Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0339 | 0.0937 | 0.5 | |
Brugia malayi | thymidylate synthase | 0.0339 | 0.0937 | 0.0937 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.0339 | 0.0937 | 0.0937 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0049 | 0.0097 | 0.0097 |
Schistosoma mansoni | hypothetical protein | 0.0166 | 0.0437 | 0.0437 |
Brugia malayi | Zinc finger, C2H2 type family protein | 0.0304 | 0.0835 | 0.0835 |
Loa Loa (eye worm) | thymidylate synthase | 0.0339 | 0.0937 | 0.0937 |
Schistosoma mansoni | hypothetical protein | 0.0033 | 0.0052 | 0.0052 |
Brugia malayi | Dihydrofolate reductase | 0.3469 | 1 | 1 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.1795 | 0.5151 | 1 |
Brugia malayi | hypothetical protein | 0.0035 | 0.0057 | 0.0057 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0049 | 0.0097 | 0.0097 |
Echinococcus multilocularis | geminin | 0.0166 | 0.0437 | 0.0437 |
Schistosoma mansoni | hypothetical protein | 0.0035 | 0.0057 | 0.0057 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0339 | 0.0937 | 0.0937 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.0057 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.0057 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0052 | 0.0052 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0161 | 0.0422 | 0.5 |
Echinococcus multilocularis | zinc finger transcription factor gli2 | 0.0304 | 0.0835 | 0.0835 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.1795 | 0.5151 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0166 | 0.0437 | 0.0437 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase, putative | 0.0161 | 0.0422 | 0.0819 |
Loa Loa (eye worm) | zinc finger protein | 0.0304 | 0.0835 | 0.0835 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0033 | 0.0052 | 0.0052 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.3469 | 1 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.0057 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.0097 | 0.0097 |
Echinococcus granulosus | thymidylate synthase | 0.0339 | 0.0937 | 0.0937 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.3469 | 1 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0049 | 0.0097 | 0.0097 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.3469 | 1 | 1 |
Chlamydia trachomatis | dihydrofolate reductase | 0.3469 | 1 | 0.5 |
Schistosoma mansoni | dihydrofolate reductase | 0.3469 | 1 | 1 |
Echinococcus granulosus | dihydrofolate reductase | 0.3469 | 1 | 1 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0035 | 0.0057 | 0.0057 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.3469 | 1 | 1 |
Mycobacterium tuberculosis | Hypothetical protein | 0.0161 | 0.0422 | 0.0422 |
Echinococcus multilocularis | thymidylate synthase | 0.0339 | 0.0937 | 0.0937 |
Echinococcus granulosus | zinc finger transcription factor gli2 | 0.0304 | 0.0835 | 0.0835 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.1795 | 0.5151 | 1 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.1795 | 0.5151 | 1 |
Echinococcus multilocularis | dihydrofolate reductase | 0.3469 | 1 | 1 |
Echinococcus granulosus | geminin | 0.0166 | 0.0437 | 0.0437 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.1795 | 0.5151 | 1 |
Brugia malayi | hypothetical protein | 0.0161 | 0.0422 | 0.0422 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.0057 | 0.5 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.1795 | 0.5151 | 1 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0035 | 0.0057 | 0.0057 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0035 | 0.0057 | 0.0057 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (binding) | = 0 % | In vitro inhibitory activity against H1N9 strain of Influenza neuraminidase (membrane) at 7 mM concentration | ChEMBL. | 9406595 |
Inhibition (binding) | = 0 % | In vitro inhibitory activity against H1N9 strain of Influenza neuraminidase (membrane) at 7 mM concentration | ChEMBL. | 9406595 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.