Detailed information for compound 226838

Basic information

Technical information
  • TDR Targets ID: 226838
  • Name: 7-methyl-2-(3-methyl-1-benzothiophen-2-yl)-1H -1,8-naphthyridin-4-one
  • MW: 306.382 | Formula: C18H14N2OS
  • H donors: 1 H acceptors: 3 LogP: 4.58 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1ccc2c(n1)nc(cc2O)c1sc2c(c1C)cccc2
  • InChi: 1S/C18H14N2OS/c1-10-7-8-13-15(21)9-14(20-18(13)19-10)17-11(2)12-5-3-4-6-16(12)22-17/h3-9H,1-2H3,(H,19,20,21)
  • InChiKey: YYWOOVGOMGHNOU-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

  • 7-methyl-2-(3-methylbenzothiophen-2-yl)-1H-1,8-naphthyridin-4-one
  • 7-methyl-2-(3-methyl-2-benzothiophenyl)-1H-1,8-naphthyridin-4-one
  • NCI60_037943
  • NSC706463

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Bos taurus Tubulin Starlite/ChEMBL References
Trypanosoma cruzi trypanothione reductase, putative Curated by TDR Targets References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) tubulin alpha 2 Get druggable targets OG5_126605 All targets in OG5_126605
Brugia malayi tubulin alpha-2 chain Get druggable targets OG5_126605 All targets in OG5_126605
Brugia malayi tubulin alpha chain - mouse Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus multilocularis tubulin alpha 3 chain Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus multilocularis tubulin subunit TubB Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania major alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Neospora caninum MGC84926 protein, related Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus multilocularis tubulin alpha chain Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania major alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Plasmodium berghei alpha tubulin 2 Get druggable targets OG5_126605 All targets in OG5_126605
Loa Loa (eye worm) tubulin alpha chain Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania mexicana trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trichomonas vaginalis tubulin beta chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus multilocularis tubulin alpha 1C chain Get druggable targets OG5_126605 All targets in OG5_126605
Schistosoma japonicum ko:K07374 tubulin alpha, putative Get druggable targets OG5_126605 All targets in OG5_126605
Trypanosoma brucei alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Trypanosoma brucei gambiense alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus granulosus peroxisome assembly protein 26 Get druggable targets OG5_126605 All targets in OG5_126605
Loa Loa (eye worm) alpha-tubulin isotype 2 Get druggable targets OG5_126605 All targets in OG5_126605
Brugia malayi Tubulin alpha-2 chain Get druggable targets OG5_126605 All targets in OG5_126605
Loa Loa (eye worm) alpha-tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania major trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium vivax thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania mexicana alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Plasmodium berghei glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Trichomonas vaginalis tubulin alpha-1 chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Trichomonas vaginalis tubulin beta chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Plasmodium falciparum alpha tubulin 2 Get druggable targets OG5_126605 All targets in OG5_126605
Schistosoma japonicum Tubulin alpha-1 chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania braziliensis trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Giardia lamblia Alpha-tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Loa Loa (eye worm) tubulin alpha-3 chain Get druggable targets OG5_126605 All targets in OG5_126605
Plasmodium falciparum thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma brucei trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus multilocularis Tubulin alpha 1 chain Get druggable targets OG5_126605 All targets in OG5_126605
Neospora caninum tubulin alpha chain Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania mexicana alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Schistosoma mansoni tubulin subunit alpha Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus multilocularis hypothetical protein Get druggable targets OG5_126605 All targets in OG5_126605
