Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | cyclin-dependent kinase 3 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Trypanosoma brucei | mitogen-activated protein kinase 5 | cyclin-dependent kinase 3 | 305 aa | 303 aa | 32.0 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | AMP deaminase, putative | 0.404 | 0.6089 | 1 |
Onchocerca volvulus | Adenosine deaminase homolog | 0.6601 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1376 | 0.2021 | 0.2021 |
Leishmania major | adenine aminohydrolase | 0.6601 | 1 | 1 |
Trypanosoma cruzi | adenosine monophosphate deaminase-like protein, putative | 0.404 | 0.6089 | 1 |
Toxoplasma gondii | Adenosine/AMP deaminase domain-containing protein | 0.6601 | 1 | 1 |
Entamoeba histolytica | adenosine deaminase, putative | 0.6601 | 1 | 1 |
Trypanosoma cruzi | AMP deaminase, putative | 0.404 | 0.6089 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.3937 | 0.5932 | 0.5932 |
Entamoeba histolytica | AMP deaminase, putative | 0.404 | 0.6089 | 0.6089 |
Trypanosoma cruzi | AMP deaminase, putative | 0.404 | 0.6089 | 1 |
Plasmodium falciparum | adenosine deaminase | 0.6601 | 1 | 1 |
Trypanosoma brucei | AMP deaminase, putative | 0.404 | 0.6089 | 1 |
Mycobacterium ulcerans | adenosine deaminase | 0.6601 | 1 | 0.5 |
Trypanosoma cruzi | AMP deaminase 2, putative | 0.2664 | 0.3989 | 0.6551 |
Loa Loa (eye worm) | hypothetical protein | 0.3937 | 0.5932 | 0.5932 |
Leishmania major | AMP deaminase, putative,amp deaminase-like protein | 0.404 | 0.6089 | 0.6089 |
Loa Loa (eye worm) | hypothetical protein | 0.6601 | 1 | 1 |
Treponema pallidum | adenosine deaminase | 0.6601 | 1 | 0.5 |
Plasmodium falciparum | AMP deaminase, putative | 0.404 | 0.6089 | 0.6089 |
Trypanosoma cruzi | adenosine monophosphate deaminase, putative | 0.404 | 0.6089 | 1 |
Plasmodium vivax | adenosine deaminase, putative | 0.6601 | 1 | 1 |
Trypanosoma brucei | adenosine monophosphate deaminase, putative | 0.404 | 0.6089 | 1 |
Leishmania major | adenosine monophosphate deaminase, putative,AMP deaminase, putative | 0.404 | 0.6089 | 0.6089 |
Toxoplasma gondii | AMP deaminase | 0.404 | 0.6089 | 0.6089 |
Leishmania major | AMP deaminase, putative,adenosine monophosphate deaminase-like protein | 0.404 | 0.6089 | 0.6089 |
Schistosoma mansoni | AMP deaminase | 0.404 | 0.6089 | 0.6089 |
Entamoeba histolytica | AMP deaminase, putative | 0.404 | 0.6089 | 0.6089 |
Schistosoma mansoni | adenosine deaminase-related | 0.6601 | 1 | 1 |
Trypanosoma brucei | AMP deaminase, putative | 0.404 | 0.6089 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.3937 | 0.5932 | 0.5932 |
Mycobacterium leprae | Probable adenosine deaminase Add (ADENOSINE AMINOHYDROLASE) | 0.6601 | 1 | 0.5 |
Leishmania major | AMP deaminase, putative | 0.404 | 0.6089 | 0.6089 |
Echinococcus multilocularis | adenosine deaminase | 0.6601 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.2664 | 0.3989 | 0.3989 |
Mycobacterium tuberculosis | Probable adenosine deaminase Add (adenosine aminohydrolase) | 0.6601 | 1 | 0.5 |
Trichomonas vaginalis | adenosine deaminase, putative | 0.6601 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.3937 | 0.5932 | 0.5932 |
Echinococcus granulosus | adenosine deaminase | 0.6601 | 1 | 1 |
Toxoplasma gondii | Adenosine/AMP deaminase domain-containing protein | 0.6601 | 1 | 1 |
Trypanosoma cruzi | AMP deaminase, putative | 0.404 | 0.6089 | 1 |
Entamoeba histolytica | adenosine deaminase, putative | 0.6601 | 1 | 1 |
Leishmania major | hypothetical protein, conserved | 0.2664 | 0.3989 | 0.3989 |
Trypanosoma brucei | AMP deaminase, putative | 0.404 | 0.6089 | 1 |
Giardia lamblia | Kinase, CMGC CDK | 0.0052 | 0 | 0.5 |
Echinococcus granulosus | AMP deaminase 2 | 0.404 | 0.6089 | 0.6089 |
Giardia lamblia | Kinase, CMGC CDK | 0.0052 | 0 | 0.5 |
Brugia malayi | adenosine monophosphate deaminase | 0.404 | 0.6089 | 0.6089 |
Onchocerca volvulus | AMP deaminase 2 homolog | 0.404 | 0.6089 | 0.3494 |
Echinococcus multilocularis | AMP deaminase 2 | 0.404 | 0.6089 | 0.6089 |
Schistosoma mansoni | adenosine deaminase | 0.6601 | 1 | 1 |
Plasmodium vivax | adenosine/AMP deaminase, putative | 0.404 | 0.6089 | 0.6089 |
Trypanosoma cruzi | AMP deaminase, putative | 0.404 | 0.6089 | 1 |
Loa Loa (eye worm) | AMP deaminase | 0.404 | 0.6089 | 0.6089 |
Trichomonas vaginalis | adenosine deaminase, putative | 0.6601 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | 0 uM | Inhibitory activity against Cyclin-dependent kinase 5; ND means Not determined | ChEMBL. | 11063606 |
IC50 (binding) | = 4.2 uM | Inhibition of Cyclin-dependent kinase 1 (CDK1) | ChEMBL. | 11063606 |
IC50 (binding) | = 4.2 uM | Inhibition of Cyclin-dependent kinase 1 (CDK1) | ChEMBL. | 11063606 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.