Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | purinergic receptor P2X, ligand-gated ion channel, 7 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0837 | 1 | 1 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.0393 | 0.4099 | 1 |
Echinococcus granulosus | Protein patched homolog 1 | 0.0345 | 0.3461 | 0.3142 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.0393 | 0.4099 | 1 |
Echinococcus multilocularis | protein dispatched 1 | 0.0345 | 0.3461 | 0.3142 |
Loa Loa (eye worm) | peptidase family M1 containing protein | 0.0096 | 0.0164 | 0.0164 |
Brugia malayi | CHE-14 protein | 0.0345 | 0.3461 | 0.3142 |
Onchocerca volvulus | 0.0119 | 0.0465 | 0.5 | |
Giardia lamblia | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | 0.0393 | 0.4099 | 0.5 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.0393 | 0.4099 | 1 |
Trypanosoma brucei | 3-hydroxy-3-methylglutaryl-CoA reductase, putative | 0.0837 | 1 | 0.5 |
Leishmania major | 3-hydroxy-3-methylglutaryl-CoA reductase | 0.0837 | 1 | 0.5 |
Mycobacterium ulcerans | hydroxymethylglutaryl-coenzyme a (HMG-CoA) reductase | 0.0837 | 1 | 0.5 |
Echinococcus multilocularis | hydroxymethylglutaryl coenzyme A reductase | 0.0837 | 1 | 1 |
Echinococcus multilocularis | protein patched | 0.0345 | 0.3461 | 0.3142 |
Trypanosoma cruzi | 3-hydroxy-3-methylglutaryl-CoA reductase, putative | 0.0837 | 1 | 0.5 |
Trypanosoma cruzi | 3-hydroxy-3-methylglutaryl-CoA reductase | 0.0837 | 1 | 0.5 |
Echinococcus granulosus | hydroxymethylglutaryl coenzyme A reductase | 0.0837 | 1 | 1 |
Loa Loa (eye worm) | abnormal chemotaxis protein 14 | 0.0345 | 0.3461 | 0.3461 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.0345 | 0.3461 | 0.3142 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.0345 | 0.3461 | 0.3142 |
Echinococcus granulosus | sterol regulatory element binding protein | 0.0345 | 0.3461 | 0.3142 |
Schistosoma mansoni | hydroxymethylglutaryl-CoA reductase (NADPH) | 0.0837 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0107 | 0.0302 | 0.0302 |
Echinococcus multilocularis | sterol regulatory element binding protein | 0.0345 | 0.3461 | 0.3142 |
Loa Loa (eye worm) | hypothetical protein | 0.0345 | 0.3461 | 0.3461 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.