Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | acetylcholinesterase | 0.0421 | 1 | 1 |
Plasmodium vivax | choline kinase, putative | 0.0128 | 0 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0421 | 1 | 1 |
Toxoplasma gondii | phosphotransferase enzyme family protein | 0.0128 | 0 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.0421 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0421 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0421 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0421 | 1 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.0421 | 1 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0421 | 1 | 0.5 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0421 | 1 | 1 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0421 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0421 | 1 | 1 |
Echinococcus granulosus | carboxylesterase 5A | 0.0421 | 1 | 1 |
Plasmodium falciparum | choline kinase | 0.0128 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ID50 (functional) | = 0.72 uM | Ability to reduce the cell count to 50% in L1210 culture cells | ChEMBL. | 3339609 |
ID50 (functional) | = 0.72 uM | Ability to reduce the cell count to 50% in L1210 culture cells | ChEMBL. | 3339609 |
K aff (binding) | = 160000 M-1 | Apparent DNA affinity constant | ChEMBL. | 3339609 |
T/C (functional) | Toxic 0 % | Antitumour activity against P388 leukemia in mice at a dose of 100 mg/kg administered intraperitoneally for 5 days | ChEMBL. | 3339609 |
T/C (functional) | = 105 % | Antitumour activity against P388 leukemia in mice at a dose of 6 mg/kg administered intraperitoneally for 5 days | ChEMBL. | 3339609 |
T/C (functional) | = 105 % | Antitumour activity against P388 leukemia in mice at a dose of 6 mg/kg administered intraperitoneally for 5 days | ChEMBL. | 3339609 |
T/C (functional) | = 110 % | Antitumour activity against P388 leukemia in mice at a dose of 12 mg/kg administered intraperitoneally for 5 days | ChEMBL. | 3339609 |
T/C (functional) | = 110 % | Antitumour activity against P388 leukemia in mice at a dose of 12 mg/kg administered intraperitoneally for 5 days | ChEMBL. | 3339609 |
T/C (functional) | = 118 % | Antitumour activity against P388 leukemia in mice at a dose of 24 mg/kg administered intraperitoneally for 5 days | ChEMBL. | 3339609 |
T/C (functional) | = 118 % | Antitumour activity against P388 leukemia in mice at a dose of 24 mg/kg administered intraperitoneally for 5 days | ChEMBL. | 3339609 |
T/C (functional) | = 131 % | Antitumour activity against P388 leukemia in mice at a dose of 50 mg/kg administered intraperitoneally for 5 days | ChEMBL. | 3339609 |
T/C (functional) | = 131 % | Antitumour activity against P388 leukemia in mice at a dose of 50 mg/kg administered intraperitoneally for 5 days | ChEMBL. | 3339609 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.