Trichomonas vaginalis tubulin epsilon chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus multilocularis tubulin alpha chain Get druggable targets OG5_126605 All targets in OG5_126605
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126605 All targets in OG5_126605
Trypanosoma brucei alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania donovani alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Babesia bovis tubulin alpha chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus granulosus tubulin subunit TubB Get druggable targets OG5_126605 All targets in OG5_126605
Brugia malayi glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania braziliensis alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126605 All targets in OG5_126605
Loa Loa (eye worm) tubulin alpha 2 Get druggable targets OG5_126605 All targets in OG5_126605
Cryptosporidium parvum alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Trichomonas vaginalis tubulin epsilon chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Cryptosporidium hominis thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium berghei thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Trichomonas vaginalis tubulin alpha-1 chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus multilocularis tubulin alpha 3 chain Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania major alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Trichomonas vaginalis tubulin beta chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Plasmodium yoelii thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus multilocularis tubulin alpha chain Get druggable targets OG5_126605 All targets in OG5_126605
Trypanosoma brucei gambiense trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Entamoeba histolytica tubulin alpha chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus granulosus Tubulin alpha 1 chain Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus granulosus tubulin alpha chain Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania major alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Brugia malayi Thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania major alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus multilocularis Tubulin alpha 1 chain Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania infantum alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Trypanosoma congolense trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Candida albicans cytoskeletal structural protein Get druggable targets OG5_126605 All targets in OG5_126605
Toxoplasma gondii alpha-tubulin I, putative Get druggable targets OG5_126605 All targets in OG5_126605
Plasmodium knowlesi glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus granulosus Tubulin alpha 1 chain Get druggable targets OG5_126605 All targets in OG5_126605
Loa Loa (eye worm) tubulin alpha chain Get druggable targets OG5_126605 All targets in OG5_126605
Schistosoma japonicum Tubulin alpha-2/alpha-4 chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus granulosus alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Plasmodium yoelii Tubulin/FtsZ family, putative Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus granulosus tubulin alpha 3 chain Get druggable targets OG5_126605 All targets in OG5_126605
Plasmodium berghei alpha tubulin 1 Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania major alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Loa Loa (eye worm) tubulin alpha 2 Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania infantum trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania major alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania major alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Toxoplasma gondii thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Toxoplasma gondii alpha tubulin TUBA1 Get druggable targets OG5_126605 All targets in OG5_126605
Theileria parva Tubulin alpha chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Plasmodium yoelii glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trichomonas vaginalis tubulin beta chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Plasmodium vivax tubulin alpha chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus granulosus tubulin alpha 1C chain Get druggable targets OG5_126605 All targets in OG5_126605
