Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | farnesyltransferase, CAAX box, alpha | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | Clan MA, family M1, aminopeptidase N-like metallopeptidase | 0.0308 | 0.0333 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.1136 | 0.916 | 0.916 |
Schistosoma mansoni | family M13 unassigned peptidase (M13 family) | 0.1136 | 0.916 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1136 | 0.916 | 0.916 |
Loa Loa (eye worm) | hypothetical protein | 0.1136 | 0.916 | 0.916 |
Mycobacterium ulcerans | zinc metalloprotease | 0.1136 | 0.916 | 1 |
Schistosoma mansoni | family M13 unassigned peptidase (M13 family) | 0.0573 | 0.316 | 0.345 |
Loa Loa (eye worm) | hypothetical protein | 0.0859 | 0.621 | 0.621 |
Echinococcus multilocularis | endothelin converting enzyme 1 | 0.1136 | 0.916 | 1 |
Trypanosoma cruzi | aminopeptidase, putative | 0.0308 | 0.0333 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0297 | 0.0211 | 0.023 |
Entamoeba histolytica | aminopeptidase, putative | 0.0308 | 0.0333 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0681 | 0.4306 | 0.4306 |
Loa Loa (eye worm) | hypothetical protein | 0.0563 | 0.305 | 0.305 |
Loa Loa (eye worm) | hypothetical protein | 0.0859 | 0.621 | 0.621 |
Leishmania major | aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 | 0.0308 | 0.0333 | 0.5 |
Schistosoma mansoni | neprilysin-2 (M13 family) | 0.0573 | 0.316 | 0.345 |
Loa Loa (eye worm) | angiotensin-converting enzyme family protein | 0.1215 | 1 | 1 |
Schistosoma mansoni | neprilysin | 0.0297 | 0.0211 | 0.023 |
Brugia malayi | Peptidase family M1 containing protein | 0.0989 | 0.7589 | 0.7589 |
Schistosoma mansoni | hypothetical protein | 0.0297 | 0.0211 | 0.023 |
Loa Loa (eye worm) | hypothetical protein | 0.0859 | 0.621 | 0.621 |
Loa Loa (eye worm) | hypothetical protein | 0.0865 | 0.6269 | 0.6269 |
Loa Loa (eye worm) | hypothetical protein | 0.084 | 0.5999 | 0.5999 |
Loa Loa (eye worm) | hypothetical protein | 0.0859 | 0.621 | 0.621 |
Toxoplasma gondii | peptidase family M13 protein | 0.1136 | 0.916 | 0.5 |
Trypanosoma cruzi | metallo-peptidase, clan MA(E), family M1, putative | 0.0308 | 0.0333 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0297 | 0.0211 | 0.023 |
Brugia malayi | Peptidase family M1 containing protein | 0.0308 | 0.0333 | 0.0333 |
Onchocerca volvulus | 0.0563 | 0.305 | 0.3744 | |
Trichomonas vaginalis | Clan MA, family M1, aminopeptidase N-like metallopeptidase | 0.0308 | 0.0333 | 0.5 |
Schistosoma mansoni | cytosol alanyl aminopeptidase (M01 family) | 0.0308 | 0.0333 | 0.0364 |
Loa Loa (eye worm) | leukotriene A4 hydrolase | 0.0552 | 0.2938 | 0.2938 |
Schistosoma mansoni | family M13 unassigned peptidase (M13 family) | 0.0297 | 0.0211 | 0.023 |
Brugia malayi | Peptidase family M13 containing protein | 0.1136 | 0.916 | 0.916 |
Echinococcus multilocularis | leukotriene A 4 hydrolase | 0.0552 | 0.2938 | 0.2951 |
Schistosoma mansoni | family M13 non-peptidase homologue (M13 family) | 0.0573 | 0.316 | 0.345 |
Trypanosoma cruzi | Aminopeptidase M1, putative | 0.0308 | 0.0333 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0297 | 0.0211 | 0.023 |
Echinococcus granulosus | endothelin converting enzyme 1 | 0.1136 | 0.916 | 1 |
Brugia malayi | Hypothetical zinc metalloproteinase T16A9.4 | 0.1136 | 0.916 | 0.916 |
Loa Loa (eye worm) | hypothetical protein | 0.084 | 0.5999 | 0.5999 |
Mycobacterium tuberculosis | Probable zinc metalloprotease Zmp1 | 0.1136 | 0.916 | 1 |
Loa Loa (eye worm) | peptidase family M13 containing protein | 0.084 | 0.5999 | 0.5999 |
Echinococcus granulosus | aminopeptidase N | 0.0989 | 0.7589 | 0.822 |
Schistosoma mansoni | hypothetical protein | 0.0297 | 0.0211 | 0.023 |
Echinococcus multilocularis | aminopeptidase N | 0.0989 | 0.7589 | 0.822 |
Echinococcus granulosus | leukotriene A 4 hydrolase | 0.0552 | 0.2938 | 0.2951 |
Loa Loa (eye worm) | hypothetical protein | 0.084 | 0.5999 | 0.5999 |
Trypanosoma brucei | Aminopeptidase M1, putative | 0.0308 | 0.0333 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0297 | 0.0211 | 0.023 |
Onchocerca volvulus | 0.0989 | 0.7589 | 1 | |
Leishmania major | aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 | 0.0308 | 0.0333 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.084 | 0.5999 | 0.5999 |
Schistosoma mansoni | aminopeptidase PILS (M01 family) | 0.0308 | 0.0333 | 0.0364 |
Loa Loa (eye worm) | peptidase family M13 containing protein | 0.084 | 0.5999 | 0.5999 |
Loa Loa (eye worm) | aminopeptidase N | 0.0308 | 0.0333 | 0.0333 |
Brugia malayi | hypothetical protein | 0.0308 | 0.0333 | 0.0333 |
Loa Loa (eye worm) | hypothetical protein | 0.0859 | 0.621 | 0.621 |
Schistosoma mansoni | family M13 unassigned peptidase (M13 family) | 0.0573 | 0.316 | 0.345 |
Loa Loa (eye worm) | hypothetical protein | 0.0859 | 0.621 | 0.621 |
Trypanosoma brucei | Aminopeptidase M1, putative | 0.0308 | 0.0333 | 0.5 |
Loa Loa (eye worm) | peptidase family M1 containing protein | 0.0805 | 0.5626 | 0.5626 |
Schistosoma mansoni | Nep2 peptidase (M13 family) | 0.0573 | 0.316 | 0.345 |
Mycobacterium leprae | probable zinc metalloprotease | 0.1136 | 0.916 | 0.5 |
Schistosoma mansoni | leukotriene A4 hydrolase (M01 family) | 0.0552 | 0.2938 | 0.3207 |
Trypanosoma brucei | metallo-peptidase, Clan MA(E) Family M1 | 0.0308 | 0.0333 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.