Detailed information for compound 225728

Basic information

Technical information
  • TDR Targets ID: 225728
  • Name: [3-[[methyl-[3-(9-oxoxanthen-3-yl)oxypropyl]a mino]methyl]phenyl] N-butylcarbamate
  • MW: 488.575 | Formula: C29H32N2O5
  • H donors: 1 H acceptors: 2 LogP: 5.65 Rotable bonds: 13
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCCNC(=O)Oc1cccc(c1)CN(CCCOc1ccc2c(c1)oc1c(c2=O)cccc1)C
  • InChi: 1S/C29H32N2O5/c1-3-4-15-30-29(33)35-23-10-7-9-21(18-23)20-31(2)16-8-17-34-22-13-14-25-27(19-22)36-26-12-6-5-11-24(26)28(25)32/h5-7,9-14,18-19H,3-4,8,15-17,20H2,1-2H3,(H,30,33)
  • InChiKey: XXYOHHNGEKCFAK-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-butylcarbamic acid [3-[[methyl-[3-[(9-oxo-3-xanthenyl)oxy]propyl]amino]methyl]phenyl] ester
  • N-butylcarbamic acid [3-[[3-(9-ketoxanthen-3-yl)oxypropyl-methyl-amino]methyl]phenyl] ester

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens acetylcholinesterase (Yt blood group) Starlite/ChEMBL References
Rattus norvegicus Acetylcholinesterase Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis acetylcholinesterase Get druggable targets OG5_126875 All targets in OG5_126875
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) Get druggable targets OG5_126875 All targets in OG5_126875
Schistosoma japonicum ko:K01049 acetylcholinesterase [EC3.1.1.7], putative Get druggable targets OG5_126875 All targets in OG5_126875
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126875 All targets in OG5_126875
Loa Loa (eye worm) carboxylesterase Get druggable targets OG5_126875 All targets in OG5_126875
Echinococcus multilocularis acetylcholinesterase Get druggable targets OG5_126875 All targets in OG5_126875
Echinococcus granulosus acetylcholinesterase Get druggable targets OG5_126875 All targets in OG5_126875
Echinococcus granulosus acetylcholinesterase Get druggable targets OG5_126875 All targets in OG5_126875
Echinococcus multilocularis carboxylesterase 5A Get druggable targets OG5_126875 All targets in OG5_126875
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126875 All targets in OG5_126875
Echinococcus granulosus carboxylesterase 5A Get druggable targets OG5_126875 All targets in OG5_126875
Loa Loa (eye worm) acetylcholinesterase 1 Get druggable targets OG5_126875 All targets in OG5_126875
Brugia malayi Carboxylesterase family protein Get druggable targets OG5_126875 All targets in OG5_126875
Brugia malayi Carboxylesterase family protein Get druggable targets OG5_126875 All targets in OG5_126875
Schistosoma japonicum Acetylcholinesterase 1 precursor, putative Get druggable targets OG5_126875 All targets in OG5_126875
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi Carboxylesterase family protein acetylcholinesterase (Yt blood group) 614 aa 510 aa 26.5 %
Onchocerca volvulus Carnitine O-palmitoyltransferase 2, mitochondrial homolog Acetylcholinesterase   614 aa 531 aa 39.7 %
Onchocerca volvulus Acetylcholinesterase   614 aa 583 aa 30.7 %
Onchocerca volvulus Molybdopterin synthase catalytic subunit homolog Acetylcholinesterase   614 aa 564 aa 29.8 %
Echinococcus multilocularis neuroligin Acetylcholinesterase   614 aa 496 aa 24.0 %
Brugia malayi Carboxylesterase family protein Acetylcholinesterase   614 aa 507 aa 26.4 %
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) Acetylcholinesterase   614 aa 602 aa 24.3 %
Onchocerca volvulus Putative nuclear protein Acetylcholinesterase   614 aa 577 aa 40.7 %
Loa Loa (eye worm) hypothetical protein Acetylcholinesterase   614 aa 574 aa 24.0 %
Echinococcus granulosus BC026374 protein S09 family Acetylcholinesterase   614 aa 642 aa 34.1 %
Onchocerca volvulus Acetylcholinesterase   614 aa 632 aa 25.6 %
Drosophila melanogaster CG10175 gene product from transcript CG10175-RE Acetylcholinesterase   614 aa 547 aa 32.5 %
Loa Loa (eye worm) hypothetical protein Acetylcholinesterase   614 aa 570 aa 25.4 %
Echinococcus multilocularis BC026374 protein (S09 family) Acetylcholinesterase   614 aa 642 aa 34.0 %
Onchocerca volvulus Acetylcholinesterase   614 aa 581 aa 27.0 %
Brugia malayi Carboxylesterase family protein Acetylcholinesterase   614 aa 573 aa 30.5 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus hypothetical protein 0.0028 0.0003 0.0003
Loa Loa (eye worm) matrixin family protein 0.079 0.0415 0.0414
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0033 0.0006 0.0005
Brugia malayi Helix-loop-helix DNA-binding domain containing protein 0.0039 0.0009 0.0007
Toxoplasma gondii isocitrate dehydrogenase 0.0033 0.0006 0.0009
Trypanosoma cruzi DNA polymerase eta, putative 0.0038 0.0008 0.0018
Schistosoma mansoni transcription factor LCR-F1 0.0117 0.0051 0.0049
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.0008 0.0246
Mycobacterium ulcerans short chain dehydrogenase 0.0028 0.0003 0.0003
Brugia malayi Carboxylesterase family protein 0.0028 0.0003 0.0001
Toxoplasma gondii NAC domain-containing protein 0.0037 0.0008 0.0014
Leishmania major quinonoid dihydropteridine reductase 0.0028 0.0003 0.0003
Brugia malayi hypothetical protein 0.059 0.0307 0.0305
Loa Loa (eye worm) hypothetical protein 0.004 0.0009 0.0009
Brugia malayi Matrixin family protein 0.079 0.0415 0.0413
Echinococcus multilocularis acetylcholinesterase 0.0164 0.0076 0.0076
Schistosoma mansoni steroid dehydrogenase 0.0028 0.0003 0.0001
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0036 0.0007 0.0012
Trypanosoma brucei trypanothione reductase 0.0103 0.0043 0.0095
Schistosoma mansoni lipoxygenase 0.0235 0.0115 0.0113
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.003 0.0004 0.0005
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0082 0.0032 0.0032
Entamoeba histolytica hypothetical protein, conserved 0.0028 0.0003 0.0183
Plasmodium vivax glutathione reductase, putative 0.0103 0.0043 0.0093
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0002 0.0004
Schistosoma mansoni thyroid hormone receptor 0.0078 0.003 0.0028
Echinococcus multilocularis importin subunit beta 1 0.0064 0.0022 0.0022
Schistosoma mansoni steroid dehydrogenase 0.0028 0.0003 0.0001
Mycobacterium ulcerans dihydrofolate reductase DfrA 1.8528 1 1
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.007 0.0025 0.0025
Loa Loa (eye worm) hypothetical protein 0.0327 0.0164 0.0164
Trypanosoma brucei beta-ketoacyl-ACP reductase 2 0.0028 0.0003 0.0004
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0037 0.0007 0.0006
Giardia lamblia High cysteine protein 0.0032 0.0005 0.0485
Plasmodium vivax basic transcription factor 3b, putative 0.0037 0.0008 0.0014
Mycobacterium ulcerans short chain dehydrogenase 0.0028 0.0003 0.0003
Toxoplasma gondii NADPH-glutathione reductase 0.0036 0.0007 0.0012
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0028 0.0003 0.0003
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0082 0.0032 0.0025
Brugia malayi EGF-like domain containing protein 0.0032 0.0005 0.0004
Trypanosoma brucei Pyrophosphate-energized vacuolar membrane proton pump 2, putative 0.0354 0.0179 0.0396
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0028 0.0003 0.0003
Trypanosoma brucei folylpolyglutamate synthase, putative 0.0426 0.0218 0.0483
Leishmania major ATP-binding cassette protein subfamily C, member 6, putative 0.003 0.0004 0.0006
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0036 0.0007 0.0012
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0036 0.0007 0.0007
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0037 0.0007 0.0007
Echinococcus granulosus fibrillin 1 0.0032 0.0005 0.0005
Brugia malayi multidrug resistance related protein 1 0.003 0.0004 0.0002
Echinococcus granulosus caspase 3 0.0077 0.0029 0.0029
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0033 0.0006 0.0005
Echinococcus granulosus Nuclear hormone receptor HR96 0.0037 0.0007 0.0007
Wolbachia endosymbiont of Brugia malayi enoyl-ACP reductase 0.0064 0.0022 0.653
Loa Loa (eye worm) hypothetical protein 0.004 0.0009 0.0009
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0028 0.0003 0.0003
Echinococcus granulosus BC026374 protein S09 family 0.0028 0.0003 0.0002
Loa Loa (eye worm) hypothetical protein 0.0164 0.0076 0.0076
Loa Loa (eye worm) matrixin family protein 0.0725 0.0379 0.0379
Leishmania major quinonoid dihydropteridine reductase 0.0028 0.0003 0.0003
Brugia malayi hypothetical protein 0.0039 0.0009 0.0007
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0036 0.0007 0.1415
Loa Loa (eye worm) CXXC zinc finger family protein 0.003 0.0004 0.0004
Schistosoma mansoni steroid dehydrogenase 0.0028 0.0003 0.0001
Schistosoma mansoni RAR-like nuclear receptor 0.0078 0.003 0.0028
Loa Loa (eye worm) reprolysin 0.0099 0.0041 0.0041
Loa Loa (eye worm) hypothetical protein 0.0107 0.0046 0.0045
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0028 0.0003 0.0089
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0153 0.007 0.0069
Trypanosoma brucei transcription factor BTF3, putative 0.0037 0.0008 0.0015
Leishmania major DNA polymerase kappa, putative 0.0043 0.0011 0.0021
Echinococcus multilocularis GPCR, family 2 0.0034 0.0006 0.0006
Giardia lamblia Multidrug resistance-associated protein 1 0.003 0.0004 0.031
Mycobacterium tuberculosis Probable esterase LipL 0.004 0.0009 0.0009
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0036 0.0007 0.1415
Mycobacterium ulcerans short chain dehydrogenase 0.0028 0.0003 0.0003
Trypanosoma cruzi trypanothione reductase, putative 0.0036 0.0007 0.0015
Echinococcus multilocularis Polycystic kidney disease protein 0.0088 0.0035 0.0035
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.022 0.0107 0.0106
Loa Loa (eye worm) steroid hormone receptor 0.0078 0.003 0.0029
Brugia malayi Carboxylesterase family protein 0.0164 0.0076 0.0075
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.004 0.0009 0.0008
Loa Loa (eye worm) hypothetical protein 0.0039 0.0009 0.0008
Loa Loa (eye worm) hypothetical protein 0.0102 0.0043 0.0043
Leishmania major short chain dehydrogenase, putative 0.0028 0.0003 0.0003
Echinococcus granulosus muscleblind protein 0.0157 0.0073 0.0073
Onchocerca volvulus 0.0102 0.0043 0.0721
Brugia malayi hypothetical protein 0.0027 0.0002 0.0001
Echinococcus granulosus carbonyl reductase 1 0.0028 0.0003 0.0003
Echinococcus multilocularis oxidoreductase 0.0028 0.0003 0.0003
Toxoplasma gondii short chain dehydrogenase family protein, putative 0.0064 0.0022 0.0046
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0043 0.0011 0.0011
Onchocerca volvulus 0.0108 0.0046 0.0774
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0078 0.003 0.0028
Trypanosoma cruzi 3-keto-dihydrosphingosine reductase 0.0028 0.0003 0.0006
Mycobacterium leprae Possible short-chain dehydrogenase EphD 0.0028 0.0003 0.0003
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0054 0.0017 0.0017
Echinococcus granulosus carbonyl reductase 1 0.0028 0.0003 0.0003
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0033 0.0006 0.0005
Brugia malayi Probable ClpP-like protease 0.0082 0.0032 0.0031
Loa Loa (eye worm) hypothetical protein 0.0032 0.0005 0.0005
Plasmodium falciparum V-type H(+)-translocating pyrophosphatase, putative 0.0354 0.0179 0.0395
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0033 0.0006 0.0012
Echinococcus granulosus FTZ F1 alpha 0.0078 0.003 0.003
Leishmania major pentamidine resistance protein 1 0.003 0.0004 0.0006
Trypanosoma cruzi DNA polymerase kappa, putative 0.0064 0.0022 0.0049
Trypanosoma brucei importin beta-1 subunit, putative 0.0064 0.0022 0.0047
Entamoeba histolytica short chain dehydrogenase family protein 0.0028 0.0003 0.0183
Mycobacterium leprae PROBABLE FOLYLPOLYGLUTAMATE SYNTHASE PROTEIN FOLC (FOLYLPOLY-GAMMA-GLUTAMATE SYNTHETASE) (FPGS) 0.0426 0.0218 0.0218
Brugia malayi nuclear receptor RXR 0.0037 0.0007 0.0006
Mycobacterium ulcerans short chain dehydrogenase 0.0028 0.0003 0.0003
Trypanosoma cruzi transcription factor btf3, putative 0.0037 0.0008 0.0016
Loa Loa (eye worm) hypothetical protein 0.0157 0.0073 0.0072
Toxoplasma gondii melibiase subfamily protein 0.0108 0.0046 0.0099
Mycobacterium ulcerans oxidoreductase 0.0064 0.0022 0.0022
Plasmodium vivax hypothetical protein, conserved 0.0028 0.0003 0.0003
Giardia lamblia High cysteine protein 0.0032 0.0005 0.0485
Loa Loa (eye worm) hypothetical protein 0.0029 0.0003 0.0003
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0002 0.0001
Onchocerca volvulus 0.0037 0.0007 0.0088
Brugia malayi EGF-like domain containing protein 0.0032 0.0005 0.0004
Echinococcus multilocularis integrin alpha ps 0.0358 0.0181 0.0181
Plasmodium vivax apurinic/apyrimidinic endonuclease Apn1, putative 0.0081 0.0031 0.0066
Loa Loa (eye worm) hypothetical protein 0.0034 0.0006 0.0006
Brugia malayi Hypothetical oxidoreductase F56D1.5 0.0028 0.0003 0.0001
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0009 0.0017
Giardia lamblia MRP-like ABC transporter 0.003 0.0004 0.0328
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0041 0.001 0.001
Brugia malayi jmjC domain containing protein 0.0064 0.0022 0.0021
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0028 0.0003 0.0001
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0028 0.0003 0.0001
Echinococcus granulosus caspase 3 apoptosis cysteine peptidase 0.0123 0.0054 0.0054
Schistosoma mansoni steroid dehydrogenase 0.0028 0.0003 0.0001
Trichomonas vaginalis conserved hypothetical protein 0.0047 0.0013 0.0418
Echinococcus granulosus neuroligin 0.0028 0.0003 0.0002
