Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | GA binding protein alpha chain | 0.007 | 0.0596 | 0.2048 |
Brugia malayi | Fli-1 protein | 0.0213 | 0.261 | 0.2599 |
Echinococcus multilocularis | leukotriene A 4 hydrolase | 0.023 | 0.2853 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0131 | 0.1452 | 0.1439 |
Brugia malayi | follicle stimulating hormone receptor | 0.0229 | 0.2838 | 0.2827 |
Echinococcus multilocularis | serotonin transporter | 0.0148 | 0.1694 | 0.5917 |
Loa Loa (eye worm) | hypothetical protein | 0.0377 | 0.4919 | 0.4912 |
Toxoplasma gondii | histone lysine methyltransferase SET/SUV39 | 0.0029 | 0.0015 | 0.5 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0173 | 0.2046 | 0.1027 |
Leishmania major | C-8 sterol isomerase-like protein | 0.0738 | 1 | 0.5 |
Onchocerca volvulus | 0.0064 | 0.0508 | 0.1743 | |
Loa Loa (eye worm) | hypothetical protein | 0.0079 | 0.0723 | 0.0709 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0202 | 0.245 | 0.2438 |
Trichomonas vaginalis | set domain proteins, putative | 0.023 | 0.2842 | 0.7593 |
Loa Loa (eye worm) | hypothetical protein | 0.0148 | 0.1694 | 0.1682 |
Schistosoma mansoni | ets-related | 0.0213 | 0.261 | 0.9143 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0173 | 0.2046 | 0.1027 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.025 | 0.3134 | 1 |
Onchocerca volvulus | 0.0148 | 0.1694 | 0.5939 | |
Brugia malayi | Cytochrome P450 family protein | 0.0032 | 0.0061 | 0.0046 |
Echinococcus multilocularis | serotonin receptor | 0.0131 | 0.1452 | 0.5064 |
Echinococcus granulosus | single minded 2 | 0.0035 | 0.0099 | 0.0347 |
Loa Loa (eye worm) | leukotriene A4 hydrolase | 0.023 | 0.2853 | 0.2842 |
Echinococcus granulosus | jun protein | 0.0081 | 0.0754 | 0.2643 |
Schistosoma mansoni | leukotriene A4 hydrolase (M01 family) | 0.023 | 0.2853 | 1 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription factor | 0.0081 | 0.0754 | 0.2604 |
Loa Loa (eye worm) | serotonin transporter b | 0.0148 | 0.1694 | 0.1682 |
Brugia malayi | Sodium:neurotransmitter symporter family protein | 0.0148 | 0.1694 | 0.1682 |
Brugia malayi | Ets-domain containing protein | 0.007 | 0.0596 | 0.0582 |
Brugia malayi | O-Glycosyl hydrolase family 30 protein | 0.025 | 0.3134 | 0.3124 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.025 | 0.3134 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0148 | 0.1694 | 0.1682 |
Echinococcus granulosus | serotonin transporter | 0.0148 | 0.1694 | 0.5938 |
Trypanosoma cruzi | C-8 sterol isomerase, putative | 0.0738 | 1 | 0.5 |
Brugia malayi | hypothetical protein | 0.0106 | 0.11 | 0.1086 |
Trypanosoma brucei | C-8 sterol isomerase, putative | 0.0738 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0422 | 0.5552 | 0.5546 |
Onchocerca volvulus | Glucosylceramidase homolog | 0.0164 | 0.1921 | 0.6743 |
Loa Loa (eye worm) | O-glycosyl hydrolase family 30 protein | 0.025 | 0.3134 | 0.3124 |
Loa Loa (eye worm) | norepinephrine transporter | 0.0148 | 0.1694 | 0.1682 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription factor | 0.0081 | 0.0754 | 0.2643 |
Mycobacterium ulcerans | putative regulatory protein | 0.0035 | 0.0099 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0131 | 0.1452 | 0.1439 |
