Detailed information for compound 227017

Basic information

Technical information
  • TDR Targets ID: 227017
  • Name: N-[3-(propylamino)propyl]-5-(trifluoromethyl) -1-[4-[3-(trifluoromethyl)phenyl]-1,3-thiazol -2-yl]pyrazole-4-carboxamide
  • MW: 505.48 | Formula: C21H21F6N5OS
  • H donors: 2 H acceptors: 3 LogP: 4.82 Rotable bonds: 12
    Rule of 5 violations (Lipinski): 2
  • SMILES: CCCNCCCNC(=O)c1cnn(c1C(F)(F)F)c1scc(n1)c1cccc(c1)C(F)(F)F
  • InChi: 1S/C21H21F6N5OS/c1-2-7-28-8-4-9-29-18(33)15-11-30-32(17(15)21(25,26)27)19-31-16(12-34-19)13-5-3-6-14(10-13)20(22,23)24/h3,5-6,10-12,28H,2,4,7-9H2,1H3,(H,29,33)
  • InChiKey: LERGQFAABXNVDV-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • N-[3-(propylamino)propyl]-5-(trifluoromethyl)-1-[4-[3-(trifluoromethyl)phenyl]thiazol-2-yl]pyrazole-4-carboxamide
  • N-[3-(propylamino)propyl]-5-(trifluoromethyl)-1-[4-[3-(trifluoromethyl)phenyl]-2-thiazolyl]-4-pyrazolecarboxamide
  • N-(3-propylaminopropyl)-5-(trifluoromethyl)-1-[4-[3-(trifluoromethyl)phenyl]-1,3-thiazol-2-yl]pyrazole-4-carboxamide
  • N-(3-propylaminopropyl)-5-(trifluoromethyl)-1-[4-[3-(trifluoromethyl)phenyl]thiazol-2-yl]pyrazole-4-carboxamide
  • N-(3-propylaminopropyl)-5-(trifluoromethyl)-1-[4-[3-(trifluoromethyl)phenyl]-2-thiazolyl]-4-pyrazolecarboxamide

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41) Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum IPR013513,Integrin alpha chain, C-terminal cytoplasmic region,domain-containing Get druggable targets OG5_129341 All targets in OG5_129341
Loa Loa (eye worm) integrin alpha pat-2 Get druggable targets OG5_129341 All targets in OG5_129341
Schistosoma japonicum ko:K06476 integrin alpha 2B, putative Get druggable targets OG5_129341 All targets in OG5_129341
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_129341 All targets in OG5_129341
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_129341 All targets in OG5_129341
Schistosoma mansoni integrin alpha Get druggable targets OG5_129341 All targets in OG5_129341
Echinococcus multilocularis integrin alpha 3 Get druggable targets OG5_129341 All targets in OG5_129341
Echinococcus granulosus integrin alpha 3 Get druggable targets OG5_129341 All targets in OG5_129341
Brugia malayi Integrin alpha pat-2 precursor Get druggable targets OG5_129341 All targets in OG5_129341
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei adenosine monophosphate deaminase, putative 0.3617 0.7815 1
Schistosoma mansoni tar DNA-binding protein 0.0135 0.027 0.0266
Echinococcus multilocularis serotonin receptor 0.0066 0.0121 0.0121
Brugia malayi neuropeptide F receptor 0.0066 0.0121 0.0117
Echinococcus granulosus AMP deaminase 2 0.3617 0.7815 0.7815
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0066 0.0121 0.0117
Leishmania major phosphoglycerate kinase C, glycosomal 0.0189 0.0388 0.0383
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0043 0.0071 0.0067
Loa Loa (eye worm) cytochrome P450 family protein 0.0026 0.0034 0.0034
Loa Loa (eye worm) hypothetical protein 0.0066 0.0121 0.0121
Loa Loa (eye worm) DR-78 0.002 0.0022 0.0022
Echinococcus multilocularis g-protein coupled receptor 0.0066 0.0121 0.0121
Brugia malayi cytochrome P450 0.0016 0.0013 0.0009
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0066 0.0121 0.0117
Loa Loa (eye worm) hypothetical protein 0.0043 0.0071 0.0071
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.007 0.0129 0.0157
Onchocerca volvulus 0.0107 0.0209 0.0198
Loa Loa (eye worm) hypothetical protein 0.0027 0.0036 0.0036
Schistosoma mansoni steroid hormone receptor ad4bp 0.0043 0.0071 0.0067
Echinococcus granulosus nuclear receptor nhr 48 0.002 0.0022 0.0022
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0043 0.0071 0.0071
Loa Loa (eye worm) hypothetical protein 0.0073 0.0136 0.0136
Trypanosoma cruzi cytochrome P450, putative 0.0026 0.0034 0.0036
Schistosoma mansoni neuropeptide F-like receptor 0.0066 0.0121 0.0117
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0025 0.0033 0.0033
Loa Loa (eye worm) MH1 domain-containing protein 0.0017 0.0016 0.0016
Echinococcus multilocularis fmrfamide receptor 0.0066 0.0121 0.0121
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.007 0.0129 0.0157
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0043 0.0071 0.0071
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.002 0.0022 0.0011
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0047 0.0081 0.0068
Trypanosoma cruzi adenosine monophosphate deaminase, putative 0.3617 0.7815 1
Brugia malayi Serotonin receptor 0.0066 0.0121 0.0117
Schistosoma mansoni nuclear receptor nhr-48 0.002 0.0022 0.0018
Onchocerca volvulus 0.0066 0.0121 0.011
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0021 0.002
Loa Loa (eye worm) hypothetical protein 0.2545 0.5492 0.5492
Loa Loa (eye worm) hypothetical protein 0.0023 0.0027 0.0027
Brugia malayi Steroid receptor seven-up type 2 0.0043 0.0071 0.0067
Echinococcus granulosus fetal alzheimer antigen falz 0.0025 0.0033 0.0033
Schistosoma mansoni cpg binding protein 0.0032 0.0049 0.0045
Brugia malayi photoreceptor-specific nuclear receptor 0.0043 0.0071 0.0067
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0043 0.0071 0.006
Trichomonas vaginalis D-aminoacylase, putative 0.0039 0.0062 0.0056
Loa Loa (eye worm) hypothetical protein 0.002 0.0022 0.0022
Brugia malayi beta-lactamase family protein 0.0039 0.0062 0.0058
Treponema pallidum adenosine deaminase 0.4626 1 1
Schistosoma mansoni biogenic amine receptor 0.0066 0.0121 0.0117
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0043 0.0071 0.0071
Trypanosoma brucei DNA polymerase eta, putative 0.002 0.0021 0.002
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0066 0.0121 0.0121
