Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | topoisomerase (DNA) II beta 180kDa | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | adenosine monophosphate deaminase, putative | 0.2552 | 0.6392 | 1 |
Trypanosoma cruzi | DNA topoisomerase II, putative | 0.007 | 0.0112 | 0.0035 |
Loa Loa (eye worm) | hypothetical protein | 0.0915 | 0.2249 | 0.2232 |
Plasmodium vivax | adenosine deaminase, putative | 0.3978 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.2341 | 0.5857 | 0.5848 |
Trypanosoma cruzi | AMP deaminase, putative | 0.2552 | 0.6392 | 1 |
Toxoplasma gondii | AMP deaminase | 0.2552 | 0.6392 | 0.6392 |
Plasmodium falciparum | DNA topoisomerase 2 | 0.0078 | 0.0132 | 0.0132 |
Trichomonas vaginalis | adenosine deaminase, putative | 0.3978 | 1 | 1 |
Treponema pallidum | adenosine deaminase | 0.3978 | 1 | 1 |
Leishmania major | adenine aminohydrolase | 0.3978 | 1 | 1 |
Entamoeba histolytica | adenosine deaminase, putative | 0.3978 | 1 | 1 |
Toxoplasma gondii | Adenosine/AMP deaminase domain-containing protein | 0.3978 | 1 | 1 |
Echinococcus granulosus | AMP deaminase 2 | 0.2552 | 0.6392 | 0.6344 |
Trypanosoma brucei | AMP deaminase, putative | 0.2552 | 0.6392 | 1 |
Wolbachia endosymbiont of Brugia malayi | DNA gyrase, topoisomerase II, B subunit, GyrB | 0.0026 | 0 | 0.5 |
Trypanosoma brucei | DNA topoisomerase II beta, putative | 0.007 | 0.0112 | 0.0035 |
Mycobacterium ulcerans | adenosine deaminase | 0.3978 | 1 | 1 |
Brugia malayi | adenosine monophosphate deaminase | 0.2552 | 0.6392 | 0.6344 |
Loa Loa (eye worm) | hypothetical protein | 0.3978 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.0067 | 0.0045 |
Trypanosoma brucei | AMP deaminase, putative | 0.2552 | 0.6392 | 1 |
Trypanosoma cruzi | AMP deaminase, putative | 0.2552 | 0.6392 | 1 |
Plasmodium vivax | adenosine/AMP deaminase, putative | 0.2552 | 0.6392 | 0.6392 |
Loa Loa (eye worm) | hypothetical protein | 0.2341 | 0.5857 | 0.5848 |
Toxoplasma gondii | Adenosine/AMP deaminase domain-containing protein | 0.3978 | 1 | 1 |
Entamoeba histolytica | AMP deaminase, putative | 0.2552 | 0.6392 | 0.6344 |
Mycobacterium tuberculosis | Probable adenosine deaminase Add (adenosine aminohydrolase) | 0.3978 | 1 | 1 |
Plasmodium falciparum | adenosine deaminase | 0.3978 | 1 | 1 |
Mycobacterium leprae | Probable adenosine deaminase Add (ADENOSINE AMINOHYDROLASE) | 0.3978 | 1 | 0.5 |
Chlamydia trachomatis | DNA gyrase subunit B | 0.0042 | 0.0042 | 1 |
Leishmania major | AMP deaminase, putative | 0.2552 | 0.6392 | 0.6359 |
Trypanosoma cruzi | AMP deaminase, putative | 0.2552 | 0.6392 | 1 |
Trypanosoma cruzi | DNA topoisomerase II, putative | 0.007 | 0.0112 | 0.0035 |
Trypanosoma cruzi | AMP deaminase, putative | 0.2552 | 0.6392 | 1 |
Echinococcus granulosus | adenosine deaminase | 0.3978 | 1 | 1 |
Echinococcus multilocularis | AMP deaminase 2 | 0.2552 | 0.6392 | 0.6344 |
Trichomonas vaginalis | adenosine deaminase, putative | 0.3978 | 1 | 1 |
Trypanosoma cruzi | AMP deaminase, putative | 0.2552 | 0.6392 | 1 |
Leishmania major | hypothetical protein, conserved | 0.1638 | 0.4078 | 0.4025 |
Entamoeba histolytica | adenosine deaminase, putative | 0.3978 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.0067 | 0.0045 |
Trypanosoma brucei | AMP deaminase, putative | 0.2552 | 0.6392 | 1 |
Leishmania major | DNA topoisomerase ii | 0.007 | 0.0112 | 0.0022 |
Trypanosoma cruzi | AMP deaminase 2, putative | 0.1638 | 0.4078 | 0.6329 |
Schistosoma mansoni | adenosine deaminase | 0.3978 | 1 | 1 |
Loa Loa (eye worm) | TOPoisomerase family member | 0.0078 | 0.0132 | 0.011 |
Trypanosoma cruzi | adenosine monophosphate deaminase, putative | 0.2552 | 0.6392 | 1 |
Leishmania major | AMP deaminase, putative,amp deaminase-like protein | 0.2552 | 0.6392 | 0.6359 |
Onchocerca volvulus | Adenosine deaminase homolog | 0.3978 | 1 | 1 |
Leishmania major | adenosine monophosphate deaminase, putative,AMP deaminase, putative | 0.2552 | 0.6392 | 0.6359 |
Leishmania major | AMP deaminase, putative,adenosine monophosphate deaminase-like protein | 0.2552 | 0.6392 | 0.6359 |
Loa Loa (eye worm) | hypothetical protein | 0.1638 | 0.4078 | 0.4065 |
Schistosoma mansoni | AMP deaminase | 0.2552 | 0.6392 | 0.6344 |
Loa Loa (eye worm) | hypothetical protein | 0.2341 | 0.5857 | 0.5848 |
Entamoeba histolytica | AMP deaminase, putative | 0.2552 | 0.6392 | 0.6344 |
Loa Loa (eye worm) | hypothetical protein | 0.2341 | 0.5857 | 0.5848 |
Plasmodium vivax | DNA topoisomerase II, putative | 0.0078 | 0.0132 | 0.0132 |
Schistosoma mansoni | adenosine deaminase-related | 0.3978 | 1 | 1 |
Trypanosoma cruzi | adenosine monophosphate deaminase-like protein, putative | 0.2552 | 0.6392 | 1 |
Onchocerca volvulus | 0.1638 | 0.4078 | 0.4032 | |
Onchocerca volvulus | AMP deaminase 2 homolog | 0.2552 | 0.6392 | 0.6364 |
Toxoplasma gondii | DNA topoisomerase 2, putative | 0.0078 | 0.0132 | 0.0132 |
Loa Loa (eye worm) | AMP deaminase | 0.2552 | 0.6392 | 0.6384 |
Plasmodium falciparum | AMP deaminase, putative | 0.2552 | 0.6392 | 0.6392 |
Giardia lamblia | DNA topoisomerase II | 0.0074 | 0.0123 | 0.5 |
Trypanosoma brucei | DNA topoisomerase II alpha, putative | 0.007 | 0.0112 | 0.0035 |
Echinococcus multilocularis | adenosine deaminase | 0.3978 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (binding) | = 1.9 uM | Inhibitory activity in a cell-free assay of DNA cleavage mediated by purified HeLa cell topoisomerase II. | ChEMBL. | No reference |
EC50 (binding) | = 1.9 uM | Inhibitory activity in a cell-free assay of DNA cleavage mediated by purified HeLa cell topoisomerase II. | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.