Loa Loa (eye worm) hypothetical protein 0.0032 0.0005 0.0005
Schistosoma mansoni steroid dehydrogenase 0.0028 0.0003 0.0001
Schistosoma mansoni hypothetical protein 0.0157 0.0073 0.0071
Giardia lamblia Histone acetyltransferase GCN5 0.0041 0.001 0.1121
Toxoplasma gondii oxidoreductase, putative 0.0028 0.0003 0.0003
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0041 0.001 0.0008
Trypanosoma cruzi short-chain dehydrogenase, putative 0.0028 0.0003 0.0006
Entamoeba histolytica Acid sphingomyelinase-like phosphodiesterase, putative 0.0087 0.0035 0.4436
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0028 0.0003 0.0089
Brugia malayi Muscleblind-like protein 0.0157 0.0073 0.0071
Echinococcus granulosus lamin 0.0028 0.0003 0.0003
Entamoeba histolytica 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0064 0.0022 0.2743
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.007 0.0025 0.0025
Loa Loa (eye worm) hypothetical protein 0.0037 0.0007 0.0007
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0164 0.0076 0.2493
Leishmania major quinonoid dihydropteridine reductase 0.0028 0.0003 0.0003
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0054 0.0017 0.0017
Schistosoma mansoni matrix metallopeptidase-7 (M10 family) 0.0327 0.0164 0.0163
Trypanosoma brucei DNA polymerase eta, putative 0.0062 0.0021 0.0046
Onchocerca volvulus 0.0028 0.0003 0.0007
Loa Loa (eye worm) hypothetical protein 0.01 0.0042 0.0042
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0064 0.0022 0.0022
Brugia malayi Nuclear hormone receptor E75 0.0037 0.0007 0.0006
Brugia malayi hypothetical protein 0.0172 0.008 0.0079
Echinococcus multilocularis matrix metallopeptidase 7 (M10 family) 0.1188 0.063 0.063
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0082 0.0032 0.0032
Echinococcus granulosus 3 ketodihydrosphingosine reductase 0.0028 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.004 0.0009 0.0009
Onchocerca volvulus 0.0028 0.0003 0.0003
Mycobacterium ulcerans lipase LipD 0.004 0.0009 0.0009
Mycobacterium tuberculosis Conserved protein 0.004 0.0009 0.0009
Mycobacterium ulcerans carboxylesterase, LipT 0.0028 0.0003 0.0003
Giardia lamblia Tenascin-like 0.0032 0.0005 0.0485
Schistosoma mansoni short chain dehydrogenase 0.0028 0.0003 0.0001
Onchocerca volvulus 0.0102 0.0043 0.0721
Echinococcus multilocularis retinol dehydrogenase 11 0.0028 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0028 0.0003 0.0002
Trypanosoma cruzi NAD(P)-dependent oxidoreductase, putative 0.0028 0.0003 0.0006
Plasmodium vivax 3-oxoacyl-[acyl-carrier-protein] reductase, putative 0.0064 0.0022 0.0046
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0078 0.003 0.0029
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0028 0.0003 0.0001
Giardia lamblia Reductase, putative 0.0028 0.0003 0.017
Entamoeba histolytica hypothetical protein 0.003 0.0004 0.0341
Mycobacterium leprae Probable lipase LipE 0.004 0.0009 0.0009
Echinococcus multilocularis tar DNA binding protein 0.0133 0.006 0.0059
Trypanosoma brucei metacaspase MCA3 0.0047 0.0013 0.0027
Schistosoma mansoni carbonyl reductase 0.0028 0.0003 0.0001
Echinococcus multilocularis cpg binding protein 0.0032 0.0005 0.0005
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0107 0.0046 0.0045
Trypanosoma brucei DNA polymerase kappa, putative 0.0064 0.0022 0.0047
Loa Loa (eye worm) hypothetical protein 0.0039 0.0009 0.0008
Echinococcus granulosus caspase 2 0.009 0.0036 0.0036
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0164 0.0076 0.2493
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0028 0.0003 0.0089
Mycobacterium ulcerans carveol-like dehydrogenase 0.0028 0.0003 0.0003
Echinococcus granulosus dihydrofolate reductase 1.8528 1 1
Mycobacterium ulcerans 3-oxoacyl-ACP reductase 0.0064 0.0022 0.0022
Brugia malayi Integrin alpha pat-2 precursor 0.0799 0.042 0.0418
Mycobacterium ulcerans DNA polymerase IV 0.0064 0.0022 0.0022
Trypanosoma cruzi oxidoreductase-like protein, putative 0.0028 0.0003 0.0006
Echinococcus granulosus microtubule associated protein 2 0.0727 0.0381 0.0381
Loa Loa (eye worm) hypothetical protein 0.0029 0.0003 0.0003
Brugia malayi Disintegrin family protein 0.0099 0.0041 0.0039
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.007 0.0025 0.0025
Entamoeba histolytica hypothetical protein 0.0117 0.0051 0.6594
Brugia malayi EGF-like domain containing protein 0.0032 0.0005 0.0004
Trypanosoma brucei DNA polymerase kappa, putative 0.0064 0.0022 0.0047
Trypanosoma cruzi beta-ketoacyl-ACP reductase 0.0064 0.0022 0.0049
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0053 0.0016 0.0015
Echinococcus granulosus epidermal retinal dehydrogenase 2 0.0028 0.0003 0.0003
Schistosoma mansoni dihydrofolate reductase 1.8528 1 1
Mycobacterium ulcerans short-chain dehydrogenase 0.0028 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0072 0.0027 0.0026
Mycobacterium ulcerans short chain dehydrogenase 0.0092 0.0037 0.0037
Trypanosoma brucei Metacaspase-4 0.0047 0.0013 0.0027
Giardia lamblia Short-chain dehydrogenase, putative 0.0028 0.0003 0.017
Trypanosoma cruzi MFS transporter, putative 0.0029 0.0003 0.0007
Echinococcus multilocularis steroid dehydrogenase 0.0028 0.0003 0.0003
Trypanosoma cruzi hypothetical protein, conserved 0.0028 0.0003 0.0006
Schistosoma mansoni hypothetical protein 0.0034 0.0006 0.0005
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0032 0.0005 0.0004
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0028 0.0003 0.0003
Trypanosoma cruzi NAD(P)-dependent oxidoreductase, putative 0.0028 0.0003 0.0006
Echinococcus granulosus transcription factor btf3 0.0037 0.0008 0.0007
Loa Loa (eye worm) hypothetical protein 0.0073 0.0027 0.0027
Trypanosoma brucei DNA polymerase IV, putative 0.0057 0.0018 0.0039
Schistosoma mansoni hypothetical protein 0.0034 0.0006 0.0005
Echinococcus granulosus histone lysine methyltransferase setb 0.0032 0.0005 0.0005
Echinococcus multilocularis tumor protein p63 0.0736 0.0385 0.0385
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0047 0.0013 0.0418
Loa Loa (eye worm) oxidoreductase 0.0028 0.0003 0.0002
Mycobacterium ulcerans short-chain type oxidoreductase 0.0028 0.0003 0.0003
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0078 0.003 0.0028
Toxoplasma gondii redoxin domain-containing protein 0.009 0.0036 0.0077
Brugia malayi hypothetical protein 0.0055 0.0017 0.0016
Loa Loa (eye worm) runx1 0.0059 0.0019 0.0019
Plasmodium vivax vacuolar-type H+ pumping pyrophosphatase, putative 0.0354 0.0179 0.0395
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0078 0.003 0.003
Onchocerca volvulus 0.025 0.0123 0.2152
Leishmania major hypothetical protein, conserved 0.0028 0.0003 0.0003
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0082 0.0032 0.0032
Loa Loa (eye worm) helix-loop-helix DNA-binding domain-containing protein 0.0039 0.0009 0.0008
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0082 0.0032 0.0068
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0037 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0029 0.0003 0.0003
Onchocerca volvulus 0.0029 0.0003 0.0017
Echinococcus multilocularis ecdysone induced protein 78C 0.0078 0.003 0.003
Echinococcus multilocularis Protein lozenge 0.0059 0.0019 0.0019
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0145 0.0066 0.0066
Echinococcus multilocularis folate receptor beta 0.0878 0.0462 0.0462
Trypanosoma cruzi Vacuolar proton pyrophosphatase 1, putative 0.0354 0.0179 0.0398
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0028 0.0003 0.0001
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0036 0.0007 0.0013
Brugia malayi ecdysone receptor 0.0037 0.0007 0.0006
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0036 0.0007 0.0012
Trypanosoma cruzi quinonoid dihydropteridine reductase, putative 0.0028 0.0003 0.0006
Trypanosoma brucei DNA polymerase kappa, putative 0.0064 0.0022 0.0047
Schistosoma mansoni microtubule-associated protein tau 0.0727 0.0381 0.0379
Echinococcus multilocularis FTZ F1 alpha 0.0078 0.003 0.003
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.007 0.0025 0.3178
Echinococcus multilocularis organic anion transporting polypeptide 30B 0.0029 0.0003 0.0003
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0036 0.0007 0.0012
Loa Loa (eye worm) hypothetical protein 0.0037 0.0007 0.0007
Brugia malayi hypothetical protein 0.0088 0.0035 0.0034
Schistosoma mansoni 3-keto-dihydrosphingosine reductase 0.0028 0.0003 0.0001
Mycobacterium tuberculosis Probable oxidoreductase 0.0028 0.0003 0.0003
Trichomonas vaginalis DNA polymerase eta, putative 0.0064 0.0022 0.0718
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0235 0.0115 0.0115
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0045 0.0012 0.0388
Giardia lamblia hypothetical protein 0.0032 0.0005 0.0485
Schistosoma mansoni short chain dehydrogenase 0.0028 0.0003 0.0001
Loa Loa (eye worm) carboxylesterase 0.0028 0.0003 0.0002
Echinococcus granulosus thyroid hormone receptor alpha 0.0037 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.004 0.0009 0.0009
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0153 0.007 0.007
Trypanosoma cruzi oxidoreductase-like protein, putative 0.0092 0.0037 0.0082
Onchocerca volvulus Folate transporter 1 homolog 0.0102 0.0043 0.0721
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0002 0.0004
Schistosoma mansoni 3-oxoacyl-[ACP] reductase 0.0064 0.0022 0.002
Brugia malayi Pre-SET motif family protein 0.0032 0.0005 0.0004
Mycobacterium ulcerans dehydrogenase 0.0028 0.0003 0.0003
Brugia malayi hypothetical protein 0.0117 0.0051 0.0049
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0036 0.0007 0.0012
Loa Loa (eye worm) hypothetical protein 0.0073 0.0027 0.0027
Loa Loa (eye worm) hypothetical protein 0.0268 0.0132 0.0132
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0037 0.0007 0.0007
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0028 0.0003 0.0089
Loa Loa (eye worm) hypothetical protein 0.0028 0.0003 0.0002
Toxoplasma gondii hypothetical protein 0.0028 0.0003 0.0003
Loa Loa (eye worm) oxidoreductase 0.0028 0.0003 0.0002
Echinococcus granulosus Polycystic kidney disease protein 0.0088 0.0035 0.0035
Trypanosoma cruzi hypothetical protein, conserved 0.0028 0.0003 0.0006
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0078 0.003 0.0029
Trichomonas vaginalis DNA helicase recq1, putative 0.0048 0.0013 0.0436
Mycobacterium ulcerans short chain dehydrogenase 0.0028 0.0003 0.0003
Schistosoma mansoni lamin 0.0028 0.0003 0.0002
Onchocerca volvulus 0.0043 0.0011 0.0152
Onchocerca volvulus 0.0028 0.0003 0.0003
Brugia malayi EGF-like domain containing protein 0.0032 0.0005 0.0004
Schistosoma mansoni matrix metallopeptidase-9 (M10 family) 0.0222 0.0107 0.0106
Echinococcus multilocularis isocitrate dehydrogenase 0.0033 0.0006 0.0005
Schistosoma mansoni short chain dehydrogenase 0.0028 0.0003 0.0001
Entamoeba histolytica estradiol 17-beta-dehydrogenase, putative 0.0028 0.0003 0.0183
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0108 0.0046 0.0044
Mycobacterium tuberculosis Carboxylesterase LipT 0.0028 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0028 0.0003 0.0002
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0033 0.0006 0.0009
Loa Loa (eye worm) oxidoreductase 0.0028 0.0003 0.0002
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0043 0.0011 0.0021
Loa Loa (eye worm) aryl Hydrocarbon receptor Associated protein family member 0.0055 0.0017 0.0017
Mycobacterium ulcerans short-chain dehydrogenase 0.0028 0.0003 0.0003
Trypanosoma brucei short-chain dehydrogenase, putative 0.0028 0.0003 0.0004
Loa Loa (eye worm) hypothetical protein 0.0028 0.0003 0.0002
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0078 0.003 0.003
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.007 0.0025 0.0054
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0078 0.003 0.0028
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0028 0.0003 0.0001
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0009 0.0021
Entamoeba histolytica ATP-binding cassette protein, putative 0.003 0.0004 0.0341
Brugia malayi sodium-independent organic anion transporter family protein 0.0029 0.0003 0.0002
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0261 0.0129 0.0129
Loa Loa (eye worm) hypothetical protein 0.0028 0.0003 0.0002
Echinococcus granulosus oxidoreductase 0.0028 0.0003 0.0003
Brugia malayi RNA recognition motif domain containing protein 0.0133 0.006 0.0058
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0028 0.0003 0.0001
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0036 0.0007 0.0007
Schistosoma mansoni carbonyl reductase 0.0028 0.0003 0.0001
Trypanosoma brucei multidrug resistance-associated protein, putative 0.003 0.0004 0.0007
Schistosoma mansoni nuclear receptor nhr-48 0.0037 0.0007 0.0006
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0164 0.0076 0.2493
Trichomonas vaginalis conserved hypothetical protein 0.0047 0.0013 0.0418
Entamoeba histolytica ATP-binding cassette protein, putative 0.003 0.0004 0.0341
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0078 0.003 0.0028
Schistosoma mansoni importin beta-1 0.0064 0.0022 0.0021
Brugia malayi nuclear hormone receptor 0.0078 0.003 0.0028
Echinococcus multilocularis RUN 0.0088 0.0035 0.0035
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0028 0.0003 0.0001
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0182 0.0086 0.0086
