Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | adenosine deaminase | 0.2809 | 1 | 1 |
Trypanosoma cruzi | AMP deaminase, putative | 0.2581 | 0.8332 | 0.5 |
Trypanosoma brucei | adenosine monophosphate deaminase, putative | 0.2581 | 0.8332 | 0.5 |
Onchocerca volvulus | Adenosine deaminase homolog | 0.2809 | 1 | 1 |
Mycobacterium leprae | Probable adenosine deaminase Add (ADENOSINE AMINOHYDROLASE) | 0.2809 | 1 | 0.5 |
Trypanosoma brucei | AMP deaminase, putative | 0.2581 | 0.8332 | 0.5 |
Trypanosoma cruzi | AMP deaminase, putative | 0.2581 | 0.8332 | 0.5 |
Leishmania major | adenine aminohydrolase | 0.2809 | 1 | 1 |
Treponema pallidum | adenosine deaminase | 0.2809 | 1 | 0.5 |
Toxoplasma gondii | Adenosine/AMP deaminase domain-containing protein | 0.2809 | 1 | 1 |
Entamoeba histolytica | adenosine deaminase, putative | 0.2809 | 1 | 1 |
Entamoeba histolytica | adenosine deaminase, putative | 0.2809 | 1 | 1 |
Schistosoma mansoni | adenosine deaminase | 0.2809 | 1 | 1 |
Plasmodium falciparum | adenosine deaminase | 0.2809 | 1 | 1 |
Trichomonas vaginalis | adenosine deaminase, putative | 0.2809 | 1 | 0.5 |
Trypanosoma brucei | AMP deaminase, putative | 0.2581 | 0.8332 | 0.5 |
Plasmodium vivax | adenosine deaminase, putative | 0.2809 | 1 | 1 |
Trypanosoma cruzi | AMP deaminase, putative | 0.2581 | 0.8332 | 0.5 |
Toxoplasma gondii | Adenosine/AMP deaminase domain-containing protein | 0.2809 | 1 | 1 |
Trypanosoma cruzi | AMP deaminase, putative | 0.2581 | 0.8332 | 0.5 |
Trypanosoma cruzi | adenosine monophosphate deaminase-like protein, putative | 0.2581 | 0.8332 | 0.5 |
Mycobacterium ulcerans | adenosine deaminase | 0.2809 | 1 | 0.5 |
Echinococcus multilocularis | adenosine deaminase | 0.2809 | 1 | 1 |
Trypanosoma cruzi | AMP deaminase, putative | 0.2581 | 0.8332 | 0.5 |
Loa Loa (eye worm) | AMP deaminase | 0.2581 | 0.8332 | 0.8332 |
Mycobacterium tuberculosis | Probable adenosine deaminase Add (adenosine aminohydrolase) | 0.2809 | 1 | 0.5 |
Trichomonas vaginalis | adenosine deaminase, putative | 0.2809 | 1 | 0.5 |
Trypanosoma cruzi | adenosine monophosphate deaminase, putative | 0.2581 | 0.8332 | 0.5 |
Schistosoma mansoni | adenosine deaminase-related | 0.2809 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.2809 | 1 | 1 |
Trypanosoma brucei | AMP deaminase, putative | 0.2581 | 0.8332 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 290 nM | In vitro inhibition of human Platelet-rich plasma (PRP) aggregation induced by 5 uM ADP | ChEMBL. | 9767641 |
IC50 (functional) | = 290 nM | In vitro inhibition of human Platelet-rich plasma (PRP) aggregation induced by 5 uM ADP | ChEMBL. | 9767641 |
IC50 (functional) | = 6600 nM | In vitro inhibition of guinea pig Platelet-rich plasma (PRP) aggregation induced by 5 uM ADP | ChEMBL. | 9767641 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 9767641 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.