Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.309 | 0.3516 | 0.3516 |
Plasmodium falciparum | adenosine deaminase | 0.5554 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.309 | 0.3516 | 0.3516 |
Treponema pallidum | adenosine deaminase | 0.5554 | 1 | 0.5 |
Schistosoma mansoni | adenosine deaminase | 0.5554 | 1 | 1 |
Leishmania major | adenine aminohydrolase | 0.5554 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.2464 | 0.1871 | 0.1871 |
Loa Loa (eye worm) | hypothetical protein | 0.309 | 0.3516 | 0.3516 |
Loa Loa (eye worm) | AMP deaminase | 0.4218 | 0.6484 | 0.6484 |
Trypanosoma cruzi | AMP deaminase, putative | 0.4218 | 0.6484 | 1 |
Mycobacterium ulcerans | adenosine deaminase | 0.5554 | 1 | 0.5 |
Onchocerca volvulus | Adenosine deaminase homolog | 0.5554 | 1 | 1 |
Leishmania major | AMP deaminase, putative,amp deaminase-like protein | 0.4218 | 0.6484 | 0.5675 |
Trypanosoma cruzi | AMP deaminase, putative | 0.4218 | 0.6484 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.309 | 0.3516 | 0.3516 |
Trypanosoma brucei | AMP deaminase, putative | 0.4218 | 0.6484 | 0.5 |
Echinococcus granulosus | adenosine deaminase | 0.5554 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.5554 | 1 | 1 |
Schistosoma mansoni | adenosine deaminase-related | 0.5554 | 1 | 1 |
Trypanosoma cruzi | AMP deaminase, putative | 0.4218 | 0.6484 | 1 |
Trypanosoma brucei | adenosine monophosphate deaminase, putative | 0.4218 | 0.6484 | 0.5 |
Trypanosoma cruzi | AMP deaminase, putative | 0.4218 | 0.6484 | 1 |
Trypanosoma brucei | AMP deaminase, putative | 0.4218 | 0.6484 | 0.5 |
Plasmodium vivax | adenosine deaminase, putative | 0.5554 | 1 | 1 |
Trypanosoma cruzi | adenosine monophosphate deaminase, putative | 0.4218 | 0.6484 | 1 |
Trypanosoma cruzi | adenosine monophosphate deaminase-like protein, putative | 0.4218 | 0.6484 | 1 |
Toxoplasma gondii | Adenosine/AMP deaminase domain-containing protein | 0.5554 | 1 | 1 |
Echinococcus multilocularis | adenosine deaminase | 0.5554 | 1 | 1 |
Mycobacterium tuberculosis | Probable adenosine deaminase Add (adenosine aminohydrolase) | 0.5554 | 1 | 0.5 |
Entamoeba histolytica | adenosine deaminase, putative | 0.5554 | 1 | 1 |
Trypanosoma cruzi | AMP deaminase, putative | 0.4218 | 0.6484 | 1 |
Trichomonas vaginalis | adenosine deaminase, putative | 0.5554 | 1 | 0.5 |
Mycobacterium leprae | Probable adenosine deaminase Add (ADENOSINE AMINOHYDROLASE) | 0.5554 | 1 | 0.5 |
Entamoeba histolytica | adenosine deaminase, putative | 0.5554 | 1 | 1 |
Leishmania major | adenosine monophosphate deaminase, putative,AMP deaminase, putative | 0.4218 | 0.6484 | 0.5675 |
Leishmania major | AMP deaminase, putative,adenosine monophosphate deaminase-like protein | 0.4218 | 0.6484 | 0.5675 |
Leishmania major | AMP deaminase, putative | 0.4218 | 0.6484 | 0.5675 |
Trichomonas vaginalis | adenosine deaminase, putative | 0.5554 | 1 | 0.5 |
Trypanosoma brucei | AMP deaminase, putative | 0.4218 | 0.6484 | 0.5 |
Onchocerca volvulus | AMP deaminase 2 homolog | 0.4218 | 0.6484 | 0.5675 |
Toxoplasma gondii | Adenosine/AMP deaminase domain-containing protein | 0.5554 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ED50 (functional) | = 0.9 mg kg-1 | Effect on the antagonism of nicotine-induced tonic-extensor convulsions (TE) in mice | ChEMBL. | 6103959 |
ED50 (functional) | = 0.9 mg kg-1 | Effect on the antagonism of nicotine-induced tonic-extensor convulsions (TE) in mice | ChEMBL. | 6103959 |
ED50 (functional) | = 1.1 mg kg-1 | Effect on the antagonism of nicotine-induced death (D) | ChEMBL. | 6103959 |
ED50 (functional) | = 1.1 mg kg-1 | Effect on the antagonism of nicotine-induced death (D) | ChEMBL. | 6103959 |
ED50 (functional) | = 2.2 mg kg-1 | Effect on the potentiation of gamma-butyrolactone-induced sleep (gamma-B) | ChEMBL. | 6103959 |
ED50 (functional) | = 2.2 mg kg-1 | Effect on the potentiation of gamma-butyrolactone-induced sleep (gamma-B) | ChEMBL. | 6103959 |
ED50 (functional) | = 6.3 mg kg-1 | Effect on the antagonism of pentylenetetrazole-induced clonic convulsions (P) | ChEMBL. | 6103959 |
ED50 (functional) | = 6.3 mg kg-1 | Effect on the antagonism of pentylenetetrazole-induced clonic convulsions (P) | ChEMBL. | 6103959 |
ED50 (functional) | = 7.4 mg kg-1 | Effect of test compound on the potentiation of apomorphine-induced gnawing (AG) in aggregated mice | ChEMBL. | 6103959 |
ED50 (functional) | = 7.4 mg kg-1 | Effect of test compound on the potentiation of apomorphine-induced gnawing (AG) in aggregated mice | ChEMBL. | 6103959 |
ED50 (functional) | = 14.9 mg kg-1 | Effect on the antagonism of bicuculline-induced tonic-extensor convulsions (B) | ChEMBL. | 6103959 |
ED50 (functional) | = 14.9 mg kg-1 | Effect on the antagonism of bicuculline-induced tonic-extensor convulsions (B) | ChEMBL. | 6103959 |
ED50 (functional) | > 50 mg kg-1 | Effect on the prolongation of hypoxic survival time (HS) | ChEMBL. | 6103959 |
ED50 (functional) | > 50 mg kg-1 | Effect on the potentiation of yohimbine-induced toxicity (Y) in aggregated mice | ChEMBL. | 6103959 |
ED50 (functional) | > 50 mg kg-1 | Effect on the antagonism of oxotremorine-induced hypothermia (OX) | ChEMBL. | 6103959 |
ED50 (functional) | > 50 mg kg-1 | Effect on the prolongation of hypoxic survival time (HS) | ChEMBL. | 6103959 |
ED50 (functional) | > 50 mg kg-1 | Effect on the potentiation of yohimbine-induced toxicity (Y) in aggregated mice | ChEMBL. | 6103959 |
ED50 (functional) | > 50 mg kg-1 | Effect on the antagonism of oxotremorine-induced hypothermia (OX) | ChEMBL. | 6103959 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.