Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | O-6-methylguanine-DNA methyltransferase | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.3442 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0159 | 0.0375 | 0.0374 |
Brugia malayi | thymidylate synthase | 0.0665 | 0.1858 | 0.1857 |
Chlamydia trachomatis | dihydrofolate reductase | 0.3442 | 1 | 1 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.3442 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0159 | 0.0375 | 0.0374 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.009 | 0.0173 | 0.0272 |
Echinococcus granulosus | thymidylate synthase | 0.0665 | 0.1858 | 0.182 |
Schistosoma mansoni | chromobox protein | 0.0047 | 0.0046 | 0.0042 |
Trypanosoma brucei | mitochondrial DNA polymerase beta-PAK | 0.009 | 0.0173 | 0.0279 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.2148 | 0.6207 | 0.5 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.0665 | 0.1858 | 0.1345 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0159 | 0.0375 | 0.033 |
Mycobacterium tuberculosis | Methylated-DNA--protein-cysteine methyltransferase Ogt (6-O-methylguanine-DNA methyltransferase) (O-6-methylguanine-DNA-alkyltra | 0.0233 | 0.0592 | 0.0397 |
Treponema pallidum | methylated-DNA-protein-cysteine S-methyltransferase (dat) | 0.0077 | 0.0133 | 0.5 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.2148 | 0.6207 | 1 |
Leishmania major | mitochondrial DNA polymerase beta-PAK, putative | 0.009 | 0.0173 | 0.0065 |
Trypanosoma brucei | mitochondrial DNA polymerase beta | 0.0191 | 0.0467 | 0.0753 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.0665 | 0.1858 | 0.1689 |
Schistosoma mansoni | dihydrofolate reductase | 0.3442 | 1 | 1 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0159 | 0.0375 | 0.033 |
Mycobacterium ulcerans | hypothetical protein | 0.01 | 0.0203 | 0.0203 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0191 | 0.0467 | 0.0746 |
Mycobacterium tuberculosis | Hypothetical protein | 0.0316 | 0.0836 | 0.0646 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0665 | 0.1858 | 0.1855 |
Mycobacterium ulcerans | thymidylate synthase | 0.0665 | 0.1858 | 0.1858 |
Onchocerca volvulus | 0.0665 | 0.1858 | 1 | |
Leishmania major | mitochondrial DNA polymerase beta | 0.0191 | 0.0467 | 0.055 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.3442 | 1 | 1 |
Loa Loa (eye worm) | heterochromatin protein 1 | 0.0047 | 0.0046 | 0.0045 |
Mycobacterium ulcerans | methylated-DNA--protein-cysteine methyltransferase Ogt | 0.0233 | 0.0592 | 0.0592 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.2148 | 0.6207 | 1 |
Brugia malayi | Heterochromatin protein 1 | 0.0047 | 0.0046 | 0.0045 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.3442 | 1 | 1 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.2148 | 0.6207 | 1 |
Trichomonas vaginalis | methylated-DNA--protein-cysteine methyltransferase, putative | 0.0077 | 0.0133 | 0.1107 |
Echinococcus granulosus | dihydrofolate reductase | 0.3442 | 1 | 1 |
Echinococcus multilocularis | dihydrofolate reductase | 0.3442 | 1 | 1 |
Schistosoma mansoni | chromobox protein | 0.0047 | 0.0046 | 0.0042 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.2148 | 0.6207 | 0.5 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0191 | 0.0467 | 0.0746 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.0032 | 0.0004 | 0.0003 |
Loa Loa (eye worm) | thymidylate synthase | 0.0665 | 0.1858 | 0.1857 |
Trypanosoma cruzi | O-6 methyl-guanine alkyl transferase, putative | 0.0077 | 0.0133 | 0.0208 |
Brugia malayi | hypothetical protein | 0.0316 | 0.0836 | 0.0835 |
Brugia malayi | Dihydrofolate reductase | 0.3442 | 1 | 1 |
Echinococcus multilocularis | thymidylate synthase | 0.0665 | 0.1858 | 0.182 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.2148 | 0.6207 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0316 | 0.0836 | 1 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase, putative | 0.0316 | 0.0836 | 0.134 |
Trypanosoma cruzi | O-6 methyl-guanine alkyl transferase, putative | 0.0077 | 0.0133 | 0.0208 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.