Detailed information for compound 224516

Basic information

Technical information
  • TDR Targets ID: 224516
  • Name: 2-(2-methoxyethyl)-4-pyridin-3-ylphthalazin-1 -one
  • MW: 281.309 | Formula: C16H15N3O2
  • H donors: 0 H acceptors: 2 LogP: 1.64 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: COCCn1nc(c2cccnc2)c2c(c1=O)cccc2
  • InChi: 1S/C16H15N3O2/c1-21-10-9-19-16(20)14-7-3-2-6-13(14)15(18-19)12-5-4-8-17-11-12/h2-8,11H,9-10H2,1H3
  • InChiKey: ANHOUWBUOFVAEB-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-(2-methoxyethyl)-4-(3-pyridyl)phthalazin-1-one
  • 2-(2-methoxyethyl)-4-(3-pyridyl)-1-phthalazinone
  • 2-(2-methoxyethyl)-4-pyridin-3-yl-phthalazin-1-one

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.036 0.4334 1
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0044 0.0381 0.0894
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0044 0.0381 0.0351
Trypanosoma brucei transcription factor BTF3, putative 0.0035 0.0271 0.7126
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0044 0.0381 0.0932
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0044 0.0381 0.0813
Loa Loa (eye worm) calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase 0.0044 0.0381 0.0814
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0044 0.0381 0.0894
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0075 0.1971
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0044 0.0381 0.0894
Brugia malayi Probable 3',5'-cyclic phosphodiesterase T04D3.3, putative 0.0044 0.0381 0.0932
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.0381 0.0894
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0044 0.0381 0.0894
Brugia malayi nuclear receptor NHR-88 0.002 0.0087 0.0148
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0316 0.3786 0.8727
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0293 0.3498 1
Loa Loa (eye worm) hypothetical protein 0.0257 0.3046 0.7008
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.026 0.0611
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.0316 0.3786 1
Echinococcus granulosus apoptotic protease activating factor 1 0.0031 0.0221 0.0441
Schistosoma mansoni caspase-7 (C14 family) 0.0031 0.0221 0.0441
Onchocerca volvulus Cell death protein 3 homolog 0.0031 0.0221 0.0485
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0044 0.0381 1
Loa Loa (eye worm) PDE1B protein 0.0044 0.0381 0.0814
Echinococcus granulosus caspase 2 0.0031 0.0221 0.0441
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0044 0.0381 0.0932
Echinococcus multilocularis caspase 2 0.0031 0.0221 0.019
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0044 0.0381 0.0813
Loa Loa (eye worm) hypothetical protein 0.002 0.0087 0.0129
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0044 0.0381 0.0813
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0293 0.3498 1
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.002 0.0087 0.0129
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0044 0.0381 0.0894
Loa Loa (eye worm) hypothetical protein 0.0044 0.0381 0.0814
Giardia lamblia CAMP-specific 3,5-cyclic phosphodiesterase 4B 0.036 0.4334 1
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.0381 0.0894
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0044 0.0381 0.0894
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.002 0.0087 0.0129
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0044 0.0381 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0075 0.1971
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0075 0.0044
Trypanosoma cruzi hypothetical protein, conserved 0.0044 0.0381 1
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0044 0.0381 0.0814
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0293 0.3498 1
Plasmodium vivax basic transcription factor 3b, putative 0.0035 0.0271 0.687
Loa Loa (eye worm) hypothetical protein 0.0031 0.0221 0.0441
Schistosoma mansoni camp-specific cyclic nucleotide phosphodiesterase 0.0044 0.0381 0.0814
Loa Loa (eye worm) hypothetical protein 0.002 0.0087 0.0129
Brugia malayi Nuclear hormone receptor family member nhr-3 0.002 0.0087 0.0148
Brugia malayi hypothetical protein 0.0031 0.0221 0.0505
Trypanosoma brucei DNA polymerase eta, putative 0.0019 0.0075 0.1971
Loa Loa (eye worm) cyclic AMP specific phosphodiesterase PDE4D5A 0.0316 0.3786 0.8727
Leishmania major hypothetical protein, conserved 0.0044 0.0381 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0044 0.0381 0.0813
Loa Loa (eye worm) ICD-1 protein 0.0035 0.0271 0.0559
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0044 0.0381 0.0894
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.002 0.0087 0.0129
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.005 0.0458 0.1138
