Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | coagulation factor III (thromboplastin, tissue factor) | References | |
Homo sapiens | coagulation factor II (thrombin) | Starlite/ChEMBL | References |
Homo sapiens | coagulation factor VII (serum prothrombin conversion accelerator) | References | |
Homo sapiens | Coagulation factor VII/tissue factor | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus granulosus | glycoprotein Antigen 5 | coagulation factor VII (serum prothrombin conversion accelerator) | 466 aa | 384 aa | 23.7 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Dihydrofolate reductase | 0.62 | 1 | 1 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.4243 | 0.6764 | 0.5 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.62 | 1 | 1 |
Echinococcus granulosus | dihydrofolate reductase | 0.62 | 1 | 1 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.4243 | 0.6764 | 0.5 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.4243 | 0.6764 | 0.5 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.62 | 1 | 1 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.4243 | 0.6764 | 0.5 |
Chlamydia trachomatis | dihydrofolate reductase | 0.62 | 1 | 0.5 |
Onchocerca volvulus | 0.115 | 0.1648 | 1 | |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.62 | 1 | 1 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.62 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0547 | 0.065 | 0.5 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.115 | 0.1648 | 0.1067 |
Schistosoma mansoni | dihydrofolate reductase | 0.62 | 1 | 1 |
Brugia malayi | thymidylate synthase | 0.115 | 0.1648 | 0.1067 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.4243 | 0.6764 | 1 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.4243 | 0.6764 | 0.5 |
Echinococcus multilocularis | dihydrofolate reductase | 0.62 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.9 uM | Inhibitory activity against tissue coagulation factor VII complex was determined (TF/VIIa complex) | ChEMBL. | 12954058 |
IC50 (binding) | = 0.9 uM | Inhibitory activity against tissue coagulation factor VII complex was determined (TF/VIIa complex) | ChEMBL. | 12954058 |
IC50 (binding) | = 1.2 uM | Inhibitory activity against thrombin (IIa) was determined | ChEMBL. | 12954058 |
IC50 (binding) | = 1.2 uM | Inhibitory activity against thrombin (IIa) was determined | ChEMBL. | 12954058 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.