Plasmodium falciparum enoyl-acyl carrier reductase 0.0064 0.0022 0.0046
Mycobacterium ulcerans short chain dehydrogenase 0.0028 0.0003 0.0003
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0078 0.003 0.0029
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0032 0.0005 0.0008
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0053 0.0016 0.0016
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0034 0.0006 0.0006
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0064 0.0022 0.0022
Trypanosoma brucei importin beta-1 subunit, putative 0.0064 0.0022 0.0047
Plasmodium falciparum histone acetyltransferase GCN5 0.0041 0.001 0.0019
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0141 0.0064 0.0063
Trypanosoma brucei oxidoreductase-like protein 0.0092 0.0037 0.0081
Brugia malayi aryl hydrocarbon receptor nuclear translocator protein, putative 0.0039 0.0009 0.0007
Toxoplasma gondii bifunctional protein FolC subfamily protein 0.0426 0.0218 0.0482
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0028 0.0003 0.0003
Echinococcus granulosus integrin alpha ps 0.0358 0.0181 0.0181
Brugia malayi Nuclear hormone receptor-like 1 0.0078 0.003 0.0028
Mycobacterium ulcerans esterase/lipase LipP 0.004 0.0009 0.0009
Trypanosoma cruzi vacuolar-type proton translocating pyrophosphatase 1 0.0354 0.0179 0.0398
Loa Loa (eye worm) hypothetical protein 0.0172 0.008 0.008
Loa Loa (eye worm) oxidoreductase 0.0028 0.0003 0.0002
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0028 0.0003 0.0003
Toxoplasma gondii thioredoxin reductase 0.0103 0.0043 0.0093
Brugia malayi nuclear hormone receptor 0.0037 0.0007 0.0006
Trypanosoma cruzi beta-ketoacyl-ACP reductase 2, putative 0.0028 0.0003 0.0006
Mycobacterium leprae PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) 0.1062 0.0562 0.0562
Mycobacterium ulcerans short chain dehydrogenase 0.0064 0.0022 0.0022
Entamoeba histolytica ABC transporter, putative 0.003 0.0004 0.0341
Mycobacterium ulcerans short chain dehydrogenase 0.0028 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0037 0.0007 0.0007
Mycobacterium ulcerans short chain dehydrogenase 0.0028 0.0003 0.0003
Onchocerca volvulus Dehydrogenase\/reductase SDR family member 13 homolog 0.0028 0.0003 0.0003
Mycobacterium tuberculosis Probable conserved lipoprotein 0.004 0.0009 0.0009
Loa Loa (eye worm) hypothetical protein 0.0037 0.0007 0.0007
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.0008 0.0246
Brugia malayi Matrixin family protein 0.0327 0.0164 0.0163
Trichomonas vaginalis hypothetical protein 0.0032 0.0005 0.0167
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0028 0.0003 0.0003
Schistosoma mansoni multidrug resistance protein 0.003 0.0004 0.0002
Brugia malayi hypothetical protein 0.0028 0.0003 0.0001
Echinococcus granulosus histone acetyltransferase MYST2 0.0114 0.0049 0.0049
Brugia malayi Dehydrogenases, short chain protein 30 0.0028 0.0003 0.0001
Echinococcus granulosus folylpolyglutamate synthase mitochondrial 0.0426 0.0218 0.0218
Brugia malayi Hemopexin family protein 0.0463 0.0238 0.0237
Onchocerca volvulus Dehydrogenase\/reductase SDR family member 1 homolog 0.0028 0.0003 0.0003
Echinococcus multilocularis apoptotic protease activating factor 1 0.0043 0.0011 0.0011
Brugia malayi folate-like transporter 3 0.0102 0.0043 0.0041
Schistosoma mansoni short chain dehydrogenase 0.0028 0.0003 0.0001
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0107 0.0046 0.0044
Mycobacterium tuberculosis Probable peptidoglycan hydrolase 0.0398 0.0203 0.0203
Loa Loa (eye worm) hypothetical protein 0.0032 0.0005 0.0005
Echinococcus granulosus survival motor neuron protein 1 0.0501 0.0258 0.0258
Loa Loa (eye worm) hypothetical protein 0.0102 0.0043 0.0043
Onchocerca volvulus Folate transporter 1 homolog 0.0102 0.0043 0.0721
Schistosoma mansoni integrin beta subunit 0.1014 0.0536 0.0534
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0047 0.0013 0.0025
Brugia malayi prostaglandin transporter 0.0029 0.0003 0.0002
Trypanosoma cruzi multidrug resistance-associated protein, putative 0.003 0.0004 0.0008
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0036 0.0007 0.0013
Leishmania major quinonoid dihydropteridine reductase 0.0028 0.0003 0.0003
Entamoeba histolytica hypothetical protein 0.0052 0.0016 0.1891
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0036 0.0007 0.0007
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0028 0.0003 0.0003
Brugia malayi Kelch motif family protein 0.0268 0.0132 0.0131
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0235 0.0115 0.0115
Toxoplasma gondii hypothetical protein 0.0216 0.0104 0.0229
Schistosoma mansoni hypothetical protein 0.0034 0.0006 0.0005
Schistosoma mansoni multidrug resistance protein 0.003 0.0004 0.0002
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0028 0.0003 0.0001
Mycobacterium tuberculosis Possible multi-functional enzyme with acyl-CoA-reductase activity AcrA1 0.0028 0.0003 0.0003
Plasmodium vivax peroxiredoxin, putative 0.009 0.0036 0.0077
Giardia lamblia NADH oxidase lateral transfer candidate 0.0036 0.0007 0.0725
Mycobacterium tuberculosis Probable dehydrogenase/reductase 0.0028 0.0003 0.0003
Echinococcus multilocularis Blood coagulation inhibitor, Disintegrin 0.062 0.0323 0.0323
Giardia lamblia Hypothetical protein 0.0028 0.0003 0.017
Echinococcus granulosus subfamily M12B unassigned peptidase 0.0099 0.0041 0.0041
Onchocerca volvulus Protein cycle homolog 0.0039 0.0009 0.0107
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0028 0.0003 0.0001
Echinococcus granulosus caspase 8 0.0047 0.0013 0.0013
Onchocerca volvulus Putative organic anion transporter 0.0029 0.0003 0.0017
Trypanosoma cruzi metacaspase, putative 0.0047 0.0013 0.0028
Chlamydia trachomatis endonuclease IV 0.0081 0.0031 0.0024
Loa Loa (eye worm) hypothetical protein 0.0037 0.0007 0.0007
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0078 0.003 0.0028
Echinococcus multilocularis aryl hydrocarbon receptor 0.0055 0.0017 0.0017
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0052 0.0016 0.0508
Trichomonas vaginalis dihydrofolate synthase/folylpolyglutamate synthase, putative 0.0426 0.0218 0.7103
Schistosoma mansoni short chain dehydrogenase 0.0028 0.0003 0.0001
Leishmania major quinonoid dihydropteridine reductase 0.0028 0.0003 0.0003
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0028 0.0003 0.0003
Brugia malayi Matrix metalloprotease, N-terminal domain containing protein 0.0398 0.0203 0.0201
Onchocerca volvulus 0.0064 0.0022 0.0347
Echinococcus granulosus geminin 0.0733 0.0384 0.0384
Schistosoma mansoni gliotactin 0.0028 0.0003 0.0001
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0034 0.0006 0.0006
Giardia lamblia Tenascin precursor 0.0032 0.0005 0.0485
Leishmania major ATP-binding cassette protein subfamily C, member 1, putative 0.003 0.0004 0.0006
Echinococcus multilocularis neuroligin 0.0028 0.0003 0.0002
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.004 0.0009 0.0009
Trichomonas vaginalis chaperonin-60kD, ch60, putative 0.0026 0.0001 0.0048
Entamoeba histolytica deoxycytidyl transferase, putative 0.0036 0.0007 0.0731
Brugia malayi ADAM-TS Spacer 1 family protein 0.0073 0.0027 0.0026
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0028 0.0003 0.0003
Echinococcus multilocularis transient receptor potential cation channel 0.0028 0.0003 0.0003
Echinococcus granulosus acetylcholinesterase 0.0164 0.0076 0.0076
Trypanosoma cruzi hypothetical protein, conserved 0.0028 0.0003 0.0006
Echinococcus multilocularis a disintegrin and metalloproteinase with 0.0467 0.024 0.024
Loa Loa (eye worm) ICD-1 protein 0.0037 0.0008 0.0007
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0078 0.003 0.003
Loa Loa (eye worm) hypothetical protein 0.0028 0.0003 0.0002
Loa Loa (eye worm) hypothetical protein 0.0032 0.0005 0.0005
Leishmania major ABC-thiol transporter 0.003 0.0004 0.0006
Loa Loa (eye worm) hypothetical protein 0.0082 0.0032 0.0032
Onchocerca volvulus 0.0029 0.0003 0.0017
Echinococcus granulosus disintegrin and metalloproteinase 0.0099 0.0041 0.0041
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0078 0.003 0.0028
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.007 0.0025 0.0056
Schistosoma mansoni rab6-interacting 0.0088 0.0035 0.0034
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0028 0.0003 0.0001
Trypanosoma brucei PAB1-binding protein , putative 0.0027 0.0002 0.0002
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.01 0.0042 0.004
Leishmania major DNA polymerase eta, putative 0.0062 0.0021 0.0045
Onchocerca volvulus 0.004 0.0009 0.0124
Brugia malayi Integrin beta pat-3 precursor 0.174 0.0928 0.0926
Trichomonas vaginalis spcc417.12 protein, putative 0.0028 0.0003 0.0084
Echinococcus multilocularis Dehydrogenase:reductase SDR family 0.0028 0.0003 0.0003
Trypanosoma cruzi DNA polymerase eta, putative 0.0062 0.0021 0.0047
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.076 0.0398 0.0398
Mycobacterium ulcerans 3-alpha-hydroxysteroid dehydrogenase 0.0092 0.0037 0.0037
Entamoeba histolytica hypothetical protein 0.0028 0.0003 0.0183
Echinococcus granulosus Blood coagulation inhibitor Disintegrin 0.062 0.0323 0.0323
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0028 0.0003 0.0003
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.004 0.0009 0.0009
Plasmodium vivax enoyl-acyl carrier protein reductase 0.0064 0.0022 0.0046
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0028 0.0003 0.0001
Mycobacterium ulcerans hypothetical protein 0.004 0.0009 0.0009
Trichomonas vaginalis penicillin-binding protein, putative 0.004 0.0009 0.031
Brugia malayi beta-lactamase family protein 0.004 0.0009 0.0008
Mycobacterium tuberculosis Decaprenylphosphoryl-D-2-keto erythro pentose reductase 0.0028 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0088 0.0035 0.0035
Loa Loa (eye worm) hypothetical protein 0.004 0.0009 0.0009
Plasmodium falciparum metacaspase-like protein 0.0047 0.0013 0.0025
Trichomonas vaginalis alpha-galactosidase/alpha-N-acetylgalactosaminidase, putative 0.0072 0.0027 0.0865
Echinococcus granulosus aryl hydrocarbon receptor 0.0055 0.0017 0.0017
Loa Loa (eye worm) hypothetical protein 0.0039 0.0009 0.0008
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0047 0.0013 0.0418
Schistosoma mansoni rab6-interacting 0.0088 0.0035 0.0034
Brugia malayi nuclear receptor NHR-67 0.0037 0.0007 0.0006
Trypanosoma brucei DNA polymerase kappa, putative 0.0064 0.0022 0.0047
Onchocerca volvulus 0.0028 0.0003 0.0003
Echinococcus multilocularis lamin 0.0028 0.0003 0.0003
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0028 0.0003 0.0003
Schistosoma mansoni acetylcholinesterase 0.0028 0.0003 0.0001
Entamoeba histolytica ATP-binding cassette protein, putative 0.003 0.0004 0.0341
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0009 0.0021
Trypanosoma cruzi short chain dehydrogenase, putative 0.0028 0.0003 0.0006
Echinococcus multilocularis integrin beta 2 0.1282 0.0681 0.068
Echinococcus multilocularis peptidase Clp (S14 family) 0.0054 0.0017 0.0017
Schistosoma mansoni steroid dehydrogenase 0.0028 0.0003 0.0001
Brugia malayi sodium-independent organic anion transporter family protein 0.0029 0.0003 0.0002
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0032 0.0005 0.0007
Echinococcus multilocularis steroid dehydrogenase 0.0028 0.0003 0.0003
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0034 0.0006 0.0006
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0078 0.003 0.0028
Brugia malayi Bloom's syndrome protein homolog 0.0048 0.0013 0.0012
Echinococcus granulosus SAM and MBT domain containing protein 0.01 0.0042 0.0042
Onchocerca volvulus 0.0078 0.003 0.0485
Trypanosoma cruzi T-complex protein 1, beta subunit, putative 0.0026 0.0001 0.0003
Entamoeba histolytica hypothetical protein, conserved 0.0028 0.0003 0.0183
Loa Loa (eye worm) hypothetical protein 0.0467 0.024 0.024
Loa Loa (eye worm) hypothetical protein 0.0037 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0028 0.0003 0.0002
Schistosoma mansoni hypothetical protein 0.0681 0.0355 0.0354
Trypanosoma brucei beta-D-hydroxybutyrate dehydrogenase 0.0028 0.0003 0.0004
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0145 0.0066 0.0066
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0092 0.0037 0.0037
Brugia malayi Nuclear hormone receptor-like 1 0.0041 0.001 0.0008
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0078 0.003 0.0028
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.018 0.0085 0.0085
Mycobacterium ulcerans folylpolyglutamate synthase protein FolC 0.0426 0.0218 0.0218
Echinococcus granulosus Solute carrier organic anion transporter family 0.0029 0.0003 0.0003
Brugia malayi Matrixin family protein 0.0327 0.0164 0.0163
Brugia malayi latrophilin 2 splice variant baaae 0.0073 0.0027 0.0026
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0028 0.0003 0.0001
Loa Loa (eye worm) retinol dehydrogenase 12 0.0064 0.0022 0.0022
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0078 0.003 0.0029
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.004 0.0009 0.0009
Mycobacterium leprae Probable short-chain type dehydrogenase/reductase 0.0028 0.0003 0.0003
Trypanosoma brucei multidrug resistance-associated protein, putative 0.003 0.0004 0.0007
Echinococcus granulosus thioredoxin glutathione reductase 0.0103 0.0043 0.0043
Trypanosoma brucei beta-ketoacyl-ACP reductase 3, putative 0.0028 0.0003 0.0004
