TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 571.625 | Formula: C34H29N5O4
H donors: 1 H acceptors: 3 LogP: 3.75 Rotable bonds: 4
Rule of 5 violations (Lipinski): 2
SMILES: CO[C@H]1[C@H](C[C@@H]2O[C@@]1(C)n1c3ccccc3c3c1c1n2c2ccccc2c1c1c3CNC1=O)N(C(=O)c1cccnc1)C
InChi: 1S/C34H29N5O4/c1-34-31(42-3)24(37(2)33(41)18-9-8-14-35-16-18)15-25(43-34)38-22-12-6-4-10-19(22)27-28-21(17-36-32(28)40)26-20-11-5-7-13-23(20)39(34)30(26)29(27)38/h4-14,16,24-25,31H,15,17H2,1-3H3,(H,36,40)/t24-,25-,31-,34+/m0/s1
InChiKey: FELQRVDTGNDOSI-RJNAIGRJSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	protein kinase, cAMP-dependent, catalytic, alpha		No references
Homo sapiens	protein kinase, cAMP-dependent, catalytic, gamma	Starlite/ChEMBL	No references
Homo sapiens	protein kinase D1	Starlite/ChEMBL	No references
Homo sapiens	protein kinase C, gamma		No references
Homo sapiens	protein kinase C, iota		No references
Homo sapiens	protein kinase C, alpha		No references
Homo sapiens	protein kinase C, eta		No references
Homo sapiens	protein kinase D3		No references
Homo sapiens	protein kinase C, beta		No references
Homo sapiens	protein kinase C, delta		No references
Homo sapiens	protein kinase C, epsilon		No references
Homo sapiens	epidermal growth factor receptor	Starlite/ChEMBL	No references
Homo sapiens	protein kinase C, theta		No references
Homo sapiens	protein kinase, cAMP-dependent, catalytic, beta		No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Leishmania mexicana	protein kinase A catalytic subunit isoform 2	Get druggable targets OG5_126748	All targets in OG5_126748
Schistosoma mansoni	atypical protein kinase C	Get druggable targets OG5_131830	All targets in OG5_131830
Neospora caninum	AGC kinase, putative	Get druggable targets OG5_126748	All targets in OG5_126748
Neospora caninum	AGC kinase, putative	Get druggable targets OG5_126748	All targets in OG5_126748
Loa Loa (eye worm)	CAMK/PKD protein kinase	Get druggable targets OG5_130080	All targets in OG5_130080
Echinococcus granulosus	melanoma receptor tyrosine protein kinase	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma mansoni	tyrosine kinase	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma japonicum	Protein kinase C alpha type, putative	Get druggable targets OG5_129482	All targets in OG5_129482
Trypanosoma brucei	cAMP-dependent protein kinase catalytic subunit 2	Get druggable targets OG5_126748	All targets in OG5_126748
Schistosoma mansoni	tyrosine kinase	Get druggable targets OG5_128597	All targets in OG5_128597
Candida albicans	protein kinase A	Get druggable targets OG5_126748	All targets in OG5_126748
Schistosoma mansoni	serine/threonine protein kinase	Get druggable targets OG5_126748	All targets in OG5_126748
Echinococcus multilocularis	serine:threonine protein kinase N2	Get druggable targets OG5_129314	All targets in OG5_129314
Echinococcus multilocularis	RNA directed DNA polymerase	Get druggable targets OG5_129482	All targets in OG5_129482
Brugia malayi	Protein kinase c protein 2	Get druggable targets OG5_129482	All targets in OG5_129482
Echinococcus granulosus	protein kinase c epsilon type	Get druggable targets OG5_129314	All targets in OG5_129314
Echinococcus multilocularis	cAMP dependent protein kinase catalytic subunit	Get druggable targets OG5_126748	All targets in OG5_126748
Schistosoma japonicum	Receptor tyrosine-protein kinase erbB-2 precursor, putative	Get druggable targets OG5_128597	All targets in OG5_128597
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126748	All targets in OG5_126748
Leishmania major	protein kinase A catalytic subunit isoform 2	Get druggable targets OG5_126748	All targets in OG5_126748
Schistosoma japonicum	Epidermal growth factor receptor precursor, putative	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma japonicum	expressed protein	Get druggable targets OG5_130080	All targets in OG5_130080
Trypanosoma cruzi	cAMP-dependent protein kinase catalytic subunit 2	Get druggable targets OG5_126748	All targets in OG5_126748