Schistosoma mansoni nuclear receptor 0.002 0.0022 0.0018
Brugia malayi hypothetical protein 0.0066 0.0121 0.0117
Loa Loa (eye worm) hypothetical protein 0.0043 0.0071 0.0071
Echinococcus granulosus neuropeptide s receptor 0.0524 0.1113 0.1113
Brugia malayi hypothetical protein 0.0066 0.0121 0.0117
Brugia malayi nuclear receptor RXR 0.0023 0.0027 0.0023
Onchocerca volvulus Adenosine deaminase homolog 0.4626 1 1
Schistosoma mansoni bromodomain containing protein 0.0071 0.0132 0.0128
Schistosoma mansoni nuclear hormone receptor 0.0043 0.0071 0.0067
Echinococcus granulosus ecdysone induced protein 78C 0.0043 0.0071 0.0071
Loa Loa (eye worm) hypothetical protein 0.0066 0.0121 0.0121
Onchocerca volvulus 0.0066 0.0121 0.011
Loa Loa (eye worm) hypothetical protein 0.0023 0.0027 0.0027
Trypanosoma cruzi AMP deaminase 2, putative 0.2081 0.4486 0.5738
Leishmania major DNA polymerase eta, putative 0.002 0.0021 0.0015
Trichomonas vaginalis D-aminoacylase, putative 0.0039 0.0062 0.0056
Brugia malayi Dopamine receptor protein 2 0.0066 0.0121 0.0117
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0015 0.0011 0.0007
Loa Loa (eye worm) hypothetical protein 0.0066 0.0121 0.0121
Mycobacterium tuberculosis Conserved protein 0.0039 0.0062 0.0049
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0021 0.002
Loa Loa (eye worm) hypothetical protein 0.0103 0.02 0.02
Trypanosoma brucei unspecified product 0.0014 0.0008 0.0003
Brugia malayi putative neuropeptide receptor 0.0066 0.0121 0.0117
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0066 0.0121 0.0121
Schistosoma mansoni Smad4 0.0017 0.0016 0.0012
Loa Loa (eye worm) hypothetical protein 0.002 0.0021 0.0021
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0067 0.0124 0.0124
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0039 0.0062 0.0062
Mycobacterium tuberculosis Conserved protein 0.0039 0.0062 0.0049
Trichomonas vaginalis DNA helicase recq1, putative 0.0024 0.003 0.0024
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0018 0.0018 0.0014
Echinococcus multilocularis zinc finger protein 0.0026 0.0034 0.0034
Onchocerca volvulus 0.0039 0.0062 0.0051
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.007 0.0129 0.0123
Brugia malayi Serotonin receptor 0.0066 0.0121 0.0117
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0043 0.0071 0.0071
Plasmodium falciparum histone acetyltransferase GCN5 0.0041 0.0067 0.0044
Brugia malayi nuclear receptor NHR-88 0.0043 0.0071 0.0067
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0043 0.0071 0.0071
Loa Loa (eye worm) hypothetical protein 0.1536 0.3307 0.3307
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0043 0.0071 0.0067
Leishmania major alpha glucosidase II subunit, putative 0.0041 0.0067 0.0061
Trichomonas vaginalis alpha-glucosidase, putative 0.0015 0.0011 0.0005
Schistosoma mansoni thyroid hormone receptor 0.0043 0.0071 0.0067
Brugia malayi adenosine monophosphate deaminase 0.3617 0.7815 0.7814
Schistosoma mansoni growth hormone secretagogue receptor 0.0066 0.0121 0.0117
Schistosoma mansoni coup transcription factor 0.0043 0.0071 0.0067
Loa Loa (eye worm) hypothetical protein 0.0066 0.0121 0.0121
Trypanosoma brucei phosphoglycerate kinase 0.0189 0.0388 0.049
Loa Loa (eye worm) TAR-binding protein 0.0135 0.027 0.027
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0047 0.0081 0.0068
Loa Loa (eye worm) hypothetical protein 0.0043 0.0071 0.0071
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0016 0.0013 0.0009
Loa Loa (eye worm) hypothetical protein 0.005 0.0086 0.0086
Echinococcus multilocularis 0.0016 0.0013 0.0013
Trichomonas vaginalis alpha-glucosidase, putative 0.0041 0.0067 0.0061
Brugia malayi hypothetical protein 0.002 0.0022 0.0018
Brugia malayi nuclear receptor RXR 0.002 0.0022 0.0018
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0066 0.0121 0.0121
Schistosoma mansoni biogenic amine receptor 0.0066 0.0121 0.0117
Mycobacterium leprae Probable adenosine deaminase Add (ADENOSINE AMINOHYDROLASE) 0.4626 1 1
Loa Loa (eye worm) hypothetical protein 0.0023 0.0027 0.0027
Schistosoma mansoni hypothetical protein 0.0032 0.0049 0.0044
Echinococcus multilocularis ecdysone induced protein 78C 0.0043 0.0071 0.0071
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0021 0.002
Trichomonas vaginalis alpha-glucosidase, putative 0.0041 0.0067 0.0061
Brugia malayi nuclear hormone receptor family member odr-7 0.002 0.0022 0.0018
Trichomonas vaginalis alpha-glucosidase, putative 0.0041 0.0067 0.0061
Loa Loa (eye worm) RNA binding protein 0.0135 0.027 0.027
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0043 0.0071 0.0067
Schistosoma mansoni opsin-like receptor 0.0066 0.0121 0.0117
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0051 0.0089 0.0085
Toxoplasma gondii ABC1 family protein 0.0039 0.0062 0.0049
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0066 0.0121 0.0117
Trypanosoma cruzi AMP deaminase, putative 0.3617 0.7815 1
Schistosoma mansoni opsin-like receptor 0.0066 0.0121 0.0117
Echinococcus multilocularis cpg binding protein 0.0036 0.0057 0.0057
Trichomonas vaginalis DNA helicase recq, putative 0.0024 0.003 0.0024
Echinococcus multilocularis Nuclear hormone receptor HR96 0.002 0.0022 0.0022
Echinococcus granulosus g protein coupled receptor 0.0066 0.0121 0.0121
Brugia malayi tailless protein 0.002 0.0022 0.0018
Onchocerca volvulus 0.0066 0.0121 0.011
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0021 0.002
Echinococcus multilocularis Smad4 0.0017 0.0016 0.0016
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0052 0.009 0.009
Echinococcus multilocularis rhodopsin orphan GPCR 0.0066 0.0121 0.0121
Loa Loa (eye worm) nuclear receptor NHR-67 0.002 0.0022 0.0022