Leishmania major 3-keto-dihydrosphingosine reductase 0.0028 0.0003 0.0003
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0037 0.0007 0.0007
Toxoplasma gondii HEAT repeat-containing protein 0.0064 0.0022 0.0046
Schistosoma mansoni nuclear hormone receptor 0.0037 0.0007 0.0006
Mycobacterium tuberculosis Probable reductase 0.0235 0.0115 0.0115
Schistosoma mansoni subfamily M12B unassigned peptidase (M12 family) 0.0099 0.0041 0.0039
Brugia malayi mbt repeat family protein 0.01 0.0042 0.004
Schistosoma mansoni ADAM17 peptidase (M12 family) 0.0989 0.0522 0.052
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0028 0.0003 0.0001
Trypanosoma cruzi 3-ketoacyl-CoA reductase, putative 0.0028 0.0003 0.0006
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0103 0.0043 0.0043
Echinococcus multilocularis conserved hypothetical protein 0.0028 0.0003 0.0003
Schistosoma mansoni caspase-7 (C14 family) 0.009 0.0036 0.0035
Trypanosoma brucei metacaspase 5, putative 0.0047 0.0013 0.0027
Echinococcus granulosus carbonyl reductase 1 0.0028 0.0003 0.0003
Schistosoma mansoni ADAMTS5 peptidase (M12 family) 0.0467 0.024 0.0238
Trypanosoma cruzi importin beta-1 subunit, putative 0.0052 0.0016 0.0034
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0005 0.0004
Trichomonas vaginalis conserved hypothetical protein 0.0047 0.0013 0.0418
Entamoeba histolytica hypothetical protein 0.0102 0.0043 0.5536
Loa Loa (eye worm) hypothetical protein 0.0055 0.0017 0.0017
Toxoplasma gondii hypothetical protein 0.0032 0.0005 0.0008
Trypanosoma brucei DNA polymerase kappa, putative 0.0064 0.0022 0.0047
Echinococcus multilocularis SAM and MBT domain containing protein 0.01 0.0042 0.0042
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0072 0.0027 0.0025
Loa Loa (eye worm) DR-78 0.0037 0.0007 0.0007
Brugia malayi TAR-binding protein 0.0133 0.006 0.0058
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0036 0.0007 0.0007
Mycobacterium ulcerans short chain dehydrogenase 0.0064 0.0022 0.0022
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0033 0.0006 0.0012
Brugia malayi mbt repeat family protein 0.01 0.0042 0.004
Mycobacterium leprae PROBABLE SHORT CHAIN ALCOHOL DEHYDROGENASE/REDUCTASE 0.0028 0.0003 0.0003
Plasmodium falciparum importin beta, putative 0.0064 0.0022 0.0046
Leishmania major dihydrofolate reductase-thymidylate synthase 0.8325 0.4487 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.0007 0.0007
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0037 0.0007 0.0007
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0064 0.0022 0.0022
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0145 0.0066 0.0143
Echinococcus granulosus integrin alpha 3 0.0613 0.0319 0.0319
Brugia malayi hypothetical protein 0.0029 0.0003 0.0002
Echinococcus granulosus lysine specific demethylase 5A 0.0064 0.0022 0.0022
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0033 0.0006 0.0004
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0036 0.0007 0.0015
Loa Loa (eye worm) hypothetical protein 0.2077 0.111 0.111
Loa Loa (eye worm) nuclear hormone receptor 0.0037 0.0007 0.0007
Schistosoma mansoni carbonyl reductase 0.0028 0.0003 0.0001
Trypanosoma cruzi DNA polymerase kappa, putative 0.0064 0.0022 0.0049
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0036 0.0007 0.0013
Echinococcus multilocularis multidrug resistance associated protein 1 0.003 0.0004 0.0004
Mycobacterium tuberculosis Probable short-chain dehydrogenase/reductase 0.0028 0.0003 0.0003
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0082 0.0032 0.0068
Schistosoma mansoni hypothetical protein 0.0431 0.0221 0.0219
Brugia malayi hypothetical protein 0.0037 0.0007 0.0006
Toxoplasma gondii 2,4-dienoyl CoA reductase 2, peroxisomal family protein 0.0092 0.0037 0.0079
Toxoplasma gondii oxidoreductase, putative 0.0028 0.0003 0.0003
Onchocerca volvulus Putative organic anion transporter 0.0029 0.0003 0.0017
Mycobacterium ulcerans short-chain dehydrogenase 0.0028 0.0003 0.0003
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.0028 0.0003 0.0003
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0053 0.0016 0.0015
Mycobacterium tuberculosis Possible fatty acyl-CoA reductase 0.0028 0.0003 0.0003
Plasmodium vivax hypothetical protein, conserved 0.004 0.0009 0.0018
Trypanosoma brucei 3-keto-dihydrosphingosine reductase 0.0028 0.0003 0.0004
Loa Loa (eye worm) hypothetical protein 0.0081 0.0031 0.0031
Echinococcus granulosus multidrug resistance associated protein 7 0.003 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.0088 0.0035 0.0035
Trypanosoma cruzi hypothetical protein, conserved 0.0028 0.0003 0.0006
Chlamydia trachomatis oxoacy-ACP reductase 0.0064 0.0022 0.0015
Loa Loa (eye worm) hypothetical protein 0.0398 0.0203 0.0202
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0681 0.0355 0.0355
Schistosoma mansoni zinc finger protein 0.0037 0.0007 0.0006
Trypanosoma brucei DNA polymerase kappa, putative 0.0031 0.0005 0.0008
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0036 0.0007 0.0015
Mycobacterium tuberculosis Possible 20-beta-hydroxysteroid dehydrogenase FabG3 (cortisone reductase) ((R)-20-hydroxysteroid dehydrogenase) 0.0064 0.0022 0.0022
Echinococcus granulosus nuclear receptor nhr 48 0.0037 0.0007 0.0007
Brugia malayi Isocitrate dehydrogenase 0.0033 0.0006 0.0004
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.003 0.0004 0.0004
Schistosoma mansoni adam (A disintegrin and metalloprotease 0.0172 0.008 0.0079
Brugia malayi hypothetical protein 0.0028 0.0003 0.0001
Brugia malayi oxidoreductase 0.0028 0.0003 0.0001
Brugia malayi hypothetical protein 0.0467 0.024 0.0238
Loa Loa (eye worm) hypothetical protein 0.0078 0.003 0.0029
Echinococcus granulosus Alpha N acetylgalactosaminidase 0.0108 0.0046 0.0046
Loa Loa (eye worm) hypothetical protein 0.0441 0.0226 0.0226
Echinococcus multilocularis thyroid hormone receptor alpha 0.0078 0.003 0.003
Loa Loa (eye worm) carboxylesterase 0.0164 0.0076 0.0076
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0045 0.0012 0.0023
Onchocerca volvulus 0.0088 0.0035 0.0582
Brugia malayi Matrixin family protein 0.0327 0.0164 0.0163
Echinococcus multilocularis 3 ketodihydrosphingosine reductase 0.0028 0.0003 0.0003
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0028 0.0003 0.0003
Mycobacterium ulcerans glutaminase 0.0286 0.0142 0.0142
Schistosoma mansoni steroid dehydrogenase 0.0028 0.0003 0.0001
Mycobacterium ulcerans short chain dehydrogenase 0.0064 0.0022 0.0022
Onchocerca volvulus 0.0029 0.0003 0.0017
Loa Loa (eye worm) dihydrofolate reductase 1.8528 1 1
Mycobacterium ulcerans dehydrogenase/decarboxylase protein 0.0028 0.0003 0.0003
Brugia malayi DNA-(Apurinic or apyrimidinic site) lyase 0.0081 0.0031 0.003
Plasmodium vivax SET domain protein, putative 0.0032 0.0005 0.0008
Mycobacterium tuberculosis Conserved protein 0.004 0.0009 0.0009
Trypanosoma brucei short-chain dehydrogenase, putative 0.0028 0.0003 0.0004
Mycobacterium ulcerans short chain dehydrogenase 0.0028 0.0003 0.0003
Onchocerca volvulus 0.0467 0.024 0.4244
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0037 0.0007 0.0088
Echinococcus multilocularis lipoxygenase domain containing protein 0.0088 0.0035 0.0035
Mycobacterium tuberculosis Probable endonuclease IV End (endodeoxyribonuclease IV) (apurinase) 0.0081 0.0031 0.0031
Echinococcus multilocularis retinol dehydrogenase 13 0.0028 0.0003 0.0003
Trichomonas vaginalis glutathione reductase, putative 0.0036 0.0007 0.0225
Brugia malayi hypothetical protein 0.0039 0.0009 0.0007
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0164 0.0076 1
Plasmodium falciparum dihydrofolate synthase/folylpolyglutamate synthase 0.0426 0.0218 0.0482
Loa Loa (eye worm) T-complex protein 1 0.0026 0.0001 0.0001
Mycobacterium ulcerans short chain dehydrogenase 0.0028 0.0003 0.0003
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0028 0.0003 0.0003
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0078 0.003 0.0029
Loa Loa (eye worm) hypothetical protein 0.0028 0.0003 0.0002
Entamoeba histolytica short chain dehydrogenase family protein 0.0028 0.0003 0.0183
Loa Loa (eye worm) hypothetical protein 0.0028 0.0003 0.0002
Echinococcus granulosus tar DNA binding protein 0.0133 0.006 0.0059
Brugia malayi beta-lactamase family protein 0.004 0.0009 0.0008
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.076 0.0398 0.0398
Echinococcus granulosus acetylcholinesterase 0.0164 0.0076 0.0076
Wolbachia endosymbiont of Brugia malayi Short-chain alcohol dehydrogenase family enzyme 0.0064 0.0022 0.653
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0164 0.0076 0.2493
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0036 0.0007 0.0012
Echinococcus granulosus adam 17 protease 0.1087 0.0575 0.0575
Trichomonas vaginalis D-aminoacylase, putative 0.004 0.0009 0.031
Leishmania major ATP-binding cassette protein subfamily C, member 5, putative 0.003 0.0004 0.0006
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0062 0.0021 0.0021
Loa Loa (eye worm) nuclear receptor NHR-67 0.0037 0.0007 0.0007
Treponema pallidum NADH oxidase 0.0036 0.0007 0.0317
Loa Loa (eye worm) hypothetical protein 0.0605 0.0314 0.0314
Loa Loa (eye worm) hypothetical protein 0.0028 0.0003 0.0002
Mycobacterium ulcerans short chain dehydrogenase 0.0028 0.0003 0.0003
Trypanosoma cruzi short chain dehydrogenase/reductase, putative 0.0028 0.0003 0.0006
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0036 0.0007 0.0007
Onchocerca volvulus 0.0327 0.0164 0.2891
Mycobacterium tuberculosis Possible ketoacyl reductase 0.0028 0.0003 0.0003
Leishmania major biopterin transporter, putative;with=GeneDB:LinJ35_V3.5120 0.0467 0.024 0.0533
Loa Loa (eye worm) hypothetical protein 0.0102 0.0043 0.0043
Onchocerca volvulus 0.0029 0.0003 0.0017
Trichomonas vaginalis set domain proteins, putative 0.025 0.0123 0.4009
Loa Loa (eye worm) FolC protein 0.0426 0.0218 0.0217
Echinococcus multilocularis caspase 8 0.0047 0.0013 0.0013
Schistosoma mansoni tar DNA-binding protein 0.0133 0.006 0.0058
Loa Loa (eye worm) hypothetical protein 0.009 0.0036 0.0036
Loa Loa (eye worm) hypothetical protein 0.0037 0.0007 0.0007
Loa Loa (eye worm) acetylcholinesterase 1 0.0164 0.0076 0.0076
Brugia malayi hypothetical protein 0.0128 0.0057 0.0055
Brugia malayi Dehydrogenases, short chain protein 2 0.0028 0.0003 0.0001
Echinococcus multilocularis subfamily M12B unassigned peptidase 0.0099 0.0041 0.0041
Mycobacterium tuberculosis Probable dehydrogenase/reductase 0.0028 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0027 0.0002 0.0002
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0002 0.0001
Echinococcus granulosus folylpolyglutamate synthase, mitochondrial 0.0426 0.0218 0.0218
Loa Loa (eye worm) hypothetical protein 0.0028 0.0003 0.0002
Toxoplasma gondii 3-ketoacyl-(acyl-carrier-protein) reductase 0.0064 0.0022 0.0046
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0028 0.0003 0.0003
Trichomonas vaginalis D-aminoacylase, putative 0.004 0.0009 0.031
Onchocerca volvulus 0.0028 0.0003 0.0003
Mycobacterium ulcerans 3-oxoacyl-ACP reductase 0.0064 0.0022 0.0022
Loa Loa (eye worm) acetyltransferase 0.0153 0.007 0.007
Schistosoma mansoni short chain dehydrogenase 0.0028 0.0003 0.0001
Entamoeba histolytica acetyltransferase, GNAT family 0.0041 0.001 0.1133
Loa Loa (eye worm) thymidylate synthase 0.1062 0.0562 0.0561
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0028 0.0003 0.0001
Schistosoma mansoni thyroid hormone receptor 0.0078 0.003 0.0028
Trichomonas vaginalis penicillin-binding protein, putative 0.004 0.0009 0.031
Mycobacterium leprae PROBABLE ENDONUCLEASE IV END (ENDODEOXYRIBONUCLEASE IV) (APURINASE) 0.0081 0.0031 0.0031
Loa Loa (eye worm) hypothetical protein 0.0102 0.0043 0.0043
Echinococcus multilocularis folylpolyglutamate synthase, mitochondrial 0.0426 0.0218 0.0218
Echinococcus multilocularis epidermal retinal dehydrogenase 2 0.0028 0.0003 0.0003
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0145 0.0066 0.0066
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0045 0.0012 0.0023
Brugia malayi Pre-SET motif family protein 0.022 0.0107 0.0105
Echinococcus multilocularis histone acetyltransferase MYST2 0.0114 0.0049 0.0049
Trypanosoma cruzi 3-ketoacyl-CoA reductase, putative 0.0028 0.0003 0.0006
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0028 0.0003 0.0001
Mycobacterium tuberculosis Possible oxidoreductase 0.0028 0.0003 0.0003
Brugia malayi hypothetical protein 0.0041 0.001 0.0008
Loa Loa (eye worm) hypothetical protein 0.0041 0.001 0.001
Onchocerca volvulus 0.0028 0.0003 0.0007
Mycobacterium tuberculosis Possible oxidoreductase 0.0028 0.0003 0.0003
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0053 0.0016 0.0015
Toxoplasma gondii sterol carrier protein-2 HAD-2SCP-2 0.0028 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0078 0.003 0.0029
Loa Loa (eye worm) integrin alpha pat-2 0.1232 0.0654 0.0653
Trichomonas vaginalis conserved hypothetical protein 0.0047 0.0013 0.0418
Loa Loa (eye worm) hypothetical protein 0.0032 0.0005 0.0005
Brugia malayi photoreceptor-specific nuclear receptor 0.0078 0.003 0.0028
Mycobacterium ulcerans enoyl-(acyl carrier protein) reductase 0.0064 0.0022 0.0022
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0025 0.0001 0.0003
Trypanosoma brucei metacaspase 0.0047 0.0013 0.0027
Brugia malayi Nuclear hormone receptor-like 1 0.0041 0.001 0.0008
