CC50 (functional)
|
= 4.1 uM
|
Compound concentration required to reduce the exponential growth of MT-4 cells by 50%
|
ChEMBL.
|
9767632
|
CC50 (functional)
|
= 4.1 uM
|
Compound concentration required to reduce the exponential growth of MT-4 cells by 50%
|
ChEMBL.
|
9767632
|
CC50 (functional)
|
= 6.7 uM
|
Compound concentration required to reduce the exponential growth of KB cells by 50%
|
ChEMBL.
|
9767632
|
CC50 (functional)
|
= 6.7 uM
|
Compound concentration required to reduce the exponential growth of KB cells by 50%
|
ChEMBL.
|
9767632
|
Fold increase (functional)
|
= 1.1
|
Fold increase in protein-linked DNA breaks (PLDB) with respect to untreated controls.
|
ChEMBL.
|
9767632
|
GI50 (functional)
|
= 1.5 uM
|
Growth inhibition of human HCT116 cells after 48 hrs by MTS assay
|
ChEMBL.
|
20060305
|
GI50 (functional)
|
= 2 uM
|
Cytotoxicity against human DLD1 cells
|
ChEMBL.
|
20060305
|
IC50 (binding)
|
= -4
|
Inhibitory activity against HIV-1 Integrase (HIV-1-IN)
|
ChEMBL.
|
11831895
|
IC50 (functional)
|
= 1.6 uM
|
Antiproliferative activity against human MDA-MB-231 cells after 72 hrs by MTT assay
|
ChEMBL.
|
19249204
|
IC50 (functional)
|
= 1.69 uM
|
Antiplasmodial activity against blood stage of chloroquine-resistant Plasmodium falciparum isolate RKL9 infected in human O positive erythrocytes after 48 hrs by SYBR green I-based fluorescence assay
|
ChEMBL.
|
21493068
|
IC50 (functional)
|
= 1.83 uM
|
Antitumor activity against human K562 cells after 48 hrs by SRB assay
|
ChEMBL.
|
20696583
|
IC50 (functional)
|
= 1.86 uM
|
Antitumor activity against human NCI-H460 cells after 48 hrs by SRB assay
|
ChEMBL.
|
20696583
|
IC50 (functional)
|
= 1.97 uM
|
Antiplasmodial activity against blood stage of chloroquine-sensitive Plasmodium falciparum 3D7 infected in human O positive erythrocytes after 48 hrs by SYBR green-I based fluorescence assay
|
ChEMBL.
|
21493068
|
IC50 (functional)
|
= 2 uM
|
Antitumor activity against human MCF7 cells after 48 hrs by SRB assay
|
ChEMBL.
|
20696583
|
IC50 (functional)
|
= 2.12 uM
|
Antitumor activity against human UACC62 cells after 48 hrs by SRB assay
|
ChEMBL.
|
20696583
|
IC50 (functional)
|
= 2.2 uM
|
Antiproliferative activity against human LNCAP cells after 72 hrs by MTT assay
|
ChEMBL.
|
19249204
|
IC50 (functional)
|
= 2.32 uM
|
Antitumor activity against human PC3 cells after 48 hrs by SRB assay
|
ChEMBL.
|
20696583
|
IC50 (functional)
|
= 2.32 uM
|
Antitumor activity against human OVCAR-3 cells after 48 hrs by SRB assay
|
ChEMBL.
|
20696583
|
IC50 (functional)
|
= 2.43 uM
|
Antitumor activity against human HT-29 cells after 48 hrs by SRB assay
|
ChEMBL.
|
20696583
|
IC50 (functional)
|
= 2.5 uM
|
Antiproliferative activity against human MCF7 cells after 72 hrs by MTT assay
|
ChEMBL.
|
19249204
|
IC50 (functional)
|
= 2.9 uM
|
Antiproliferative activity against human PC3 cells after 72 hrs by MTT assay
|
ChEMBL.
|
19249204
|
IC50 (functional)
|
= 2.98 uM
|
Cytotoxicity against human PC3 cells after 72 hrs by MTT assay
|
ChEMBL.
|
22551677
|
IC50 (functional)
|
= 3.4 uM
|
Cytotoxicity against human LNCaP cell line
|
ChEMBL.
|
16789753
|
IC50 (functional)
|
= 3.4 uM
|
Cytotoxicity against human LNCaP cell line
|
ChEMBL.
|
16789753
|
IC50 (functional)
|
= 3.8 uM
|
Cytotoxicity against human PC3 cell line
|
ChEMBL.
|
16789753
|
IC50 (functional)
|
= 3.8 uM
|
Cytotoxicity against human PC3 cell line
|
ChEMBL.
|
16789753
|
IC50 (functional)
|
= 39.94 uM
|
Antiproliferative activity against human MCF7 cells after 72 hrs by MTT assay
|
ChEMBL.
|
25728027
|
IC50 (binding)
|
> 100 uM
|
Compound concentration required to reduce HIV-1 Integrase 3'-processing activity by 50%
|
ChEMBL.
|
9767632
|
IC50 (binding)
|
> 100 uM
|
Compound concentration required to reduce HIV-1 Integrase 3'-processing activity by 50%
|
ChEMBL.
|
9767632
|
Log IC50 (binding)
|
= 4
|
Inhibitory activity against HIV-1 Integrase (HIV-1-IN)
|
ChEMBL.
|
11831895
|
Ratio IC50 (functional)
|
= 0.85
|
Resistance index, ratio for IC50 for chloroquine-resistant Plasmodium falciparum isolate RKL9 to IC50 for chloroquine-sensitive Plasmodium falciparum 3D7
|
ChEMBL.
|
21493068
|
TC50 (ADMET)
|
= 282.16 uM
|
Cytotoxic activity against human HeLa cells after 24 to 48 hrs by MTT assay
|
ChEMBL.
|
21493068
|