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0052 0.009 0.009
Loa Loa (eye worm) hypothetical protein 0.0066 0.0121 0.0121
Trypanosoma brucei phosphoglycerate kinase, putative 0.007 0.0129 0.0157
Loa Loa (eye worm) hypothetical protein 0.0043 0.0071 0.0071
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0043 0.0071 0.0071
Schistosoma mansoni nuclear receptor 0.002 0.0022 0.0018
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0015 0.0011 0.0005
Echinococcus multilocularis FTZ F1 alpha 0.0043 0.0071 0.0071
Echinococcus granulosus dnaJ subfamily B 0.0462 0.098 0.098
Onchocerca volvulus 0.0066 0.0121 0.011
Echinococcus multilocularis bloom syndrome protein 0.0024 0.003 0.003
Loa Loa (eye worm) hypothetical protein 0.002 0.0022 0.0022
Loa Loa (eye worm) hypothetical protein 0.0066 0.0121 0.0121
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0043 0.0071 0.0067
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0047 0.0081 0.0075
Echinococcus granulosus orexin receptor type 2 0.0066 0.0121 0.0121
Brugia malayi Nuclear hormone receptor E75 0.002 0.0022 0.0018
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0066 0.0121 0.0121
Entamoeba histolytica hypothetical protein 0.0073 0.0136 0.013
Trypanosoma cruzi 3-phosphoglycerate kinase, glycosomal 0.007 0.0129 0.0157
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0047 0.0081 0.0068
Schistosoma mansoni hypothetical protein 0.0021 0.0024 0.002
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0052 0.009 0.0086
Brugia malayi GnHR receptor homolog 0.0066 0.0121 0.0117
Loa Loa (eye worm) glutaminase 2 0.0309 0.0648 0.0648
Trypanosoma cruzi phosphoglycerate kinase, putative 0.007 0.0129 0.0157
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0021 0.002
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0135 0.027 0.027
Loa Loa (eye worm) hypothetical protein 0.0145 0.0292 0.0292
Leishmania major AMP deaminase, putative,amp deaminase-like protein 0.3617 0.7815 0.7814
Trypanosoma cruzi AMP deaminase, putative 0.3617 0.7815 1
Echinococcus granulosus allatostatin A receptor 0.0066 0.0121 0.0121
Wolbachia endosymbiont of Brugia malayi phosphoglycerate kinase 0.0189 0.0388 0.5
Brugia malayi MH2 domain containing protein 0.0253 0.0526 0.0522
Loa Loa (eye worm) neuropeptide F receptor 0.0066 0.0121 0.0121
Loa Loa (eye worm) hypothetical protein 0.0066 0.0121 0.0121
Onchocerca volvulus 0.0066 0.0121 0.011
Onchocerca volvulus 0.0066 0.0121 0.011
Trypanosoma cruzi AMP deaminase, putative 0.3617 0.7815 1
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0021 0.0017
Loa Loa (eye worm) hypothetical protein 0.0066 0.0121 0.0121
Loa Loa (eye worm) hypothetical protein 0.0066 0.0121 0.0121
Mycobacterium tuberculosis Probable lipase LipD 0.0039 0.0062 0.0049
Echinococcus granulosus zinc finger protein 0.0026 0.0034 0.0034
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0155 0.0315 0.0315
Loa Loa (eye worm) hypothetical protein 0.014 0.0281 0.0281
Brugia malayi Integrin alpha pat-2 precursor 0.0185 0.0378 0.0374
Schistosoma mansoni phosphoglycerate kinase 0.0189 0.0388 0.0385
Loa Loa (eye worm) hypothetical protein 0.0066 0.0121 0.0121
Schistosoma mansoni zinc finger protein 0.002 0.0022 0.0018
Echinococcus granulosus beta LACTamase domain containing family member 0.0039 0.0062 0.0062
Trichomonas vaginalis bromodomain-containing protein, putative 0.0047 0.0081 0.0075
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0066 0.0121 0.0121
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0066 0.0121 0.0117
Echinococcus multilocularis dro:myosuppressin receptor 0.0066 0.0121 0.0121
Loa Loa (eye worm) hypothetical protein 0.0102 0.0199 0.0199
Schistosoma mansoni nuclear hormone receptor 0.002 0.0022 0.0018
Echinococcus multilocularis dna polymerase kappa 0.002 0.0021 0.0021
Loa Loa (eye worm) hypothetical protein 0.002 0.0022 0.0022
Schistosoma mansoni hypothetical protein 0.0066 0.0121 0.0117
Echinococcus granulosus neuropeptide Y receptor 0.0066 0.0121 0.0121
Schistosoma mansoni amine GPCR 0.0066 0.0121 0.0117
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0021 0.002
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0066 0.0121 0.0117
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0037 0.0059 0.0059
Trichomonas vaginalis penicillin-binding protein, putative 0.0039 0.0062 0.0056
Trypanosoma cruzi AMP deaminase, putative 0.3617 0.7815 1
Loa Loa (eye worm) hypothetical protein 0.0066 0.0121 0.0121
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0039 0.0062 0.0049
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0066 0.0121 0.0121
Trichomonas vaginalis alpha-glucosidase, putative 0.0015 0.0011 0.0005
Brugia malayi G-protein coupled receptor 0.0066 0.0121 0.0117
Brugia malayi RNA binding protein 0.0135 0.027 0.0266
Echinococcus granulosus serotonin receptor 0.0066 0.0121 0.0121
Brugia malayi MH1 domain containing protein 0.0017 0.0016 0.0012
Schistosoma mansoni adenoreceptor 0.0066 0.0121 0.0117
Brugia malayi ecdysone receptor 0.002 0.0022 0.0018
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0066 0.0121 0.0117
Brugia malayi hypothetical protein 0.0023 0.0027 0.0023
Trypanosoma brucei unspecified product 0.0014 0.0008 0.0003
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0043 0.0071 0.0067
Loa Loa (eye worm) hypothetical protein 0.0043 0.0072 0.0072
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0043 0.0071 0.0071
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0017 0.0016 0.0012
Brugia malayi hypothetical protein 0.0066 0.0121 0.0117
Echinococcus granulosus microtubule associated protein 2 0.0733 0.1566 0.1566
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.002 0.0021 0.0021
Brugia malayi neuropeptide F receptor 0.0066 0.0121 0.0117