Mycobacterium ulcerans short chain dehydrogenase 0.0064 0.0022 0.0022
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0005 0.0004
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0041 0.001 0.001
Leishmania major short chain dehydrogenase/reductase, putative 0.0028 0.0003 0.0003
Mycobacterium leprae Probable oxidoreductase 0.0028 0.0003 0.0003
Echinococcus multilocularis transcription factor Dp 1 0.004 0.0009 0.0009
Schistosoma mansoni blooms syndrome DNA helicase 0.0038 0.0008 0.0006
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0036 0.0007 0.0012
Onchocerca volvulus 0.0028 0.0003 0.0003
Echinococcus multilocularis caspase 3, apoptosis cysteine peptidase 0.0123 0.0054 0.0054
Loa Loa (eye worm) hypothetical protein 0.0501 0.0258 0.0258
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0036 0.0007 0.0012
Echinococcus multilocularis survival motor neuron protein 1 0.0501 0.0258 0.0258
Brugia malayi Nuclear hormone receptor E75 0.0037 0.0007 0.0006
Mycobacterium tuberculosis Possible oxidoreductase 0.0064 0.0022 0.0022
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0028 0.0003 0.0002
Loa Loa (eye worm) hypothetical protein 0.0078 0.003 0.0029
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0041 0.001 0.001
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0036 0.0007 0.0005
Loa Loa (eye worm) hypothetical protein 0.0102 0.0043 0.0043
Mycobacterium leprae DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) 1.8528 1 1
Loa Loa (eye worm) jmjC domain-containing protein 0.0064 0.0022 0.0022
Schistosoma mansoni hypothetical protein 0.0088 0.0035 0.0034
Onchocerca volvulus 0.0463 0.0238 0.4211
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.007 0.0025 0.0056
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0034 0.0006 0.0006
Schistosoma mansoni polycystin 1-related 0.0088 0.0035 0.0034
Giardia lamblia Neurogenic locus Notch protein precursor 0.0032 0.0005 0.0485
Schistosoma mansoni DNA polymerase eta 0.0062 0.0021 0.002
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0036 0.0007 0.0015
Schistosoma mansoni caspase-3 (C14 family) 0.0123 0.0054 0.0053
Trypanosoma cruzi multidrug resistance protein E, putative 0.003 0.0004 0.0008
Plasmodium falciparum oxidoreductase, short-chain dehydrogenase family, putative 0.0028 0.0003 0.0003
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0145 0.0066 0.0064
Echinococcus multilocularis Major facilitator superfamily, general substrate transporter 0.0158 0.0073 0.0073
Trypanosoma brucei multidrug resistance protein E 0.003 0.0004 0.0007
Echinococcus multilocularis dnaJ subfamily B 0.0431 0.0221 0.022
Brugia malayi isocitrate dehydrogenase 0.0033 0.0006 0.0004
Toxoplasma gondii isocitrate dehydrogenase 0.0033 0.0006 0.0009
Schistosoma mansoni dihydroceramide desaturase 0.0099 0.0041 0.0039
Brugia malayi beta-lactamase 0.004 0.0009 0.0008
Plasmodium vivax V-type H(+)-translocating pyrophosphatase, putative 0.0354 0.0179 0.0395
Entamoeba histolytica oxidoreductase, short chain dehydrogenase/reductase family 0.0028 0.0003 0.0183
Loa Loa (eye worm) hypothetical protein 0.0043 0.0011 0.0011
Onchocerca volvulus Bile acid receptor homolog 0.0078 0.003 0.0485
Schistosoma mansoni short chain dehydrogenase 0.0028 0.0003 0.0001
Loa Loa (eye worm) hypothetical protein 0.0041 0.001 0.001
Schistosoma mansoni hypothetical protein 0.0463 0.0238 0.0237
Onchocerca volvulus 0.0102 0.0043 0.0721
Loa Loa (eye worm) hypothetical protein 0.0327 0.0164 0.0164
Loa Loa (eye worm) hypothetical protein 0.0102 0.0043 0.0043
Mycobacterium ulcerans short chain dehydrogenase 0.0028 0.0003 0.0003
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.01 0.0042 0.0702
Echinococcus granulosus dna polymerase kappa 0.0064 0.0022 0.0022
Mycobacterium ulcerans oxidoreductase 0.0028 0.0003 0.0003
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0145 0.0066 0.0066
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0064 0.0022 0.0022
Echinococcus granulosus transcription factor Dp 1 0.004 0.0009 0.0009
Brugia malayi Reduced folate carrier family protein 0.0102 0.0043 0.0041
Brugia malayi hypothetical protein 0.0028 0.0003 0.0001
Leishmania major dehydrogenase/oxidoreductase-like protein 0.0064 0.0022 0.0046
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0092 0.0037 0.0037
Loa Loa (eye worm) hypothetical protein 0.0041 0.001 0.001
Plasmodium falciparum thioredoxin reductase 0.0036 0.0007 0.0012
Schistosoma mansoni steroid dehydrogenase 0.0028 0.0003 0.0001
Echinococcus multilocularis microtubule associated protein 2 0.0727 0.0381 0.0381
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0082 0.0032 0.1477
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.007 0.0025 0.0024
Loa Loa (eye worm) beta-lactamase 0.004 0.0009 0.0009
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0078 0.003 0.003
Loa Loa (eye worm) hypothetical protein 0.0037 0.0007 0.0007
Brugia malayi tailless protein 0.0037 0.0007 0.0006
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0054 0.0017 0.0017
Schistosoma mansoni peptidase Clp (S14 family) 0.0082 0.0032 0.0031
Schistosoma mansoni short chain dehydrogenase 0.0028 0.0003 0.0001
Echinococcus multilocularis protein jagged 2 0.0032 0.0005 0.0005
Leishmania major quinonoid dihydropteridine reductase 0.0028 0.0003 0.0003
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0033 0.0006 0.001
Schistosoma mansoni short chain dehydrogenase 0.0028 0.0003 0.0001
Brugia malayi hypothetical protein 0.0029 0.0003 0.0002
Brugia malayi Carboxylesterase family protein 0.0028 0.0003 0.0001
Loa Loa (eye worm) dehydrogenase 0.0028 0.0003 0.0002
Brugia malayi hypothetical protein 0.0043 0.0011 0.001
Schistosoma mansoni organic anion transporter 0.0029 0.0003 0.0002
Schistosoma mansoni cpg binding protein 0.0032 0.0005 0.0003
Echinococcus multilocularis carbonyl reductase 1 0.0028 0.0003 0.0003
Leishmania major short chain dehydrogenase, putative 0.0028 0.0003 0.0003
Brugia malayi nuclear receptor NHR-88 0.0037 0.0007 0.0006
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0028 0.0003 0.0001
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0053 0.0016 0.0015
Trypanosoma brucei DNA polymerase IV, putative 0.0064 0.0022 0.0047
Trypanosoma brucei short-chain dehydrogenase, putative 0.0028 0.0003 0.0004
Toxoplasma gondii V-type H(+)-translocating pyrophosphatase VP1 0.0354 0.0179 0.0395
Giardia lamblia Fructose-bisphosphate aldolase 0.0164 0.0076 1
Loa Loa (eye worm) matrix metalloproteinase 0.0327 0.0164 0.0164
Schistosoma mansoni tar DNA-binding protein 0.0133 0.006 0.0058
Echinococcus multilocularis caspase 0.0123 0.0054 0.0054
Echinococcus granulosus matrix metallopeptidase 7 M10 family 0.1188 0.063 0.063
Loa Loa (eye worm) hypothetical protein 0.0078 0.003 0.0029
Brugia malayi Cell death protein 3 precursor 0.009 0.0036 0.0035
Brugia malayi beta-NAC-like protein 0.0037 0.0008 0.0006
Schistosoma mansoni retinal dehydrogenase 0.0028 0.0003 0.0001
Echinococcus multilocularis adam 17 protease 0.0989 0.0522 0.0522
Loa Loa (eye worm) hypothetical protein 0.003 0.0004 0.0004
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0062 0.0021 0.0021
Schistosoma mansoni survival motor neuron protein 0.0102 0.0043 0.0041
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase 0.8325 0.4487 1
Trypanosoma cruzi short-chain dehydrogenase, putative 0.0028 0.0003 0.0006
Schistosoma mansoni multidrug resistance protein 0.003 0.0004 0.0002
Echinococcus multilocularis dna polymerase eta 0.0062 0.0021 0.0021
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0078 0.003 0.0028
Schistosoma mansoni cellular tumor antigen P53 0.0108 0.0046 0.0044
Mycobacterium ulcerans short chain dehydrogenase 0.0028 0.0003 0.0003
Schistosoma mansoni hypothetical protein 0.0034 0.0006 0.0005
Plasmodium falciparum basic transcription factor 3b, putative 0.0037 0.0008 0.0014
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0028 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0102 0.0043 0.0043
Mycobacterium tuberculosis Probable folylpolyglutamate synthase protein FolC (folylpoly-gamma-glutamate synthetase) (FPGS) 0.0426 0.0218 0.0218
Trypanosoma brucei metacaspase MCA2 0.0047 0.0013 0.0027
Giardia lamblia Tenascin-X 0.0032 0.0005 0.0485
Brugia malayi glutathione reductase 0.0103 0.0043 0.0042
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0028 0.0003 0.0003
Mycobacterium ulcerans oxidoreductase 0.0028 0.0003 0.0003
Leishmania major short chain dehydrogenase/reductase, putative 0.0028 0.0003 0.0003
Plasmodium falciparum V-type K+-independent H+-translocating inorganic pyrophosphatase 0.0354 0.0179 0.0395
Onchocerca volvulus 0.0028 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0064 0.0022 0.0022
Echinococcus granulosus carbonyl reductase 1 0.0028 0.0003 0.0003
Brugia malayi ImpB/MucB/SamB family protein 0.0062 0.0021 0.002
Brugia malayi hypothetical protein 0.0037 0.0007 0.0006
Loa Loa (eye worm) glutathione reductase 0.0103 0.0043 0.0043
Echinococcus multilocularis polycomb protein SCMH1 0.01 0.0042 0.0042
Onchocerca volvulus 0.0092 0.0037 0.0617
Loa Loa (eye worm) hypothetical protein 0.0157 0.0073 0.0072
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0065 0.0023 0.0021
Onchocerca volvulus 0.004 0.0009 0.0124
Mycobacterium leprae POSSIBLE OXIDOREDUCTASE 0.0064 0.0022 0.0022
Mycobacterium leprae 3-OXOACYL-[ACYL-CARRIER PROTEIN] REDUCTASE FABG1 (3-KETOACYL-ACYL CARRIER PROTEIN REDUCTASE) (MYCOLIC ACID BIOSYNTHESIS A PROTEI 0.0064 0.0022 0.0022
Loa Loa (eye worm) thioredoxin reductase 0.0103 0.0043 0.0043
Trichomonas vaginalis hypothetical protein 0.0064 0.0022 0.0716
Brugia malayi glutaminase DH11.1 0.0286 0.0142 0.0141
Echinococcus granulosus cpg binding protein 0.0032 0.0005 0.0005
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0028 0.0003 0.0089
Leishmania major metacaspase, putative 0.0047 0.0013 0.0026
Loa Loa (eye worm) RecQ helicase 0.0048 0.0013 0.0013
Brugia malayi aryl hydrocarbon receptor AHR-1 0.0039 0.0009 0.0007
Loa Loa (eye worm) hypothetical protein 0.003 0.0004 0.0004
Mycobacterium leprae PROBABLE HYDROLASE 0.0398 0.0203 0.0203
Trichomonas vaginalis esterase, putative 0.004 0.0009 0.031
Treponema pallidum folylpolyglutamate synthetase (folC) 0.0426 0.0218 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.0007 0.0007
Mycobacterium leprae ROBABLE SHORT-CHAIN TYPE DEHYDROGENASE/REDUCTASE 0.0028 0.0003 0.0003
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.076 0.0398 0.0398
Loa Loa (eye worm) mbt repeat family protein 0.01 0.0042 0.0042
Loa Loa (eye worm) hypothetical protein 0.0028 0.0003 0.0002
Trypanosoma brucei DNA polymerase kappa, putative 0.0064 0.0022 0.0047
Echinococcus multilocularis geminin 0.0733 0.0384 0.0384
Giardia lamblia Multidrug resistance-associated protein 1 0.003 0.0004 0.0328
Brugia malayi FolC bifunctional protein 0.0426 0.0218 0.0216
Mycobacterium tuberculosis Probable shortchain dehydrogenase 0.0028 0.0003 0.0003
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0033 0.0006 0.0005
Brugia malayi ABC transporter transmembrane region family protein 0.003 0.0004 0.0002
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0064 0.0022 0.0718
Onchocerca volvulus 0.004 0.0009 0.0124
Loa Loa (eye worm) ABC transporter transmembrane region family protein 0.003 0.0004 0.0004
Mycobacterium ulcerans thymidylate synthase 0.1062 0.0562 0.0562
Loa Loa (eye worm) hypothetical protein 0.0187 0.0088 0.0088
Mycobacterium ulcerans short chain dehydrogenase 0.0064 0.0022 0.0022
Brugia malayi dehydrogenases, short chain protein 2 0.0028 0.0003 0.0001
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0037 0.0007 0.0088
Schistosoma mansoni integrin alpha-ps 0.0187 0.0088 0.0087
Schistosoma mansoni steroid hormone receptor ad4bp 0.0078 0.003 0.0028
Mycobacterium tuberculosis Probable oxidoreductase 0.0261 0.0129 0.0129
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0028 0.0003 0.0084
Schistosoma mansoni caspase-7 (C14 family) 0.0123 0.0054 0.0053
Loa Loa (eye worm) hypothetical protein 0.0028 0.0003 0.0003
Echinococcus granulosus para nitrobenzyl esterase 0.0028 0.0003 0.0002
Loa Loa (eye worm) hypothetical protein 0.0029 0.0003 0.0003
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0037 0.0007 0.0006
Entamoeba histolytica multidrug resistance protein, putative 0.003 0.0004 0.0341
Echinococcus granulosus expressed protein 0.0393 0.02 0.02
Trypanosoma cruzi hypothetical protein, conserved 0.0028 0.0003 0.0006
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0036 0.0007 0.0007
Onchocerca volvulus Matrilysin homolog 0.0725 0.0379 0.6738
Schistosoma mansoni nuclear receptor 0.0037 0.0007 0.0006
Mycobacterium tuberculosis Probable short-chain type oxidoreductase 0.0028 0.0003 0.0003
Schistosoma mansoni hypothetical protein 0.0172 0.008 0.0079
Trichomonas vaginalis glutaminase, putative 0.0286 0.0142 0.4644
Schistosoma mansoni short chain dehydrogenase 0.0028 0.0003 0.0001
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0078 0.003 0.003
Loa Loa (eye worm) hypothetical protein 0.0108 0.0046 0.0046
Toxoplasma gondii 3-ketoacyl-CoA reductase, putative 0.0028 0.0003 0.0003
Entamoeba histolytica estradiol 17-beta-dehydrogenase, putative 0.0028 0.0003 0.0183
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0045 0.0012 0.0023
Echinococcus granulosus bloom syndrome protein 0.0048 0.0013 0.0013
Trypanosoma cruzi metacaspase, putative 0.0047 0.0013 0.0028