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_132502	All targets in OG5_132502
Schistosoma mansoni	serine/threonine protein kinase	Get druggable targets OG5_126748	All targets in OG5_126748
Brugia malayi	cAMP-dependent protein kinase catalytic subunit, putative	Get druggable targets OG5_126748	All targets in OG5_126748
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_132502	All targets in OG5_132502
Echinococcus multilocularis	cAMP dependent protein kinase catalytic subunit	Get druggable targets OG5_126748	All targets in OG5_126748
Cryptosporidium parvum	protein kinase, cAMP-dependent, catalytic chain	Get druggable targets OG5_126748	All targets in OG5_126748
Trypanosoma brucei gambiense	protein kinase A catalytic subunit isoform 1,protein kinase A catalytic subunit	Get druggable targets OG5_126748	All targets in OG5_126748
Candida albicans	cAMP-dependent protein kinase	Get druggable targets OG5_126748	All targets in OG5_126748
Theileria parva	cAMP-dependent protein kinase, putative	Get druggable targets OG5_126748	All targets in OG5_126748
Loa Loa (eye worm)	AGC/PKA protein kinase	Get druggable targets OG5_126748	All targets in OG5_126748
Brugia malayi	protein kinase C II.	Get druggable targets OG5_129314	All targets in OG5_129314
Onchocerca volvulus		Get druggable targets OG5_130080	All targets in OG5_130080
Leishmania infantum	protein kinase A catalytic subunit isoform 2	Get druggable targets OG5_126748	All targets in OG5_126748
Leishmania donovani	protein kinase A catalytic subunit 3	Get druggable targets OG5_126748	All targets in OG5_126748
Echinococcus granulosus	serine:threonine protein kinase N2	Get druggable targets OG5_129314	All targets in OG5_129314
Echinococcus granulosus	protein kinase C gamma type	Get druggable targets OG5_129482	All targets in OG5_129482
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_132502	All targets in OG5_132502
Schistosoma japonicum	Epidermal growth factor receptor precursor, putative	Get druggable targets OG5_128597	All targets in OG5_128597
Candida albicans	protein kinase C similar to S. cerevisiae PKC1 (YBL105C)	Get druggable targets OG5_129482	All targets in OG5_129482
Echinococcus granulosus	cAMP dependent protein kinase catalytic subunit	Get druggable targets OG5_126748	All targets in OG5_126748
Trypanosoma brucei gambiense	protein kinase A catalytic subunit isoform 2,protein kinase A catalytic subunit	Get druggable targets OG5_126748	All targets in OG5_126748
Echinococcus multilocularis	cAMP dependent protein kinase catalytic subunit	Get druggable targets OG5_126748	All targets in OG5_126748
Schistosoma japonicum	cAMP-dependent protein kinase catalytic subunit alpha, putative	Get druggable targets OG5_126748	All targets in OG5_126748
Schistosoma japonicum	Protein kinase C epsilon type, putative	Get druggable targets OG5_129314	All targets in OG5_129314
Schistosoma japonicum	IPR000477,RNA-directed DNA polymerase (Reverse transcriptase),domain-containing	Get druggable targets OG5_129482	All targets in OG5_129482
Schistosoma japonicum	hypothetical protein	Get druggable targets OG5_130080	All targets in OG5_130080
Schistosoma japonicum	IPR006212,Furin-like repeat;IPR009030,Growth factor, receptor,domain-containing	Get druggable targets OG5_128597	All targets in OG5_128597
Echinococcus multilocularis	cAMP dependent protein kinase catalytic subunit	Get druggable targets OG5_126748	All targets in OG5_126748
Trypanosoma cruzi	cAMP-dependent protein kinase catalytic subunit 3	Get druggable targets OG5_126748	All targets in OG5_126748
Echinococcus multilocularis	telomerase reverse transcriptase subunit	Get druggable targets OG5_129482	All targets in OG5_129482
Schistosoma mansoni	tyrosine kinase	Get druggable targets OG5_128597	All targets in OG5_128597
Echinococcus granulosus	Protein kinase C brain isozyme	Get druggable targets OG5_129482	All targets in OG5_129482