Schistosoma mansoni hypothetical protein 0.004 0.0064 0.006
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0018 0.0018 0.0014
Schistosoma mansoni hypothetical protein 0.0032 0.0049 0.0044
Schistosoma mansoni tar DNA-binding protein 0.0135 0.027 0.0266
Brugia malayi Phosphoglycerate kinase 0.0189 0.0388 0.0385
Loa Loa (eye worm) hypothetical protein 0.0066 0.0121 0.0121
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0066 0.0121 0.0117
Echinococcus multilocularis neuropeptides capa receptor 0.0066 0.0121 0.0121
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0008 0.0003
Plasmodium vivax hypothetical protein, conserved 0.0039 0.0062 0.0049
Brugia malayi ORL1-like opioid receptor 0.0066 0.0121 0.0117
Loa Loa (eye worm) hypothetical protein 0.0043 0.0071 0.0071
Loa Loa (eye worm) hypothetical protein 0.0066 0.0121 0.0121
Loa Loa (eye worm) hypothetical protein 0.4626 1 1
Trichomonas vaginalis phosphoglycerate kinase, putative 0.0189 0.0388 0.0383
Brugia malayi hypothetical protein 0.0027 0.0036 0.0032
Loa Loa (eye worm) hypothetical protein 0.0066 0.0121 0.0121
Echinococcus multilocularis integrin alpha ps 0.0083 0.0158 0.0158
Echinococcus multilocularis integrin alpha ps 0.0083 0.0158 0.0158
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0043 0.0071 0.0067
Onchocerca volvulus Bile acid receptor homolog 0.0043 0.0071 0.006
Loa Loa (eye worm) hypothetical protein 0.0066 0.0121 0.0121
Onchocerca volvulus 0.002 0.0022 0.0011
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0066 0.0121 0.0117
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0066 0.0121 0.0121
Loa Loa (eye worm) hypothetical protein 0.0066 0.0121 0.0121
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.002 0.0022 0.0018
Loa Loa (eye worm) hypothetical protein 0.002 0.0022 0.0022
Loa Loa (eye worm) hypothetical protein 0.012 0.0239 0.0239
Loa Loa (eye worm) hypothetical protein 0.0266 0.0555 0.0555
Echinococcus multilocularis phosphoglycerate kinase 1 0.0189 0.0388 0.0388
Schistosoma mansoni myosin xvIII 0.0066 0.0121 0.0117
Onchocerca volvulus AMP deaminase 2 homolog 0.3617 0.7815 0.7812
Echinococcus granulosus smad 0.0017 0.0016 0.0016
Echinococcus granulosus g-protein coupled receptor 0.0066 0.0121 0.0121
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0066 0.0121 0.0121
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0012 0.0004 0.0004
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0066 0.0121 0.0121
Echinococcus multilocularis rhodopsin orphan GPCR 0.0066 0.0121 0.0121
Onchocerca volvulus 0.0066 0.0121 0.011
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0016 0.0013 0.0009
Trypanosoma brucei AMP deaminase, putative 0.3617 0.7815 1
Trypanosoma brucei cytochrome P450, putative 0.0026 0.0034 0.0036
Toxoplasma gondii cytochrome p450 superfamily protein 0.0016 0.0013 0.0000089206
Onchocerca volvulus 0.0066 0.0121 0.011
Loa Loa (eye worm) hypothetical protein 0.0039 0.0062 0.0062
Loa Loa (eye worm) hypothetical protein 0.0039 0.0062 0.0062
Schistosoma mansoni hypothetical protein 0.0051 0.0089 0.0085
Brugia malayi nuclear hormone receptor 0.0043 0.0071 0.0067
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0189 0.0388 0.049
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0066 0.0121 0.0117
Brugia malayi RNA recognition motif domain containing protein 0.0135 0.027 0.0266
Mycobacterium ulcerans adenosine deaminase 0.4626 1 1
Leishmania major cytochrome p450-like protein 0.0026 0.0034 0.0028
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0023 0.0027 0.0027
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0043 0.0071 0.0067
Trypanosoma brucei AMP deaminase, putative 0.3617 0.7815 1
Loa Loa (eye worm) hypothetical protein 0.0066 0.0121 0.0121
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0026 0.0034 0.0021
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0015 0.0011 0.0005
Loa Loa (eye worm) hypothetical protein 0.0066 0.0121 0.0121
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.002 0.0021 0.0008
Brugia malayi beta-lactamase family protein 0.0039 0.0062 0.0058
Schistosoma mansoni biogenic amine receptor 0.0066 0.0121 0.0117
Echinococcus multilocularis allatostatin A receptor 0.0066 0.0121 0.0121
Echinococcus granulosus 7tm_1 domain containing protein 0.0066 0.0121 0.0121
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0043 0.0071 0.0071
Leishmania major adenosine monophosphate deaminase, putative,AMP deaminase, putative 0.3617 0.7815 0.7814
Loa Loa (eye worm) hypothetical protein 0.0066 0.0121 0.0121
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0066 0.0121 0.0121
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0066 0.0121 0.011
Brugia malayi Bromodomain containing protein 0.0083 0.0158 0.0154
Loa Loa (eye worm) hypothetical protein 0.002 0.0022 0.0022
Echinococcus granulosus hypothetical protein 0.0066 0.0121 0.0121
Echinococcus granulosus cytochrome P450 2K1 0.0016 0.0013 0.0013
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0066 0.0121 0.0117
Brugia malayi ecdysteroid receptor 0.0043 0.0071 0.0067
Echinococcus multilocularis tar DNA binding protein 0.0135 0.027 0.027
Echinococcus granulosus dro:myosuppressin receptor 0.0066 0.0121 0.0121
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0023 0.0027 0.0023
Brugia malayi Glycosyl hydrolases family 31 protein 0.0041 0.0067 0.0063
Schistosoma mansoni biogenic amine (5HT) receptor 0.0066 0.0121 0.0117
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0015 0.0011 0.0005
Loa Loa (eye worm) MH2 domain-containing protein 0.0017 0.0016 0.0016
Echinococcus granulosus 7TM GPCR rhodopsin 0.0066 0.0121 0.0121
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.002 0.0022 0.0018
