Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | trypanothione reductase, putative | 0.0019 | 0.0145 | 0.0875 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0027 | 0.0361 | 0.438 |
Entamoeba histolytica | hypothetical protein | 0.0071 | 0.1477 | 1 |
Schistosoma mansoni | dihydrolipoamide dehydrogenase | 0.0019 | 0.0145 | 0.036 |
Toxoplasma gondii | pyruvate dehydrogenase complex subunit PDH-E3II | 0.0019 | 0.0145 | 0.1398 |
Entamoeba histolytica | hypothetical protein | 0.0071 | 0.1477 | 1 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0123 | 0.2778 | 0.8837 |
Plasmodium vivax | glutathione reductase, putative | 0.0054 | 0.1034 | 1 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0027 | 0.0355 | 0.4297 |
Trypanosoma brucei | dihydrolipoyl dehydrogenase | 0.0019 | 0.0145 | 0.0875 |
Trypanosoma brucei | phosphatidylinositol 3-kinase tor, putative | 0.0022 | 0.0218 | 0.1626 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0019 | 0.0145 | 0.5 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0025 | 0.0294 | 0.3565 |
Echinococcus multilocularis | tumor protein p63 | 0.0408 | 1 | 1 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0019 | 0.0145 | 0.0875 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0025 | 0.0295 | 0.3576 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0123 | 0.2778 | 0.8837 |
Entamoeba histolytica | hypothetical protein | 0.0071 | 0.1477 | 1 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0047 | 0.0851 | 0.1016 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0036 | 0.0589 | 0.7143 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0034 | 0.053 | 0.6422 |
Brugia malayi | MH2 domain containing protein | 0.0121 | 0.2734 | 0.3265 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0025 | 0.0294 | 0.3565 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0071 | 0.1477 | 0.368 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0027 | 0.0361 | 0.438 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0025 | 0.0295 | 0.3576 |
Echinococcus granulosus | dihydrolipoamide dehydrogenase | 0.0019 | 0.0145 | 0.0145 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0019 | 0.0145 | 0.5 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0019 | 0.0145 | 0.0875 |
Toxoplasma gondii | NADPH-glutathione reductase | 0.0019 | 0.0145 | 0.1398 |
Echinococcus granulosus | GPCR family 2 | 0.0047 | 0.0851 | 0.0851 |
Schistosoma mansoni | hypothetical protein | 0.0047 | 0.0851 | 0.2119 |
Brugia malayi | Phosphatidylinositol 3- and 4-kinase family protein | 0.0046 | 0.0825 | 0.0985 |
Echinococcus multilocularis | Mitotic checkpoint protein PRCC, C terminal | 0.0128 | 0.2901 | 0.2901 |
Entamoeba histolytica | hypothetical protein | 0.0071 | 0.1477 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0147 | 0.3395 | 0.4055 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0136 | 0.3125 | 1 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0015 | 0.0059 | 0.0719 |
Plasmodium falciparum | dihydrolipoyl dehydrogenase, apicoplast | 0.0019 | 0.0145 | 0.1398 |
Brugia malayi | hypothetical protein | 0.0071 | 0.1477 | 0.1764 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.1184 | 0.1414 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0027 | 0.0361 | 0.438 |
Schistosoma mansoni | ataxia telangiectasia mutated (atm)-related | 0.0046 | 0.0825 | 0.2056 |
Schistosoma mansoni | hypothetical protein | 0.0047 | 0.0851 | 0.2119 |
Mycobacterium ulcerans | flavoprotein disulfide reductase | 0.0019 | 0.0145 | 0.5 |
Trypanosoma brucei | phosphatidylinositol 4-kinase, putative | 0.0046 | 0.0825 | 0.7856 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0047 | 0.0851 | 0.1016 |
Trypanosoma brucei | Phosphatidylinositol 3-kinase tor1 | 0.0046 | 0.0825 | 0.7856 |
Loa Loa (eye worm) | hypothetical protein | 0.0101 | 0.2218 | 0.2648 |
Brugia malayi | dihydrolipoyl dehydrogenase, mitochondrial precursor, putative | 0.0019 | 0.0145 | 0.0173 |
Treponema pallidum | NADH oxidase | 0.0019 | 0.0145 | 0.5 |
Trypanosoma brucei | dihydrolipoamide dehydrogenase, point mutation | 0.0019 | 0.0145 | 0.0875 |
Echinococcus multilocularis | dihydrolipoamide dehydrogenase | 0.0019 | 0.0145 | 0.0145 |
Onchocerca volvulus | 0.006 | 0.1184 | 0.1414 | |
Echinococcus granulosus | phosphatidylinositol 3 and 4 kinase | 0.0015 | 0.0059 | 0.0059 |
Schistosoma mansoni | hypothetical protein | 0.0128 | 0.2901 | 0.7226 |
