TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 465.585 | Formula: C27H35N3O4
H donors: 3 H acceptors: 4 LogP: 4.42 Rotable bonds: 15
Rule of 5 violations (Lipinski): 1
SMILES: CCNC(=O)C(=O)C(NC(=O)C(NC(=O)C(c1ccccc1)c1ccccc1)CC(C)C)CC
InChi: 1S/C27H35N3O4/c1-5-21(24(31)27(34)28-6-2)29-25(32)22(17-18(3)4)30-26(33)23(19-13-9-7-10-14-19)20-15-11-8-12-16-20/h7-16,18,21-23H,5-6,17H2,1-4H3,(H,28,34)(H,29,32)(H,30,33)
InChiKey: VRIJNWCRRYVMEO-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	calpain 2, (m/II) large subunit	Starlite/ChEMBL	References
Homo sapiens	calpain 1, (mu/I) large subunit	Starlite/ChEMBL	References
Bos taurus	Cathepsin B	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Giardia lamblia	Cathepsin B precursor	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Schistosoma mansoni	SmCB2 peptidase (C01 family)	Get druggable targets OG5_127800	All targets in OG5_127800
Schistosoma japonicum	ko:K08585 calpain, invertebrate, putative	Get druggable targets OG5_127139	All targets in OG5_127139
Leishmania donovani	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Echinococcus granulosus	cathepsin b	Get druggable targets OG5_127800	All targets in OG5_127800
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127800	All targets in OG5_127800
Echinococcus multilocularis	cathepsin b	Get druggable targets OG5_127800	All targets in OG5_127800
Loa Loa (eye worm)	calpain family protein 1	Get druggable targets OG5_127139	All targets in OG5_127139
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127139	All targets in OG5_127139
Loa Loa (eye worm)	calpain family protein 1	Get druggable targets OG5_127139	All targets in OG5_127139
Trypanosoma brucei gambiense	cysteine peptidase C (CPC), putative,CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Echinococcus granulosus	calpain A	Get druggable targets OG5_127139	All targets in OG5_127139
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma brucei	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	Get druggable targets OG5_127800	All targets in OG5_127800
Brugia malayi	calpain family protein 1	Get druggable targets OG5_127139	All targets in OG5_127139
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Giardia lamblia	Cathepsin B precursor	Get druggable targets OG5_127800	All targets in OG5_127800
Giardia lamblia	Cathepsin B precursor	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania braziliensis	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	Get druggable targets OG5_127800	All targets in OG5_127800
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127139	All targets in OG5_127139
Schistosoma japonicum	Calpain-A, putative	Get druggable targets OG5_127139	All targets in OG5_127139
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	Get druggable targets OG5_127800	All targets in OG5_127800
Echinococcus multilocularis	cathepsin b	Get druggable targets OG5_127800	All targets in OG5_127800
Brugia malayi	calpain family protein 1	Get druggable targets OG5_127139	All targets in OG5_127139
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Schistosoma japonicum	ko:K01363 cathepsin B [EC3.4.22.1], putative	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127139	All targets in OG5_127139
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127139	All targets in OG5_127139
Echinococcus multilocularis	calpain A	Get druggable targets OG5_127139	All targets in OG5_127139
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Schistosoma japonicum	Calpain-1 catalytic subunit, putative	Get druggable targets OG5_127139	All targets in OG5_127139
