Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | mitogen-activated protein kinase kinase 5 | 0.1852 | 1 | 0.5 |
Echinococcus multilocularis | retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha | 0.078 | 0.3542 | 0.3542 |
Loa Loa (eye worm) | STE/STE7/MEK1 protein kinase | 0.1852 | 1 | 1 |
Schistosoma mansoni | protein kinase | 0.1852 | 1 | 1 |
Echinococcus granulosus | dual specificity mitogen activated protein | 0.1852 | 1 | 1 |
Loa Loa (eye worm) | nuclear receptor nhr-7B | 0.161 | 0.8542 | 0.8542 |
Loa Loa (eye worm) | hypothetical protein | 0.1549 | 0.8175 | 0.8175 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0848 | 0.3952 | 0.3952 |
Echinococcus multilocularis | dual specificity mitogen activated protein | 0.1852 | 1 | 1 |
Brugia malayi | nuclear hormone receptor | 0.161 | 0.8542 | 0.8542 |
Trichomonas vaginalis | STE family protein kinase | 0.1852 | 1 | 0.5 |
Leishmania major | mitogen-activated protein kinase kinase 5, putative;with=GeneDB:LmxM36.0860 | 0.1852 | 1 | 0.5 |
Trichomonas vaginalis | STE family protein kinase | 0.1852 | 1 | 0.5 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.1678 | 0.8952 | 0.5 |
Trichomonas vaginalis | STE family protein kinase | 0.1852 | 1 | 0.5 |
Giardia lamblia | Kinase, STE STE20 | 0.1852 | 1 | 0.5 |
Trypanosoma cruzi | mitogen-activated protein kinase kinase 5 | 0.1852 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Cell viability (functional) | = -23.6 | Tested for human PBMC cell viability, cultured with alpha-CD40, IL-4 and IL-10 at 3 microM (a negative number means enhancement of cell viability) | ChEMBL. | 9046329 |
Suppression (functional) | = -26.2 % | In vitro inhibition of IgE antibody production in human PBMC cultured with alpha-CD40, IL-4 and IL-10 at 3 microM concentration (negative number means enhancement of cell viability) | ChEMBL. | 9046329 |
Suppression (functional) | = -16 % | In vitro inhibition of IgG antibody production in human PBMC cultured with alpha-CD40, IL-4 and IL-10 at 3 microM concentration (negative number means enhancement of cell viability) | ChEMBL. | 9046329 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.