Theileria parva tubulin alpha chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Trypanosoma cruzi trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus granulosus tubulin alpha 3 chain Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus multilocularis Tubulin alpha 1 chain Get druggable targets OG5_126605 All targets in OG5_126605
Schistosoma japonicum ko:K07374 tubulin alpha, putative Get druggable targets OG5_126605 All targets in OG5_126605
Plasmodium knowlesi thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus multilocularis peroxisome assembly protein 26 Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus granulosus tubulin alpha chain Get druggable targets OG5_126605 All targets in OG5_126605
Babesia bovis tubulin alpha chain Get druggable targets OG5_126605 All targets in OG5_126605
Plasmodium yoelii tubulin alpha chain Get druggable targets OG5_126605 All targets in OG5_126605
Schistosoma japonicum ko:K00384 thioredoxin reductase (NADPH) [EC1.8.1.9], putative Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium vivax glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Trichomonas vaginalis tubulin beta chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Theileria parva thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma japonicum Tubulin alpha chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Plasmodium knowlesi alpha-tubulin II, putative Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus multilocularis tubulin alpha 1C chain Get druggable targets OG5_126605 All targets in OG5_126605
Entamoeba histolytica tubulin alpha-1 chain Get druggable targets OG5_126605 All targets in OG5_126605
Giardia lamblia Alpha-tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania major alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Brugia malayi alpha-tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Loa Loa (eye worm) alpha-tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Trichomonas vaginalis tubulin beta chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Trypanosoma brucei alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Candida albicans similar to S. cerevisiae GLR1 (YPL091W) glutathione oxidoreductase Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus granulosus tubulin alpha 1C chain Get druggable targets OG5_126605 All targets in OG5_126605
Brugia malayi Tubulin alpha-2 chain Get druggable targets OG5_126605 All targets in OG5_126605
Plasmodium falciparum glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania major alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus granulosus tubulin alpha chain Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus granulosus Tubulin alpha 1 chain Get druggable targets OG5_126605 All targets in OG5_126605
Trypanosoma cruzi alpha tubulin, putative Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus granulosus thioredoxin glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma brucei alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Neospora caninum Glutathione reductase, related Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium vivax tubulin alpha chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Loa Loa (eye worm) glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma mansoni tubulin subunit alpha Get druggable targets OG5_126605 All targets in OG5_126605
Trichomonas vaginalis tubulin alpha-1 chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Schistosoma mansoni tubulin subunit alpha Get druggable targets OG5_126605 All targets in OG5_126605
Schistosoma japonicum Tubulin alpha-1C chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus granulosus tubulin alpha chain Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania infantum alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Loa Loa (eye worm) thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania donovani trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma mansoni alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Loa Loa (eye worm) tubulin alpha-2 chain Get druggable targets OG5_126605 All targets in OG5_126605
Plasmodium knowlesi alpha tubulin, putative Get druggable targets OG5_126605 All targets in OG5_126605
Cryptosporidium parvum thioredoxin reductase 1 Get druggable targets OG5_126785 All targets in OG5_126785