Echinococcus granulosus	cathepsin b	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania infantum	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	Get druggable targets OG5_127800	All targets in OG5_127800
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	Get druggable targets OG5_127139	All targets in OG5_127139
Neospora caninum	Cathepsin B-like protease (Precursor), related	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Toxoplasma gondii	cathepsin B	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	Get druggable targets OG5_127139	All targets in OG5_127139
Echinococcus multilocularis	family C2 unassigned peptidase (C02 family)	Get druggable targets OG5_127139	All targets in OG5_127139
Onchocerca volvulus		Get druggable targets OG5_127139	All targets in OG5_127139
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Loa Loa (eye worm)	cathepsin B	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	Get druggable targets OG5_127139	All targets in OG5_127139
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Echinococcus granulosus	family C2 unassigned peptidase C02 family	Get druggable targets OG5_127139	All targets in OG5_127139
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	Get druggable targets OG5_127800	All targets in OG5_127800
Echinococcus multilocularis	calpain family protein 1, d	Get druggable targets OG5_127139	All targets in OG5_127139
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	Get druggable targets OG5_127800	All targets in OG5_127800
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Brugia malayi	cathepsin B-like cysteine proteinase	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania mexicana	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	Get druggable targets OG5_127800	All targets in OG5_127800
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Cathepsin B	335 aa	271 aa	25.1 %
Trypanosoma cruzi	cysteine proteinase, putative	Cathepsin B	335 aa	276 aa	26.1 %
Dictyostelium discoideum	cathepsin L-like proteinase	Cathepsin B	335 aa	322 aa	26.4 %
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Cathepsin B	335 aa	271 aa	24.4 %
Trypanosoma cruzi	cysteine proteinase, putative	Cathepsin B	335 aa	276 aa	25.7 %
Schistosoma japonicum	Cathepsin C precursor, putative	Cathepsin B	335 aa	289 aa	28.4 %
Plasmodium knowlesi	dipeptidyl aminopeptidase 2, putative	Cathepsin B	335 aa	297 aa	24.6 %
Echinococcus granulosus	calpain A	calpain 2, (m/II) large subunit	622 aa	663 aa	31.2 %
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Cathepsin B	335 aa	272 aa	25.0 %
Plasmodium knowlesi	knowpain-2	Cathepsin B	335 aa	308 aa	23.1 %
Onchocerca volvulus		Cathepsin B	335 aa	326 aa	34.7 %
Toxoplasma gondii	cathepsin CPC1	Cathepsin B	335 aa	296 aa	28.7 %
Schistosoma japonicum	ko:K01275 cathepsin C [EC3.4.14.1], putative	Cathepsin B	335 aa	351 aa	28.5 %
Plasmodium berghei	dipeptidyl aminopeptidase 2	Cathepsin B	335 aa	311 aa	22.5 %
Cryptosporidium hominis	preprocathepsin c precursor	Cathepsin B	335 aa	280 aa	25.7 %
Onchocerca volvulus		Cathepsin B	335 aa	275 aa	24.7 %
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Cathepsin B	335 aa	272 aa	24.6 %
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Cathepsin B	335 aa	297 aa	23.6 %
Brugia malayi	Cathepsin L-like precursor	Cathepsin B	335 aa	312 aa	25.0 %
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Cathepsin B	335 aa	270 aa	25.2 %
Plasmodium yoelii	cathepsin c precursor	Cathepsin B	335 aa	313 aa	25.2 %
Babesia bovis	cathepsin C precursor, putative	Cathepsin B	335 aa	305 aa	25.9 %