Loa Loa (eye worm) hypothetical protein 0.002 0.0022 0.0022
Loa Loa (eye worm) hypothetical protein 0.0015 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.0066 0.0121 0.0121
Loa Loa (eye worm) steroid hormone receptor 0.0043 0.0071 0.0071
Brugia malayi Dopamine receptor 0.0066 0.0121 0.0117
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0066 0.0121 0.0121
Schistosoma mansoni microtubule-associated protein tau 0.0733 0.1566 0.1563
Schistosoma mansoni hypothetical protein 0.0016 0.0012 0.0008
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.0062 0.0072
Schistosoma mansoni smad 0.0017 0.0016 0.0012
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0066 0.0121 0.0121
Loa Loa (eye worm) hypothetical protein 0.2545 0.5492 0.5492
Mycobacterium tuberculosis Probable lipase LipE 0.0039 0.0062 0.0049
Brugia malayi G-protein coupled receptor 0.0066 0.0121 0.0117
Schistosoma mansoni integrin alpha 0.0185 0.0378 0.0374
Echinococcus granulosus mothers against decapentaplegic 5 0.0017 0.0016 0.0016
Brugia malayi acetyltransferase, GNAT family protein 0.0155 0.0315 0.0311
Leishmania major cytochrome p450-like protein 0.0016 0.0013 0.0007
Echinococcus granulosus sex peptide receptor 0.0066 0.0121 0.0121
Loa Loa (eye worm) nuclear receptor nhr-7B 0.002 0.0022 0.0022
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0021 0.0017
Loa Loa (eye worm) melatonin receptor type 1A 0.0066 0.0121 0.0121
Echinococcus granulosus dna polymerase eta 0.002 0.0021 0.0021
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.002 0.0022 0.0011
Mycobacterium leprae conserved hypothetical protein 0.0039 0.0062 0.0049
Schistosoma mansoni transcription factor LCR-F1 0.0073 0.0136 0.0132
Mycobacterium tuberculosis Probable hydrolase 0.0039 0.0062 0.0049
Loa Loa (eye worm) hypothetical protein 0.0039 0.0062 0.0062
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0022 0.0022
Echinococcus multilocularis rhodopsin orphan GPCR 0.0066 0.0121 0.0121
Echinococcus multilocularis neutral alpha glucosidase AB 0.0041 0.0067 0.0067
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0016 0.0013 0.0009
Mycobacterium ulcerans lipase LipD 0.0039 0.0062 0.0049
Loa Loa (eye worm) hypothetical protein 0.0066 0.0121 0.0121
Echinococcus multilocularis dna polymerase eta 0.002 0.0021 0.0021
Leishmania major hypothetical protein, conserved 0.0016 0.0012 0.0007
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0066 0.0121 0.0117
Echinococcus granulosus rhodopsin orphan GPCR 0.0066 0.0121 0.0121
Brugia malayi hypothetical protein 0.0066 0.0121 0.0117
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0008 0.0003
Loa Loa (eye worm) cytochrome P450 family protein 0.0026 0.0034 0.0034
Schistosoma mansoni tar DNA-binding protein 0.0135 0.027 0.0266
Brugia malayi Cytochrome P450 family protein 0.0059 0.0106 0.0102
Brugia malayi TAR-binding protein 0.0135 0.027 0.0266
Brugia malayi beta-lactamase 0.0039 0.0062 0.0058
Loa Loa (eye worm) hypothetical protein 0.0066 0.0121 0.0121
Echinococcus granulosus G protein coupled receptor 139 0.0066 0.0121 0.0121
Trichomonas vaginalis alpha-glucosidase, putative 0.0015 0.0011 0.0005
Echinococcus granulosus phosphoglycerate kinase 1 0.0189 0.0388 0.0388
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0032 0.0049 0.0049
Echinococcus multilocularis neuropeptide FF receptor 2 0.0066 0.0121 0.0121
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0021 0.002
Echinococcus multilocularis rhodopsin orphan GPCR 0.0066 0.0121 0.0121
Leishmania major glycosyl hydrolase-like protein 0.0015 0.0011 0.0005
Brugia malayi Glycosyl hydrolases family 31 protein 0.0015 0.0011 0.0007
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0039 0.0062 0.0049
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0023 0.0027 0.0023
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0041 0.0067 0.0054
Onchocerca volvulus 0.0066 0.0121 0.011
Loa Loa (eye worm) hypothetical protein 0.0039 0.0062 0.0062
Loa Loa (eye worm) hypothetical protein 0.0039 0.0062 0.0062
Onchocerca volvulus 0.0066 0.0121 0.011
Giardia lamblia Histone acetyltransferase GCN5 0.0041 0.0067 0.1257
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0021 0.002
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0021 0.002
Brugia malayi hypothetical protein 0.0066 0.0121 0.0117
Echinococcus multilocularis microtubule associated protein 2 0.0733 0.1566 0.1566
Loa Loa (eye worm) hypothetical protein 0.0066 0.0121 0.0121
Entamoeba histolytica deoxycytidyl transferase, putative 0.002 0.0021 0.0015
Brugia malayi PHD-finger family protein 0.0031 0.0046 0.0042
Schistosoma mansoni cpg binding protein 0.0036 0.0057 0.0053
Echinococcus granulosus tm gpcr rhodopsin 0.0066 0.0121 0.0121
Plasmodium vivax adenosine/AMP deaminase, putative 0.3617 0.7815 0.7812
Entamoeba histolytica hypothetical protein 0.0073 0.0136 0.013
Trichomonas vaginalis adenosine deaminase, putative 0.4626 1 1
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0043 0.0071 0.0071
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0041 0.0067 0.0061
Loa Loa (eye worm) hypothetical protein 0.0066 0.0121 0.0121
Echinococcus granulosus fmrfamide receptor 0.0066 0.0121 0.0121
Schistosoma mansoni hypothetical protein 0.0066 0.0121 0.0117
Trypanosoma cruzi ISWI complex protein 0.0016 0.0012 0.0008
Echinococcus multilocularis g protein coupled receptor 0.0066 0.0121 0.0121
Echinococcus multilocularis neuropeptide receptor A26 0.0524 0.1113 0.1113
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0022 0.0022
Trichomonas vaginalis D-aminoacylase, putative 0.0039 0.0062 0.0056
Loa Loa (eye worm) hypothetical protein 0.0043 0.0071 0.0071
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.002 0.0021 0.0021
