Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | coagulation factor III (thromboplastin, tissue factor) | References | |
Homo sapiens | Coagulation factor VII/tissue factor | Starlite/ChEMBL | References |
Homo sapiens | coagulation factor VII (serum prothrombin conversion accelerator) | References | |
Homo sapiens | coagulation factor II (thrombin) | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus granulosus | glycoprotein Antigen 5 | coagulation factor VII (serum prothrombin conversion accelerator) | 466 aa | 384 aa | 23.7 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Animal haem peroxidase family protein | 0.0433 | 1 | 1 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0045 | 0.0579 | 0.0566 |
Onchocerca volvulus | 0.0433 | 1 | 1 | |
Onchocerca volvulus | Chorion peroxidase homolog | 0.0433 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0433 | 1 | 1 |
Echinococcus multilocularis | lamin | 0.0045 | 0.0579 | 0.0566 |
Brugia malayi | intermediate filament protein | 0.0045 | 0.0579 | 0.0566 |
Brugia malayi | Animal haem peroxidase family protein | 0.0433 | 1 | 1 |
Onchocerca volvulus | 0.0154 | 0.3234 | 0.3224 | |
Brugia malayi | cytoplasmic intermediate filament protein | 0.0024 | 0.0077 | 0.0063 |
Toxoplasma gondii | kringle domain-containing protein | 0.0021 | 0.0014 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0433 | 1 | 1 |
Onchocerca volvulus | 0.0045 | 0.0579 | 0.0566 | |
Brugia malayi | Animal haem peroxidase family protein | 0.0433 | 1 | 1 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0024 | 0.0077 | 0.0077 |
Loa Loa (eye worm) | hypothetical protein | 0.0433 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0433 | 1 | 1 |
Echinococcus granulosus | lamin | 0.0045 | 0.0579 | 0.0566 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.0559 | 0.0559 |
Onchocerca volvulus | 0.0433 | 1 | 1 | |
Echinococcus multilocularis | musashi | 0.0045 | 0.0579 | 0.0566 |
Onchocerca volvulus | Peroxidasin homolog | 0.0433 | 1 | 1 |
Echinococcus granulosus | cytoplasmic intermediate filament protein | 0.0021 | 0.002 | 0.0005 |
Schistosoma mansoni | lamin | 0.0045 | 0.0579 | 0.0566 |
Loa Loa (eye worm) | hypothetical protein | 0.0433 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0433 | 1 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.0433 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0433 | 1 | 1 |
Loa Loa (eye worm) | blistered cuticle protein 3 | 0.0433 | 1 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.0433 | 1 | 1 |
Plasmodium vivax | cysteine repeat modular protein 1, putative | 0.0021 | 0.0014 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0433 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0433 | 1 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0021 | 0.0014 | 0.5 |
Schistosoma mansoni | intermediate filament proteins | 0.0045 | 0.0579 | 0.0566 |
Echinococcus granulosus | lamin dm0 | 0.0045 | 0.0579 | 0.0566 |
Schistosoma mansoni | peroxidasin | 0.0433 | 1 | 1 |
Echinococcus granulosus | intermediate filament protein | 0.0045 | 0.0579 | 0.0566 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.0579 | 0.0579 |
Echinococcus multilocularis | lamin dm0 | 0.0045 | 0.0579 | 0.0566 |
Leishmania major | hypothetical protein, conserved | 0.0021 | 0.0014 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0433 | 1 | 1 |
Onchocerca volvulus | Peroxidase homolog | 0.0433 | 1 | 1 |
Brugia malayi | Blistered cuticle protein 3 | 0.0433 | 1 | 1 |
Plasmodium falciparum | cysteine repeat modular protein 1 | 0.0021 | 0.0014 | 0.5 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0433 | 1 | 1 |
Schistosoma mansoni | lamin | 0.0045 | 0.0579 | 0.0566 |
Schistosoma mansoni | peroxidasin | 0.0433 | 1 | 1 |
Onchocerca volvulus | Dual oxidase homolog | 0.0433 | 1 | 1 |
Brugia malayi | Peroxidasin | 0.0433 | 1 | 1 |
Loa Loa (eye worm) | TK/ROR protein kinase | 0.0021 | 0.0014 | 0.0014 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0014 | 0.0014 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0433 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.002 | 0.002 |
Loa Loa (eye worm) | hypothetical protein | 0.0433 | 1 | 1 |
Onchocerca volvulus | Peroxidasin homolog | 0.0433 | 1 | 1 |
Onchocerca volvulus | 0.0045 | 0.0579 | 0.0566 | |
Loa Loa (eye worm) | hypothetical protein | 0.0433 | 1 | 1 |
Echinococcus multilocularis | cytoplasmic intermediate filament protein | 0.0021 | 0.002 | 0.0005 |
Loa Loa (eye worm) | intermediate filament protein | 0.0045 | 0.0579 | 0.0579 |
Onchocerca volvulus | 0.0433 | 1 | 1 | |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0045 | 0.0579 | 0.0579 |
Echinococcus granulosus | peroxidasin | 0.0433 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0433 | 1 | 1 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0433 | 1 | 1 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0433 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0433 | 1 | 1 |
Echinococcus multilocularis | peroxidasin | 0.0433 | 1 | 1 |
Onchocerca volvulus | Peroxidase homolog | 0.0433 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.1 uM | Inhibitory activity against thrombin (IIa) was determined | ChEMBL. | 12954058 |
IC50 (binding) | = 0.1 uM | Inhibitory activity against thrombin (IIa) was determined | ChEMBL. | 12954058 |
IC50 (binding) | = 8.1 uM | Inhibitory activity against tissue coagulation factor VII complex was determined (TF/VIIa complex) | ChEMBL. | 12954058 |
IC50 (binding) | = 8.1 uM | Inhibitory activity against tissue coagulation factor VII complex was determined (TF/VIIa complex) | ChEMBL. | 12954058 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.