Brugia malayi Tubulin alpha chain Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus multilocularis tubulin alpha chain Get druggable targets OG5_126605 All targets in OG5_126605
Schistosoma mansoni alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus granulosus tubulin alpha chain Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus multilocularis tubulin alpha chain Get druggable targets OG5_126605 All targets in OG5_126605
Candida albicans similar to S. cerevisiae GLR1 (YPL091W) glutathione oxidoreductase Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania major alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Schistosoma mansoni alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Babesia bovis thiodoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania major alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Trypanosoma congolense alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Plasmodium falciparum alpha tubulin 1 Get druggable targets OG5_126605 All targets in OG5_126605
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania braziliensis alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Cryptosporidium hominis alpha-tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus multilocularis thioredoxin glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Drosophila melanogaster beta-Tubulin at 60D Tubulin   445 aa 435 aa 90.6 %
Echinococcus granulosus beta tubulin Tubulin   445 aa 427 aa 82.2 %
Echinococcus granulosus Tubulin beta 2C chain Tubulin   445 aa 428 aa 92.3 %
Trichomonas vaginalis tubulin gamma chain, putative Tubulin   445 aa 415 aa 33.3 %
Giardia lamblia Beta tubulin Tubulin   445 aa 428 aa 88.3 %
Neospora caninum Beta-tubulin, related Tubulin   445 aa 446 aa 35.2 %
Brugia malayi Tubulin beta-1 chain Tubulin   445 aa 429 aa 87.4 %
Loa Loa (eye worm) tubulin beta-1 chain Tubulin   445 aa 432 aa 88.0 %
Drosophila melanogaster gamma-Tubulin at 23C Tubulin   445 aa 439 aa 34.6 %
Dictyostelium discoideum gamma tubulin Tubulin   445 aa 429 aa 34.0 %
Trypanosoma congolense tubulin gamma chain Tubulin   445 aa 436 aa 33.3 %
Cryptosporidium hominis gamma-tubulin Tubulin   445 aa 436 aa 37.6 %
Echinococcus multilocularis Tubulin beta 2C chain Tubulin   445 aa 428 aa 92.5 %
Trypanosoma cruzi epsilon tubulin, putative Tubulin   445 aa 456 aa 31.4 %
Trypanosoma congolense epsilon tubulin Tubulin   445 aa 464 aa 29.1 %
Plasmodium yoelii tubulin gamma chain Tubulin   445 aa 438 aa 33.1 %
Schistosoma japonicum Tubulin beta chain, putative Tubulin   445 aa 436 aa 96.3 %
Toxoplasma gondii beta-tubulin, putative Tubulin   445 aa 430 aa 89.8 %
Plasmodium vivax tubulin epsilon chain, putative Tubulin   445 aa 444 aa 28.6 %
Neospora caninum hypothetical protein Tubulin   445 aa 430 aa 89.1 %
Leishmania major gamma-tubulin Tubulin   445 aa 438 aa 34.0 %
Trypanosoma brucei epsilon tubulin Tubulin   445 aa 443 aa 29.1 %
Plasmodium yoelii tubulin beta chain Tubulin   445 aa 445 aa 29.7 %
Onchocerca volvulus Regulatory-associated protein of mTOR homolog Tubulin   445 aa 440 aa 38.4 %
Trichomonas vaginalis tubulin beta chain, putative Tubulin   445 aa 428 aa 80.6 %
Brugia malayi Tubulin gamma chain Tubulin   445 aa 440 aa 31.8 %
Leishmania major epsilon tubulin, putative Tubulin   445 aa 469 aa 30.9 %
Toxoplasma gondii beta tubulin Tubulin   445 aa 430 aa 89.1 %
Onchocerca volvulus Putative cytochrome c-type heme lyase Tubulin   445 aa 429 aa 87.4 %
Echinococcus multilocularis tubulin alpha Tubulin   445 aa 443 aa 30.5 %
Loa Loa (eye worm) BEN-1 protein Tubulin   445 aa 427 aa 82.2 %
Dictyostelium discoideum beta tubulin Tubulin   445 aa 432 aa 75.7 %
Brugia malayi beta-tubulin, identical Tubulin   445 aa 430 aa 90.5 %
Onchocerca volvulus 1D304 homolog Tubulin   445 aa 433 aa 40.4 %
Echinococcus multilocularis Tubulin beta 2C chain Tubulin   445 aa 430 aa 93.7 %
Neospora caninum hypothetical protein Tubulin   445 aa 430 aa 89.1 %
Entamoeba histolytica tubulin family protein Tubulin   445 aa 429 aa 57.8 %
Onchocerca volvulus Tubulin   445 aa 435 aa 39.5 %
Trichomonas vaginalis tubulin alpha chain, putative Tubulin   445 aa 428 aa 80.8 %
Echinococcus granulosus tubulin alpha Tubulin   445 aa 440 aa 30.2 %
Plasmodium knowlesi tubulin gamma chain, putative Tubulin   445 aa 438 aa 33.3 %
Onchocerca volvulus Tubulin   445 aa 441 aa 31.7 %
Babesia bovis tubulin gamma chain Tubulin   445 aa 441 aa 34.0 %