Babesia bovis	protein kinase domain containing protein	Get druggable targets OG5_126748	All targets in OG5_126748
Schistosoma japonicum	ko:K06068 novel protein kinase C, putative	Get druggable targets OG5_129314	All targets in OG5_129314
Schistosoma japonicum	Protein kinase DC2, putative	Get druggable targets OG5_126748	All targets in OG5_126748
Echinococcus granulosus	epidermal growth factor receptor	Get druggable targets OG5_128597	All targets in OG5_128597
Echinococcus multilocularis	protein kinase c epsilon type	Get druggable targets OG5_129314	All targets in OG5_129314
Schistosoma japonicum	IPR000719,Protein kinase;IPR011009,Protein kinase-like,domain-containing	Get druggable targets OG5_126748	All targets in OG5_126748
Giardia lamblia	Kinase, AGC PKA	Get druggable targets OG5_126748	All targets in OG5_126748
Schistosoma mansoni	protein kinase C mu	Get druggable targets OG5_130080	All targets in OG5_130080
Schistosoma japonicum	ko:K06070 protein kinase D, putative	Get druggable targets OG5_130080	All targets in OG5_130080
Theileria parva	cAMP-dependent protein kinase catalytic subunit, putative	Get druggable targets OG5_126748	All targets in OG5_126748
Schistosoma japonicum	ko:K06070 protein kinase D, putative	Get druggable targets OG5_130080	All targets in OG5_130080
Schistosoma japonicum	expressed protein	Get druggable targets OG5_128597	All targets in OG5_128597
Echinococcus multilocularis	epidermal growth factor receptor	Get druggable targets OG5_128597	All targets in OG5_128597
Plasmodium falciparum	cAMP-dependent protein kinase catalytic subunit	Get druggable targets OG5_126748	All targets in OG5_126748
Loa Loa (eye worm)	AGC/PKC/ALPHA protein kinase	Get druggable targets OG5_129482	All targets in OG5_129482
Schistosoma japonicum	cAMP-dependent protein kinase catalytic subunit alpha, putative	Get druggable targets OG5_126748	All targets in OG5_126748
Echinococcus granulosus	RNA directed DNA polymerase	Get druggable targets OG5_129482	All targets in OG5_129482
Schistosoma mansoni	tyrosine kinase	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma mansoni	tyrosine kinase	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma mansoni	serine/threonine protein kinase	Get druggable targets OG5_129482	All targets in OG5_129482
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_130080	All targets in OG5_130080
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_130080	All targets in OG5_130080
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_132502	All targets in OG5_132502
Schistosoma japonicum	Calcium-dependent protein kinase C, putative	Get druggable targets OG5_129482	All targets in OG5_129482
Trypanosoma brucei	protein kinase A catalytic subunit, putative	Get druggable targets OG5_126748	All targets in OG5_126748
Schistosoma japonicum	Protein kinase C gamma type, putative	Get druggable targets OG5_129482	All targets in OG5_129482
Leishmania infantum	protein kinase A catalytic subunit	Get druggable targets OG5_126748	All targets in OG5_126748
Trypanosoma congolense	cAMP-dependent protein kinase catalytic subunit 1	Get druggable targets OG5_126748	All targets in OG5_126748
Entamoeba histolytica	PH domain containing protein kinase, putative	Get druggable targets OG5_129314	All targets in OG5_129314
Schistosoma japonicum	ko:K04345 protein kinase A, putative	Get druggable targets OG5_126748	All targets in OG5_126748
Echinococcus granulosus	cAMP dependent protein kinase catalytic subunit	Get druggable targets OG5_126748	All targets in OG5_126748
Echinococcus granulosus	epidermal growth factor receptor	Get druggable targets OG5_128597	All targets in OG5_128597
Leishmania mexicana	protein kinase A catalytic subunit	Get druggable targets OG5_126748	All targets in OG5_126748
Echinococcus multilocularis	Protein kinase C, brain isozyme	Get druggable targets OG5_129482	All targets in OG5_129482
Loa Loa (eye worm)	AGC/PKC/IOTA protein kinase	Get druggable targets OG5_131830	All targets in OG5_131830
