Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Glutamate (NMDA) receptor subunit zeta 1 | Starlite/ChEMBL | No references |
Rattus norvegicus | Glutamate NMDA receptor | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus multilocularis | glutamate (NMDA) receptor subunit | Glutamate (NMDA) receptor subunit zeta 1 | 938 aa | 822 aa | 23.2 % |
Drosophila melanogaster | NMDA receptor 2 | Glutamate (NMDA) receptor subunit zeta 1 | 938 aa | 878 aa | 27.4 % |
Drosophila melanogaster | Glutamate receptor IA | Glutamate (NMDA) receptor subunit zeta 1 | 938 aa | 979 aa | 23.7 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | adenosine monophosphate deaminase-like protein, putative | 0.1642 | 0.4741 | 1 |
Echinococcus granulosus | adenosine deaminase | 0.3348 | 1 | 1 |
Trypanosoma brucei | AMP deaminase, putative | 0.1642 | 0.4741 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.2107 | 0.6175 | 0.6054 |
Echinococcus multilocularis | AMP deaminase 2 | 0.1642 | 0.4741 | 0.4741 |
Schistosoma mansoni | adenosine deaminase | 0.3348 | 1 | 1 |
Leishmania major | adenine aminohydrolase | 0.3348 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0402 | 0.0916 | 0.0628 |
Loa Loa (eye worm) | hypothetical protein | 0.0412 | 0.0948 | 0.0661 |
Loa Loa (eye worm) | angiotensin-converting enzyme family protein | 0.2704 | 0.8015 | 0.7952 |
Echinococcus granulosus | AMP deaminase 2 | 0.1642 | 0.4741 | 0.4741 |
Loa Loa (eye worm) | hypothetical protein | 0.0304 | 0.0616 | 0.0319 |
Trypanosoma brucei | AMP deaminase, putative | 0.1642 | 0.4741 | 0.5 |
Schistosoma mansoni | family M13 non-peptidase homologue (M13 family) | 0.0208 | 0.0319 | 0.031 |
Loa Loa (eye worm) | hypothetical protein | 0.0312 | 0.0639 | 0.0342 |
Mycobacterium leprae | Probable adenosine deaminase Add (ADENOSINE AMINOHYDROLASE) | 0.3348 | 1 | 1 |
Leishmania major | adenosine monophosphate deaminase, putative,AMP deaminase, putative | 0.1642 | 0.4741 | 0.1906 |
Onchocerca volvulus | Adenosine deaminase homolog | 0.3348 | 1 | 1 |
Trypanosoma cruzi | adenosine monophosphate deaminase, putative | 0.1642 | 0.4741 | 1 |
Schistosoma mansoni | family M13 unassigned peptidase (M13 family) | 0.0412 | 0.0948 | 0.0939 |
Loa Loa (eye worm) | hypothetical protein | 0.2107 | 0.6175 | 0.6054 |
Echinococcus granulosus | endothelin converting enzyme 1 | 0.0412 | 0.0948 | 0.0948 |
Toxoplasma gondii | Adenosine/AMP deaminase domain-containing protein | 0.3348 | 1 | 1 |
Schistosoma mansoni | adenosine deaminase-related | 0.3348 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.3348 | 1 | 1 |
Leishmania major | AMP deaminase, putative | 0.1642 | 0.4741 | 0.1906 |
Toxoplasma gondii | AMP deaminase | 0.1642 | 0.4741 | 0.419 |
Loa Loa (eye worm) | hypothetical protein | 0.0312 | 0.0639 | 0.0342 |
Brugia malayi | Angiotensin-converting enzyme family protein | 0.2704 | 0.8015 | 0.7807 |
Onchocerca volvulus | AMP deaminase 2 homolog | 0.1642 | 0.4741 | 0.4574 |
Trypanosoma cruzi | AMP deaminase, putative | 0.1642 | 0.4741 | 1 |
Trichomonas vaginalis | adenosine deaminase, putative | 0.3348 | 1 | 0.5 |
Treponema pallidum | adenosine deaminase | 0.3348 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0312 | 0.0639 | 0.0342 |
Echinococcus multilocularis | endothelin converting enzyme 1 | 0.0412 | 0.0948 | 0.0948 |
Entamoeba histolytica | adenosine deaminase, putative | 0.3348 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.2107 | 0.6175 | 0.6054 |
Loa Loa (eye worm) | peptidase family M13 containing protein | 0.0304 | 0.0616 | 0.0319 |