Trypanosoma cruzi hypothetical protein, conserved 0.0028 0.0003 0.0006
Brugia malayi Importin beta-1 subunit 0.0064 0.0022 0.0021
Entamoeba histolytica hypothetical protein 0.0117 0.0051 0.6594
Mycobacterium tuberculosis Possible oxidoreductase 0.0064 0.0022 0.0022
Trypanosoma cruzi beta-ketoacyl-ACP reductase 2, putative 0.0028 0.0003 0.0006
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0064 0.0022 0.0022
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0078 0.003 0.0485
Entamoeba histolytica 3-ketodihydrosphingosine reductase protein, putative 0.0028 0.0003 0.0183
Schistosoma mansoni dihydropteridine reductase 0.0064 0.0022 0.002
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0028 0.0003 0.0003
Schistosoma mansoni cpg binding protein 0.0032 0.0005 0.0003
Schistosoma mansoni neuroligin 3 (S09 family) 0.0028 0.0003 0.0001
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0064 0.0022 0.0022
Plasmodium falciparum steroid dehydrogenase, putative 0.0028 0.0003 0.0003
Trypanosoma cruzi metacaspase, putative 0.0047 0.0013 0.0028
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0114 0.0049 0.0049
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0053 0.0016 0.0016
Brugia malayi Steroid receptor seven-up type 2 0.0078 0.003 0.0028
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0036 0.0007 0.0012
Mycobacterium tuberculosis Possible iron-regulated short-chain dehydrogenase/reductase 0.0028 0.0003 0.0003
Brugia malayi Doublecortin family protein 0.0088 0.0035 0.0034
Echinococcus granulosus thymidylate synthase 0.1062 0.0562 0.0562
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0028 0.0003 0.0001
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0078 0.003 0.0028
Trypanosoma cruzi metacaspase 5, putative 0.0047 0.0013 0.0028
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0259 0.0127 0.0127
Brugia malayi hypothetical protein 0.0268 0.0132 0.0131
Schistosoma mansoni coup transcription factor 0.0078 0.003 0.0028
Schistosoma mansoni tar DNA-binding protein 0.0133 0.006 0.0058
Mycobacterium tuberculosis Conserved protein 0.004 0.0009 0.0009
Mycobacterium ulcerans short chain dehydrogenase 0.0028 0.0003 0.0003
Echinococcus granulosus hypothetical protein 0.0028 0.0003 0.0003
Echinococcus multilocularis 3 oxoacyl acyl carrier protein reductase 0.0064 0.0022 0.0022
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0047 0.0013 0.0418
Entamoeba histolytica hypothetical protein 0.0037 0.0008 0.0821
Schistosoma mansoni BC026374 protein (S09 family) 0.0028 0.0003 0.0001
Brugia malayi RNA binding protein 0.0133 0.006 0.0058
Echinococcus granulosus apoptotic protease activating factor 1 0.0043 0.0011 0.0011
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0078 0.003 0.0029
Loa Loa (eye worm) hypothetical protein 0.0102 0.0043 0.0043
Mycobacterium tuberculosis Probable dehydrogenase 0.0028 0.0003 0.0003
Leishmania major folylpolyglutamate synthetase 0.0426 0.0218 0.0482
Trypanosoma cruzi short chain dehydrogenase, putative 0.0028 0.0003 0.0006
Onchocerca volvulus 0.1062 0.0562 1
Leishmania major hypothetical protein, conserved 0.0028 0.0003 0.0003
Mycobacterium tuberculosis Probable oxidoreductase 0.0092 0.0037 0.0037
Loa Loa (eye worm) carboxylesterase 0.0028 0.0003 0.0002
Loa Loa (eye worm) isocitrate dehydrogenase 0.0033 0.0006 0.0005
Loa Loa (eye worm) reduced folate carrier family protein 0.0102 0.0043 0.0043
Mycobacterium ulcerans short chain dehydrogenase 0.0028 0.0003 0.0003
Echinococcus granulosus integrin beta 2 0.1282 0.0681 0.068
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0078 0.003 0.003
Echinococcus multilocularis caspase 2 0.009 0.0036 0.0036
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.007 0.0025 0.0024
Loa Loa (eye worm) hypothetical protein 0.0078 0.003 0.0029
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0078 0.003 0.0028
Echinococcus multilocularis caspase 3 0.0077 0.0029 0.0029
Leishmania major hypothetical protein, conserved 0.0027 0.0002 0.0001
Trypanosoma cruzi DNA polymerase kappa, putative 0.0064 0.0022 0.0049
Loa Loa (eye worm) kelch domain-containing protein family protein 0.0268 0.0132 0.0132
Loa Loa (eye worm) short chain dehydrogenase/reductase family oxidoreductase 0.0028 0.0003 0.0002
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.004 0.0009 0.0008
Onchocerca volvulus 0.0055 0.0017 0.0267
Toxoplasma gondii histone lysine methyltransferase SET1 0.0062 0.0021 0.0044
Loa Loa (eye worm) oxidoreductase 0.0064 0.0022 0.0022
Schistosoma mansoni steroid dehydrogenase 0.0028 0.0003 0.0001
Brugia malayi orphan nuclear receptor NR2E1 0.0037 0.0007 0.0006
Brugia malayi Matrixin family protein 0.0327 0.0164 0.0163
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0064 0.0022 0.002
Brugia malayi conserved hypotetical protein 0.0037 0.0007 0.0006
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0037 0.0007 0.0006
Echinococcus multilocularis bloom syndrome protein 0.0048 0.0013 0.0013
Schistosoma mansoni hypothetical protein 0.0733 0.0384 0.0383
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0047 0.0013 0.0418
Onchocerca volvulus 0.01 0.0042 0.0702
Trichomonas vaginalis estradiol 17 beta-dehydrogenase, putative 0.0028 0.0003 0.0089
Echinococcus granulosus polycomb protein SCMH1 0.01 0.0042 0.0042
Trichomonas vaginalis DNA helicase recq, putative 0.0025 0.0001 0.0045
Loa Loa (eye worm) hypothetical protein 0.0028 0.0003 0.0002
Echinococcus granulosus peptidase Clp S14 family 0.0054 0.0017 0.0017
Loa Loa (eye worm) hypothetical protein 0.0073 0.0027 0.0027
Entamoeba histolytica T-complex protein 1 beta subunit, putative 0.0026 0.0001 0.0014
Leishmania major importin beta-1 subunit, putative 0.0052 0.0016 0.0032
Entamoeba histolytica ATP-binding cassette protein, putative 0.003 0.0004 0.0341
Echinococcus multilocularis dihydrofolate reductase 1.8528 1 1
Onchocerca volvulus Matrix metalloproteinase homolog 0.0725 0.0379 0.6738
Loa Loa (eye worm) hypothetical protein 0.003 0.0004 0.0004
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0082 0.0032 1
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0047 0.0013 0.0418
Echinococcus multilocularis multidrug resistance associated protein 7 0.003 0.0004 0.0004
Echinococcus multilocularis carbonyl reductase 1 0.0028 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0145 0.0066 0.0065
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0028 0.0003 0.0003
Mycobacterium ulcerans short-chain membrane-associated dehydrogenase 0.0028 0.0003 0.0003
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0078 0.003 0.0028
Onchocerca volvulus 0.0028 0.0003 0.0003
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0078 0.003 0.003
Trypanosoma cruzi trypanothione reductase, putative 0.0103 0.0043 0.0096
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0036 0.0007 0.0015
Echinococcus multilocularis snurportin 1 0.0681 0.0355 0.0355
Leishmania major basic transcription factor 3a, putative 0.0037 0.0008 0.0014
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0052 0.0016 0.0508
Brugia malayi angiogenesis inhibito 0.0073 0.0027 0.0026
Brugia malayi Calcitonin receptor-like protein seb-1 0.0107 0.0046 0.0044
Trichomonas vaginalis conserved hypothetical protein 0.0047 0.0013 0.0418
Trichomonas vaginalis hydroxyacyl dehydrogenase, putative 0.0028 0.0003 0.0089
Mycobacterium tuberculosis Probable lipase LipD 0.004 0.0009 0.0009
Mycobacterium ulcerans ketoacyl reductase 0.0028 0.0003 0.0003
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0078 0.003 0.0028
Trypanosoma brucei T-complex protein 1, beta subunit, putative 0.0026 0.0001 0.0001
Schistosoma mansoni myelin transcription factor 1 myt1 0.0114 0.0049 0.0048
Trypanosoma brucei hypothetical protein, conserved 0.004 0.0009 0.0019
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0028 0.0003 0.0003
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0028 0.0003 0.0003
Brugia malayi hypothetical protein 0.0088 0.0035 0.0034
Loa Loa (eye worm) hypothetical protein 0.0028 0.0003 0.0002
Mycobacterium tuberculosis Conserved hypothetical protein 0.0036 0.0007 0.0007
Schistosoma mansoni hypothetical protein 0.0055 0.0017 0.0016
Mycobacterium ulcerans short chain dehydrogenase 0.0064 0.0022 0.0022
Trypanosoma brucei pteridine reductase 1 0.1478 0.0786 0.1751
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0047 0.0013 0.0418
Giardia lamblia ABC transporter, putative 0.003 0.0004 0.0328
Plasmodium falciparum metacaspase 1 0.0047 0.0013 0.0025
Schistosoma mansoni integrin alpha-ps 0.0358 0.0181 0.018
Trypanosoma brucei DNA polymerase kappa, putative 0.0064 0.0022 0.0047
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0025 0.0001 0.0001
Leishmania major pteridine reductase 1 0.1506 0.0801 0.1784
Brugia malayi CXXC zinc finger family protein 0.003 0.0004 0.0003
Mycobacterium tuberculosis Probable lipase LipE 0.004 0.0009 0.0009
Mycobacterium ulcerans short chain dehydrogenase 0.0028 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0039 0.0009 0.0008
Loa Loa (eye worm) hypothetical protein 0.0078 0.003 0.0029
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0078 0.003 0.0028
Loa Loa (eye worm) hypothetical protein 0.0164 0.0076 0.0076
Trichomonas vaginalis bromodomain-containing protein, putative 0.0045 0.0012 0.0388
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0036 0.0007 0.0005
Trypanosoma cruzi multidrug resistance-associated protein, putative 0.003 0.0004 0.0008
Schistosoma mansoni short chain dehydrogenase 0.0028 0.0003 0.0001
Plasmodium vivax importin-beta 2, putative 0.0064 0.0022 0.0046
Plasmodium vivax thioredoxin reductase, putative 0.0103 0.0043 0.0093
Giardia lamblia Neurogenic locus notch-like protein 0.0032 0.0005 0.0485
Plasmodium vivax multidomain scavenger receptor, putative 0.0088 0.0035 0.0075
Mycobacterium ulcerans ketoacyl reductase 0.0028 0.0003 0.0003
Brugia malayi RNA, U transporter 1 0.0181 0.0086 0.0084
Schistosoma mansoni jumonji/arid domain-containing protein 0.0064 0.0022 0.0021
Loa Loa (eye worm) hypothetical protein 0.0037 0.0007 0.0007
Mycobacterium tuberculosis Probable short chain alcohol dehydrogenase/reductase 0.0028 0.0003 0.0003
Echinococcus multilocularis carboxylesterase 5A 0.0164 0.0076 0.0076
Brugia malayi hypothetical protein 0.0041 0.001 0.0008
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0082 0.0032 0.0068
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0047 0.0013 0.0025
Schistosoma mansoni loxhd1 0.0088 0.0035 0.0034
Brugia malayi sodium-independent organic anion transporter family protein 0.0029 0.0003 0.0002
Loa Loa (eye worm) TAR-binding protein 0.0133 0.006 0.0059
Brugia malayi Intermediate filament tail domain containing protein 0.0028 0.0003 0.0002
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0047 0.0013 0.0418
Mycobacterium tuberculosis Probable oxidoreductase 0.0028 0.0003 0.0003
Echinococcus granulosus fibrillin 2 0.0032 0.0005 0.0005
Chlamydia trachomatis enoyl-acyl-carrier protein reductase 0.0064 0.0022 0.0015
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0036 0.0007 0.0013
Loa Loa (eye worm) intermediate filament protein 0.0028 0.0003 0.0003
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0078 0.003 0.0028
Echinococcus multilocularis fibrillin 2 0.0032 0.0005 0.0005
Plasmodium falciparum apurinic/apyrimidinic endonuclease Apn1, putative 0.0081 0.0031 0.0066
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0028 0.0003 0.0136
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0033 0.0006 0.0009
Onchocerca volvulus 0.0102 0.0043 0.0721
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0037 0.0007 0.0007
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0011 0.0022
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0028 0.0003 0.0001
Schistosoma mansoni bifunctional dihydrofolate reductase-thymidylate synthase 0.1062 0.0562 0.056
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0393 0.02 0.02
Schistosoma mansoni jumonji domain containing protein 0.0062 0.0021 0.002
Trypanosoma brucei beta-ketoacyl-ACP reductase 0.0064 0.0022 0.0047
Brugia malayi Carboxylesterase family protein 0.0028 0.0003 0.0001
Entamoeba histolytica hypothetical protein 0.0117 0.0051 0.6594
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0028 0.0003 0.0001
Loa Loa (eye worm) hypothetical protein 0.0028 0.0003 0.0002
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0117 0.0051 0.0051
Echinococcus multilocularis lamin dm0 0.0028 0.0003 0.0003
Mycobacterium ulcerans hydrolase 0.0398 0.0203 0.0203
Echinococcus multilocularis thymidylate synthase 0.1062 0.0562 0.0562
Trypanosoma cruzi short chain dehydrogenase/reductase, putative 0.0028 0.0003 0.0006
Schistosoma mansoni folylpolyglutamate synthase 0.0426 0.0218 0.0216
Brugia malayi acetyltransferase, GNAT family protein 0.0153 0.007 0.0069
Brugia malayi Carboxylesterase family protein 0.0028 0.0003 0.0001
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0235 0.0115 0.0115
Schistosoma mansoni hypothetical protein 0.0613 0.0319 0.0318
Echinococcus multilocularis disintegrin and metalloproteinase 0.0099 0.0041 0.0041
Echinococcus multilocularis expressed protein 0.0393 0.02 0.02
Brugia malayi steroid hormone receptor 0.0078 0.003 0.0028
Mycobacterium ulcerans short chain dehydrogenase 0.0028 0.0003 0.0003
Brugia malayi ecdysteroid receptor 0.0078 0.003 0.0028
Mycobacterium ulcerans short-chain dehydrogenase 0.0028 0.0003 0.0003