Brugia malayi Integrin alpha cytoplasmic region family protein 0.014 0.0281 0.0277
Loa Loa (eye worm) G-protein coupled receptor 0.0066 0.0121 0.0121
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0043 0.0071 0.0071
Trypanosoma brucei phosphoglycerate kinase 0.007 0.0129 0.0157
Echinococcus multilocularis rhodopsin orphan GPCR 0.0066 0.0121 0.0121
Echinococcus granulosus neuropeptide receptor 0.0066 0.0121 0.0121
Schistosoma mansoni hypothetical protein 0.0032 0.0049 0.0044
Loa Loa (eye worm) hypothetical protein 0.0066 0.0121 0.0121
Schistosoma mansoni nuclear hormone receptor 0.002 0.0022 0.0018
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0017 0.0016 0.0016
Brugia malayi MH2 domain containing protein 0.0017 0.0016 0.0012
Trichomonas vaginalis penicillin-binding protein, putative 0.0039 0.0062 0.0056
Trypanosoma cruzi adenosine monophosphate deaminase-like protein, putative 0.3617 0.7815 1
Echinococcus granulosus TGF beta signal transducer SmadC 0.0017 0.0016 0.0016
Trypanosoma brucei glycosyl hydrolase-like protein 0.0015 0.0011 0.0007
Brugia malayi sulfakinin receptor protein 0.0066 0.0121 0.0117
Schistosoma mansoni histamine h1 receptor 0.0066 0.0121 0.0117
Leishmania major AMP deaminase, putative,adenosine monophosphate deaminase-like protein 0.3617 0.7815 0.7814
Trypanosoma brucei phosphoglycerate kinase 0.0189 0.0388 0.049
Trichomonas vaginalis alpha-glucosidase, putative 0.0041 0.0067 0.0061
Loa Loa (eye worm) hypothetical protein 0.0066 0.0121 0.0121
Echinococcus granulosus integrin alpha ps 0.0083 0.0158 0.0158
Toxoplasma gondii LsmAD domain-containing protein 0.0027 0.0036 0.0023
Echinococcus multilocularis serotonin receptor 0.0066 0.0121 0.0121
Onchocerca volvulus 0.2081 0.4486 0.448
Brugia malayi hypothetical protein 0.0023 0.0027 0.0023
Trichomonas vaginalis maltase-glucoamylase, putative 0.0041 0.0067 0.0061
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0041 0.0067 0.0067
Echinococcus granulosus neuropeptides capa receptor 0.0066 0.0121 0.0121
Echinococcus granulosus cpg binding protein 0.0036 0.0057 0.0057
Onchocerca volvulus 0.0066 0.0121 0.011
Loa Loa (eye worm) hypothetical protein 0.0043 0.0071 0.0071
Toxoplasma gondii phosphoglycerate kinase PGKI 0.0189 0.0388 0.0376
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0021 0.002
Echinococcus granulosus tm gpcr rhodopsin 0.0066 0.0121 0.0121
Brugia malayi AKH receptor 0.0066 0.0121 0.0117
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0043 0.0071 0.0071
Schistosoma mansoni integrin alpha-ps 0.0083 0.0158 0.0154
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0246 0.0512 0.0499
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0066 0.0121 0.0117
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0025 0.0033 0.0029
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0041 0.0067 0.0061
Schistosoma mansoni hypothetical protein 0.0066 0.0121 0.0117
Brugia malayi hypothetical protein 0.0266 0.0555 0.0552
Onchocerca volvulus 0.0066 0.0121 0.011
Echinococcus multilocularis dnaJ subfamily B 0.0462 0.098 0.098
Loa Loa (eye worm) hypothetical protein 0.0066 0.0121 0.0121
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0043 0.0071 0.0071
Brugia malayi Tachykinin-like peptides receptor 99D 0.0066 0.0121 0.0117
Loa Loa (eye worm) hypothetical protein 0.0066 0.0121 0.0121
Echinococcus granulosus histone acetyltransferase KAT2B 0.0149 0.03 0.03
Schistosoma mansoni cpg binding protein 0.0036 0.0057 0.0053
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0039 0.0062 0.0058
Brugia malayi G protein-coupled receptor 0.0066 0.0121 0.0117
Loa Loa (eye worm) hypothetical protein 0.0066 0.0121 0.0121
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0043 0.0071 0.0071
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0066 0.0121 0.0121
Leishmania major hypothetical protein, conserved 0.0039 0.0062 0.0056
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0052 0.009 0.0086
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0018 0.0016 0.0016
Brugia malayi hypothetical protein 0.0251 0.0522 0.0519
Leishmania major DNA polymerase kappa, putative 0.002 0.0021 0.0015
Leishmania major cytochrome p450-like protein 0.0016 0.0013 0.0007
Echinococcus multilocularis somatostatin receptor 0.0066 0.0121 0.0121
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0023 0.0027 0.0027
Echinococcus multilocularis neuropeptides capa receptor 0.0066 0.0121 0.0121
Mycobacterium ulcerans phosphoglycerate kinase 0.0189 0.0388 0.0376
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0012 0.0004 0.0004
Schistosoma mansoni hypothetical protein 0.0462 0.098 0.0976
Schistosoma mansoni neuropeptide receptor 0.0066 0.0121 0.0117
Trypanosoma brucei AMP deaminase, putative 0.3617 0.7815 1
Schistosoma mansoni blooms syndrome DNA helicase 0.0019 0.0019 0.0015
Schistosoma mansoni opsin-like receptor 0.0066 0.0121 0.0117
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0066 0.0121 0.0117
Echinococcus granulosus tm gpcr rhodopsin 0.0066 0.0121 0.0121
Loa Loa (eye worm) nuclear hormone receptor 0.002 0.0022 0.0022
Loa Loa (eye worm) hypothetical protein 0.0066 0.0121 0.0121
Plasmodium vivax phosphoglycerate kinase, putative 0.0189 0.0388 0.0376
Echinococcus granulosus g protein coupled receptor 0.0066 0.0121 0.0121
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0037 0.0059 0.0059
Echinococcus multilocularis survival motor neuron protein 1 0.0251 0.0522 0.0522
Loa Loa (eye worm) hypothetical protein 0.0032 0.0049 0.0049
Schistosoma mansoni hypothetical protein 0.0016 0.0013 0.0009
Echinococcus multilocularis fmrfamide receptor 0.0066 0.0121 0.0121
Schistosoma mansoni hypothetical protein 0.0073 0.0136 0.0132