Leishmania major | AMP deaminase, putative,amp deaminase-like protein | 0.1642 | 0.4741 | 0.1906 |
Loa Loa (eye worm) | hypothetical protein | 0.0412 | 0.0948 | 0.0661 |
Plasmodium vivax | adenosine deaminase, putative | 0.3348 | 1 | 1 |
Trypanosoma cruzi | AMP deaminase, putative | 0.1642 | 0.4741 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1241 | 0.3503 | 0.3297 |
Loa Loa (eye worm) | hypothetical protein | 0.0304 | 0.0616 | 0.0319 |
Trypanosoma brucei | adenosine monophosphate deaminase, putative | 0.1642 | 0.4741 | 0.5 |
Entamoeba histolytica | adenosine deaminase, putative | 0.3348 | 1 | 1 |
Trypanosoma brucei | AMP deaminase, putative | 0.1642 | 0.4741 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0412 | 0.0948 | 0.0661 |
Loa Loa (eye worm) | hypothetical protein | 0.0312 | 0.0639 | 0.0342 |
Brugia malayi | adenosine monophosphate deaminase | 0.1642 | 0.4741 | 0.419 |
Schistosoma mansoni | family M13 unassigned peptidase (M13 family) | 0.0208 | 0.0319 | 0.031 |
Trypanosoma cruzi | AMP deaminase, putative | 0.1642 | 0.4741 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.2107 | 0.6175 | 0.6054 |
Loa Loa (eye worm) | AMP deaminase | 0.1642 | 0.4741 | 0.4574 |
Schistosoma mansoni | neprilysin-2 (M13 family) | 0.0208 | 0.0319 | 0.031 |
Echinococcus granulosus | nmda type glutamate receptor | 0.0159 | 0.0169 | 0.0169 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.0159 | 0.0169 | 0.0169 |
Plasmodium falciparum | adenosine deaminase | 0.3348 | 1 | 1 |
Toxoplasma gondii | Adenosine/AMP deaminase domain-containing protein | 0.3348 | 1 | 1 |
Schistosoma mansoni | glutamate receptor NMDA | 0.0122 | 0.0055 | 0.0046 |
Loa Loa (eye worm) | hypothetical protein | 0.0312 | 0.0639 | 0.0342 |
Mycobacterium tuberculosis | Probable adenosine deaminase Add (adenosine aminohydrolase) | 0.3348 | 1 | 1 |
Onchocerca volvulus | 0.1241 | 0.3503 | 0.3297 | |
Echinococcus multilocularis | adenosine deaminase | 0.3348 | 1 | 1 |
Trichomonas vaginalis | adenosine deaminase, putative | 0.3348 | 1 | 0.5 |
Schistosoma mansoni | AMP deaminase | 0.1642 | 0.4741 | 0.4736 |
Loa Loa (eye worm) | hypothetical protein | 0.0304 | 0.0616 | 0.0319 |
Schistosoma mansoni | Nep2 peptidase (M13 family) | 0.0208 | 0.0319 | 0.031 |
Schistosoma mansoni | family M13 unassigned peptidase (M13 family) | 0.0208 | 0.0319 | 0.031 |
Mycobacterium ulcerans | adenosine deaminase | 0.3348 | 1 | 1 |
Trypanosoma cruzi | AMP deaminase, putative | 0.1642 | 0.4741 | 1 |
Leishmania major | AMP deaminase, putative,adenosine monophosphate deaminase-like protein | 0.1642 | 0.4741 | 0.1906 |
Loa Loa (eye worm) | peptidase family M13 containing protein | 0.0304 | 0.0616 | 0.0319 |
Loa Loa (eye worm) | hypothetical protein | 0.0312 | 0.0639 | 0.0342 |
Trypanosoma cruzi | AMP deaminase, putative | 0.1642 | 0.4741 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0304 | 0.0616 | 0.0319 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 110 nM | Ability of compound to compete with [3H]-glycine for the strychnine-insensitive NMDA receptor glycine binding sites on rat cortical and hippocampus | ChEMBL. | No reference |
IC50 (binding) | = 110 nM | Ability of compound to compete with [3H]-glycine for the strychnine-insensitive NMDA receptor glycine binding sites on rat cortical and hippocampus | ChEMBL. | No reference |
IC50 (binding) | = 0.11 uM | In vitro inhibition of [3H]-Glycine at NMDA receptor | ChEMBL. | 7990104 |
IC50 (binding) | = 0.11 uM | In vitro inhibition of [3H]-Glycine at NMDA receptor | ChEMBL. | 7990104 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.