Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Type-1B angiotensin II receptor | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | adenosine monophosphate deaminase, putative | 0.3172 | 0.7654 | 1 |
Plasmodium vivax | adenosine deaminase, putative | 0.3706 | 1 | 1 |
Echinococcus multilocularis | adenosine deaminase | 0.3706 | 1 | 1 |
Toxoplasma gondii | Adenosine/AMP deaminase domain-containing protein | 0.3706 | 1 | 1 |
Trypanosoma cruzi | adenosine monophosphate deaminase-like protein, putative | 0.3172 | 0.7654 | 1 |
Trichomonas vaginalis | adenosine deaminase, putative | 0.3706 | 1 | 0.5 |
Mycobacterium leprae | Probable adenosine deaminase Add (ADENOSINE AMINOHYDROLASE) | 0.3706 | 1 | 0.5 |
Entamoeba histolytica | adenosine deaminase, putative | 0.3706 | 1 | 1 |
Trypanosoma cruzi | AMP deaminase, putative | 0.3172 | 0.7654 | 1 |
Mycobacterium tuberculosis | Probable adenosine deaminase Add (adenosine aminohydrolase) | 0.3706 | 1 | 0.5 |
Entamoeba histolytica | adenosine deaminase, putative | 0.3706 | 1 | 1 |
Onchocerca volvulus | AMP deaminase 2 homolog | 0.3172 | 0.7654 | 0.7283 |
Toxoplasma gondii | Adenosine/AMP deaminase domain-containing protein | 0.3706 | 1 | 1 |
Leishmania major | AMP deaminase, putative | 0.3172 | 0.7654 | 0.7283 |
Trypanosoma brucei | AMP deaminase, putative | 0.3172 | 0.7654 | 0.5 |
Trichomonas vaginalis | adenosine deaminase, putative | 0.3706 | 1 | 0.5 |
Leishmania major | AMP deaminase, putative,adenosine monophosphate deaminase-like protein | 0.3172 | 0.7654 | 0.7283 |
Leishmania major | adenosine monophosphate deaminase, putative,AMP deaminase, putative | 0.3172 | 0.7654 | 0.7283 |
Leishmania major | adenine aminohydrolase | 0.3706 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1964 | 0.2346 | 0.2346 |
Schistosoma mansoni | adenosine deaminase | 0.3706 | 1 | 1 |
Treponema pallidum | adenosine deaminase | 0.3706 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.1964 | 0.2346 | 0.2346 |
Plasmodium falciparum | adenosine deaminase | 0.3706 | 1 | 1 |
Onchocerca volvulus | Adenosine deaminase homolog | 0.3706 | 1 | 1 |
Mycobacterium ulcerans | adenosine deaminase | 0.3706 | 1 | 0.5 |
Trypanosoma cruzi | AMP deaminase, putative | 0.3172 | 0.7654 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1964 | 0.2346 | 0.2346 |
Loa Loa (eye worm) | AMP deaminase | 0.3172 | 0.7654 | 0.7654 |
Loa Loa (eye worm) | hypothetical protein | 0.1742 | 0.1367 | 0.1367 |
Leishmania major | AMP deaminase, putative,amp deaminase-like protein | 0.3172 | 0.7654 | 0.7283 |
Trypanosoma brucei | AMP deaminase, putative | 0.3172 | 0.7654 | 0.5 |
Trypanosoma brucei | adenosine monophosphate deaminase, putative | 0.3172 | 0.7654 | 0.5 |
Trypanosoma cruzi | AMP deaminase, putative | 0.3172 | 0.7654 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.3706 | 1 | 1 |
Echinococcus granulosus | adenosine deaminase | 0.3706 | 1 | 1 |
Trypanosoma brucei | AMP deaminase, putative | 0.3172 | 0.7654 | 0.5 |
Schistosoma mansoni | adenosine deaminase-related | 0.3706 | 1 | 1 |
Trypanosoma cruzi | AMP deaminase, putative | 0.3172 | 0.7654 | 1 |
Trypanosoma cruzi | AMP deaminase, putative | 0.3172 | 0.7654 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1964 | 0.2346 | 0.2346 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 8 nM | Inhibition of specific binding of [125I]-angiotensin-II to angiotensin 1 receptor in rat lung membrane preparation | ChEMBL. | 8258826 |
IC50 (binding) | = 8 nM | Inhibition of specific binding of [125I]-angiotensin-II to angiotensin 1 receptor in rat lung membrane preparation | ChEMBL. | 8258826 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.