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.002 0.0087 0.0056
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0075 0.0118
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0044 0.0381 0.0894
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0031 0.0819
Echinococcus multilocularis ecdysone induced protein 78C 0.002 0.0087 0.0056
Schistosoma mansoni hypothetical protein 0.0031 0.0221 0.0441
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0044 0.0381 0.0813
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0044 0.0381 0.0894
Plasmodium vivax phosphodiesterase gamma, putative 0.0044 0.0381 1
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.036 0.4334 0.4316
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.002 0.0087 0.0129
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0075 0.0103
Loa Loa (eye worm) hypothetical protein 0.0034 0.026 0.0533
Echinococcus multilocularis dual 3',5' cyclic AMP and GMP phosphodiesterase 0.0044 0.0381 0.0351
Schistosoma mansoni hypothetical protein 0.017 0.1958 0.4478
Plasmodium falciparum phosphodiesterase gamma, putative 0.0044 0.0381 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.002 0.0087 0.0129
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0044 0.0381 0.0813
Brugia malayi ecdysteroid receptor 0.002 0.0087 0.0148
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0044 0.0381 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0075 0.1971
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0044 0.0381 0.0894
Loa Loa (eye worm) hypothetical protein 0.002 0.0087 0.0129
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.002 0.0087 0.0129
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.002 0.0087 0.0129
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.002 0.0087 0.0056
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0044 0.0381 0.0351
Loa Loa (eye worm) MH2 domain-containing protein 0.012 0.133 0.3019
Leishmania major cAMP phosphodiesterase A, putative;with=GeneDB:LinJ18_V3.1100 0.0044 0.0381 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0087 0.0148
Entamoeba histolytica hypothetical protein 0.0035 0.0271 0.0574
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0044 0.0381 0.0894
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0044 0.0381 1
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.0381 0.0894
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.0044 0.0381 0.0932
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0087 0.0148
Trypanosoma cruzi hypothetical protein, conserved 0.0044 0.0381 1
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0044 0.0381 0.0894
Trypanosoma cruzi transcription factor btf3, putative 0.0035 0.0271 0.687
Echinococcus multilocularis high affinity cAMP specific 3',5' cyclic 0.0044 0.0381 0.0351
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0044 0.0381 0.0813
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0293 0.3498 1
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0044 0.0381 0.0894
Brugia malayi photoreceptor-specific nuclear receptor 0.0257 0.3046 0.803
Brugia malayi Nuclear hormone receptor family member nhr-49 0.002 0.0087 0.0148
Brugia malayi Nuclear hormone receptor family member nhr-41 0.002 0.0087 0.0148
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0143 0.1623 1
Trypanosoma cruzi hypothetical protein, conserved 0.0044 0.0381 1
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0044 0.0381 0.0894
Loa Loa (eye worm) pax transcription factor protein 2 0.0241 0.2851 0.6553
Echinococcus granulosus high affinity cgmp specific 3' 5' cyclic 0.0044 0.0381 0.0814
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0044 0.0381 0.0894
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0044 0.0381 1
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0044 0.0381 0.0814
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0075 0.1971
Echinococcus granulosus muscleblind protein 0.015 0.1706 0.3893
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0075 0.1255
Plasmodium falciparum phosphodiesterase delta, putative 0.0044 0.0381 1
Brugia malayi beta-NAC-like protein 0.0035 0.0271 0.0641
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0087 0.0056
Plasmodium vivax cyclic nucleotide phosphodiesterase, putative 0.0044 0.0381 1
Trypanosoma brucei hypothetical protein, conserved 0.0044 0.0381 1
Schistosoma mansoni camp/cgmp cyclic nucleotide phosphodiesterase 0.0044 0.0381 0.0814
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.036 0.4334 0.4316
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0087 0.0129
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0044 0.0381 0.0814
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0044 0.0381 1
Entamoeba histolytica transcription factor BTF3, putative 0.0035 0.0271 0.0574