Candida albicans	protein kinase C similar to S. cerevisiae PKC1 (YBL105C)	Get druggable targets OG5_129482	All targets in OG5_129482
Loa Loa (eye worm)	TK/EGFR protein kinase	Get druggable targets OG5_128597	All targets in OG5_128597
Onchocerca volvulus		Get druggable targets OG5_130080	All targets in OG5_130080
Schistosoma japonicum	IPR000494,EGF receptor, L domain,domain-containing	Get druggable targets OG5_128597	All targets in OG5_128597
Echinococcus granulosus	protein kinase c iota type	Get druggable targets OG5_131830	All targets in OG5_131830
Schistosoma japonicum	Protein kinase C alpha type, putative	Get druggable targets OG5_129482	All targets in OG5_129482
Schistosoma mansoni	serine/threonine protein kinase	Get druggable targets OG5_126748	All targets in OG5_126748
Candida albicans	protein kinase A	Get druggable targets OG5_126748	All targets in OG5_126748
Trypanosoma cruzi	cAMP-dependent protein kinase catalytic subunit 3	Get druggable targets OG5_126748	All targets in OG5_126748
Brugia malayi	C1-like domain containing protein	Get druggable targets OG5_130080	All targets in OG5_130080
Leishmania mexicana	protein kinase A catalytic subunit isoform 1	Get druggable targets OG5_126748	All targets in OG5_126748
Trypanosoma brucei gambiense	protein kinase A catalytic subunit	Get druggable targets OG5_126748	All targets in OG5_126748
Plasmodium vivax	cAMP-dependent protein kinase catalytic subunit, putative	Get druggable targets OG5_126748	All targets in OG5_126748
Leishmania braziliensis	protein kinase A catalytic subunit isoform 1	Get druggable targets OG5_126748	All targets in OG5_126748
Leishmania major	protein kinase A catalytic subunit isoform 1	Get druggable targets OG5_126748	All targets in OG5_126748
Brugia malayi	protein kinase C3,putative	Get druggable targets OG5_131830	All targets in OG5_131830
Echinococcus granulosus	cAMP dependent protein kinase catalytic subunit	Get druggable targets OG5_126748	All targets in OG5_126748
Echinococcus granulosus	enhancer of mRNA decapping protein 4	Get druggable targets OG5_126748	All targets in OG5_126748
Plasmodium yoelii	Protein kinase domain, putative	Get druggable targets OG5_126748	All targets in OG5_126748
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_130080	All targets in OG5_130080
Trypanosoma brucei	cAMP-dependent protein kinase catalytic subunit 1	Get druggable targets OG5_126748	All targets in OG5_126748
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_132502	All targets in OG5_132502
Entamoeba histolytica	PH domain containing protein kinase, putative	Get druggable targets OG5_126748	All targets in OG5_126748
Toxoplasma gondii	AGC kinase	Get druggable targets OG5_126748	All targets in OG5_126748
Schistosoma japonicum	Tyrosine-protein kinase transforming protein erbB, putative	Get druggable targets OG5_128597	All targets in OG5_128597
Cryptosporidium hominis	protein kinase (EC 2.7.1.37), cAMP-dependent, catalytic chain	Get druggable targets OG5_126748	All targets in OG5_126748
Schistosoma mansoni	serine/threonine protein kinase	Get druggable targets OG5_129314	All targets in OG5_129314
Schistosoma japonicum	hypothetical protein	Get druggable targets OG5_128597	All targets in OG5_128597
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_129482	All targets in OG5_129482
Plasmodium berghei	cAMP-dependent protein kinase catalytic subunit	Get druggable targets OG5_126748	All targets in OG5_126748
Schistosoma japonicum	Epidermal growth factor receptor precursor, putative	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma japonicum	hypothetical protein	Get druggable targets OG5_130080	All targets in OG5_130080
Schistosoma mansoni	serine/threonine protein kinase	Get druggable targets OG5_129482	All targets in OG5_129482
Trichomonas vaginalis	AGC family protein kinase	Get druggable targets OG5_126748	All targets in OG5_126748
Schistosoma japonicum	Epidermal growth factor receptor precursor, putative	Get druggable targets OG5_128597	All targets in OG5_128597