Brugia malayi | Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein | 0.0014 | 0.0019 | 0.0023 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0031 | 0.0446 | 0.5403 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0036 | 0.0589 | 0.7143 |
Plasmodium falciparum | glutathione reductase | 0.0054 | 0.1034 | 1 |
Echinococcus multilocularis | GPCR, family 2 | 0.0047 | 0.0851 | 0.0851 |
Trypanosoma brucei | FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative | 0.0019 | 0.0151 | 0.0945 |
Brugia malayi | alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase | 0.0014 | 0.0019 | 0.0023 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0047 | 0.0851 | 0.1016 |
Brugia malayi | hypothetical protein | 0.0344 | 0.8374 | 1 |
Plasmodium falciparum | dihydrolipoyl dehydrogenase, mitochondrial | 0.0019 | 0.0145 | 0.1398 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0123 | 0.2778 | 0.8837 |
Loa Loa (eye worm) | phosphatidylinositol 3 | 0.0015 | 0.0059 | 0.0071 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0121 | 0.2734 | 0.3265 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0015 | 0.0059 | 0.0719 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.003 | 0.0421 | 0.5101 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0046 | 0.0825 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0101 | 0.2218 | 0.5524 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0138 | 0.316 | 0.316 |
Leishmania major | dihydrolipoamide dehydrogenase, putative | 0.0019 | 0.0145 | 0.0875 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0136 | 0.3125 | 1 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0046 | 0.0825 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0147 | 0.3395 | 0.4055 |
Loa Loa (eye worm) | phosphatidylinositol 3 | 0.0046 | 0.0825 | 0.0985 |
Trypanosoma cruzi | dihydrolipoyl dehydrogenase, putative | 0.0019 | 0.0145 | 0.0875 |
Leishmania major | trypanothione reductase | 0.0054 | 0.1034 | 1 |
Plasmodium falciparum | thioredoxin reductase | 0.0054 | 0.1034 | 1 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0034 | 0.053 | 0.6422 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0025 | 0.0295 | 0.3576 |
Trypanosoma brucei | target of rapamycin kinase 3, putative | 0.0036 | 0.059 | 0.5447 |
Schistosoma mansoni | phosphatidylinositol 3-and 4-kinase | 0.0015 | 0.0059 | 0.0148 |
Brugia malayi | Phosphatidylinositol 3- and 4-kinase family protein | 0.0015 | 0.0059 | 0.0071 |
Plasmodium falciparum | thioredoxin reductase | 0.0019 | 0.0145 | 0.1398 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0071 | 0.1477 | 0.1477 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase | 0.0019 | 0.0145 | 0.5 |
Toxoplasma gondii | target of rapamycin (TOR), putative | 0.0034 | 0.053 | 0.5124 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0019 | 0.0145 | 0.0875 |
Plasmodium vivax | dihydrolipoyl dehydrogenase, mitochondrial, putative | 0.0019 | 0.0145 | 0.1398 |
Trypanosoma cruzi | Phosphatidylinositol 3-kinase tor1 | 0.0046 | 0.0825 | 0.7856 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0034 | 0.053 | 0.6422 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0025 | 0.0294 | 0.3565 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0015 | 0.0059 | 0.0719 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0047 | 0.0851 | 0.0851 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0039 | 0.0657 | 0.7958 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase, LpdB | 0.0019 | 0.0145 | 0.5 |
Schistosoma mansoni | cellular tumor antigen P53 | 0.006 | 0.1184 | 0.295 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0019 | 0.0145 | 0.0875 |
Giardia lamblia | GTOR | 0.0046 | 0.0825 | 1 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0036 | 0.0589 | 0.7143 |
Schistosoma mansoni | hypothetical protein | 0.0071 | 0.1477 | 0.368 |
Trypanosoma cruzi | dihydrolipoyl dehydrogenase, putative | 0.0019 | 0.0145 | 0.0875 |
Echinococcus multilocularis | FKBP12 rapamycin complex associated protein | 0.0046 | 0.0825 | 0.0825 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0034 | 0.053 | 0.6422 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0054 | 0.1034 | 0.2985 |
Brugia malayi | glutathione reductase | 0.0054 | 0.1034 | 0.1235 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0034 | 0.053 | 0.6422 |
Trypanosoma cruzi | Phosphatidylinositol 3-kinase tor2 | 0.0046 | 0.0825 | 0.7856 |
