Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Arachidonate 5-lipoxygenase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Schistosoma mansoni | lipoxygenase | Get druggable targets OG5_127482 | All targets in OG5_127482 |
Echinococcus granulosus | arachidonate 5 lipoxygenase | Get druggable targets OG5_127482 | All targets in OG5_127482 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | Get druggable targets OG5_127482 | All targets in OG5_127482 |
Schistosoma mansoni | lipoxygenase | Get druggable targets OG5_127482 | All targets in OG5_127482 |
Schistosoma japonicum | ko:K00461 arachidonate 5-lipoxygenase [EC1.13.11.34], putative | Get druggable targets OG5_127482 | All targets in OG5_127482 |
Schistosoma japonicum | IPR001024,Lipoxygenase, LH2;IPR013819,Lipoxygenase, C-terminal,domain-containing | Get druggable targets OG5_127482 | All targets in OG5_127482 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Chlamydia trachomatis | dihydrofolate reductase | 0.1804 | 1 | 0.5 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.0437 | 0.1977 | 0.1434 |
Onchocerca volvulus | 0.0437 | 0.1977 | 0.5 | |
Loa Loa (eye worm) | dihydrofolate reductase | 0.1804 | 1 | 1 |
Echinococcus multilocularis | dihydrofolate reductase | 0.1804 | 1 | 1 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.1804 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0208 | 0.0634 | 0.5 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.1276 | 0.6899 | 0.5 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.1276 | 0.6899 | 0.5 |
Echinococcus multilocularis | thymidylate synthase | 0.0437 | 0.1977 | 0.177 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.1804 | 1 | 1 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.1276 | 0.6899 | 0.5 |
Echinococcus granulosus | dihydrofolate reductase | 0.1804 | 1 | 1 |
Schistosoma mansoni | dihydrofolate reductase | 0.1804 | 1 | 1 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.1276 | 0.6899 | 0.5 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.1276 | 0.6899 | 1 |
Echinococcus granulosus | thymidylate synthase | 0.0437 | 0.1977 | 0.177 |
Schistosoma mansoni | lipoxygenase | 0.0142 | 0.0251 | 0.0251 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.1804 | 1 | 1 |
Brugia malayi | Dihydrofolate reductase | 0.1804 | 1 | 1 |
Brugia malayi | thymidylate synthase | 0.0437 | 0.1977 | 0.1434 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0437 | 0.1977 | 0.1977 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.1276 | 0.6899 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 1.6 uM | inhibitory activity against 5-lipoxygenase in rat basophilic leukemia cell line. | ChEMBL. | 1433212 |
IC50 (binding) | = 1.6 uM | inhibitory activity against 5-lipoxygenase in rat basophilic leukemia cell line. | ChEMBL. | 1433212 |
IC50 (functional) | = 5.4 uM | Inhibition of IL-1 beta biosynthesis in human monocytes | ChEMBL. | 1433212 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.