Schistosoma mansoni tubulin subunit gamma Tubulin   445 aa 436 aa 33.7 %
Toxoplasma gondii beta-1 tubulin, putative Tubulin   445 aa 430 aa 89.1 %
Neospora caninum hypothetical protein Tubulin   445 aa 430 aa 89.8 %
Onchocerca volvulus Tubulin   445 aa 433 aa 40.0 %
Schistosoma mansoni tubulin subunit epsilon Tubulin   445 aa 464 aa 31.7 %
Leishmania mexicana beta tubulin Tubulin   445 aa 429 aa 85.8 %
Onchocerca volvulus 60S ribosomal protein L13 homolog Tubulin   445 aa 430 aa 91.4 %
Echinococcus granulosus Tubulin beta 2C chain Tubulin   445 aa 430 aa 94.4 %
Giardia lamblia Gamma tubulin Tubulin   445 aa 460 aa 32.4 %
Leishmania braziliensis gamma-tubulin Tubulin   445 aa 438 aa 34.2 %
Leishmania donovani tubulin gamma chain Tubulin   445 aa 438 aa 34.2 %
Plasmodium berghei tubulin gamma chain, putative Tubulin   445 aa 438 aa 33.3 %
Leishmania donovani epsilon tubulin, putative Tubulin   445 aa 475 aa 30.3 %
Trypanosoma brucei tubulin gamma chain Tubulin   445 aa 436 aa 33.5 %
Echinococcus multilocularis tubulin gamma 1 chain Tubulin   445 aa 436 aa 34.4 %
Entamoeba histolytica tubulin family protein Tubulin   445 aa 428 aa 56.3 %
Leishmania infantum gamma-tubulin Tubulin   445 aa 438 aa 34.2 %
Onchocerca volvulus Tubulin   445 aa 427 aa 82.4 %
Onchocerca volvulus Tubulin   445 aa 434 aa 39.9 %
Plasmodium knowlesi tubulin epsilon chain, putative Tubulin   445 aa 441 aa 29.0 %
Plasmodium falciparum tubulin epsilon chain, putative Tubulin   445 aa 461 aa 27.8 %
Trypanosoma brucei epsilon tubulin Tubulin   445 aa 443 aa 29.3 %
Trypanosoma brucei gambiense gamma tubulin Tubulin   445 aa 436 aa 33.5 %
Leishmania mexicana gamma-tubulin Tubulin   445 aa 438 aa 34.2 %
Onchocerca volvulus Tyrosine kinase homolog Tubulin   445 aa 434 aa 38.2 %
Neospora caninum tubulin alpha chain, putative Tubulin   445 aa 433 aa 30.9 %
Trypanosoma brucei gambiense epsilon tubulin Tubulin   445 aa 443 aa 29.3 %
Plasmodium berghei tubulin epsilon chain, putative Tubulin   445 aa 445 aa 29.4 %
Trypanosoma cruzi epsilon tubulin, putative Tubulin   445 aa 456 aa 31.4 %
Echinococcus granulosus tubulin beta 4A class IVa Tubulin   445 aa 381 aa 71.1 %
Onchocerca volvulus Tubulin   445 aa 433 aa 39.0 %
Schistosoma mansoni tubulin subunit beta Tubulin   445 aa 430 aa 95.8 %
Loa Loa (eye worm) tubulin beta-2A chain Tubulin   445 aa 430 aa 91.4 %
Cryptosporidium parvum gamma tubulin Tubulin   445 aa 436 aa 37.6 %
Trichomonas vaginalis tubulin, putative Tubulin   445 aa 428 aa 80.8 %
Schistosoma mansoni tubulin subunit beta Tubulin   445 aa 430 aa 92.3 %
Leishmania infantum epsilon tubulin, putative Tubulin   445 aa 475 aa 30.3 %
Entamoeba histolytica tubulin gamma chain Tubulin   445 aa 428 aa 33.2 %
Echinococcus granulosus tubulin gamma 1 chain Tubulin   445 aa 436 aa 34.4 %
Trypanosoma cruzi tubulin gamma chain Tubulin   445 aa 436 aa 33.5 %
Giardia lamblia Beta tubulin Tubulin   445 aa 428 aa 88.3 %
Giardia lamblia Epsilon tubulin Tubulin   445 aa 442 aa 27.6 %
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein Tubulin   445 aa 433 aa 30.7 %
Echinococcus multilocularis tubulin delta chain Tubulin   445 aa 461 aa 25.8 %
Onchocerca volvulus Putative methyltransferase KIAA1456 Tubulin   445 aa 426 aa 49.8 %
Trichomonas vaginalis tubulin epsilon chain, putative Tubulin   445 aa 428 aa 80.8 %
Trypanosoma brucei epsilon tubulin Tubulin   445 aa 443 aa 29.3 %
Plasmodium falciparum tubulin gamma chain Tubulin   445 aa 438 aa 32.9 %
Echinococcus multilocularis tubulin, beta 4A class IVa Tubulin   445 aa 381 aa 71.1 %
Leishmania braziliensis epsilon tubulin, putative Tubulin   445 aa 465 aa 30.1 %
Theileria parva tubulin gamma chain, putative Tubulin   445 aa 420 aa 34.5 %
Onchocerca volvulus Tubulin   445 aa 427 aa 49.9 %
Onchocerca volvulus Tubulin   445 aa 445 aa 36.2 %
Plasmodium vivax tubulin gamma chain, putative Tubulin   445 aa 438 aa 33.3 %
Loa Loa (eye worm) BEN-1 protein Tubulin   445 aa 427 aa 57.1 %
Schistosoma japonicum ko:K10389 tubulin gamma, putative Tubulin   445 aa 436 aa 34.2 %
Giardia lamblia Beta tubulin Tubulin   445 aa 428 aa 88.3 %
Leishmania mexicana epsilon tubulin, putative Tubulin   445 aa 469 aa 30.9 %
Babesia bovis tubulin, putative Tubulin   445 aa 459 aa 21.1 %
