Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | AMP deaminase, putative | 0.445 | 0.5666 | 0.5 |
Mycobacterium ulcerans | adenosine deaminase | 0.7811 | 1 | 0.5 |
Brugia malayi | adenosine monophosphate deaminase | 0.445 | 0.5666 | 0.5666 |
Entamoeba histolytica | adenosine deaminase, putative | 0.7811 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.7811 | 1 | 1 |
Trypanosoma brucei | AMP deaminase, putative | 0.445 | 0.5666 | 0.5 |
Trypanosoma cruzi | AMP deaminase, putative | 0.445 | 0.5666 | 1 |
Leishmania major | AMP deaminase, putative,amp deaminase-like protein | 0.445 | 0.5666 | 0.2922 |
Treponema pallidum | adenosine deaminase | 0.7811 | 1 | 0.5 |
Plasmodium vivax | adenosine deaminase, putative | 0.7811 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.3063 | 0.3877 | 0.3877 |
Onchocerca volvulus | AMP deaminase 2 homolog | 0.445 | 0.5666 | 0.2922 |
Trypanosoma cruzi | AMP deaminase, putative | 0.445 | 0.5666 | 1 |
Toxoplasma gondii | Adenosine/AMP deaminase domain-containing protein | 0.7811 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.4748 | 0.605 | 0.605 |
Trypanosoma cruzi | adenosine monophosphate deaminase-like protein, putative | 0.445 | 0.5666 | 1 |
Trypanosoma brucei | adenosine monophosphate deaminase, putative | 0.445 | 0.5666 | 0.5 |
Leishmania major | AMP deaminase, putative,adenosine monophosphate deaminase-like protein | 0.445 | 0.5666 | 0.2922 |
Trichomonas vaginalis | adenosine deaminase, putative | 0.7811 | 1 | 0.5 |
Loa Loa (eye worm) | AMP deaminase | 0.445 | 0.5666 | 0.5666 |
Onchocerca volvulus | Adenosine deaminase homolog | 0.7811 | 1 | 1 |
Trypanosoma brucei | AMP deaminase, putative | 0.445 | 0.5666 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.4748 | 0.605 | 0.605 |
Toxoplasma gondii | Adenosine/AMP deaminase domain-containing protein | 0.7811 | 1 | 1 |
Plasmodium falciparum | adenosine deaminase | 0.7811 | 1 | 1 |
Leishmania major | adenine aminohydrolase | 0.7811 | 1 | 1 |
Entamoeba histolytica | adenosine deaminase, putative | 0.7811 | 1 | 1 |
Mycobacterium leprae | Probable adenosine deaminase Add (ADENOSINE AMINOHYDROLASE) | 0.7811 | 1 | 0.5 |
Leishmania major | adenosine monophosphate deaminase, putative,AMP deaminase, putative | 0.445 | 0.5666 | 0.2922 |
Trichomonas vaginalis | adenosine deaminase, putative | 0.7811 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.4748 | 0.605 | 0.605 |
Trypanosoma cruzi | adenosine monophosphate deaminase, putative | 0.445 | 0.5666 | 1 |
Schistosoma mansoni | adenosine deaminase-related | 0.7811 | 1 | 1 |
Mycobacterium tuberculosis | Probable adenosine deaminase Add (adenosine aminohydrolase) | 0.7811 | 1 | 0.5 |
Leishmania major | AMP deaminase, putative | 0.445 | 0.5666 | 0.2922 |
Loa Loa (eye worm) | hypothetical protein | 0.1387 | 0.1717 | 0.1717 |
Echinococcus granulosus | adenosine deaminase | 0.7811 | 1 | 1 |
Trypanosoma cruzi | AMP deaminase, putative | 0.445 | 0.5666 | 1 |
Trypanosoma cruzi | AMP deaminase, putative | 0.445 | 0.5666 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.4748 | 0.605 | 0.605 |
Echinococcus multilocularis | adenosine deaminase | 0.7811 | 1 | 1 |
Schistosoma mansoni | adenosine deaminase | 0.7811 | 1 | 1 |
Trypanosoma cruzi | AMP deaminase, putative | 0.445 | 0.5666 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Cell viability (functional) | = -2.9 | Tested for human PBMC cell viability, cultured with alpha-CD40, IL-4 and IL-10 at 3 microM (a negative number means enhancement of cell viability) | ChEMBL. | 9046329 |
Suppression (functional) | = -41.2 % | In vitro inhibition of IgG antibody production in human PBMC cultured with alpha-CD40, IL-4 and IL-10 at 3 microM concentration (negative number means enhancement of cell viability) | ChEMBL. | 9046329 |
Suppression (functional) | = 8.5 % | In vitro inhibition of IgE antibody production in human PBMC cultured with alpha-CD40, IL-4 and IL-10 at 3 microM concentration | ChEMBL. | 9046329 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.