Brugia malayi Calcitonin receptor-like protein seb-1 0.005 0.0458 0.1138
Giardia lamblia Hypothetical protein 0.0044 0.0381 0.0718
Loa Loa (eye worm) hypothetical protein 0.0019 0.0075 0.0103
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0044 0.0381 1
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0044 0.0381 1
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0316 0.3786 0.3767
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0271 0.0574
Brugia malayi Muscleblind-like protein 0.015 0.1706 0.4461
Trypanosoma cruzi cyclic nucleotide phosphodiesterase 0.0044 0.0381 1
Brugia malayi isocitrate dehydrogenase 0.0016 0.0031 0.0001
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0044 0.0381 0.0894
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0293 0.3498 1
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0044 0.0381 0.0894
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0044 0.0381 0.0894
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0016 0.0031 0.0819
Loa Loa (eye worm) hypothetical protein 0.005 0.0458 0.0993
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0044 0.0381 0.0894
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0143 0.1623 0.5
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0044 0.0381 0.0894
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0087 0.0148
Echinococcus granulosus ecdysone induced protein 78C 0.002 0.0087 0.0129
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.002 0.0087 0.0129
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0044 0.0381 0.0813
Trypanosoma cruzi transcription factor btf3, putative 0.0035 0.0271 0.687
Schistosoma mansoni retinoic acid receptor RXR 0.002 0.0087 0.0129
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0075 0.1971
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0044 0.0381 0.0894
Leishmania major DNA polymerase kappa, putative 0.0019 0.0075 0.1255
Echinococcus multilocularis FTZ F1 alpha 0.002 0.0087 0.0056
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0075 0.1971
Brugia malayi Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative 0.0044 0.0381 0.0932
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.036 0.4334 1
Schistosoma mansoni RAR-like nuclear receptor 0.002 0.0087 0.0129
Brugia malayi Nuclear hormone receptor family member nhr-14 0.002 0.0087 0.0148
Leishmania major DNA polymerase eta, putative 0.0019 0.0075 0.1255
Loa Loa (eye worm) hypothetical protein 0.002 0.0087 0.0129
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0044 0.0381 0.0894
Treponema pallidum fructose-bisphosphate aldolase 0.0293 0.3498 0.5
Loa Loa (eye worm) hypothetical protein 0.0031 0.0221 0.0441
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0271 0.0574
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0075 0.1971
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0044 0.0381 0.0932
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0075 0.1971
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.002 0.0087 0.0056
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0044 0.0381 0.0813
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0087 0.0056
Schistosoma mansoni transcription factor btf3 0.0035 0.0271 0.0559
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0044 0.0381 0.0894
Trypanosoma cruzi hypothetical protein, conserved 0.0044 0.0381 1
Loa Loa (eye worm) hypothetical protein 0.015 0.1706 0.3893
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0019 0.0075 0.0276
Mycobacterium tuberculosis Conserved hypothetical protein 0.0019 0.0075 0.0276
Onchocerca volvulus 0.0241 0.2851 1
Echinococcus multilocularis dna polymerase eta 0.0019 0.0075 0.0044
Leishmania major basic transcription factor 3a, putative 0.0035 0.0271 0.687
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0143 0.1623 1
Trypanosoma brucei cAMP-specific phosphodiesterase, putative 0.0044 0.0381 1
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0044 0.0381 0.0894
Schistosoma mansoni DNA polymerase eta 0.0019 0.0075 0.0103
Schistosoma mansoni hypothetical protein 0.0034 0.026 0.0533
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0075 0.1255
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.002 0.0087 0.0056
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0044 0.0381 0.0813
Loa Loa (eye worm) steroid hormone receptor 0.002 0.0087 0.0129
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0044 0.0381 0.0894
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0044 0.0381 0.0813
Loa Loa (eye worm) hypothetical protein 0.002 0.0087 0.0129
Trypanosoma cruzi cAMP-specific phosphodiesterase, putative 0.0044 0.0381 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0293 0.3498 1
