Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Toxoplasma gondii | Adenosine/AMP deaminase domain-containing protein | 0.3408 | 1 | 1 |
Onchocerca volvulus | Adenosine deaminase homolog | 0.3408 | 1 | 1 |
Mycobacterium tuberculosis | Probable adenosine deaminase Add (adenosine aminohydrolase) | 0.3408 | 1 | 0.5 |
Trichomonas vaginalis | adenosine deaminase, putative | 0.3408 | 1 | 0.5 |
Trypanosoma cruzi | adenosine monophosphate deaminase-like protein, putative | 0.2218 | 0.1568 | 0.5 |
Trichomonas vaginalis | adenosine deaminase, putative | 0.3408 | 1 | 0.5 |
Trypanosoma cruzi | AMP deaminase, putative | 0.2218 | 0.1568 | 0.5 |
Trypanosoma cruzi | adenosine monophosphate deaminase, putative | 0.2218 | 0.1568 | 0.5 |
Plasmodium falciparum | adenosine deaminase | 0.3408 | 1 | 1 |
Trypanosoma brucei | AMP deaminase, putative | 0.2218 | 0.1568 | 0.5 |
Schistosoma mansoni | adenosine deaminase-related | 0.3408 | 1 | 1 |
Plasmodium vivax | adenosine deaminase, putative | 0.3408 | 1 | 1 |
Treponema pallidum | adenosine deaminase | 0.3408 | 1 | 0.5 |
Mycobacterium ulcerans | adenosine deaminase | 0.3408 | 1 | 0.5 |
Mycobacterium leprae | Probable adenosine deaminase Add (ADENOSINE AMINOHYDROLASE) | 0.3408 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.3408 | 1 | 1 |
Trypanosoma cruzi | AMP deaminase, putative | 0.2218 | 0.1568 | 0.5 |
Echinococcus granulosus | adenosine deaminase | 0.3408 | 1 | 1 |
Trypanosoma brucei | adenosine monophosphate deaminase, putative | 0.2218 | 0.1568 | 0.5 |
Trypanosoma cruzi | AMP deaminase, putative | 0.2218 | 0.1568 | 0.5 |
Entamoeba histolytica | adenosine deaminase, putative | 0.3408 | 1 | 1 |
Schistosoma mansoni | adenosine deaminase | 0.3408 | 1 | 1 |
Toxoplasma gondii | Adenosine/AMP deaminase domain-containing protein | 0.3408 | 1 | 1 |
Echinococcus multilocularis | adenosine deaminase | 0.3408 | 1 | 1 |
Leishmania major | adenine aminohydrolase | 0.3408 | 1 | 1 |
Trypanosoma cruzi | AMP deaminase, putative | 0.2218 | 0.1568 | 0.5 |
Loa Loa (eye worm) | AMP deaminase | 0.2218 | 0.1568 | 0.1568 |
Trypanosoma brucei | AMP deaminase, putative | 0.2218 | 0.1568 | 0.5 |
Trypanosoma brucei | AMP deaminase, putative | 0.2218 | 0.1568 | 0.5 |
Trypanosoma cruzi | AMP deaminase, putative | 0.2218 | 0.1568 | 0.5 |
Entamoeba histolytica | adenosine deaminase, putative | 0.3408 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (binding) | = 92 uM | Inhibitory activity in a cell-free assay of DNA cleavage mediated by purified HeLa cell topoisomerase II. | ChEMBL. | No reference |
EC50 (binding) | = 92 uM | Inhibitory activity in a cell-free assay of DNA cleavage mediated by purified HeLa cell topoisomerase II. | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.