Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | Coagulation factor VII/tissue factor | Starlite/ChEMBL | References |
Homo sapiens | coagulation factor II (thrombin) | Starlite/ChEMBL | References |
Homo sapiens | coagulation factor VII (serum prothrombin conversion accelerator) | References | |
Homo sapiens | coagulation factor III (thromboplastin, tissue factor) | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus granulosus | glycoprotein Antigen 5 | coagulation factor VII (serum prothrombin conversion accelerator) | 466 aa | 384 aa | 23.7 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.1895 | 0.5102 | 0.2412 |
Trypanosoma brucei | AMP deaminase, putative | 0.3034 | 0.8443 | 0.5 |
Leishmania major | AMP deaminase, putative | 0.3034 | 0.8443 | 0.7197 |
Onchocerca volvulus | AMP deaminase 2 homolog | 0.3034 | 0.8443 | 0.8443 |
Loa Loa (eye worm) | hypothetical protein | 0.1895 | 0.5102 | 0.2412 |
Plasmodium falciparum | adenosine deaminase | 0.3566 | 1 | 1 |
Echinococcus multilocularis | adenosine deaminase | 0.3566 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.3566 | 1 | 1 |
Leishmania major | adenosine monophosphate deaminase, putative,AMP deaminase, putative | 0.3034 | 0.8443 | 0.7197 |
Trypanosoma cruzi | AMP deaminase, putative | 0.3034 | 0.8443 | 1 |
Mycobacterium ulcerans | adenosine deaminase | 0.3566 | 1 | 0.5 |
Leishmania major | adenine aminohydrolase | 0.3566 | 1 | 1 |
Loa Loa (eye worm) | AMP deaminase | 0.3034 | 0.8443 | 0.7588 |
Leishmania major | AMP deaminase, putative,amp deaminase-like protein | 0.3034 | 0.8443 | 0.7197 |
Leishmania major | AMP deaminase, putative,adenosine monophosphate deaminase-like protein | 0.3034 | 0.8443 | 0.7197 |
Trypanosoma cruzi | AMP deaminase, putative | 0.3034 | 0.8443 | 1 |
Trypanosoma brucei | adenosine monophosphate deaminase, putative | 0.3034 | 0.8443 | 0.5 |
Onchocerca volvulus | Adenosine deaminase homolog | 0.3566 | 1 | 1 |
Trypanosoma cruzi | adenosine monophosphate deaminase-like protein, putative | 0.3034 | 0.8443 | 1 |
Trypanosoma cruzi | AMP deaminase, putative | 0.3034 | 0.8443 | 1 |
Onchocerca volvulus | 0.1671 | 0.4446 | 0.4446 | |
Entamoeba histolytica | adenosine deaminase, putative | 0.3566 | 1 | 1 |
Plasmodium vivax | adenosine deaminase, putative | 0.3566 | 1 | 1 |
Echinococcus granulosus | adenosine deaminase | 0.3566 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1895 | 0.5102 | 0.2412 |
Mycobacterium leprae | Probable adenosine deaminase Add (ADENOSINE AMINOHYDROLASE) | 0.3566 | 1 | 0.5 |
Toxoplasma gondii | Adenosine/AMP deaminase domain-containing protein | 0.3566 | 1 | 1 |
Toxoplasma gondii | Adenosine/AMP deaminase domain-containing protein | 0.3566 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1671 | 0.4446 | 0.1396 |
Loa Loa (eye worm) | hypothetical protein | 0.1895 | 0.5102 | 0.2412 |
Trypanosoma cruzi | AMP deaminase, putative | 0.3034 | 0.8443 | 1 |
Entamoeba histolytica | adenosine deaminase, putative | 0.3566 | 1 | 1 |
Trypanosoma cruzi | AMP deaminase, putative | 0.3034 | 0.8443 | 1 |
Trichomonas vaginalis | adenosine deaminase, putative | 0.3566 | 1 | 0.5 |
Treponema pallidum | adenosine deaminase | 0.3566 | 1 | 0.5 |
Trypanosoma brucei | AMP deaminase, putative | 0.3034 | 0.8443 | 0.5 |
Trichomonas vaginalis | adenosine deaminase, putative | 0.3566 | 1 | 0.5 |
Trypanosoma brucei | AMP deaminase, putative | 0.3034 | 0.8443 | 0.5 |
Mycobacterium tuberculosis | Probable adenosine deaminase Add (adenosine aminohydrolase) | 0.3566 | 1 | 0.5 |
Schistosoma mansoni | adenosine deaminase | 0.3566 | 1 | 1 |
Trypanosoma cruzi | adenosine monophosphate deaminase, putative | 0.3034 | 0.8443 | 1 |
Schistosoma mansoni | adenosine deaminase-related | 0.3566 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.4 uM | Inhibitory activity against tissue coagulation factor VII complex was determined (TF/VIIa complex) | ChEMBL. | 12954058 |
IC50 (binding) | = 0.4 uM | Inhibitory activity against tissue coagulation factor VII complex was determined (TF/VIIa complex) | ChEMBL. | 12954058 |
IC50 (binding) | = 11.3 uM | Inhibitory activity against thrombin (IIa) was determined | ChEMBL. | 12954058 |
IC50 (binding) | = 11.3 uM | Inhibitory activity against thrombin (IIa) was determined | ChEMBL. | 12954058 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.