Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Entamoeba histolytica | adenosine deaminase, putative | 0.1396 | 1 | 1 |
Trypanosoma cruzi | adenosine monophosphate deaminase, putative | 0.0931 | 0.2039 | 0.5 |
Plasmodium falciparum | adenosine deaminase | 0.1396 | 1 | 1 |
Mycobacterium leprae | Probable adenosine deaminase Add (ADENOSINE AMINOHYDROLASE) | 0.1396 | 1 | 0.5 |
Onchocerca volvulus | Adenosine deaminase homolog | 0.1396 | 1 | 1 |
Schistosoma mansoni | adenosine deaminase | 0.1396 | 1 | 1 |
Echinococcus granulosus | adenosine deaminase | 0.1396 | 1 | 1 |
Treponema pallidum | adenosine deaminase | 0.1396 | 1 | 0.5 |
Toxoplasma gondii | Adenosine/AMP deaminase domain-containing protein | 0.1396 | 1 | 1 |
Trypanosoma brucei | AMP deaminase, putative | 0.0931 | 0.2039 | 0.5 |
Schistosoma mansoni | adenosine deaminase-related | 0.1396 | 1 | 1 |
Trypanosoma cruzi | AMP deaminase, putative | 0.0931 | 0.2039 | 0.5 |
Trypanosoma cruzi | AMP deaminase, putative | 0.0931 | 0.2039 | 0.5 |
Mycobacterium ulcerans | adenosine deaminase | 0.1396 | 1 | 0.5 |
Echinococcus multilocularis | adenosine deaminase | 0.1396 | 1 | 1 |
Loa Loa (eye worm) | AMP deaminase | 0.0931 | 0.2039 | 0.2039 |
Trypanosoma brucei | adenosine monophosphate deaminase, putative | 0.0931 | 0.2039 | 0.5 |
Entamoeba histolytica | adenosine deaminase, putative | 0.1396 | 1 | 1 |
Trypanosoma cruzi | AMP deaminase, putative | 0.0931 | 0.2039 | 0.5 |
Trichomonas vaginalis | adenosine deaminase, putative | 0.1396 | 1 | 0.5 |
Toxoplasma gondii | Adenosine/AMP deaminase domain-containing protein | 0.1396 | 1 | 1 |
Plasmodium vivax | adenosine deaminase, putative | 0.1396 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1396 | 1 | 1 |
Trypanosoma cruzi | AMP deaminase, putative | 0.0931 | 0.2039 | 0.5 |
Trypanosoma brucei | AMP deaminase, putative | 0.0931 | 0.2039 | 0.5 |
Leishmania major | adenine aminohydrolase | 0.1396 | 1 | 1 |
Trichomonas vaginalis | adenosine deaminase, putative | 0.1396 | 1 | 0.5 |
Trypanosoma cruzi | adenosine monophosphate deaminase-like protein, putative | 0.0931 | 0.2039 | 0.5 |
Trypanosoma cruzi | AMP deaminase, putative | 0.0931 | 0.2039 | 0.5 |
Mycobacterium tuberculosis | Probable adenosine deaminase Add (adenosine aminohydrolase) | 0.1396 | 1 | 0.5 |
Trypanosoma brucei | AMP deaminase, putative | 0.0931 | 0.2039 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | = 217 uM | Inhibition of collagen-induced platelet aggregation in human platelet rich plasma | ChEMBL. | 8831771 |
EC50 (functional) | = 217 uM | Inhibition of collagen-induced platelet aggregation in human platelet rich plasma | ChEMBL. | 8831771 |
IC50 (functional) | = 71 uM | TXA2 receptor antagonism, measured by the displacement of [3H]SQ29,548 from the PGH-2/TXA-2 receptor on human platelets | ChEMBL. | 8831771 |
IC50 (functional) | = 71 uM | TXA2 receptor antagonism, measured by the displacement of [3H]SQ29,548 from the PGH-2/TXA-2 receptor on human platelets | ChEMBL. | 8831771 |
IC50 (binding) | > 100 uM | TXA2 synthetase inhibition measured by the inhibition of TXB2 formation by human gel-filtered platelets incubated with [14C]-arachidonic acid | ChEMBL. | 8831771 |
IC50 (binding) | > 100 uM | TXA2 synthetase inhibition measured by the inhibition of TXB2 formation by human gel-filtered platelets incubated with [14C]-arachidonic acid | ChEMBL. | 8831771 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.