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast trypanothione reductase, putative 492 aa 548 aa 21.5 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Leishmania major alpha tubulin 0.0022 0.1752 0.1542
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0026 0.2483 0.2291
Loa Loa (eye worm) BEN-1 protein 0.0012 0.0249 0.0249
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0026 0.2483 0.2291
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0026 0.2483 0.2291
Plasmodium falciparum glutathione reductase 0.0026 0.2483 0.2291
Echinococcus multilocularis tubulin alpha chain 0.0022 0.1752 0.1542
Loa Loa (eye worm) glutathione reductase 0.0076 1 1
Giardia lamblia Alpha-tubulin 0.0022 0.1752 0.673
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0026 0.2483 0.5
Trichomonas vaginalis tubulin beta chain, putative 0.0022 0.1752 0.673
Loa Loa (eye worm) tubulin beta chain 0.0012 0.0249 0.0249
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0076 1 1
Schistosoma mansoni alpha tubulin 0.0022 0.1752 0.1542
Leishmania major alpha tubulin 0.0022 0.1752 0.1542
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0026 0.2483 0.5
Echinococcus granulosus peroxisome assembly protein 26 0.0022 0.1752 0.1542
Echinococcus multilocularis tubulin alpha 3 chain 0.0022 0.1752 0.1542
Plasmodium falciparum alpha tubulin 1 0.0022 0.1752 0.1542
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0026 0.2483 0.2291
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0015 0.0761 0.2292
Trichomonas vaginalis tubulin epsilon chain, putative 0.0022 0.1752 0.673
Trypanosoma cruzi trypanothione reductase, putative 0.0076 1 1
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0026 0.2483 0.5
Echinococcus granulosus thioredoxin glutathione reductase 0.0076 1 1
Trichomonas vaginalis tubulin beta chain, putative 0.0022 0.1752 0.673
Echinococcus multilocularis tubulin alpha chain 0.0022 0.1752 0.1542
Echinococcus multilocularis tubulin alpha 1C chain 0.0022 0.1752 0.1542
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0026 0.2483 0.5
Echinococcus granulosus tubulin subunit TubB 0.0022 0.1752 0.1542
Leishmania major alpha tubulin 0.0022 0.1752 0.1542
Plasmodium falciparum thioredoxin reductase 0.0026 0.2483 0.2291
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0017 0.0991 0.3324
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0026 0.2483 0.2291
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0022 0.1752 0.673
Loa Loa (eye worm) tubulin alpha-3 chain 0.0015 0.0761 0.0761
Loa Loa (eye worm) tubulin alpha chain 0.0022 0.1752 0.1752
Trichomonas vaginalis tubulin beta chain, putative 0.0022 0.1752 0.673
Leishmania major alpha tubulin 0.0022 0.1752 0.1542
Echinococcus multilocularis tubulin alpha chain 0.0022 0.1752 0.1542
Schistosoma mansoni alpha tubulin 0.0022 0.1752 0.1542
Echinococcus granulosus tubulin alpha chain 0.0022 0.1752 0.1542
Loa Loa (eye worm) tubulin alpha 2 0.0017 0.0991 0.0991
Schistosoma mansoni alpha tubulin 0.0022 0.1752 0.1542
Echinococcus granulosus Tubulin alpha 1 chain 0.0022 0.1752 0.1542
Trichomonas vaginalis tubulin beta chain, putative 0.0022 0.1752 0.673
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0026 0.2483 0.2291
Loa Loa (eye worm) tubulin alpha-2 chain 0.0022 0.1752 0.1752
Schistosoma mansoni tubulin subunit alpha 0.0022 0.1752 0.1542
Loa Loa (eye worm) tubulin gamma chain 0.0012 0.0249 0.0249
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0026 0.2483 0.2291
Trypanosoma cruzi alpha tubulin, putative 0.0022 0.1752 0.1542
Echinococcus multilocularis peroxisome assembly protein 26 0.0022 0.1752 0.1542
Echinococcus granulosus tubulin alpha 1C chain 0.0022 0.1752 0.1542
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0026 0.2483 0.2291
Loa Loa (eye worm) hypothetical protein 0.0017 0.0991 0.0991
Echinococcus granulosus Tubulin alpha 1 chain 0.0022 0.1752 0.1542
Trypanosoma brucei trypanothione reductase 0.0076 1 1
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0026 0.2483 0.2291
Toxoplasma gondii thioredoxin reductase 0.0076 1 1
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0026 0.2483 0.2291
Trichomonas vaginalis tubulin epsilon chain, putative 0.0022 0.1752 0.673
Leishmania major alpha tubulin 0.0022 0.1752 0.1542
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0026 0.2483 0.2291
Trichomonas vaginalis tubulin beta chain, putative 0.0022 0.1752 0.673
Leishmania major alpha tubulin 0.0022 0.1752 0.1542
