Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | cysteinyl leukotriene receptor 1 | Starlite/ChEMBL | References |
Cavia porcellus | Cysteinyl leukotriene receptor 1 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Treponema pallidum | adenosine deaminase | 0.2617 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.156 | 0.3225 | 0.3225 |
Leishmania major | AMP deaminase, putative,amp deaminase-like protein | 0.1604 | 0.3507 | 0.3507 |
Trypanosoma brucei | AMP deaminase, putative | 0.1604 | 0.3507 | 0.5 |
Leishmania major | adenosine monophosphate deaminase, putative,AMP deaminase, putative | 0.1604 | 0.3507 | 0.3507 |
Toxoplasma gondii | Adenosine/AMP deaminase domain-containing protein | 0.2617 | 1 | 1 |
Trypanosoma cruzi | AMP deaminase, putative | 0.1604 | 0.3507 | 1 |
Trypanosoma brucei | AMP deaminase, putative | 0.1604 | 0.3507 | 0.5 |
Loa Loa (eye worm) | AMP deaminase | 0.1604 | 0.3507 | 0.3507 |
Echinococcus multilocularis | adenosine deaminase | 0.2617 | 1 | 1 |
Trypanosoma cruzi | AMP deaminase, putative | 0.1604 | 0.3507 | 1 |
Leishmania major | AMP deaminase, putative | 0.1604 | 0.3507 | 0.3507 |
Schistosoma mansoni | adenosine deaminase | 0.2617 | 1 | 1 |
Leishmania major | adenine aminohydrolase | 0.2617 | 1 | 1 |
Trypanosoma cruzi | AMP deaminase, putative | 0.1604 | 0.3507 | 1 |
Leishmania major | AMP deaminase, putative,adenosine monophosphate deaminase-like protein | 0.1604 | 0.3507 | 0.3507 |
Trypanosoma cruzi | adenosine monophosphate deaminase-like protein, putative | 0.1604 | 0.3507 | 1 |
Onchocerca volvulus | Adenosine deaminase homolog | 0.2617 | 1 | 1 |
Trypanosoma brucei | AMP deaminase, putative | 0.1604 | 0.3507 | 0.5 |
Mycobacterium ulcerans | adenosine deaminase | 0.2617 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.2617 | 1 | 1 |
Trichomonas vaginalis | adenosine deaminase, putative | 0.2617 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.156 | 0.3225 | 0.3225 |
Onchocerca volvulus | AMP deaminase 2 homolog | 0.1604 | 0.3507 | 0.3507 |
Trypanosoma cruzi | AMP deaminase, putative | 0.1604 | 0.3507 | 1 |
Mycobacterium tuberculosis | Probable adenosine deaminase Add (adenosine aminohydrolase) | 0.2617 | 1 | 0.5 |
Entamoeba histolytica | adenosine deaminase, putative | 0.2617 | 1 | 1 |
Toxoplasma gondii | Adenosine/AMP deaminase domain-containing protein | 0.2617 | 1 | 1 |
Trypanosoma cruzi | AMP deaminase, putative | 0.1604 | 0.3507 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.156 | 0.3225 | 0.3225 |
Trichomonas vaginalis | adenosine deaminase, putative | 0.2617 | 1 | 0.5 |
Plasmodium falciparum | adenosine deaminase | 0.2617 | 1 | 1 |
Entamoeba histolytica | adenosine deaminase, putative | 0.2617 | 1 | 1 |
Echinococcus granulosus | adenosine deaminase | 0.2617 | 1 | 1 |
Schistosoma mansoni | adenosine deaminase-related | 0.2617 | 1 | 1 |
Mycobacterium leprae | Probable adenosine deaminase Add (ADENOSINE AMINOHYDROLASE) | 0.2617 | 1 | 0.5 |
Plasmodium vivax | adenosine deaminase, putative | 0.2617 | 1 | 1 |
Trypanosoma brucei | adenosine monophosphate deaminase, putative | 0.1604 | 0.3507 | 0.5 |
Trypanosoma cruzi | adenosine monophosphate deaminase, putative | 0.1604 | 0.3507 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.156 | 0.3225 | 0.3225 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 1.5 nM | Antagonist activity at CysLT1 receptor in human dU937 cells assessed as inhibition of LTD4-induced increase of calcium level treated 30 mins before LTD4 challenge | ChEMBL. | 20621485 |
Ki (binding) | = 1.5 nM | In vitro binding affinity towards Cysteinyl leukotriene D4 receptor | ChEMBL. | 10669566 |
Ki (binding) | = 1.5 nM | In vitro binding affinity towards Cysteinyl leukotriene D4 receptor | ChEMBL. | 10669566 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.