Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Glutamate NMDA receptor | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | AMP deaminase 2 homolog | 0.1904 | 0.512 | 0.2228 |
Schistosoma mansoni | adenosine deaminase | 0.3688 | 1 | 1 |
Trypanosoma cruzi | adenosine monophosphate deaminase-like protein, putative | 0.1904 | 0.512 | 1 |
Trypanosoma cruzi | AMP deaminase, putative | 0.1904 | 0.512 | 1 |
Leishmania major | adenine aminohydrolase | 0.3688 | 1 | 1 |
Echinococcus granulosus | adenosine deaminase | 0.3688 | 1 | 1 |
Trypanosoma cruzi | adenosine monophosphate deaminase, putative | 0.1904 | 0.512 | 1 |
Trypanosoma brucei | AMP deaminase, putative | 0.1904 | 0.512 | 0.5 |
Trypanosoma brucei | AMP deaminase, putative | 0.1904 | 0.512 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.2295 | 0.6191 | 0.5617 |
Leishmania major | AMP deaminase, putative | 0.1904 | 0.512 | 0.2228 |
Trypanosoma brucei | adenosine monophosphate deaminase, putative | 0.1904 | 0.512 | 0.5 |
Trypanosoma cruzi | AMP deaminase, putative | 0.1904 | 0.512 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.2295 | 0.6191 | 0.5617 |
Loa Loa (eye worm) | AMP deaminase | 0.1904 | 0.512 | 0.4383 |
Onchocerca volvulus | Adenosine deaminase homolog | 0.3688 | 1 | 1 |
Echinococcus granulosus | AMP deaminase 2 | 0.1904 | 0.512 | 0.512 |
Schistosoma mansoni | adenosine deaminase-related | 0.3688 | 1 | 1 |
Plasmodium falciparum | adenosine deaminase | 0.3688 | 1 | 1 |
Trypanosoma cruzi | AMP deaminase, putative | 0.1904 | 0.512 | 1 |
Mycobacterium ulcerans | adenosine deaminase | 0.3688 | 1 | 0.5 |
Toxoplasma gondii | Adenosine/AMP deaminase domain-containing protein | 0.3688 | 1 | 1 |
Entamoeba histolytica | adenosine deaminase, putative | 0.3688 | 1 | 1 |
Trypanosoma cruzi | AMP deaminase, putative | 0.1904 | 0.512 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.2295 | 0.6191 | 0.5617 |
Leishmania major | adenosine monophosphate deaminase, putative,AMP deaminase, putative | 0.1904 | 0.512 | 0.2228 |
Mycobacterium leprae | Probable adenosine deaminase Add (ADENOSINE AMINOHYDROLASE) | 0.3688 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.2295 | 0.6191 | 0.5617 |
Leishmania major | AMP deaminase, putative,adenosine monophosphate deaminase-like protein | 0.1904 | 0.512 | 0.2228 |
Trichomonas vaginalis | adenosine deaminase, putative | 0.3688 | 1 | 0.5 |
Echinococcus multilocularis | AMP deaminase 2 | 0.1904 | 0.512 | 0.512 |
Loa Loa (eye worm) | hypothetical protein | 0.1392 | 0.3721 | 0.2774 |
Trichomonas vaginalis | adenosine deaminase, putative | 0.3688 | 1 | 0.5 |
Mycobacterium tuberculosis | Probable adenosine deaminase Add (adenosine aminohydrolase) | 0.3688 | 1 | 0.5 |
Treponema pallidum | adenosine deaminase | 0.3688 | 1 | 0.5 |
Plasmodium vivax | adenosine deaminase, putative | 0.3688 | 1 | 1 |
Entamoeba histolytica | adenosine deaminase, putative | 0.3688 | 1 | 1 |
Trypanosoma cruzi | AMP deaminase, putative | 0.1904 | 0.512 | 1 |
Toxoplasma gondii | Adenosine/AMP deaminase domain-containing protein | 0.3688 | 1 | 1 |
Trypanosoma brucei | AMP deaminase, putative | 0.1904 | 0.512 | 0.5 |
Echinococcus multilocularis | adenosine deaminase | 0.3688 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.3688 | 1 | 1 |
Leishmania major | AMP deaminase, putative,amp deaminase-like protein | 0.1904 | 0.512 | 0.2228 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ED50 (functional) | = 6.9 mg kg-1 | Anticonvulsant activity measured by its ability to protect against audiogenic seizure in DBA/2 mice when dosed intraperitoneally 30 min prior to seizure induction. | ChEMBL. | 9406596 |
ED50 (functional) | = 6.9 mg kg-1 | Anticonvulsant activity measured by its ability to protect against audiogenic seizure in DBA/2 mice when dosed intraperitoneally 30 min prior to seizure induction. | ChEMBL. | 9406596 |
HSAI (binding) | = 577 | Human serum albumin index was measured by retention time of the compound on an HPLC column containing human albumin | ChEMBL. | 9406596 |
HSAI (binding) | = 577 | Human serum albumin index was measured by retention time of the compound on an HPLC column containing human albumin | ChEMBL. | 9406596 |
IC50 (binding) | = 34.3 nM | Affinity for the glycine binding site on rat N-methyl-D-aspartate glutamate receptor 1, determined by displacement of the glycine site antagonist [3H]L-689,560 from rat cortical membranes | ChEMBL. | 9406596 |
IC50 (binding) | = 34.3 nM | Affinity for the glycine binding site on rat N-methyl-D-aspartate glutamate receptor 1, determined by displacement of the glycine site antagonist [3H]L-689,560 from rat cortical membranes | ChEMBL. | 9406596 |
logP (ADMET) | = 3.96 | Partition coefficient (logP) | ChEMBL. | 9406596 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.