Loa Loa (eye worm)	AGC/PKC/ETA protein kinase	Get druggable targets OG5_129314	All targets in OG5_129314
Trypanosoma congolense	protein kinase A catalytic subunit 3	Get druggable targets OG5_126748	All targets in OG5_126748
Onchocerca volvulus		Get druggable targets OG5_132502	All targets in OG5_132502
Schistosoma japonicum	ko:K04345 protein kinase A, putative	Get druggable targets OG5_126748	All targets in OG5_126748
Leishmania infantum	protein kinase A catalytic subunit isoform 1	Get druggable targets OG5_126748	All targets in OG5_126748
Leishmania major	protein kinase A catalytic subunit	Get druggable targets OG5_126748	All targets in OG5_126748
Echinococcus multilocularis	epidermal growth factor receptor	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma mansoni	tyrosine kinase	Get druggable targets OG5_128597	All targets in OG5_128597
Toxoplasma gondii	protein kinase, cAMP-dependent, catalytic chain	Get druggable targets OG5_126748	All targets in OG5_126748
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_129482	All targets in OG5_129482
Schistosoma japonicum	ko:K05085 receptor tyrosine-protein kinase erbB-4, putative	Get druggable targets OG5_128597	All targets in OG5_128597
Echinococcus multilocularis	serine threonine protein kinase	Get druggable targets OG5_129482	All targets in OG5_129482
Brugia malayi	Phorbol esters/diacylglycerol binding domain	Get druggable targets OG5_130080	All targets in OG5_130080
Entamoeba histolytica	PH domain containing protein kinase, putative	Get druggable targets OG5_126748	All targets in OG5_126748
Candida albicans	cAMP-dependent protein kinase	Get druggable targets OG5_126748	All targets in OG5_126748
Plasmodium knowlesi	cAMP-dependent protein kinase catalytic subunit, putative	Get druggable targets OG5_126748	All targets in OG5_126748
Onchocerca volvulus		Get druggable targets OG5_130080	All targets in OG5_130080
Loa Loa (eye worm)	CAMK/PKD protein kinase	Get druggable targets OG5_130080	All targets in OG5_130080
Schistosoma japonicum	ko:K06069 atypical protein kinase C, putative	Get druggable targets OG5_131830	All targets in OG5_131830
Echinococcus multilocularis	protein kinase c iota type	Get druggable targets OG5_131830	All targets in OG5_131830
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_130080	All targets in OG5_130080
Schistosoma japonicum	Receptor tyrosine-protein kinase erbB-4 precursor, putative	Get druggable targets OG5_128597	All targets in OG5_128597
Loa Loa (eye worm)	AGC/PKA protein kinase	Get druggable targets OG5_126748	All targets in OG5_126748
Echinococcus multilocularis	enhancer of mRNA decapping protein 4	Get druggable targets OG5_126748	All targets in OG5_126748
Toxoplasma gondii	AGC kinase	Get druggable targets OG5_126748	All targets in OG5_126748
Brugia malayi	Furin-like cysteine rich region family protein	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma japonicum	cAMP-dependent protein kinase catalytic subunit, putative	Get druggable targets OG5_126748	All targets in OG5_126748
Echinococcus multilocularis		Get druggable targets OG5_128597	All targets in OG5_128597
Trypanosoma congolense	cAMP-dependent protein kinase catalytic subunit 1	Get druggable targets OG5_126748	All targets in OG5_126748
Schistosoma japonicum	Epidermal growth factor receptor precursor, putative	Get druggable targets OG5_128597	All targets in OG5_128597
Trypanosoma cruzi	cAMP-dependent protein kinase catalytic subunit 1	Get druggable targets OG5_126748	All targets in OG5_126748
Leishmania braziliensis	protein kinase A catalytic subunit	Get druggable targets OG5_126748	All targets in OG5_126748

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Trypanosoma brucei	protein lipid droplet kinase (LDK)	protein kinase, cAMP-dependent, catalytic, beta	358 aa	320 aa	27.8 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trichomonas vaginalis	AGC family protein kinase	0.0095	0.0427	0.1452
Echinococcus granulosus	epidermal growth factor receptor	0.0097	0.048	0.0623