Echinococcus granulosus integrin alpha ps 0.004 0.0064 0.0064
Schistosoma mansoni smad1 5 8 and 0.0017 0.0016 0.0012
Mycobacterium tuberculosis Conserved protein 0.0039 0.0062 0.0049
Brugia malayi putative neuropeptide receptor NPR1 0.0066 0.0121 0.0117
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0066 0.0121 0.0121
Trichomonas vaginalis alpha-glucosidase, putative 0.0041 0.0067 0.0061
Loa Loa (eye worm) hypothetical protein 0.0066 0.0121 0.0121
Brugia malayi steroid hormone receptor 0.0043 0.0071 0.0067
Onchocerca volvulus Huntingtin homolog 0.0266 0.0555 0.0545
Loa Loa (eye worm) hypothetical protein 0.0066 0.0121 0.0121
Brugia malayi Nuclear hormone receptor-like 1 0.0023 0.0027 0.0023
Entamoeba histolytica AMP deaminase, putative 0.3617 0.7815 0.7814
Loa Loa (eye worm) hypothetical protein 0.0023 0.0027 0.0027
Loa Loa (eye worm) CYP4Cod1 0.0026 0.0034 0.0034
Loa Loa (eye worm) hypothetical protein 0.0018 0.0018 0.0018
Echinococcus granulosus neuropeptide receptor 0.0066 0.0121 0.0121
Mycobacterium ulcerans hypothetical protein 0.0039 0.0062 0.0049
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.2553 0.5509 0.5509
Echinococcus granulosus lysosomal alpha glucosidase 0.0184 0.0377 0.0377
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0021 0.0008
Echinococcus multilocularis neuropeptide Y receptor 0.0066 0.0121 0.0121
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0043 0.0071 0.0071
Echinococcus granulosus rhodopsin orphan GPCR 0.0066 0.0121 0.0121
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0043 0.0071 0.0071
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0066 0.0121 0.0117
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0043 0.0071 0.0071
Leishmania major phosphoglycerate kinase B, cytosolic 0.0189 0.0388 0.0383
Toxoplasma gondii Adenosine/AMP deaminase domain-containing protein 0.4626 1 1
Schistosoma mansoni tar DNA-binding protein 0.0135 0.027 0.0266
Echinococcus granulosus GPCR family 2 0.0032 0.0049 0.0049
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0032 0.0049 0.0049
Loa Loa (eye worm) cytochrome P450 0.0016 0.0013 0.0013
Echinococcus granulosus g protein coupled receptor 0.0066 0.0121 0.0121
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0052 0.009 0.009
Onchocerca volvulus 0.0066 0.0121 0.011
Schistosoma mansoni phosphoglycerate kinase 0.0189 0.0388 0.0385
Brugia malayi hypothetical protein 0.0066 0.0121 0.0117
Echinococcus multilocularis sex peptide receptor 0.0066 0.0121 0.0121
Loa Loa (eye worm) latrophilin receptor protein 2 0.0032 0.0049 0.0049
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0032 0.0049 0.0049
Loa Loa (eye worm) hypothetical protein 0.002 0.0022 0.0022
Entamoeba histolytica adenosine deaminase, putative 0.4626 1 1
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0066 0.0121 0.0117
Plasmodium vivax ataxin-2 like protein, putative 0.0027 0.0036 0.0023
Echinococcus granulosus rhodopsin orphan GPCR 0.0066 0.0121 0.0121
Brugia malayi Calcitonin receptor-like protein seb-1 0.0103 0.02 0.0197
Loa Loa (eye worm) hypothetical protein 0.2545 0.5492 0.5492
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0066 0.0121 0.0121
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0073 0.0136 0.0136
Echinococcus granulosus Nuclear hormone receptor HR96 0.002 0.0022 0.0022
Echinococcus granulosus biogenic amine 5HT receptor 0.0066 0.0121 0.0121
Loa Loa (eye worm) hypothetical protein 0.0066 0.0121 0.0121
Trichomonas vaginalis DNA polymerase eta, putative 0.002 0.0021 0.0015
Echinococcus multilocularis rhodopsin orphan GPCR 0.0066 0.0121 0.0121
Echinococcus granulosus tar DNA binding protein 0.0135 0.027 0.027
Echinococcus multilocularis g protein coupled receptor 0.0066 0.0121 0.0121
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0021 0.002
Onchocerca volvulus 0.0066 0.0121 0.011
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0184 0.0377 0.0377
Echinococcus granulosus rhodopsin orphan GPCR 0.0066 0.0121 0.0121
Schistosoma mansoni adenosine deaminase-related 0.4626 1 1
Entamoeba histolytica acetyltransferase, GNAT family 0.0041 0.0067 0.0062
Echinococcus multilocularis G protein coupled receptor 139 0.0066 0.0121 0.0121
Loa Loa (eye worm) neuropeptide F receptor 0.0066 0.0121 0.0121
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0066 0.0121 0.0117
Mycobacterium ulcerans beta-lactamase 0.0039 0.0062 0.0049
Loa Loa (eye worm) hypothetical protein 0.0066 0.0121 0.0121
Echinococcus multilocularis G-protein coupled receptor, putative 0.0066 0.0121 0.0121
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.002 0.0021 0.0017
Loa Loa (eye worm) CXXC zinc finger family protein 0.0032 0.0049 0.0049
Mycobacterium tuberculosis Probable phosphoglycerate kinase Pgk 0.0189 0.0388 0.0376
Brugia malayi nuclear hormone receptor 0.002 0.0022 0.0018
Schistosoma mansoni alpha-glucosidase 0.0159 0.0322 0.0318
Schistosoma mansoni methyl-cpg binding protein mbd 0.0018 0.0016 0.0012
Loa Loa (eye worm) hypothetical protein 0.0043 0.0071 0.0071
Schistosoma mansoni amine GPCR 0.0066 0.0121 0.0117
Trypanosoma cruzi AMP deaminase, putative 0.3617 0.7815 1
Onchocerca volvulus 0.0066 0.0121 0.011
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0032 0.0049 0.0049
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0032 0.0049 0.0045
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0018 0.0018 0.0018
Echinococcus granulosus somatostatin receptor 0.0066 0.0121 0.0121
Schistosoma mansoni zinc finger protein 0.0016 0.0012 0.0008
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0066 0.0121 0.0121
Plasmodium falciparum phosphoglycerate kinase 0.0189 0.0388 0.0366
Mycobacterium leprae Probable lipase LipE 0.0039 0.0062 0.0049
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0052 0.009 0.009
