Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | adenine aminohydrolase | 0.446 | 1 | 1 |
Trypanosoma cruzi | AMP deaminase, putative | 0.3457 | 0.4983 | 0.5 |
Trypanosoma brucei | AMP deaminase, putative | 0.3457 | 0.4983 | 0.5 |
Trypanosoma brucei | adenosine monophosphate deaminase, putative | 0.3457 | 0.4983 | 0.5 |
Onchocerca volvulus | Adenosine deaminase homolog | 0.446 | 1 | 1 |
Mycobacterium leprae | Probable adenosine deaminase Add (ADENOSINE AMINOHYDROLASE) | 0.446 | 1 | 0.5 |
Echinococcus granulosus | adenosine deaminase | 0.446 | 1 | 1 |
Trypanosoma cruzi | AMP deaminase, putative | 0.3457 | 0.4983 | 0.5 |
Trypanosoma cruzi | AMP deaminase, putative | 0.3457 | 0.4983 | 0.5 |
Plasmodium vivax | adenosine deaminase, putative | 0.446 | 1 | 1 |
Trypanosoma brucei | AMP deaminase, putative | 0.3457 | 0.4983 | 0.5 |
Trichomonas vaginalis | adenosine deaminase, putative | 0.446 | 1 | 0.5 |
Plasmodium falciparum | adenosine deaminase | 0.446 | 1 | 1 |
Schistosoma mansoni | adenosine deaminase | 0.446 | 1 | 1 |
Entamoeba histolytica | adenosine deaminase, putative | 0.446 | 1 | 1 |
Toxoplasma gondii | Adenosine/AMP deaminase domain-containing protein | 0.446 | 1 | 1 |
Entamoeba histolytica | adenosine deaminase, putative | 0.446 | 1 | 1 |
Treponema pallidum | adenosine deaminase | 0.446 | 1 | 0.5 |
Mycobacterium tuberculosis | Probable adenosine deaminase Add (adenosine aminohydrolase) | 0.446 | 1 | 0.5 |
Loa Loa (eye worm) | AMP deaminase | 0.3457 | 0.4983 | 0.4983 |
Trypanosoma cruzi | AMP deaminase, putative | 0.3457 | 0.4983 | 0.5 |
Echinococcus multilocularis | adenosine deaminase | 0.446 | 1 | 1 |
Mycobacterium ulcerans | adenosine deaminase | 0.446 | 1 | 0.5 |
Trypanosoma cruzi | adenosine monophosphate deaminase-like protein, putative | 0.3457 | 0.4983 | 0.5 |
Trypanosoma cruzi | AMP deaminase, putative | 0.3457 | 0.4983 | 0.5 |
Toxoplasma gondii | Adenosine/AMP deaminase domain-containing protein | 0.446 | 1 | 1 |
Trypanosoma brucei | AMP deaminase, putative | 0.3457 | 0.4983 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.446 | 1 | 1 |
Schistosoma mansoni | adenosine deaminase-related | 0.446 | 1 | 1 |
Trypanosoma cruzi | adenosine monophosphate deaminase, putative | 0.3457 | 0.4983 | 0.5 |
Trichomonas vaginalis | adenosine deaminase, putative | 0.446 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 2 mM | In vitro inhibitory activity against H1N9 strain of Influenza Neuraminidase (membrane) | ChEMBL. | 9406595 |
IC50 (binding) | = 2 mM | In vitro inhibitory activity against H1N9 strain of Influenza Neuraminidase (membrane) | ChEMBL. | 9406595 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.