0476
Loa Loa (eye worm)	steroid hormone receptor	0.0079	0.0248	0.0248
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0053	0.0053
Trichomonas vaginalis	aldo/keto reductase, putative	0.0129	0.0476	1
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0129	0.0476	0.0476
Echinococcus multilocularis	carbonic anhydrase	0.1085	0.4921	0.4921
Echinococcus granulosus	ecdysone induced protein 78C	0.0079	0.0248	0.0248
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0129	0.0476	0.0476
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0079	0.0248	0.0248
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0079	0.0248	0.0248
Onchocerca volvulus		0.0129	0.0476	0.1017
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0037	0.0053	0.0053
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0037	0.0053	0.0053
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0042	0.0074	0.0074
Loa Loa (eye worm)	hypothetical protein	0.1085	0.4921	0.4921
Trypanosoma cruzi	carbonic anhydrase-like protein, putative	0.2178	1	1
Brugia malayi	Eukaryotic-type carbonic anhydrase family protein	0.1085	0.4921	0.4921
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0129	0.0476	0.0476
Loa Loa (eye worm)	hypothetical protein	0.0079	0.0248	0.0248
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.0042	0.0074	0.0074
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0079	0.0248	0.0248
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0079	0.0248	0.0248
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0079	0.0248	0.0248
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0074	0.0074
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0079	0.0248	0.0248
Brugia malayi	steroid hormone receptor	0.0079	0.0248	0.0248
Trichomonas vaginalis	dihydrodiol dehydrogenase, putative	0.0129	0.0476	1
Leishmania major	carbonic anhydrase-like protein	0.2178	1	1
Trypanosoma brucei	carbonic anhydrase-like protein	0.2178	1	1
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0129	0.0476	0.0476
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0053	0.0053
Onchocerca volvulus		0.0037	0.0053	0.0114
Loa Loa (eye worm)	nuclear hormone receptor	0.0037	0.0053	0.0053
Onchocerca volvulus		0.0129	0.0476	0.1017
Echinococcus granulosus	aldo keto reductase family 1, member B4	0.0037	0.0052	0.0052
Echinococcus granulosus	aldo keto reductase	0.0129	0.0476	0.0476
Trichomonas vaginalis	aldo-keto reductase, putative	0.0129	0.0476	1
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0129	0.0476	0.0476
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0129	0.0476	0.0476
Onchocerca volvulus	Bile acid receptor homolog	0.0079	0.0248	0.053
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0129	0.0476	0.0476
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0129	0.0476	0.0476
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0079	0.0248	0.0248
Echinococcus multilocularis	aldo keto reductase	0.0129	0.0476	0.0476
Brugia malayi	nuclear receptor RXR	0.0037	0.0053	0.0053
Mycobacterium leprae	PROBABLE OXIDOREDUCTASE	0.0129	0.0476	1
Schistosoma mansoni	nuclear hormone receptor	0.0037	0.0053	0.0053
Echinococcus multilocularis	aldo keto reductase	0.0129	0.0476	0.0476
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0079	0.0248	0.0248
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0053	0.0053
Trichomonas vaginalis	aldo-keto reductase, putative	0.0129	0.0476	1
Trypanosoma brucei	prostaglandin f synthase	0.0129	0.0476	0.0426
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0129	0.0476	0.0476
Loa Loa (eye worm)	hypothetical protein	0.1085	0.4921	0.4921
Echinococcus granulosus	nuclear receptor subfamily 4 group A	0.0037	0.0053	0.0053
Echinococcus multilocularis	FTZ F1 alpha	0.0079	0.0248	0.0248
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0079	0.0248	0.0248
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.0042	0.0074	0.0074
Echinococcus multilocularis	aldo keto reductase	0.0129	0.0476	0.0476
Onchocerca volvulus		0.0129	0.0476	0.1017
Trichomonas vaginalis	aldo-keto reductase, putative	0.0129	0.0476	1
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0074	0.0074
Echinococcus granulosus	hypothetical protein	0.0129	0.0476	0.0476
Plasmodium vivax	oxidoreductase, aldo/keto reductase domain containing protein	0.0037	0.0052	0.5
Echinococcus multilocularis	carbonic anhydrase II	0.2178	1	1
Entamoeba histolytica	aldose reductase, putative	0.0129	0.0476	1
Schistosoma mansoni	retinoic acid receptor RXR	0.0523	0.2307	0.2307
Echinococcus multilocularis	carbonic anhydrase	0.1085	0.4921	0.4921
Brugia malayi	Nuclear hormone receptor-like 1	0.0042	0.0074	0.0074
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0079	0.0248	0.0248
Trypanosoma cruzi	aldo-keto reductase	0.0129	0.0476	0.0426
Plasmodium falciparum	carbonic anhydrase	0.1085	0.4921	1
Leishmania major	aldehyde reductase, putative,oxidoreductase, putative	0.0129	0.0476	0.0426
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0037	0.0053	0.0053
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0079	0.0248	0.0248
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0053	0.0053
Brugia malayi	orphan nuclear receptor NR2E1	0.0037	0.0053	0.0053
Echinococcus granulosus	voltage gated potassium channel subunit	0.0037	0.0052	0.0052
Echinococcus granulosus	carbonic anhydrase	0.1085	0.4921	0.4921
Schistosoma mansoni	nuclear hormone receptor	0.0037	0.0053	0.0053

Activities

Activity type	Activity value	Assay description	Source	Reference
Ki (binding)	= 9.9 uM	Displacement of [3H]-WEB 2086 from Platelet activating factor receptor (PAF)	ChEMBL.	12190325
Ki (binding)	= 9.9 uM	Displacement of [3H]-WEB 2086 from Platelet activating factor receptor (PAF)	ChEMBL.	12190325

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 224408