Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium leprae | Probable adenosine deaminase Add (ADENOSINE AMINOHYDROLASE) | 0.563 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.346 | 0.1516 | 0.1516 |
Onchocerca volvulus | Adenosine deaminase homolog | 0.563 | 1 | 1 |
Trypanosoma brucei | AMP deaminase, putative | 0.3072 | 0 | 0.5 |
Leishmania major | adenine aminohydrolase | 0.563 | 1 | 1 |
Trypanosoma brucei | AMP deaminase, putative | 0.3072 | 0 | 0.5 |
Plasmodium falciparum | adenosine deaminase | 0.563 | 1 | 1 |
Toxoplasma gondii | Adenosine/AMP deaminase domain-containing protein | 0.563 | 1 | 1 |
Trypanosoma brucei | adenosine monophosphate deaminase, putative | 0.3072 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.346 | 0.1516 | 0.1516 |
Echinococcus multilocularis | adenosine deaminase | 0.563 | 1 | 1 |
Trypanosoma cruzi | AMP deaminase, putative | 0.3072 | 0 | 0.5 |
Trypanosoma cruzi | adenosine monophosphate deaminase-like protein, putative | 0.3072 | 0 | 0.5 |
Trypanosoma cruzi | AMP deaminase, putative | 0.3072 | 0 | 0.5 |
Trypanosoma cruzi | AMP deaminase, putative | 0.3072 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.346 | 0.1516 | 0.1516 |
Echinococcus granulosus | adenosine deaminase | 0.563 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.346 | 0.1516 | 0.1516 |
Trichomonas vaginalis | adenosine deaminase, putative | 0.563 | 1 | 0.5 |
Entamoeba histolytica | adenosine deaminase, putative | 0.563 | 1 | 1 |
Treponema pallidum | adenosine deaminase | 0.563 | 1 | 0.5 |
Entamoeba histolytica | adenosine deaminase, putative | 0.563 | 1 | 1 |
Schistosoma mansoni | adenosine deaminase | 0.563 | 1 | 1 |
Plasmodium vivax | adenosine deaminase, putative | 0.563 | 1 | 1 |
Toxoplasma gondii | Adenosine/AMP deaminase domain-containing protein | 0.563 | 1 | 1 |
Trypanosoma cruzi | adenosine monophosphate deaminase, putative | 0.3072 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable adenosine deaminase Add (adenosine aminohydrolase) | 0.563 | 1 | 0.5 |
Trypanosoma brucei | AMP deaminase, putative | 0.3072 | 0 | 0.5 |
Mycobacterium ulcerans | adenosine deaminase | 0.563 | 1 | 0.5 |
Trypanosoma cruzi | AMP deaminase, putative | 0.3072 | 0 | 0.5 |
Schistosoma mansoni | adenosine deaminase-related | 0.563 | 1 | 1 |
Trichomonas vaginalis | adenosine deaminase, putative | 0.563 | 1 | 0.5 |
Trypanosoma cruzi | AMP deaminase, putative | 0.3072 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.563 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
CC50 (functional) | = 93.6 uM | Dose required to reduce the viability of mock-infected cells by 50%, determined by MTT method. | ChEMBL. | 9767646 |
CC50 (functional) | = 93.6 uM | Dose required to reduce the viability of mock-infected cells by 50%, determined by MTT method. | ChEMBL. | 9767646 |
EC50 (functional) | = 0.05 uM | Dose required to achieve 50% protection of MT-4 cells from HIV-1(IIIB) induced cytopathogenicity, determined by MIT method. | ChEMBL. | 9767646 |
EC50 (functional) | = 0.05 uM | Dose required to achieve 50% protection of MT-4 cells from HIV-1(IIIB) induced cytopathogenicity, determined by MIT method. | ChEMBL. | 9767646 |
SI (functional) | = 1872 | Selectivity index was measured as the ratio of CC50(HIV-1) to that of EC50(HIV-1); SI Selectivity Index | ChEMBL. | 9767646 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 9767646 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.