Onchocerca volvulus		0.0147	0.1946	0.241
Trypanosoma cruzi	cAMP-dependent protein kinase catalytic subunit 3	0.0148	0.1984	0.5
Schistosoma mansoni	serine/threonine protein kinase	0.0148	0.1984	0.2576
Entamoeba histolytica	protein kinase, putative	0.0095	0.0427	0.1534
Loa Loa (eye worm)	CAMK/PKD protein kinase	0.0151	0.2066	0.2066
Plasmodium vivax	cAMP-dependent protein kinase catalytic subunit, putative	0.0148	0.1984	0.5
Onchocerca volvulus		0.0333	0.7377	1
Leishmania major	protein kinase A catalytic subunit	0.0148	0.1984	0.5
Brugia malayi	protein kinase C II.	0.0345	0.7703	1
Schistosoma mansoni	tyrosine kinase	0.0096	0.045	0.0585
Trichomonas vaginalis	AGC family protein kinase	0.0095	0.0427	0.1452
Loa Loa (eye worm)	hypothetical protein	0.0333	0.7377	0.7377
Echinococcus granulosus	ribosomal protein S6 kinase alpha 3	0.009	0.0282	0.0367
Echinococcus multilocularis	serine:threonine protein kinase MRCK beta	0.0084	0.012	0.0156
Echinococcus multilocularis	raf serine:threonine protein kinase	0.0081	0.003	0.0039
Loa Loa (eye worm)	hypothetical protein	0.0223	0.4165	0.4165
Plasmodium falciparum	cAMP-dependent protein kinase catalytic subunit	0.0148	0.1984	0.5
Brugia malayi	Pleckstrin Homology Domain	0.0085	0.0144	0.0188
Loa Loa (eye worm)	AGC/RSK/MSK protein kinase	0.009	0.0282	0.0282
Trichomonas vaginalis	AGC family protein kinase	0.0095	0.0427	0.1452
Echinococcus granulosus	myotubularin protein 13	0.0085	0.0144	0.0188
Loa Loa (eye worm)	hypothetical protein	0.0088	0.0221	0.0221
Loa Loa (eye worm)	hypothetical protein	0.0147	0.1946	0.1946
Trichomonas vaginalis	AGC family protein kinase	0.0095	0.0427	0.1452
Brugia malayi	Hr1 repeat family protein	0.009	0.0282	0.0367
Toxoplasma gondii	AGC kinase	0.0148	0.1984	1
Schistosoma mansoni	tyrosine kinase	0.0097	0.048	0.0623
Loa Loa (eye worm)	AGC/PKC/ALPHA protein kinase	0.0155	0.2165	0.2165
Echinococcus granulosus	NDR protein kinase	0.009	0.0282	0.0367
Schistosoma mansoni	unc-13 (munc13)	0.0088	0.0221	0.0287
Echinococcus multilocularis	enhancer of mRNA decapping protein 4	0.0144	0.1864	0.242
Loa Loa (eye worm)	AGC/AKT protein kinase	0.0095	0.0427	0.0427
Loa Loa (eye worm)	TK/EGFR protein kinase	0.018	0.291	0.291
Echinococcus granulosus	Serine/threonine-protein kinase Genghis Khan	0.0084	0.012	0.0156
Echinococcus granulosus	melanoma receptor tyrosine protein kinase	0.0097	0.048	0.0623
Trichomonas vaginalis	AGC family protein kinase	0.0095	0.0427	0.1452
Giardia lamblia	Kinase, AGC PKA	0.0148	0.1984	0.5
Echinococcus granulosus	cAMP dependent protein kinase catalytic subunit	0.0148	0.1984	0.2576
Trypanosoma brucei	protein kinase A catalytic subunit, putative	0.0148	0.1984	1
Brugia malayi	Protein kinase c protein 2	0.0235	0.4506	0.5849
Loa Loa (eye worm)	hypothetical protein	0.0333	0.7377	0.7377
Trypanosoma brucei	cAMP-dependent protein kinase catalytic subunit 2	0.0148	0.1984	1
Schistosoma mansoni	serine/threonine protein kinase	0.0345	0.7703	1
Loa Loa (eye worm)	AGC/PKA protein kinase	0.0148	0.1984	0.1984
Schistosoma mansoni	tyrosine kinase	0.0096	0.045	0.0585
Schistosoma mansoni	serine/threonine protein kinase	0.0084	0.012	0.0156
Loa Loa (eye worm)	hypothetical protein	0.0148	0.1984	0.1984
Loa Loa (eye worm)	hypothetical protein	0.0085	0.0144	0.0144
Toxoplasma gondii	protein kinase, cAMP-dependent, catalytic chain	0.0148	0.1984	1
Echinococcus multilocularis	C2 calcium dependent membrane targeting	0.0088	0.0221	0.0287
Schistosoma mansoni	atypical protein kinase C	0.0277	0.5739	0.745
Trichomonas vaginalis	AGC family protein kinase	0.0095	0.0427	0.1452
Schistosoma mansoni	protein kinase C	0.0088	0.0221	0.0287
Echinococcus granulosus	protein kinase c iota type	0.027	0.5526	0.7173
Schistosoma mansoni	tyrosine kinase	0.0096	0.045	0.0585
Echinococcus granulosus	enhancer of mRNA decapping protein 4	0.0144	0.1864	0.242
Schistosoma mansoni	protein kinase C mu	0.0231	0.4406	0.572
Brugia malayi	Phorbol esters/diacylglycerol binding domain	0.0231	0.4406	0.572