Leishmania major | target of rapamycin (TOR) kinase 2, putative | 0.0046 | 0.0825 | 0.7856 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0054 | 0.1034 | 0.1034 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0047 | 0.0851 | 0.0851 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0034 | 0.053 | 0.6422 |
Brugia malayi | Thioredoxin reductase | 0.0054 | 0.1034 | 0.1235 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0047 | 0.0851 | 0.0851 |
Schistosoma mansoni | thyroid hormone receptor | 0.0138 | 0.316 | 0.7872 |
Loa Loa (eye worm) | hypothetical protein | 0.0344 | 0.8374 | 1 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0054 | 0.1034 | 1 |
Leishmania major | target of rapamycin kinase (TOR) kinase 3 | 0.0036 | 0.059 | 0.5447 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0036 | 0.0589 | 0.7143 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0147 | 0.3395 | 0.4055 |
Leishmania major | dihydrolipoamide dehydrogenase, putative | 0.0019 | 0.0145 | 0.0875 |
Leishmania major | 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein | 0.0019 | 0.0145 | 0.0875 |
Trypanosoma brucei | dihydrolipoamide dehydrogenase | 0.0019 | 0.0145 | 0.0875 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0101 | 0.2218 | 0.2648 |
Loa Loa (eye worm) | glutathione reductase | 0.0054 | 0.1034 | 0.1235 |
Plasmodium falciparum | glutathione reductase | 0.0019 | 0.0145 | 0.1398 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0015 | 0.0059 | 0.0719 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0121 | 0.2734 | 0.3265 |
Mycobacterium tuberculosis | Probable reductase | 0.0123 | 0.2778 | 0.8837 |
Leishmania major | acetoin dehydrogenase e3 component-like protein | 0.0019 | 0.0145 | 0.0875 |
Trypanosoma brucei | trypanothione reductase | 0.0054 | 0.1034 | 1 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0025 | 0.0295 | 0.3576 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0054 | 0.1034 | 0.1235 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0123 | 0.2778 | 0.8837 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0019 | 0.0145 | 0.0875 |
Leishmania major | target of rapamycin (TOR) kinase 1, putative | 0.0046 | 0.0825 | 0.7856 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0027 | 0.0355 | 0.4297 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0136 | 0.3125 | 1 |
Plasmodium vivax | dihydrolipoyl dehydrogenase, apicoplast, putative | 0.0019 | 0.0145 | 0.1398 |
Chlamydia trachomatis | dihydrolipoyl dehydrogenase | 0.0019 | 0.0145 | 1 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0071 | 0.1477 | 0.1477 |
Loa Loa (eye worm) | hypothetical protein | 0.0047 | 0.0851 | 0.1016 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0047 | 0.0851 | 0.0851 |
Echinococcus granulosus | FKBP12 rapamycin complex associated protein | 0.0046 | 0.0825 | 0.0825 |
Schistosoma mansoni | thyroid hormone receptor | 0.0138 | 0.316 | 0.7872 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0054 | 0.1034 | 1 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0123 | 0.2778 | 0.8837 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0147 | 0.3395 | 0.4055 |
Onchocerca volvulus | 0.0344 | 0.8374 | 1 | |
Schistosoma mansoni | hypothetical protein | 0.0047 | 0.0851 | 0.2119 |
Trypanosoma cruzi | target of rapamycin kinase 3 | 0.0036 | 0.059 | 0.5447 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0054 | 0.1034 | 0.1034 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0019 | 0.0145 | 0.0875 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0015 | 0.0059 | 0.0719 |
Toxoplasma gondii | thioredoxin reductase | 0.0054 | 0.1034 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0047 | 0.0851 | 0.2119 |
Trichomonas vaginalis | mercuric reductase, putative | 0.0019 | 0.0145 | 0.1753 |
Trichomonas vaginalis | glutathione reductase, putative | 0.0019 | 0.0145 | 0.1753 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0136 | 0.3125 | 1 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0034 | 0.053 | 0.6422 |
Trypanosoma brucei | dihydrolipoamide dehydrogenase | 0.0019 | 0.0145 | 0.0875 |
Echinococcus multilocularis | phosphatidylinositol 3 and 4 kinase | 0.0015 | 0.0059 | 0.0059 |
Echinococcus granulosus | Mitotic checkpoint protein PRCC C terminal | 0.0128 | 0.2901 | 0.2901 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0036 | 0.0589 | 0.7143 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0046 | 0.0825 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 200 nM | Homogenous Time-Resolved Fluorescence Assay (HTRF1 Assay) | BINDINGDB. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.