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0044 0.0381 0.0894
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0075 0.1971
Echinococcus granulosus retinoic acid receptor rxr beta a 0.002 0.0087 0.0129
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0044 0.0381 0.0894
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0044 0.0381 0.0813
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0271 0.0574
Schistosoma mansoni cgmp-dependent 35-cyclic phosphodiesterase 0.0044 0.0381 0.0814
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0087 0.0148
Trichomonas vaginalis cAMP/cGMP cyclic nucleotide phosphodiesterase, putative 0.0044 0.0381 0.0894
Schistosoma mansoni thyroid hormone receptor 0.002 0.0087 0.0129
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0044 0.0381 0.0814
Plasmodium falciparum basic transcription factor 3b, putative 0.0035 0.0271 0.687
Echinococcus granulosus dna polymerase eta 0.0019 0.0075 0.0103
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0044 0.0381 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0044 0.0381 0.0813
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0293 0.3498 1
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0044 0.0381 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0075 0.1255
Schistosoma mansoni thyroid hormone receptor 0.002 0.0087 0.0129
Brugia malayi Isocitrate dehydrogenase 0.0016 0.0031 0.0001
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.002 0.0087 0.0129
Loa Loa (eye worm) pigment dispersing factor receptor c 0.005 0.0458 0.0993
Echinococcus granulosus cAMP and cAMP inhibited cGMP 3'5' cyclic 0.0044 0.0381 0.0814
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0044 0.0381 0.0814
Echinococcus multilocularis high affinity cgmp specific 3' 5' cyclic 0.0044 0.0381 0.0351
Echinococcus multilocularis geminin 0.017 0.1958 0.1933
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0044 0.0381 0.0894
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.002 0.0087 0.0129
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0044 0.0381 0.0894
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0044 0.0381 0.0894
Giardia lamblia Fructose-bisphosphate aldolase 0.0293 0.3498 0.8036
Brugia malayi Nuclear hormone receptor family member nhr-1 0.002 0.0087 0.0148
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.002 0.0087 0.0129
Trypanosoma brucei unspecified product 0.0019 0.0075 0.1971
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.002 0.0087 0.0129
Schistosoma mansoni nuclear hormone receptor 0.002 0.0087 0.0129
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0075 0.0103
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0075 0.1971
Schistosoma mansoni calcium/calmodulin-dependent 35-cyclic nucleotide phosphodiesterase 0.0044 0.0381 0.0814
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0044 0.0381 0.0894
Leishmania major cAMP-specific phosphodiesterase, putative 0.0044 0.0381 1
Leishmania major hypothetical protein, conserved 0.0044 0.0381 1
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0044 0.0381 0.0894
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0075 0.0118
Loa Loa (eye worm) hypothetical protein 0.015 0.1706 0.3893
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0075 0.0103
Trypanosoma brucei cAMP phosphodiesterase A, putative 0.0044 0.0381 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0087 0.0148
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.002 0.0087 0.0129
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0075 0.0044
Schistosoma mansoni coup transcription factor 0.002 0.0087 0.0129
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0087 0.0148
Brugia malayi Nuclear hormone receptor-like 1 0.002 0.0087 0.0148
Onchocerca volvulus 0.0031 0.0221 0.0485
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0044 0.0381 0.0813
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.036 0.4334 1
Echinococcus multilocularis apoptotic protease activating factor 1 0.0031 0.0221 0.019
Echinococcus multilocularis muscleblind protein 1 0.015 0.1706 0.168
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0075 0.1255
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0044 0.0381 0.0894
Brugia malayi MH2 domain containing protein 0.012 0.133 0.3459
Echinococcus granulosus dna polymerase kappa 0.0019 0.0075 0.0103
Echinococcus multilocularis cAMP and cAMP inhibited cGMP 3',5' cyclic 0.0044 0.0381 0.0351
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0044 0.0381 0.0813
Echinococcus multilocularis muscleblind protein 0.015 0.1706 0.168
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0293 0.3498 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0075 0.1971
Brugia malayi Nuclear hormone receptor family member nhr-40 0.002 0.0087 0.0148