Echinococcus granulosus	raf serine:threonine protein kinase	0.0081	0.003	0.0039
Trichomonas vaginalis	AGC family protein kinase	0.0148	0.1984	1
Toxoplasma gondii	AGC kinase	0.009	0.0282	0.1423
Leishmania major	protein kinase A catalytic subunit isoform 2	0.0148	0.1984	0.5
Onchocerca volvulus		0.0232	0.4431	0.5883
Loa Loa (eye worm)	AGC/PKN protein kinase	0.009	0.0282	0.0282
Echinococcus multilocularis	RNA directed DNA polymerase	0.0143	0.1824	0.2368
Brugia malayi	Protein kinase domain containing protein	0.009	0.0282	0.0367
Echinococcus multilocularis	Protein kinase C, brain isozyme	0.0321	0.7009	0.9099
Echinococcus multilocularis	unc 13 (munc13)	0.0088	0.0221	0.0287
Schistosoma mansoni	serine/threonine protein kinase	0.0081	0.003	0.0039
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0176	0.2783	1
Trypanosoma cruzi	cAMP-dependent protein kinase catalytic subunit 1	0.0148	0.1984	0.5
Brugia malayi	cAMP-dependent protein kinase catalytic subunit, putative	0.0148	0.1984	0.2576
Trypanosoma cruzi	cAMP-dependent protein kinase catalytic subunit 2	0.0148	0.1984	0.5
Loa Loa (eye worm)	hypothetical protein	0.0333	0.7377	0.7377
Trypanosoma cruzi	cAMP-dependent protein kinase catalytic subunit 3	0.0148	0.1984	0.5
Schistosoma mansoni	tyrosine kinase	0.0097	0.048	0.0623
Trichomonas vaginalis	AGC family protein kinase	0.0095	0.0427	0.1452
Loa Loa (eye worm)	CAMK/PKD protein kinase	0.0231	0.4406	0.4406
Echinococcus multilocularis	serine:threonine protein kinase 38	0.009	0.0282	0.0367
Echinococcus granulosus	epidermal growth factor receptor	0.018	0.291	0.3777
Schistosoma mansoni	serine/threonine kinase	0.009	0.0282	0.0367
Brugia malayi	p70 ribosomal S6 kinase beta	0.009	0.0282	0.0367
Echinococcus multilocularis	myotubularin protein 13	0.0085	0.0144	0.0188
Schistosoma mansoni	unc-13 (munc13)	0.0088	0.0221	0.0287
Loa Loa (eye worm)	AGC/NDR protein kinase	0.009	0.0282	0.0282
Schistosoma mansoni	serine/threonine protein kinase	0.009	0.0282	0.0367
Toxoplasma gondii	AGC kinase	0.0148	0.1984	1
Loa Loa (eye worm)	AGC/PKA protein kinase	0.0148	0.1984	0.1984
Echinococcus multilocularis	cAMP dependent protein kinase catalytic subunit	0.0148	0.1984	0.2576
Echinococcus multilocularis	Ribosomal protein S6 kinase beta 2	0.009	0.0282	0.0367
Loa Loa (eye worm)	AGC/RSK/RSK protein kinase	0.009	0.0282	0.0282
Loa Loa (eye worm)	AGC/PKC/IOTA protein kinase	0.0191	0.3236	0.3236
Entamoeba histolytica	protein kinase, putative	0.009	0.0282	0.1015
Echinococcus granulosus	serine:threonine protein kinase N2	0.0171	0.2638	0.3425
Echinococcus granulosus	protein kinase C gamma type	0.024	0.4668	0.606
Schistosoma mansoni	serine/threonine protein kinase	0.009	0.0282	0.0367
Leishmania major	protein kinase A catalytic subunit isoform 1	0.0148	0.1984	0.5
Echinococcus granulosus	ribosomal protein s6 kinase beta 1	0.009	0.0282	0.0367
Echinococcus multilocularis	ribosomal protein S6 kinase alpha 3	0.009	0.0282	0.0367
Echinococcus granulosus	C2 calcium dependent membrane targeting	0.0088	0.0221	0.0287
Brugia malayi	Protein kinase domain containing protein	0.009	0.0282	0.0367
Echinococcus granulosus	Ribosomal protein S6 kinase beta 2	0.009	0.0282	0.0367
Echinococcus multilocularis	ribosomal protein s6 kinase beta 1	0.009	0.0282	0.0367
Loa Loa (eye worm)	hypothetical protein	0.0414	0.9718	0.9718
Echinococcus multilocularis	serine threonine protein kinase	0.024	0.4668	0.606
Brugia malayi	Furin-like cysteine rich region family protein	0.018	0.291	0.3777
Loa Loa (eye worm)	hypothetical protein	0.0232	0.4431	0.4431
Brugia malayi	C1-like domain containing protein	0.0231	0.4406	0.572
Loa Loa (eye worm)	AGC/RSK/P70 protein kinase	0.009	0.0282	0.0282
Loa Loa (eye worm)	hypothetical protein	0.0147	0.1946	0.1946
Onchocerca volvulus		0.0227	0.4286	0.5681
Echinococcus granulosus	Protein kinase C brain isozyme	0.0321	0.7009	0.9099
Brugia malayi	Protein kinase domain containing protein	0.0084	0.012	0.0156
Schistosoma mansoni	serine/threonine protein kinase	0.0321	0.7009	0.9099