Loa Loa (eye worm) sodium-independent organic anion transporter 0.0029 0.0003 0.0003
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0037 0.0007 0.0007
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase 0.8325 0.4487 1
Mycobacterium tuberculosis Probable dehydrogenase/reductase 0.0064 0.0022 0.0022
Onchocerca volvulus 0.0028 0.0003 0.0003
Echinococcus multilocularis lipoxygenase domain containing protein 0.0088 0.0035 0.0035
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0041 0.001 0.0008
Loa Loa (eye worm) hypothetical protein 0.0037 0.0007 0.0007
Onchocerca volvulus Sepiapterin reductase homolog 0.0028 0.0003 0.0003
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0042 0.001 0.002
Echinococcus granulosus chaperonin containing TCP1 subunit 2 beta 0.0026 0.0001 0.0001
Leishmania major hypothetical protein, conserved 0.004 0.0009 0.0018
Echinococcus multilocularis beta LACTamase domain containing family member 0.004 0.0009 0.0009
Leishmania major 3-oxoacyl-ACP reductase, putative 0.0064 0.0022 0.0046
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0114 0.0049 0.0048
Echinococcus multilocularis adam 0.0204 0.0098 0.0098
Schistosoma mansoni lozenge 0.0059 0.0019 0.0018
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0108 0.0046 0.0044
Echinococcus granulosus multidrug resistance associated protein 1 0.003 0.0004 0.0004
Brugia malayi Carboxylesterase family protein 0.0164 0.0076 0.0075
Schistosoma mansoni steroid dehydrogenase 0.0028 0.0003 0.0001
Mycobacterium ulcerans DNA polymerase IV 0.0064 0.0022 0.0022
Entamoeba histolytica estradiol 17-beta-dehydrogenase, putative 0.0028 0.0003 0.0183
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0082 0.0032 0.0025
Entamoeba histolytica hypothetical protein 0.0117 0.0051 0.6594
Echinococcus granulosus a disintegrin and metalloproteinase with 0.0467 0.024 0.024
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0047 0.0013 0.0418
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.0008 0.0246
Echinococcus multilocularis carbonyl reductase 1 0.0028 0.0003 0.0003
Toxoplasma gondii enoyl-acyl carrier reductase ENR 0.0064 0.0022 0.0046
Echinococcus multilocularis transcription factor btf3 0.0037 0.0008 0.0007
Echinococcus granulosus Nuclear hormone receptor HR96 0.0037 0.0007 0.0007
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0164 0.0076 0.2493
Loa Loa (eye worm) hypothetical protein 0.0064 0.0022 0.0022
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0028 0.0003 0.0002
Onchocerca volvulus 0.0028 0.0003 0.0003
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0164 0.0076 0.2493
Trypanosoma cruzi folylpolyglutamate synthetase 0.0426 0.0218 0.0485
Leishmania major dehydrogenase/oxidoreductase-like protein 0.0064 0.0022 0.0046
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0252 0.0124 0.0123
Schistosoma mansoni oxidoreductase short chain dehydrogenase/reductase family 0.0028 0.0003 0.0001
Schistosoma mansoni short-chain dehydrogenase/reductase 0.0028 0.0003 0.0001
Echinococcus granulosus retinol dehydrogenase 11 0.0028 0.0003 0.0003
Schistosoma mansoni lipoxygenase 0.0393 0.02 0.0199
Loa Loa (eye worm) hypothetical protein 0.0029 0.0003 0.0003
Onchocerca volvulus Protein ultraspiracle homolog 0.0078 0.003 0.0485
Loa Loa (eye worm) MBCTL1 0.0114 0.0049 0.0049
Mycobacterium tuberculosis Hypothetical protein 0.059 0.0307 0.0307
Mycobacterium ulcerans endonuclease IV 0.0081 0.0031 0.0031
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0028 0.0003 0.0089
Brugia malayi Dihydrofolate reductase 1.8528 1 1
Toxoplasma gondii LsmAD domain-containing protein 0.0027 0.0002 0.0001
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0082 0.0032 0.0032
Echinococcus multilocularis carbonyl reductase 1 0.0028 0.0003 0.0003
Brugia malayi mucosa associated lymphoid tissue lymphoma translocation protein 1 0.0047 0.0013 0.0011
Mycobacterium tuberculosis Possible short-chain dehydrogenase EphD 0.0028 0.0003 0.0003
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0072 0.0027 0.0025
Echinococcus granulosus 3 oxoacyl acyl carrier protein reductase 0.0064 0.0022 0.0022
Schistosoma mansoni multidrug resistance protein 0.003 0.0004 0.0002
Schistosoma mansoni lamin 0.0028 0.0003 0.0002
Brugia malayi hypothetical protein 0.0501 0.0258 0.0257
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0036 0.0007 0.0015
Loa Loa (eye worm) hypothetical protein 0.0099 0.0041 0.0041
Leishmania major short chain dehydrogenase-like protein 0.0028 0.0003 0.0003
Trypanosoma cruzi beta-ketoacyl-ACP reductase 0.0064 0.0022 0.0049
Loa Loa (eye worm) hypothetical protein 0.0028 0.0003 0.0002
Mycobacterium tuberculosis Probable hydrolase 0.004 0.0009 0.0009
Plasmodium falciparum thioredoxin reductase 0.0103 0.0043 0.0093
Echinococcus granulosus Major facilitator superfamily general substrate transporter 0.0158 0.0073 0.0073
Giardia lamblia Multidrug resistance-associated protein 1 0.003 0.0004 0.0328
Echinococcus granulosus RUN 0.0088 0.0035 0.0035
Schistosoma mansoni short chain dehydrogenase 0.0028 0.0003 0.0001
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0047 0.0013 0.0025
Schistosoma mansoni sex comb on midleg homolog 0.01 0.0042 0.004
Schistosoma mansoni short chain dehydrogenase 0.0028 0.0003 0.0001
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0033 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.0073 0.0027 0.0027
Schistosoma mansoni hypothetical protein 0.0043 0.0011 0.001
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0064 0.0022 0.0022
Echinococcus granulosus retinol dehydrogenase 11 0.0028 0.0003 0.0003
Echinococcus multilocularis Alpha N acetylgalactosaminidase 0.0108 0.0046 0.0046
Onchocerca volvulus 0.0088 0.0035 0.0582
Plasmodium vivax steroid dehydrogenase, putative 0.0028 0.0003 0.0003
Echinococcus multilocularis integrin alpha 3 0.0613 0.0319 0.0319
Onchocerca volvulus 0.0028 0.0003 0.0003
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0036 0.0007 0.0007
Echinococcus granulosus integrin alpha ps 0.0172 0.008 0.008
Echinococcus granulosus beta LACTamase domain containing family member 0.004 0.0009 0.0009
Trypanosoma brucei short-chain dehydrogenase, putative 0.0028 0.0003 0.0004
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0053 0.0016 0.0016
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0399 0.0203 0.0203
Brugia malayi Latrophilin receptor protein 2 0.0034 0.0006 0.0005
Brugia malayi Melibiase family protein 0.0072 0.0027 0.0025
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0036 0.0007 0.0015
Echinococcus multilocularis Glycoside hydrolase, family 27 0.0108 0.0046 0.0046
Loa Loa (eye worm) hypothetical protein 0.0102 0.0043 0.0043
Onchocerca volvulus 0.0032 0.0005 0.0043
Brugia malayi small heat shock protein 0.0609 0.0317 0.0315
Schistosoma mansoni hypothetical protein 0.0073 0.0027 0.0026
Treponema pallidum fructose-bisphosphate aldolase 0.0164 0.0076 0.3509
Trypanosoma cruzi DNA polymerase kappa, putative 0.0064 0.0022 0.0049
Brugia malayi polk-prov protein 0.0039 0.0009 0.0007
Echinococcus multilocularis lysine specific demethylase 5A 0.0062 0.0021 0.0021
Plasmodium falciparum 3-oxoacyl-[acyl-carrier-protein] reductase 0.0064 0.0022 0.0046
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0036 0.0007 0.0015
Loa Loa (eye worm) hypothetical protein 0.0047 0.0013 0.0013
Leishmania major hypothetical protein, conserved 0.0028 0.0003 0.0003
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0078 0.003 0.003
Loa Loa (eye worm) hypothetical protein 0.0041 0.001 0.001
Toxoplasma gondii transporter, major facilitator family protein 0.003 0.0004 0.0005
Leishmania major p-glycoprotein e 0.003 0.0004 0.0006
Echinococcus multilocularis acetylcholinesterase 0.0164 0.0076 0.0076
Echinococcus granulosus folate receptor beta 0.0878 0.0462 0.0462
Loa Loa (eye worm) hypothetical protein 0.0078 0.003 0.0029
Leishmania major ATP-binding cassette protein subfamily C, member 2, putative 0.003 0.0004 0.0006
Onchocerca volvulus 0.0028 0.0003 0.0003
Mycobacterium tuberculosis Probable oxidoreductase 0.0028 0.0003 0.0003
Plasmodium falciparum glutathione reductase 0.0036 0.0007 0.0012
Loa Loa (eye worm) hypothetical protein 0.0102 0.0043 0.0043
Brugia malayi nuclear receptor RXR 0.0041 0.001 0.0008
Trypanosoma brucei DNA polymerase kappa, putative 0.0064 0.0022 0.0047
Toxoplasma gondii carbonyl reductase 1, putative 0.0028 0.0003 0.0003
Onchocerca volvulus Putative folylpolyglutamate synthase 0.0426 0.0218 0.3848
Brugia malayi nuclear hormone receptor family member nhr-6 0.0037 0.0007 0.0006
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0145 0.0066 0.0066
Echinococcus multilocularis dna polymerase kappa 0.0064 0.0022 0.0022
Echinococcus granulosus lipoxygenase domain containing protein 0.0088 0.0035 0.0035
Mycobacterium leprae Probable short-chain type dehydrogenase/reductase 0.0028 0.0003 0.0003
Mycobacterium ulcerans 20-beta-hydroxysteroid dehydrogenase FabG3 0.0064 0.0022 0.0022
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0009 0.0017
Mycobacterium ulcerans ketoacyl reductase 0.0028 0.0003 0.0003
Schistosoma mansoni sex comb on midleg homolog 0.01 0.0042 0.004
Plasmodium falciparum glutathione reductase 0.0103 0.0043 0.0093
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0047 0.0013 0.0418
Echinococcus multilocularis muscleblind protein 1 0.0157 0.0073 0.0073
Loa Loa (eye worm) hypothetical protein 0.004 0.0009 0.0009
Echinococcus multilocularis retinol dehydrogenase 11 0.0028 0.0003 0.0003
Brugia malayi nuclear hormone receptor family member odr-7 0.0037 0.0007 0.0006
Schistosoma mansoni organic anion transporter 0.0029 0.0003 0.0002
Trypanosoma brucei p-glycoprotein 0.003 0.0004 0.0007
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0133 0.006 0.0059
Trypanosoma brucei DNA polymerase IV, putative 0.0064 0.0022 0.0047
Trichomonas vaginalis DNA helicase recq, putative 0.0048 0.0013 0.0436
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0028 0.0003 0.0003
Schistosoma mansoni intermediate filament proteins 0.0028 0.0003 0.0002
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0078 0.003 0.0028
Loa Loa (eye worm) hypothetical protein 0.0334 0.0168 0.0168
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0033 0.0006 0.001
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0036 0.0007 0.0007
Schistosoma mansoni subfamily C14A unassigned peptidase (C14 family) 0.0047 0.0013 0.0011
Brugia malayi D-beta-hydroxybutyrate dehydrogenase, mitochondrial precursor 0.0028 0.0003 0.0001
Echinococcus multilocularis chaperonin containing TCP1, subunit 2 (beta) 0.0026 0.0001 0.0001
Loa Loa (eye worm) oxidoreductase 0.0028 0.0003 0.0002
Trypanosoma cruzi transcription factor btf3, putative 0.0037 0.0008 0.0016
Toxoplasma gondii endonuclease IV APN 0.0081 0.0031 0.0066
Loa Loa (eye worm) integrin beta-2 0.174 0.0928 0.0927
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0164 0.0076 0.0075
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0032 0.0005 0.0005
Onchocerca volvulus Matrilysin homolog 0.0327 0.0164 0.2891
Loa Loa (eye worm) hypothetical protein 0.0028 0.0003 0.0002
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.004 0.0009 0.0009
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0078 0.003 0.003
Loa Loa (eye worm) hypothetical protein 0.0062 0.0021 0.0021
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0032 0.0005 0.0005
Trypanosoma cruzi folylpolyglutamate synthase, putative 0.0426 0.0218 0.0485
Entamoeba histolytica transcription factor BTF3, putative 0.0037 0.0008 0.0821
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0082 0.0032 0.0068
Mycobacterium ulcerans short chain dehydrogenase 0.0064 0.0022 0.0022
Schistosoma mansoni short chain dehydrogenase 0.0028 0.0003 0.0001
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0028 0.0003 0.0003
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0261 0.0129 0.0129
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0033 0.0006 0.0005
Trichomonas vaginalis conserved hypothetical protein 0.0047 0.0013 0.0418
Echinococcus granulosus lipoxygenase domain containing protein 0.0088 0.0035 0.0035
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0855 0.0449 0.0449
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0164 0.0076 0.2493
Loa Loa (eye worm) hypothetical protein 0.0041 0.001 0.001
Mycobacterium ulcerans short chain dehydrogenase 0.0028 0.0003 0.0003
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0064 0.0022 0.0022
Echinococcus multilocularis muscleblind protein 0.0157 0.0073 0.0073
Loa Loa (eye worm) hypothetical protein 0.0467 0.024 0.024
Leishmania major trypanothione reductase 0.0103 0.0043 0.0093
Entamoeba histolytica Acid sphingomyelinase-like phosphodiesterase, putative 0.0087 0.0035 0.4436
Echinococcus multilocularis BC026374 protein (S09 family) 0.0028 0.0003 0.0002
Giardia lamblia Oxidoreductase, short chain dehydrogenase/reductase family 0.0028 0.0003 0.017
Loa Loa (eye worm) RNA binding protein 0.0133 0.006 0.0059
Schistosoma mansoni integrin alpha 0.0799 0.042 0.0418
Toxoplasma gondii ABC1 family protein 0.004 0.0009 0.0018
Loa Loa (eye worm) hypothetical protein 0.0628 0.0327 0.0327
Loa Loa (eye worm) hypothetical protein 0.0039 0.0009 0.0008
Schistosoma mansoni tar DNA-binding protein 0.0133 0.006 0.0058
Echinococcus granulosus histone acetyltransferase KAT2B 0.0045 0.0012 0.0012
Brugia malayi metalloprotease disintegrin 16 with thrombospondin type I motif 0.0467 0.024 0.0238