Schistosoma mansoni	dipeptidyl-peptidase I (C01 family)	Cathepsin B	335 aa	275 aa	32.7 %
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Cathepsin B	335 aa	288 aa	26.4 %
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Cathepsin B	335 aa	271 aa	25.1 %
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Cathepsin B	335 aa	287 aa	25.1 %
Toxoplasma gondii	preprocathepsin c precursor, putative	Cathepsin B	335 aa	272 aa	24.3 %
Dictyostelium discoideum	cysteine proteinase 3	Cathepsin B	335 aa	275 aa	28.7 %
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Cathepsin B	335 aa	297 aa	23.6 %
Dictyostelium discoideum	cysteine proteinase 5 precursor	Cathepsin B	335 aa	271 aa	24.4 %
Onchocerca volvulus	Cathepsin L homolog	Cathepsin B	335 aa	316 aa	25.6 %
Giardia lamblia	Cathepsin L precursor	Cathepsin B	335 aa	280 aa	25.0 %
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Cathepsin B	335 aa	289 aa	22.8 %
Plasmodium vivax	dipeptidyl aminopeptidase 2, putative	Cathepsin B	335 aa	286 aa	26.6 %
Plasmodium berghei	dipeptidyl aminopeptidase 1, putative	Cathepsin B	335 aa	313 aa	25.6 %
Echinococcus granulosus	calpain A	calpain 1, (mu/I) large subunit	714 aa	753 aa	31.7 %
Plasmodium knowlesi	knowpain-3	Cathepsin B	335 aa	301 aa	22.6 %
Onchocerca volvulus	Cathepsin B-like cysteine proteinase 6 homolog	Cathepsin B	335 aa	315 aa	49.2 %
Neospora caninum	hypothetical protein	Cathepsin B	335 aa	303 aa	28.4 %
Plasmodium falciparum	dipeptidyl aminopeptidase 2	Cathepsin B	335 aa	312 aa	23.7 %
Plasmodium knowlesi	knowpain-4	Cathepsin B	335 aa	304 aa	25.3 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Entamoeba histolytica	adenosine deaminase, putative	0.3323	1	1
Trypanosoma brucei	AMP deaminase, putative	0.2255	0.6734	1
Loa Loa (eye worm)	hypothetical protein	0.0132	0.0235	0.0235
Leishmania major	hypothetical protein, conserved	0.1401	0.4121	0.4121
Entamoeba histolytica	adenosine deaminase, putative	0.3323	1	1
Onchocerca volvulus	Adenosine deaminase homolog	0.3323	1	1
Brugia malayi	cathepsin B-like cysteine proteinase	0.0166	0.034	0.0107
Echinococcus granulosus	adenosine deaminase	0.3323	1	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0166	0.034	0.034
Echinococcus multilocularis	cathepsin b	0.0166	0.034	0.0214
Giardia lamblia	Cathepsin B precursor	0.0055	0	0.5
Mycobacterium tuberculosis	Probable adenosine deaminase Add (adenosine aminohydrolase)	0.3323	1	0.5
Onchocerca volvulus		0.1401	0.4121	0.4071
Leishmania major	AMP deaminase, putative,adenosine monophosphate deaminase-like protein	0.2255	0.6734	0.6734
Loa Loa (eye worm)	hypothetical protein	0.0166	0.034	0.034
Loa Loa (eye worm)	AMP deaminase	0.2255	0.6734	0.6734
Schistosoma mansoni	adenosine deaminase	0.3323	1	1
Leishmania major	AMP deaminase, putative	0.2255	0.6734	0.6734
Plasmodium vivax	adenosine deaminase, putative	0.3323	1	1
Giardia lamblia	Cathepsin B precursor	0.0055	0	0.5
Echinococcus multilocularis	AMP deaminase 2	0.2255	0.6734	0.6691
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0166	0.034	0.034
Loa Loa (eye worm)	hypothetical protein	0.0097	0.0129	0.0129
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0166	0.034	0.0505
Trypanosoma cruzi	AMP deaminase, putative	0.2255	0.6734	1
Echinococcus multilocularis	adenosine deaminase	0.3323	1	1
Loa Loa (eye worm)	hypothetical protein	0.3323	1	1
Loa Loa (eye worm)	hypothetical protein	0.0117	0.019	0.019
Giardia lamblia	Cathepsin B precursor	0.0055	0	0.5
Loa Loa (eye worm)	calpain family protein 1	0.0132	0.0235	0.0235
Trypanosoma cruzi	adenosine monophosphate deaminase, putative	0.2255	0.6734	1
Schistosoma mansoni	AMP deaminase	0.2255	0.6734	0.6734
