Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Glutamate NMDA receptor | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | adenosine deaminase-related | 0.2141 | 1 | 1 |
Leishmania major | AMP deaminase, putative,amp deaminase-like protein | 0.1046 | 0.4805 | 0.1877 |
Schistosoma mansoni | adenosine deaminase | 0.2141 | 1 | 1 |
Trypanosoma brucei | AMP deaminase, putative | 0.1046 | 0.4805 | 0.5 |
Mycobacterium tuberculosis | Probable adenosine deaminase Add (adenosine aminohydrolase) | 0.2141 | 1 | 0.5 |
Plasmodium vivax | adenosine deaminase, putative | 0.2141 | 1 | 1 |
Entamoeba histolytica | adenosine deaminase, putative | 0.2141 | 1 | 1 |
Echinococcus multilocularis | AMP deaminase 2 | 0.1046 | 0.4805 | 0.4805 |
Trichomonas vaginalis | adenosine deaminase, putative | 0.2141 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0792 | 0.3604 | 0.2854 |
Trypanosoma cruzi | adenosine monophosphate deaminase-like protein, putative | 0.1046 | 0.4805 | 1 |
Echinococcus granulosus | adenosine deaminase | 0.2141 | 1 | 1 |
Trypanosoma cruzi | AMP deaminase, putative | 0.1046 | 0.4805 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1349 | 0.6245 | 0.5804 |
Loa Loa (eye worm) | AMP deaminase | 0.1046 | 0.4805 | 0.4196 |
Trypanosoma cruzi | AMP deaminase, putative | 0.1046 | 0.4805 | 1 |
Treponema pallidum | adenosine deaminase | 0.2141 | 1 | 0.5 |
Mycobacterium leprae | Probable adenosine deaminase Add (ADENOSINE AMINOHYDROLASE) | 0.2141 | 1 | 0.5 |
Toxoplasma gondii | Adenosine/AMP deaminase domain-containing protein | 0.2141 | 1 | 1 |
Entamoeba histolytica | adenosine deaminase, putative | 0.2141 | 1 | 1 |
Toxoplasma gondii | Adenosine/AMP deaminase domain-containing protein | 0.2141 | 1 | 1 |
Trichomonas vaginalis | adenosine deaminase, putative | 0.2141 | 1 | 0.5 |
Onchocerca volvulus | AMP deaminase 2 homolog | 0.1046 | 0.4805 | 0.1877 |
Trypanosoma brucei | AMP deaminase, putative | 0.1046 | 0.4805 | 0.5 |
Trypanosoma brucei | AMP deaminase, putative | 0.1046 | 0.4805 | 0.5 |
Leishmania major | AMP deaminase, putative | 0.1046 | 0.4805 | 0.1877 |
Trypanosoma cruzi | AMP deaminase, putative | 0.1046 | 0.4805 | 1 |
Onchocerca volvulus | Adenosine deaminase homolog | 0.2141 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1349 | 0.6245 | 0.5804 |
Trypanosoma brucei | adenosine monophosphate deaminase, putative | 0.1046 | 0.4805 | 0.5 |
Echinococcus granulosus | AMP deaminase 2 | 0.1046 | 0.4805 | 0.4805 |
Leishmania major | adenine aminohydrolase | 0.2141 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1349 | 0.6245 | 0.5804 |
Mycobacterium ulcerans | adenosine deaminase | 0.2141 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.2141 | 1 | 1 |
Leishmania major | adenosine monophosphate deaminase, putative,AMP deaminase, putative | 0.1046 | 0.4805 | 0.1877 |
Echinococcus multilocularis | adenosine deaminase | 0.2141 | 1 | 1 |
Plasmodium falciparum | adenosine deaminase | 0.2141 | 1 | 1 |
Trypanosoma cruzi | adenosine monophosphate deaminase, putative | 0.1046 | 0.4805 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1349 | 0.6245 | 0.5804 |
Trypanosoma cruzi | AMP deaminase, putative | 0.1046 | 0.4805 | 1 |
Leishmania major | AMP deaminase, putative,adenosine monophosphate deaminase-like protein | 0.1046 | 0.4805 | 0.1877 |
Trypanosoma cruzi | AMP deaminase, putative | 0.1046 | 0.4805 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ED50 (functional) | = 41 mg kg-1 | Anticonvulsant activity measured by its ability to protect against audiogenic seizure in DBA/2 mice when dosed intraperitoneally 30 min prior to seizure induction. | ChEMBL. | 9406596 |
ED50 (functional) | = 41 mg kg-1 | Anticonvulsant activity measured by its ability to protect against audiogenic seizure in DBA/2 mice when dosed intraperitoneally 30 min prior to seizure induction. | ChEMBL. | 9406596 |
IC50 (binding) | = 16700 nM | Affinity for the glycine binding site on rat N-methyl-D-aspartate glutamate receptor 1, determined by displacement of the glycine site antagonist [3H]L-689,560 from rat cortical membranes | ChEMBL. | 9406596 |
IC50 (binding) | = 16700 nM | Affinity for the glycine binding site on rat N-methyl-D-aspartate glutamate receptor 1, determined by displacement of the glycine site antagonist [3H]L-689,560 from rat cortical membranes | ChEMBL. | 9406596 |
logP (ADMET) | = 0.7 | Partition coefficient (logP) | ChEMBL. | 9406596 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.