Echinococcus granulosus	protein kinase c epsilon type	0.0345	0.7703	1
Echinococcus multilocularis	epidermal growth factor receptor	0.0097	0.048	0.0623
Echinococcus granulosus	cAMP dependent protein kinase catalytic subunit	0.0148	0.1984	0.2576
Echinococcus granulosus	unc 13 munc13	0.0088	0.0221	0.0287
Echinococcus granulosus	cAMP dependent protein kinase catalytic subunit	0.0148	0.1984	0.2576
Schistosoma mansoni	serine/threonine protein kinase	0.0148	0.1984	0.2576
Entamoeba histolytica	protein kinase, putative	0.0095	0.0427	0.1534
Brugia malayi	Protein kinase domain containing protein	0.0095	0.0427	0.0554
Schistosoma mansoni	serine/threonine protein kinase	0.009	0.0282	0.0367
Schistosoma mansoni	serine/threonine protein kinase	0.0084	0.012	0.0156
Brugia malayi	protein kinase C3,putative	0.0184	0.3023	0.3924
Echinococcus multilocularis	serine:threonine protein kinase N2	0.0257	0.5141	0.6674
Loa Loa (eye worm)	AGC/PKC/ETA protein kinase	0.0345	0.7703	0.7703
Schistosoma mansoni	tyrosine kinase	0.018	0.291	0.3777
Schistosoma mansoni	serine/threonine protein kinase	0.0321	0.7009	0.9099
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0153	0.2129	0.7649
Echinococcus multilocularis	epidermal growth factor receptor	0.018	0.291	0.3777
Trichomonas vaginalis	AGC family protein kinase	0.009	0.0282	0.0659
Loa Loa (eye worm)	AGC/DMPK/GEK protein kinase	0.009	0.0282	0.0282
Loa Loa (eye worm)	hypothetical protein	0.0143	0.1824	0.1824
Echinococcus granulosus	serine:threonine protein kinase N2	0.009	0.0282	0.0367
Echinococcus multilocularis	cAMP dependent protein kinase catalytic subunit	0.0148	0.1984	0.2576
Echinococcus multilocularis	cAMP dependent protein kinase catalytic subunit	0.0148	0.1984	0.2576
Echinococcus granulosus	RNA directed DNA polymerase	0.0143	0.1824	0.2368
Echinococcus multilocularis	telomerase reverse transcriptase subunit	0.0143	0.1824	0.2368
Loa Loa (eye worm)	hypothetical protein	0.0227	0.4286	0.4286
Trichomonas vaginalis	AGC family protein kinase	0.009	0.0282	0.0659
Trichomonas vaginalis	AGC family protein kinase	0.009	0.0282	0.0659
Schistosoma mansoni	vav2	0.0085	0.0144	0.0188
Schistosoma mansoni	serine/threonine protein kinase	0.009	0.0282	0.0367
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0153	0.2129	0.7649
Echinococcus multilocularis	protein kinase c iota type	0.027	0.5526	0.7173
Echinococcus multilocularis	serine:threonine protein kinase N2	0.009	0.0282	0.0367
Trichomonas vaginalis	AGC family protein kinase	0.0095	0.0427	0.1452
Trypanosoma brucei	cAMP-dependent protein kinase catalytic subunit 1	0.0148	0.1984	1
Schistosoma mansoni	serine/threonine protein kinase	0.0148	0.1984	0.2576
Echinococcus multilocularis	cAMP dependent protein kinase catalytic subunit	0.0148	0.1984	0.2576
Echinococcus multilocularis	protein kinase c epsilon type	0.0345	0.7703	1
Entamoeba histolytica	protein kinase, putative	0.009	0.0282	0.1015

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 0.012 uM	Inhibitory activity against phosphorylase kinase was determined	ChEMBL.	No reference
IC50 (binding)	= 0.031 uM	Inhibitory activity against protein kinase C	ChEMBL.	No reference
IC50 (binding)	= 0.031 uM	Inhibitory activity against protein kinase C	ChEMBL.	No reference
IC50 (binding)	= 0.38 uM	Inhibitory activity against cAMP-dependent protein kinase A was determined	ChEMBL.	No reference
IC50 (binding)	= 0.38 uM	Inhibitory activity against cAMP-dependent protein kinase A was determined	ChEMBL.	No reference
IC50 (binding)	= 8.18 uM	Inhibitory activity against protein tyrosine kinase of Epidermal growth factor receptor was determined	ChEMBL.	No reference
IC50 (binding)	= 8.18 uM	Inhibitory activity against protein tyrosine kinase of Epidermal growth factor receptor was determined	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL335012

Bibliographic References

No literature references available for this target.

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Detailed information for compound 225943