Echinococcus granulosus | biogenic amine 5HT receptor | 0.0131 | 0.1452 | 0.509 |
Schistosoma mansoni | norepinephrine/norepinephrine transporter | 0.0148 | 0.1694 | 0.5917 |
Brugia malayi | Ets-domain containing protein | 0.007 | 0.0596 | 0.0582 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.025 | 0.3134 | 1 |
Loa Loa (eye worm) | fli-1 protein | 0.0213 | 0.261 | 0.2599 |
Plasmodium vivax | SET domain protein, putative | 0.0029 | 0.0015 | 0.5 |
Echinococcus multilocularis | serotonin receptor | 0.0131 | 0.1452 | 0.5064 |
Brugia malayi | Pre-SET motif family protein | 0.0202 | 0.245 | 0.2438 |
Loa Loa (eye worm) | D-ets-4 DNA binding domain-containing protein | 0.007 | 0.0596 | 0.0582 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0032 | 0.0061 | 0.0046 |
Schistosoma mansoni | sodium/chloride dependent transporter | 0.0148 | 0.1694 | 0.5917 |
Brugia malayi | hypoxia-induced factor 1 | 0.0146 | 0.1663 | 0.1651 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0029 | 0.0015 | 0.0053 |
Loa Loa (eye worm) | hypothetical protein | 0.0422 | 0.5552 | 0.5546 |
Brugia malayi | hypothetical protein | 0.0064 | 0.0508 | 0.0494 |
Schistosoma mansoni | jun-related protein | 0.0066 | 0.0539 | 0.1847 |
Treponema pallidum | sodium- and chloride- dependent transporter | 0.0148 | 0.1694 | 0.5 |
Echinococcus granulosus | leukotriene A 4 hydrolase | 0.023 | 0.2853 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.025 | 0.3134 | 1 |
Schistosoma mansoni | biogenic amine (5HT) receptor | 0.0131 | 0.1452 | 0.5064 |
Echinococcus granulosus | GA binding protein alpha chain | 0.007 | 0.0596 | 0.209 |
Loa Loa (eye worm) | hypoxia-induced factor 1 | 0.0146 | 0.1663 | 0.1651 |
Brugia malayi | bZIP transcription factor family protein | 0.0081 | 0.0754 | 0.074 |
Schistosoma mansoni | gabp alpha | 0.007 | 0.0596 | 0.2048 |
Brugia malayi | hypothetical protein | 0.0158 | 0.1836 | 0.1824 |
Loa Loa (eye worm) | solute carrier family 6 member 4 | 0.0148 | 0.1694 | 0.1682 |
Schistosoma mansoni | hypothetical protein | 0.0066 | 0.0539 | 0.1847 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.025 | 0.3134 | 1 |
Schistosoma mansoni | single-minded | 0.0047 | 0.0272 | 0.0904 |
Loa Loa (eye worm) | hypothetical protein | 0.0158 | 0.1836 | 0.1824 |
Loa Loa (eye worm) | follicle stimulating hormone receptor | 0.0229 | 0.2838 | 0.2827 |
Echinococcus multilocularis | transfer RNA-Lys | 0.0035 | 0.0099 | 0.0296 |
Onchocerca volvulus | 0.0035 | 0.0099 | 0.0297 | |
Loa Loa (eye worm) | hypothetical protein | 0.0148 | 0.1694 | 0.1682 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.0453 | 0.0439 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.025 | 0.3134 | 1 |
Brugia malayi | bHLH-PAS transcription factor | 0.0035 | 0.0099 | 0.0084 |
Echinococcus multilocularis | jun protein | 0.0081 | 0.0754 | 0.2604 |
Loa Loa (eye worm) | hypothetical protein | 0.0738 | 1 | 1 |
Onchocerca volvulus | 0.023 | 0.2842 | 1 | |
Schistosoma mansoni | aryl hydrocarbon receptor | 0.0047 | 0.0272 | 0.0904 |
Brugia malayi | PAS domain containing protein | 0.0047 | 0.0272 | 0.0257 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.