Onchocerca volvulus 0.003 0.0004 0.0025
Loa Loa (eye worm) hypothetical protein 0.0037 0.0007 0.0007
Brugia malayi ADAMTS-like protease 0.0073 0.0027 0.0026
Schistosoma mansoni tar DNA-binding protein 0.0133 0.006 0.0058
Mycobacterium leprae NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE) 0.0064 0.0022 0.0022
Onchocerca volvulus Putative organic anion transporter 0.0029 0.0003 0.0017
Echinococcus granulosus organic anion transporting polypeptide 30B 0.0029 0.0003 0.0003
Echinococcus granulosus GPCR family 2 0.0034 0.0006 0.0006
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0102 0.0043 0.0041
Echinococcus granulosus WW domain containing oxidoreductase 0.0028 0.0003 0.0003
Giardia lamblia Hypothetical protein 0.0102 0.0043 0.553
Schistosoma mansoni subfamily M12B unassigned peptidase (M12 family) 0.0099 0.0041 0.0039
Trichomonas vaginalis teneurin and N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase, putative 0.0032 0.0005 0.0167
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0064 0.0022 0.0022
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0028 0.0003 0.0089
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0028 0.0003 0.0089
Schistosoma mansoni hypothetical protein 0.0102 0.0043 0.0041
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0078 0.003 0.003
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0117 0.0051 0.0051
Plasmodium falciparum 1-cys peroxiredoxin 0.009 0.0036 0.0077
Trypanosoma brucei unspecified product 0.0057 0.0018 0.0039
Leishmania major hypothetical protein, conserved 0.0028 0.0003 0.0003
Trichomonas vaginalis conserved hypothetical protein 0.059 0.0307 1
Leishmania major hypothetical protein, conserved 0.0028 0.0003 0.0003
Trypanosoma brucei DNA polymerase kappa, putative 0.0031 0.0005 0.0008
Leishmania major dehydrogenase-like protein 0.0028 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0327 0.0164 0.0164
Mycobacterium ulcerans short chain dehydrogenase 0.0028 0.0003 0.0003
Echinococcus multilocularis Solute carrier organic anion transporter family 0.0029 0.0003 0.0003
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0036 0.0007 0.0007
Schistosoma mansoni transcription factor btf3 0.0037 0.0008 0.0006
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0064 0.0022 0.0022
Echinococcus granulosus tumor protein p63 0.0736 0.0385 0.0385
Trichomonas vaginalis short-chain dehydrogenases/reductase, putative 0.0028 0.0003 0.0089
Echinococcus granulosus Dehydrogenase:reductase SDR family 0.0028 0.0003 0.0003
Trypanosoma cruzi 3-keto-dihydrosphingosine reductase 0.0028 0.0003 0.0006
Echinococcus multilocularis musashi 0.0028 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0114 0.0049 0.0049
Echinococcus multilocularis para nitrobenzyl esterase 0.0028 0.0003 0.0002
Echinococcus granulosus carboxylesterase 5A 0.0164 0.0076 0.0076
Loa Loa (eye worm) hypothetical protein 0.0028 0.0003 0.0002
Loa Loa (eye worm) hypothetical protein 0.0028 0.0003 0.0002
Leishmania major quinonoid dihydropteridine reductase 0.0028 0.0003 0.0003
Onchocerca volvulus Dehydrogenase\/reductase SDR family member 13 homolog 0.0028 0.0003 0.0003
Echinococcus granulosus caspase 0.0123 0.0054 0.0054
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0064 0.0022 0.0022
Giardia lamblia Tenascin-37 0.0032 0.0005 0.0485
Brugia malayi intermediate filament protein 0.0028 0.0003 0.0002
Mycobacterium ulcerans short chain dehydrogenase 0.0064 0.0022 0.0022
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0034 0.0006 0.0005
Mycobacterium ulcerans short chain dehydrogenase 0.0028 0.0003 0.0003
Schistosoma mansoni hypothetical protein 0.0117 0.0051 0.0049
Mycobacterium ulcerans short chain dehydrogenase 0.0028 0.0003 0.0003
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0028 0.0003 0.0003
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0078 0.003 0.0028
Plasmodium vivax bifunctional dihydrofolate reductase-thymidylate synthase, putative 0.8325 0.4487 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0031 0.0005 0.0008
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0064 0.0022 0.0022
Mycobacterium ulcerans short chain dehydrogenase 0.0064 0.0022 0.0022
Trypanosoma brucei Pyrophosphate-energized vacuolar membrane proton pump 1 0.0354 0.0179 0.0396
Leishmania major oxidoreductase-like protein 0.0092 0.0037 0.008
Loa Loa (eye worm) oxidoreductase 0.0028 0.0003 0.0002
Trichomonas vaginalis chaperonin, putative 0.0026 0.0001 0.0048
Onchocerca volvulus 0.0032 0.0005 0.0045
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0036 0.0007 0.0015
Loa Loa (eye worm) hypothetical protein 0.0029 0.0003 0.0003
Echinococcus multilocularis folylpolyglutamate synthase, mitochondrial 0.0426 0.0218 0.0218
Loa Loa (eye worm) dehydrogenase 0.0028 0.0003 0.0002
Trypanosoma brucei short-chain dehydrogenase, putative 0.0028 0.0003 0.0004
Schistosoma mansoni nuclear hormone receptor 0.0078 0.003 0.0028
Trichomonas vaginalis mercuric reductase, putative 0.0036 0.0007 0.0225
Onchocerca volvulus 0.0029 0.0003 0.0017
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0053 0.0016 0.0016
Onchocerca volvulus Folate transporter 1 homolog 0.0102 0.0043 0.0721
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0053 0.0016 0.0016
Trichomonas vaginalis steroid dehydrogenase, putative 0.0028 0.0003 0.0089
Mycobacterium tuberculosis Probable dehydrogenase 0.0235 0.0115 0.0115
Mycobacterium tuberculosis NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase) 0.0064 0.0022 0.0022
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.007 0.0025 0.0053
Schistosoma mansoni jumonji/arid domain-containing protein 0.0064 0.0022 0.0021
Onchocerca volvulus Cell death protein 3 homolog 0.009 0.0036 0.0603
Trichomonas vaginalis D-aminoacylase, putative 0.004 0.0009 0.031
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0164 0.0076 1
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0028 0.0003 0.0001
Echinococcus granulosus lamin dm0 0.0028 0.0003 0.0003
Trypanosoma brucei DNA polymerase kappa, putative 0.0064 0.0022 0.0047
Schistosoma mansoni nuclear hormone receptor 0.0037 0.0007 0.0006
Leishmania major DNA polymerase eta, putative 0.0038 0.0008 0.0015
Mycobacterium ulcerans short chain dehydrogenase 0.0064 0.0022 0.0022
Schistosoma mansoni cpg binding protein 0.003 0.0004 0.0003
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0005 0.0004
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0078 0.003 0.0028
Mycobacterium tuberculosis Probable thymidylate synthase ThyA (ts) (TSASE) 0.1062 0.0562 0.0562
Mycobacterium tuberculosis Probable 3-oxoacyl-[acyl-carrier protein] reductase FabG2 (3-ketoacyl-acyl carrier protein reductase) 0.0064 0.0022 0.0022
Echinococcus granulosus dna polymerase eta 0.0062 0.0021 0.0021
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0235 0.0115 0.0115
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0078 0.003 0.003
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0078 0.003 0.003
Brugia malayi thymidylate synthase 0.1062 0.0562 0.056
Mycobacterium tuberculosis Probable oxidoreductase 0.0028 0.0003 0.0003
Echinococcus granulosus steroid dehydrogenase 0.0028 0.0003 0.0003
Plasmodium falciparum LCCL domain-containing protein 0.0088 0.0035 0.0075
Loa Loa (eye worm) hypothetical protein 0.0609 0.0317 0.0316
Brugia malayi dehydrogenases, short chain protein 9 0.0028 0.0003 0.0001
Brugia malayi jmjC domain containing protein 0.0062 0.0021 0.002
Echinococcus multilocularis integrin alpha ps 0.0358 0.0181 0.0181
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0078 0.003 0.0028
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0033 0.0006 0.0009
Loa Loa (eye worm) latrophilin receptor protein 2 0.0034 0.0006 0.0006
Schistosoma mansoni aryl hydrocarbon receptor nuclear translocator homolog (darnt) 0.0039 0.0009 0.0007
Onchocerca volvulus 0.0102 0.0043 0.072
Brugia malayi ImpB/MucB/SamB family protein 0.0036 0.0007 0.0005
Schistosoma mansoni nuclear receptor 0.0037 0.0007 0.0006
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0108 0.0046 0.0044
Mycobacterium ulcerans short chain dehydrogenase 0.0064 0.0022 0.0022
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0028 0.0003 0.0001
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0399 0.0203 0.0203
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0064 0.0022 0.0022
Plasmodium vivax dihydrofolate synthase/folylpolyglutamate synthase, putative 0.0426 0.0218 0.0482
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0064 0.0022 0.002
Schistosoma mansoni terminal deoxycytidyl transferase 0.0036 0.0007 0.0005
Giardia lamblia DINP protein human, muc B family 0.0043 0.0011 0.1219
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0145 0.0066 0.0064
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0032 0.0005 0.0008
Echinococcus multilocularis thioredoxin glutathione reductase 0.0103 0.0043 0.0043
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0064 0.0022 0.0022
Echinococcus granulosus histone acetyltransferase KAT2B 0.0148 0.0068 0.0068
Mycobacterium tuberculosis Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) 1.8528 1 1
Echinococcus multilocularis integrin alpha ps 0.0172 0.008 0.008
Loa Loa (eye worm) doublecortin family protein 0.0088 0.0035 0.0035
Leishmania major vacuolar-type proton translocating pyrophosphatase 1, putative 0.0354 0.0179 0.0395
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0108 0.0046 0.0044
Trypanosoma cruzi metacaspase, putative 0.0047 0.0013 0.0028
Brugia malayi Thioredoxin reductase 0.0103 0.0043 0.0042
Trypanosoma cruzi metacaspase 5, putative 0.0047 0.0013 0.0028
Chlamydia trachomatis dihydrofolate reductase 1.8528 1 1
Mycobacterium leprae conserved hypothetical protein 0.004 0.0009 0.0009
Brugia malayi Integrin alpha cytoplasmic region family protein 0.0605 0.0314 0.0313
Schistosoma mansoni short chain dehydrogenase 0.0028 0.0003 0.0001
Schistosoma mansoni retinoic acid receptor RXR 0.0182 0.0086 0.0084
Schistosoma mansoni hypothetical protein 0.0733 0.0384 0.0383
Toxoplasma gondii bifunctional dihydrofolate reductase-thymidylate synthase 0.8325 0.4487 1
Plasmodium vivax metacaspase 1, putative 0.0047 0.0013 0.0025
Echinococcus granulosus adam 0.0204 0.0098 0.0098
Echinococcus granulosus intermediate filament protein 0.0028 0.0003 0.0003
Loa Loa (eye worm) glutaminase 2 0.0286 0.0142 0.0142
Plasmodium vivax hypothetical protein, conserved 0.0047 0.0013 0.0025
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase, putative 0.059 0.0307 0.0683
Mycobacterium ulcerans beta-lactamase 0.004 0.0009 0.0009
Onchocerca volvulus 0.0037 0.0007 0.0088
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.004 0.0009 0.0008
Trypanosoma brucei dihydrofolate reductase-thymidylate synthase 0.8325 0.4487 1
Brugia malayi nuclear receptor NHR-88 0.0078 0.003 0.0028
Schistosoma mansoni glutaminase 0.0286 0.0142 0.0141
Echinococcus granulosus ecdysone induced protein 78C 0.0078 0.003 0.003
Plasmodium vivax ataxin-2 like protein, putative 0.0027 0.0002 0.0001
Loa Loa (eye worm) oxidoreductase 0.0028 0.0003 0.0002
Loa Loa (eye worm) hypothetical protein 0.0029 0.0003 0.0003
Loa Loa (eye worm) glutaminase 0.0286 0.0142 0.0142
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0082 0.0032 0.0032
Echinococcus multilocularis estradiol 17 beta dehydrogenase 12 0.0028 0.0003 0.0003
Echinococcus granulosus dnaJ subfamily B 0.0431 0.0221 0.022
Loa Loa (eye worm) oxidoreductase 0.0028 0.0003 0.0002
Echinococcus multilocularis nuclear receptor nhr 48 0.0037 0.0007 0.0007
Mycobacterium tuberculosis Probable oxidoreductase 0.0028 0.0003 0.0003
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0038 0.0008 0.0015
Trichomonas vaginalis importin beta-1, putative 0.0052 0.0016 0.0508
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0393 0.02 0.02
Echinococcus granulosus snurportin 1 0.0681 0.0355 0.0355
Loa Loa (eye worm) oxidoreductase 0.0028 0.0003 0.0002
Echinococcus granulosus importin subunit beta 1 0.0064 0.0022 0.0022
Onchocerca volvulus 0.0028 0.0003 0.0003
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0164 0.0076 0.2493
Loa Loa (eye worm) hypothetical protein 0.0087 0.0035 0.0034
Loa Loa (eye worm) hypothetical protein 0.0078 0.003 0.0029
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0261 0.0129 0.0129
Brugia malayi Retinol dehydrogenase 12 0.0028 0.0003 0.0001
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0078 0.003 0.0029
Brugia malayi follicle stimulating hormone receptor 0.0252 0.0124 0.0122
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0114 0.0049 0.0049
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0235 0.0115 0.0115
Echinococcus multilocularis fibrillin 1 0.0032 0.0005 0.0005
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0028 0.0003 0.0003
Mycobacterium ulcerans dehydrogenase/reductase 0.0028 0.0003 0.0003
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0036 0.0007 0.0005
Trypanosoma brucei 3-ketoacyl-CoA reductase, putative 0.0028 0.0003 0.0004

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 36 nM Inhibition of rat acetylcholinesterase (AChE) ChEMBL. 9767635
IC50 (binding) = 36 nM Inhibition of rat acetylcholinesterase (AChE) ChEMBL. 9767635
IC50 (binding) = 36 nM Inhibition of AChE ChEMBL. 20053484

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

2 literature references were collected for this gene.

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