Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Entamoeba histolytica | adenosine deaminase, putative | 0.4878 | 1 | 1 |
Entamoeba histolytica | adenosine deaminase, putative | 0.4878 | 1 | 1 |
Treponema pallidum | adenosine deaminase | 0.4878 | 1 | 0.5 |
Toxoplasma gondii | Adenosine/AMP deaminase domain-containing protein | 0.4878 | 1 | 1 |
Schistosoma mansoni | adenosine deaminase | 0.4878 | 1 | 1 |
Trichomonas vaginalis | adenosine deaminase, putative | 0.4878 | 1 | 0.5 |
Plasmodium falciparum | adenosine deaminase | 0.4878 | 1 | 1 |
Plasmodium vivax | adenosine deaminase, putative | 0.4878 | 1 | 1 |
Trypanosoma brucei | AMP deaminase, putative | 0.3859 | 0.538 | 0.5 |
Trypanosoma cruzi | AMP deaminase, putative | 0.3859 | 0.538 | 0.5 |
Echinococcus granulosus | adenosine deaminase | 0.4878 | 1 | 1 |
Trypanosoma cruzi | AMP deaminase, putative | 0.3859 | 0.538 | 0.5 |
Onchocerca volvulus | Adenosine deaminase homolog | 0.4878 | 1 | 1 |
Mycobacterium leprae | Probable adenosine deaminase Add (ADENOSINE AMINOHYDROLASE) | 0.4878 | 1 | 0.5 |
Trypanosoma brucei | adenosine monophosphate deaminase, putative | 0.3859 | 0.538 | 0.5 |
Trypanosoma brucei | AMP deaminase, putative | 0.3859 | 0.538 | 0.5 |
Trypanosoma cruzi | AMP deaminase, putative | 0.3859 | 0.538 | 0.5 |
Leishmania major | adenine aminohydrolase | 0.4878 | 1 | 1 |
Trichomonas vaginalis | adenosine deaminase, putative | 0.4878 | 1 | 0.5 |
Trypanosoma cruzi | adenosine monophosphate deaminase, putative | 0.3859 | 0.538 | 0.5 |
Schistosoma mansoni | adenosine deaminase-related | 0.4878 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.4878 | 1 | 1 |
Trypanosoma brucei | AMP deaminase, putative | 0.3859 | 0.538 | 0.5 |
Toxoplasma gondii | Adenosine/AMP deaminase domain-containing protein | 0.4878 | 1 | 1 |
Trypanosoma cruzi | adenosine monophosphate deaminase-like protein, putative | 0.3859 | 0.538 | 0.5 |
Trypanosoma cruzi | AMP deaminase, putative | 0.3859 | 0.538 | 0.5 |
Mycobacterium ulcerans | adenosine deaminase | 0.4878 | 1 | 0.5 |
Echinococcus multilocularis | adenosine deaminase | 0.4878 | 1 | 1 |
Loa Loa (eye worm) | AMP deaminase | 0.3859 | 0.538 | 0.538 |
Mycobacterium tuberculosis | Probable adenosine deaminase Add (adenosine aminohydrolase) | 0.4878 | 1 | 0.5 |
Trypanosoma cruzi | AMP deaminase, putative | 0.3859 | 0.538 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
MIC (functional) | = 0.15 ug ml-1 | In vitro inhibitory activity against Streptococcus pyogenes (02A1UC1) | ChEMBL. | 9767644 |
MIC (functional) | = 0.6 ug ml-1 | In vitro inhibitory activity against Staphylococcus aureus (011UC4) | ChEMBL. | 9767644 |
MIC (functional) | = 0.6 ug ml-1 | In vitro inhibitory activity against Staphylococcus epidermidis (EryRi 012GO11i) | ChEMBL. | 9767644 |
MIC (functional) | = 2.5 ug ml-1 | In vitro inhibitory activity against Staphylococcus aureus (EryRi 011GO25i) | ChEMBL. | 9767644 |
MIC (functional) | = 10 ug ml-1 | In vitro inhibitory activity against Streptococcus pneumoniae (032UC1) | ChEMBL. | 9767644 |
MIC (functional) | = 20 ug ml-1 | In vitro inhibitory activity against Streptococcus pneumoniae (EryRc 030SJ1) | ChEMBL. | 9767644 |
MIC (functional) | = 20 ug ml-1 | In vitro inhibitory activity against Haemophilus influenzae (351CB12) | ChEMBL. | 9767644 |
MIC (functional) | = 40 ug ml-1 | In vitro inhibitory activity against Staphylococcus aureus (EryRc 011CB20) | ChEMBL. | 9767644 |
MIC (functional) | = 40 ug ml-1 | In vitro inhibitory activity against Streptococcus pneumoniae (EryRi 030SJ5i) | ChEMBL. | 9767644 |
MIC (functional) | = 40 ug ml-1 | In vitro inhibitory activity against Haemophilus influenzae (351HT3) | ChEMBL. | 9767644 |
MIC (functional) | = 40 ug ml-1 | In vitro inhibitory activity against Escherichia coli (250 UC5) | ChEMBL. | 9767644 |
MIC (functional) | = 40 ug ml-1 | In vitro inhibitory activity against Escherichia coli (250 UC5) | ChEMBL. | 9767644 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.