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.002 0.0087 0.0129
Trichomonas vaginalis calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0044 0.0381 0.0894
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0044 0.0381 0.0813
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0044 0.0381 0.0894
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0044 0.0381 1
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0016 0.0031 0.0001
Brugia malayi Steroid receptor seven-up type 2 0.002 0.0087 0.0148
Schistosoma mansoni steroid hormone receptor ad4bp 0.002 0.0087 0.0129
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0044 0.0381 0.0894
Echinococcus granulosus high affinity cAMP specific 3'5' cyclic 0.0044 0.0381 0.0814
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.002 0.0087 0.0129
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.036 0.4334 1
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0044 0.0381 0.0894
Brugia malayi Cell death protein 3 precursor 0.0031 0.0221 0.0505
Loa Loa (eye worm) isocitrate dehydrogenase 0.0016 0.0031 0.0001
Echinococcus granulosus geminin 0.017 0.1958 0.4478
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0293 0.3498 1
Schistosoma mansoni hypothetical protein 0.017 0.1958 0.4478
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0044 0.0381 0.0813
Giardia lamblia hypothetical protein 0.0044 0.0381 0.0718
Echinococcus multilocularis transcription factor btf3 0.0035 0.0271 0.0241
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0044 0.0381 0.0814
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0075 0.1971
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0044 0.0381 1
Loa Loa (eye worm) hypothetical protein 0.036 0.4334 1
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0016 0.0031 0.0001
Echinococcus granulosus transcription factor btf3 0.0035 0.0271 0.0559
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0044 0.0381 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0087 0.0129
Loa Loa (eye worm) transcription factor SMAD2 0.012 0.133 0.3019
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0087 0.0129
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.0075 0.1255
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0044 0.0381 0.0814
Echinococcus multilocularis thyroid hormone receptor alpha 0.002 0.0087 0.0056
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0075 0.1971
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0044 0.0381 1
Loa Loa (eye worm) hypothetical protein 0.0044 0.0381 0.0814
Echinococcus granulosus dual 3'5' cyclic AMP and GMP phosphodiesterase 0.0044 0.0381 0.0814
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0044 0.0381 0.0894
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0044 0.0381 1
Schistosoma mansoni Tr4/Tr2 (homologue) 0.002 0.0087 0.0129
Toxoplasma gondii NAC domain-containing protein 0.0035 0.0271 0.0558
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0044 0.0381 0.0894
Brugia malayi steroid hormone receptor 0.002 0.0087 0.0148
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0044 0.0381 1
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0044 0.0381 0.0814
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0044 0.0381 0.0894
Brugia malayi nuclear hormone receptor 0.002 0.0087 0.0148
Brugia malayi Pax transcription factor protein 2 0.0241 0.2851 0.7509
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0075 0.0103
Loa Loa (eye worm) hypothetical protein 0.0044 0.0381 0.0814
Trypanosoma cruzi hypothetical protein, conserved 0.0044 0.0381 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0087 0.0129
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0293 0.3498 1
Echinococcus granulosus FTZ F1 alpha 0.002 0.0087 0.0129
Schistosoma mansoni retinoid-x-receptor (RXR) 0.002 0.0087 0.0129
Trypanosoma cruzi DNA polymerase eta, putative 0.0019 0.0075 0.1255
Trypanosoma cruzi hypothetical protein, conserved 0.0044 0.0381 1
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0044 0.0381 0.0894
Brugia malayi Nuclear hormone receptor family member nhr-31 0.002 0.0087 0.0148
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0044 0.0381 0.0894

Activities

Activity type Activity value Assay description Source Reference
-Log IC50 (functional) = 5.03 In vitro bronchodilatory activity in guinea pig isolated tracheal strips ChEMBL. 8258828
Inhibition (binding) = 55 % Tested in vitro against rabbit thromboxane A2 synthetase (TXA2) at 1 microM ChEMBL. 8258828
Inhibition (binding) = 55 % Tested in vitro against rabbit thromboxane A2 synthetase (TXA2) at 1 microM ChEMBL. 8258828

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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