Plasmodium falciparum alpha tubulin 2 0.0022 0.1752 0.1542
Echinococcus multilocularis tubulin alpha 3 chain 0.0022 0.1752 0.1542
Loa Loa (eye worm) tubulin alpha 2 0.0017 0.0991 0.0991
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0026 0.2483 0.2291
Loa Loa (eye worm) BEN-1 protein 0.0012 0.0249 0.0249
Leishmania major alpha tubulin 0.0022 0.1752 0.1542
Loa Loa (eye worm) tubulin beta-2A chain 0.0012 0.0249 0.0249
Treponema pallidum NADH oxidase 0.0026 0.2483 0.5
Echinococcus multilocularis tubulin subunit TubB 0.0022 0.1752 0.1542
Leishmania major trypanothione reductase 0.0076 1 1
Echinococcus granulosus alpha tubulin 0.0022 0.1752 0.1542
Echinococcus granulosus tubulin alpha 1C chain 0.0022 0.1752 0.1542
Echinococcus granulosus tubulin alpha chain 0.0022 0.1752 0.1542
Loa Loa (eye worm) alpha-tubulin isotype 2 0.0017 0.0991 0.0991
Giardia lamblia NADH oxidase lateral transfer candidate 0.0026 0.2483 1
Trypanosoma brucei alpha tubulin 0.0022 0.1752 0.1542
Echinococcus multilocularis Tubulin alpha 1 chain 0.0022 0.1752 0.1542
Echinococcus multilocularis Tubulin alpha 1 chain 0.0022 0.1752 0.1542
Echinococcus granulosus tubulin alpha 3 chain 0.0022 0.1752 0.1542
Loa Loa (eye worm) tubulin alpha chain 0.0022 0.1752 0.1752
Echinococcus multilocularis tubulin alpha chain 0.0022 0.1752 0.1542
Brugia malayi tubulin alpha-2 chain 0.0022 0.1752 0.1542
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0026 0.2483 0.2291
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0026 0.2483 0.2291
Plasmodium vivax glutathione reductase, putative 0.0076 1 1
Trichomonas vaginalis mercuric reductase, putative 0.0026 0.2483 1
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0026 0.2483 0.2291
Plasmodium falciparum thioredoxin reductase 0.0076 1 1
Echinococcus granulosus tubulin alpha 3 chain 0.0022 0.1752 0.1542
Giardia lamblia Alpha-tubulin 0.0022 0.1752 0.673
Brugia malayi Thioredoxin reductase 0.0076 1 1
Echinococcus granulosus tubulin alpha chain 0.0022 0.1752 0.1542
Toxoplasma gondii alpha tubulin TUBA1 0.0022 0.1752 0.1542
Loa Loa (eye worm) tubulin beta-4 chain 0.0012 0.0249 0.0249
Leishmania major alpha tubulin 0.0022 0.1752 0.1542
Echinococcus multilocularis tubulin alpha 1C chain 0.0022 0.1752 0.1542
Trypanosoma brucei alpha tubulin 0.0022 0.1752 0.1542
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0026 0.2483 0.2291
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0026 0.2483 0.2291
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0026 0.2483 0.2291
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0026 0.2483 0.2291
Loa Loa (eye worm) alpha-tubulin 0.0022 0.1752 0.1752
Plasmodium vivax thioredoxin reductase, putative 0.0076 1 1
Loa Loa (eye worm) hypothetical protein 0.0022 0.1752 0.1752
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0019 0.1425 0.1206
Loa Loa (eye worm) beta-tubulin 0.0012 0.0249 0.0249
Loa Loa (eye worm) thioredoxin reductase 0.0076 1 1
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0026 0.2483 0.2291
Plasmodium falciparum glutathione reductase 0.0076 1 1
Leishmania major alpha tubulin 0.0022 0.1752 0.1542
Echinococcus multilocularis hypothetical protein 0.0022 0.1752 0.1542
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0026 0.2483 0.2291
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0026 0.2483 0.2291
Trichomonas vaginalis glutathione reductase, putative 0.0026 0.2483 1
Loa Loa (eye worm) tubulin beta-1 chain 0.0012 0.0249 0.0249
Plasmodium vivax tubulin alpha chain, putative 0.0022 0.1752 0.1542
Echinococcus multilocularis Tubulin alpha 1 chain 0.0022 0.1752 0.1542
Brugia malayi alpha-tubulin 0.0022 0.1752 0.1542
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0026 0.2483 0.5
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0026 0.2483 0.2291
Echinococcus granulosus tubulin alpha chain 0.0022 0.1752 0.1542
Trypanosoma cruzi trypanothione reductase, putative 0.0026 0.2483 0.2291
Echinococcus granulosus Tubulin alpha 1 chain 0.0022 0.1752 0.1542
Leishmania major alpha tubulin 0.0022 0.1752 0.1542
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0026 0.2483 0.5
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0026 0.2483 0.2291
Echinococcus granulosus tubulin alpha chain 0.0022 0.1752 0.1542
Toxoplasma gondii alpha-tubulin I, putative 0.0022 0.1752 0.1542
Echinococcus multilocularis thioredoxin glutathione reductase 0.0076 1 1