Leishmania major	adenine aminohydrolase	0.3323	1	1
Trichomonas vaginalis	adenosine deaminase, putative	0.3323	1	1
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	0.0138	0.0254	0.0254
Echinococcus granulosus	cathepsin b	0.0166	0.034	0.0089
Echinococcus multilocularis	cathepsin b	0.0166	0.034	0.0214
Leishmania major	adenosine monophosphate deaminase, putative,AMP deaminase, putative	0.2255	0.6734	0.6734
Loa Loa (eye worm)	hypothetical protein	0.1401	0.4121	0.4121
Trypanosoma brucei	AMP deaminase, putative	0.2255	0.6734	1
Loa Loa (eye worm)	hypothetical protein	0.1921	0.5712	0.5712
Trichomonas vaginalis	adenosine deaminase, putative	0.3323	1	1
Schistosoma mansoni	adenosine deaminase-related	0.3323	1	1
Treponema pallidum	adenosine deaminase	0.3323	1	0.5
Brugia malayi	adenosine monophosphate deaminase	0.2255	0.6734	0.6655
Toxoplasma gondii	AMP deaminase	0.2255	0.6734	0.6734
Onchocerca volvulus	AMP deaminase 2 homolog	0.2255	0.6734	0.6706
Loa Loa (eye worm)	hypothetical protein	0.0082	0.0083	0.0083
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0166	0.034	0.034
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	0.0138	0.0254	0.0254
Trypanosoma brucei	AMP deaminase, putative	0.2255	0.6734	1
Toxoplasma gondii	Adenosine/AMP deaminase domain-containing protein	0.3323	1	1
Loa Loa (eye worm)	hypothetical protein	0.0854	0.2445	0.2445
Trypanosoma cruzi	adenosine monophosphate deaminase-like protein, putative	0.2255	0.6734	1
Loa Loa (eye worm)	hypothetical protein	0.1921	0.5712	0.5712
Mycobacterium ulcerans	adenosine deaminase	0.3323	1	0.5
Mycobacterium leprae	Probable adenosine deaminase Add (ADENOSINE AMINOHYDROLASE)	0.3323	1	0.5
Loa Loa (eye worm)	calpain family protein 1	0.0097	0.0129	0.0129
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	0.0132	0.0235	0.0235
Loa Loa (eye worm)	hypothetical protein	0.1921	0.5712	0.5712
Echinococcus multilocularis	calpain A	0.0138	0.0254	0.0126
Leishmania major	AMP deaminase, putative,amp deaminase-like protein	0.2255	0.6734	0.6734
Loa Loa (eye worm)	hypothetical protein	0.1921	0.5712	0.5712
Plasmodium falciparum	adenosine deaminase	0.3323	1	1
Trypanosoma cruzi	AMP deaminase, putative	0.2255	0.6734	1
Echinococcus granulosus	cathepsin b	0.0166	0.034	0.0089
Toxoplasma gondii	Adenosine/AMP deaminase domain-containing protein	0.3323	1	1
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.0166	0.034	0.034
Trypanosoma cruzi	AMP deaminase 2, putative	0.1401	0.4121	0.612
Trypanosoma cruzi	AMP deaminase, putative	0.2255	0.6734	1
Trypanosoma cruzi	AMP deaminase, putative	0.2255	0.6734	1
Echinococcus multilocularis	family C2 unassigned peptidase (C02 family)	0.0138	0.0254	0.0126
Trypanosoma cruzi	AMP deaminase, putative	0.2255	0.6734	1
Trypanosoma brucei	adenosine monophosphate deaminase, putative	0.2255	0.6734	1
Echinococcus granulosus	AMP deaminase 2	0.2255	0.6734	0.6649

Activities

Activity type	Activity value	Assay description	Source	Reference
Ki (binding)	= 0.55 nM	Inhibition of bovine cathepsin B	ChEMBL.	8831774
Ki (binding)	= 1.2 nM	Compound was evaluated for the inhibition of Cysteine protease Calpain 2	ChEMBL.	8831774
Ki (binding)	= 5 nM	Inhibition of the cysteine protease human Calpain 1	ChEMBL.	8831774
Ki (binding)	= 0.55 uM	Inhibition of bovine cathepsin B	ChEMBL.	8831774
Ki (binding)	= 1.2 uM	Compound was evaluated for the inhibition of Cysteine protease Calpain 2	ChEMBL.	8831774
Ki (binding)	= 5 uM	Inhibition of the cysteine protease human Calpain 1	ChEMBL.	8831774

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL131779

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 225870