Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Type-1B angiotensin II receptor | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | AMP deaminase, putative | 0.3389 | 0.6036 | 1 |
Loa Loa (eye worm) | AMP deaminase | 0.3389 | 0.6036 | 0.6036 |
Loa Loa (eye worm) | hypothetical protein | 0.2688 | 0.3964 | 0.3964 |
Toxoplasma gondii | Adenosine/AMP deaminase domain-containing protein | 0.4732 | 1 | 1 |
Entamoeba histolytica | adenosine deaminase, putative | 0.4732 | 1 | 1 |
Trypanosoma brucei | AMP deaminase, putative | 0.3389 | 0.6036 | 0.5 |
Trypanosoma cruzi | adenosine monophosphate deaminase-like protein, putative | 0.3389 | 0.6036 | 1 |
Onchocerca volvulus | AMP deaminase 2 homolog | 0.3389 | 0.6036 | 0.5005 |
Trypanosoma cruzi | AMP deaminase, putative | 0.3389 | 0.6036 | 1 |
Mycobacterium tuberculosis | Probable adenosine deaminase Add (adenosine aminohydrolase) | 0.4732 | 1 | 0.5 |
Trypanosoma brucei | AMP deaminase, putative | 0.3389 | 0.6036 | 0.5 |
Leishmania major | AMP deaminase, putative | 0.3389 | 0.6036 | 0.5005 |
Echinococcus granulosus | adenosine deaminase | 0.4732 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.2044 | 0.2063 | 0.2063 |
Leishmania major | adenine aminohydrolase | 0.4732 | 1 | 1 |
Trypanosoma cruzi | AMP deaminase, putative | 0.3389 | 0.6036 | 1 |
Leishmania major | AMP deaminase, putative,amp deaminase-like protein | 0.3389 | 0.6036 | 0.5005 |
Leishmania major | adenosine monophosphate deaminase, putative,AMP deaminase, putative | 0.3389 | 0.6036 | 0.5005 |
Mycobacterium ulcerans | adenosine deaminase | 0.4732 | 1 | 0.5 |
Trypanosoma brucei | adenosine monophosphate deaminase, putative | 0.3389 | 0.6036 | 0.5 |
Onchocerca volvulus | Adenosine deaminase homolog | 0.4732 | 1 | 1 |
Schistosoma mansoni | adenosine deaminase-related | 0.4732 | 1 | 1 |
Trypanosoma brucei | AMP deaminase, putative | 0.3389 | 0.6036 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.2688 | 0.3964 | 0.3964 |
Trichomonas vaginalis | adenosine deaminase, putative | 0.4732 | 1 | 0.5 |
Schistosoma mansoni | adenosine deaminase | 0.4732 | 1 | 1 |
Echinococcus multilocularis | adenosine deaminase | 0.4732 | 1 | 1 |
Trypanosoma cruzi | AMP deaminase, putative | 0.3389 | 0.6036 | 1 |
Plasmodium vivax | adenosine deaminase, putative | 0.4732 | 1 | 1 |
Trypanosoma cruzi | AMP deaminase, putative | 0.3389 | 0.6036 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.2688 | 0.3964 | 0.3964 |
Trichomonas vaginalis | adenosine deaminase, putative | 0.4732 | 1 | 0.5 |
Plasmodium falciparum | adenosine deaminase | 0.4732 | 1 | 1 |
Toxoplasma gondii | Adenosine/AMP deaminase domain-containing protein | 0.4732 | 1 | 1 |
Mycobacterium leprae | Probable adenosine deaminase Add (ADENOSINE AMINOHYDROLASE) | 0.4732 | 1 | 0.5 |
Entamoeba histolytica | adenosine deaminase, putative | 0.4732 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.4732 | 1 | 1 |
Treponema pallidum | adenosine deaminase | 0.4732 | 1 | 0.5 |
Leishmania major | AMP deaminase, putative,adenosine monophosphate deaminase-like protein | 0.3389 | 0.6036 | 0.5005 |
Trypanosoma cruzi | adenosine monophosphate deaminase, putative | 0.3389 | 0.6036 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.2688 | 0.3964 | 0.3964 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 13 nM | Inhibition of specific binding of [125I]-angiotensin-II to angiotensin 1 receptor in rat lung membrane preparation | ChEMBL. | 8258826 |
IC50 (binding) | = 13 nM | Inhibition of specific binding of [125I]-angiotensin-II to angiotensin 1 receptor in rat lung membrane preparation | ChEMBL. | 8258826 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.