Brugia malayi Tubulin alpha-2 chain 0.0022 0.1752 0.1542
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0019 0.1425 0.1206
Entamoeba histolytica tubulin alpha chain, putative 0.0022 0.1752 1
Schistosoma mansoni tubulin subunit alpha 0.0022 0.1752 0.1542
Plasmodium vivax tubulin alpha chain, putative 0.0022 0.1752 0.1542
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0026 0.2483 0.2291
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0026 0.2483 0.5
Brugia malayi Tubulin alpha-2 chain 0.0022 0.1752 0.1542
Toxoplasma gondii NADPH-glutathione reductase 0.0026 0.2483 0.2291
Schistosoma mansoni tubulin subunit alpha 0.0022 0.1752 0.1542
Trypanosoma brucei alpha tubulin 0.0022 0.1752 0.1542
Echinococcus multilocularis tubulin alpha chain 0.0022 0.1752 0.1542
Loa Loa (eye worm) alpha-tubulin 0.0022 0.1752 0.1752
Trypanosoma brucei alpha tubulin 0.0022 0.1752 0.1542
Trichomonas vaginalis tubulin beta chain, putative 0.0022 0.1752 0.673
Leishmania major alpha tubulin 0.0022 0.1752 0.1542
Leishmania major alpha tubulin 0.0022 0.1752 0.1542
Entamoeba histolytica tubulin alpha-1 chain 0.0022 0.1752 1
Brugia malayi Tubulin alpha chain 0.0022 0.1752 0.1542
Loa Loa (eye worm) hypothetical protein 0.0015 0.0761 0.0761
Brugia malayi tubulin alpha chain - mouse 0.0022 0.1752 0.1542

Activities

Activity type Activity value Assay description Source Reference
GI50 (functional) -6.18 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -5.351 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) = -5.32 In vitro growth inhibition of MDA-MB-435 breast cancer cell line. ChEMBL. 10514278
GI50 (functional) -4.879 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) = -4.83 In vitro growth inhibition of SK-MEL-5 melanoma cell line. ChEMBL. 10514278
GI50 (functional) -4.827 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) = -4.77 In vitro growth inhibition of RXF-393 renal cancer cell line. ChEMBL. 10514278
GI50 (functional) = -4.77 In vitro growth inhibition of MDA-N breast cancer cell line. ChEMBL. 10514278
GI50 (functional) -4.733 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) = -4.73 In vitro growth inhibition of HL-60 (TB) leukemia cell line. ChEMBL. 10514278
GI50 (functional) = -4.71 In vitro growth inhibition of NCI-H23 non small cell lung cancer cell line. ChEMBL. 10514278
GI50 (functional) = -4.71 In vitro growth inhibition of OVCAR-3 ovarian cancer cell line. ChEMBL. 10514278
GI50 (functional) -4.705 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) = -4.7 In vitro growth inhibition of SW-620 colon cancer cell line. ChEMBL. 10514278
GI50 (functional) -4.641 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.538 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) = -4.48 In vitro growth inhibition of PC-3 prostrate cancer cell line. ChEMBL. 10514278
GI50 (functional) = -4.41 In vitro growth inhibition of U251 CNS cancer cell line. ChEMBL. 10514278
IC50 (functional) = 13 uM Inhibition of tubulin polymerization(ITP) ChEMBL. 10514278
IC50 (functional) = 13 uM Inhibition of tubulin polymerization(ITP) ChEMBL. 10514278
Log GI50 (functional) = -5.32 M In vitro growth inhibition of MDA-MB-435 breast cancer cell line. ChEMBL. 10514278
Log GI50 (functional) = -4.83 M In vitro growth inhibition of SK-MEL-5 melanoma cell line. ChEMBL. 10514278
Log GI50 (functional) = -4.77 M In vitro growth inhibition of RXF-393 renal cancer cell line. ChEMBL. 10514278
Log GI50 (functional) = -4.77 M In vitro growth inhibition of MDA-N breast cancer cell line. ChEMBL. 10514278
Log GI50 (functional) = -4.73 M In vitro growth inhibition of HL-60 (TB) leukemia cell line. ChEMBL. 10514278
Log GI50 (functional) = -4.71 M In vitro growth inhibition of NCI-H23 non small cell lung cancer cell line. ChEMBL. 10514278
Log GI50 (functional) = -4.71 M In vitro growth inhibition of OVCAR-3 ovarian cancer cell line. ChEMBL. 10514278
Log GI50 (functional) = -4.7 M In vitro growth inhibition of SW-620 colon cancer cell line. ChEMBL. 10514278
Log GI50 (functional) = -4.48 M In vitro growth inhibition of PC-3 prostrate cancer cell line. ChEMBL. 10514278
Log GI50 (functional) = -4.41 M In vitro growth inhibition of U251 CNS cancer cell line. ChEMBL. 10514278

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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