Leishmania major hypothetical protein, conserved 0.0027 0.0036 0.003
Schistosoma mansoni tar DNA-binding protein 0.0135 0.027 0.0266
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0066 0.0121 0.0117
Loa Loa (eye worm) integrin alpha pat-2 0.0285 0.0595 0.0595
Schistosoma mansoni neuropeptide F-like receptor 0.0066 0.0121 0.0117
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0066 0.0121 0.0121
Echinococcus granulosus rhodopsin orphan GPCR 0.0066 0.0121 0.0121
Toxoplasma gondii histone lysine methyltransferase SET1 0.0068 0.0125 0.0112
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0066 0.0121 0.0121
Loa Loa (eye worm) AMP deaminase 0.3617 0.7815 0.7815
Brugia malayi hypothetical protein 0.0066 0.0121 0.0117
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0043 0.0071 0.0067
Brugia malayi Bromodomain containing protein 0.0043 0.0072 0.0068
Brugia malayi Glycosyl hydrolases family 31 protein 0.0184 0.0377 0.0373
Schistosoma mansoni zinc finger protein 0.0026 0.0034 0.003
Schistosoma mansoni alpha glucosidase 0.0041 0.0067 0.0063
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0021 0.002
Trypanosoma cruzi phosphoglycerate kinase, putative 0.007 0.0129 0.0157
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0043 0.0071 0.0071
Leishmania major AMP deaminase, putative 0.3617 0.7815 0.7814
Echinococcus granulosus FTZ F1 alpha 0.0043 0.0071 0.0071
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0069 0.0127 0.0123
Echinococcus multilocularis neuropeptide Y receptor 0.0066 0.0121 0.0121
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0066 0.0121 0.0117
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0066 0.0121 0.0117
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0039 0.0062 0.0058
Loa Loa (eye worm) hypothetical protein 0.0189 0.0388 0.0388
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0043 0.0071 0.0071
Brugia malayi Phosphoglycerate kinase 0.007 0.0129 0.0125
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0043 0.0071 0.0067
Brugia malayi orphan nuclear receptor NR2E1 0.002 0.0022 0.0018
Loa Loa (eye worm) hypothetical protein 0.007 0.013 0.013
Leishmania major adenine aminohydrolase 0.4626 1 1
Schistosoma mansoni RAR-like nuclear receptor 0.0043 0.0071 0.0067
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0066 0.0121 0.0121
Echinococcus granulosus neutral alpha glucosidase AB 0.0041 0.0067 0.0067
Schistosoma mansoni neuropeptide receptor 0.0066 0.0121 0.0117
Echinococcus granulosus tachykinin peptides receptor 99D 0.0066 0.0121 0.0121
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0008 0.0003
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0039 0.0062 0.0049
Echinococcus granulosus integrin alpha 3 0.0142 0.0285 0.0285
Loa Loa (eye worm) PHD-finger family protein 0.0021 0.0024 0.0024
Trypanosoma brucei ISWI complex protein 0.0016 0.0012 0.0008
Echinococcus granulosus survival motor neuron protein 1 0.0251 0.0522 0.0522
Echinococcus granulosus neuropeptide receptor A26 0.0524 0.1113 0.1113
Onchocerca volvulus 0.0066 0.0121 0.011
Loa Loa (eye worm) hypothetical protein 0.0251 0.0522 0.0522
Brugia malayi hypothetical protein 0.0017 0.0015 0.0011
Brugia malayi Cytochrome P450 family protein 0.0016 0.0013 0.0009
Loa Loa (eye worm) hypothetical protein 0.002 0.0022 0.0022
Chlamydia trachomatis phosphoglycerate kinase 0.0189 0.0388 0.5
Schistosoma mansoni hypothetical protein 0.0032 0.0049 0.0044
Onchocerca volvulus 0.002 0.0022 0.0011
Brugia malayi hypothetical protein 0.0066 0.0121 0.0117
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.002 0.0021 0.0015
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0073 0.0136 0.0136
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0052 0.009 0.009
Brugia malayi CXXC zinc finger family protein 0.0032 0.0049 0.0045
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.002 0.0022 0.0022
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0043 0.0071 0.0067
Entamoeba histolytica hypothetical protein 0.0073 0.0136 0.013
Entamoeba histolytica AMP deaminase, putative 0.3617 0.7815 0.7814
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0043 0.0071 0.0067
Loa Loa (eye worm) hypothetical protein 0.0266 0.0555 0.0555
Schistosoma mansoni DNA polymerase eta 0.002 0.0021 0.0017
Brugia malayi hypothetical protein 0.0073 0.0136 0.0132
Schistosoma mansoni survival motor neuron protein 0.0051 0.0089 0.0085
Plasmodium vivax adenosine deaminase, putative 0.4626 1 1
Echinococcus granulosus histone lysine methyltransferase setb 0.0018 0.0018 0.0018
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0023 0.0027 0.0027
Brugia malayi MH2 domain containing protein 0.0017 0.0016 0.0012
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.002 0.0022 0.0022
Schistosoma mansoni adenosine deaminase 0.4626 1 1
Echinococcus granulosus peptide allatostatin:somatostatin 0.0066 0.0121 0.0121
Schistosoma mansoni amine GPCR 0.0066 0.0121 0.0117
Loa Loa (eye worm) hypothetical protein 0.002 0.0022 0.0022
Brugia malayi nuclear receptor NHR-88 0.002 0.0022 0.0018
Echinococcus multilocularis adenosine deaminase 0.4626 1 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0022 0.0022
Onchocerca volvulus Huntingtin homolog 0.0266 0.0555 0.0545
Leishmania major hypothetical protein, conserved 0.2081 0.4486 0.4483
Echinococcus multilocularis integrin alpha 3 0.0142 0.0285 0.0285
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0043 0.0071 0.0067
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0052 0.009 0.0086
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0043 0.0071 0.0067
Loa Loa (eye worm) MH2 domain-containing protein 0.0253 0.0526 0.0526
Echinococcus multilocularis orexin receptor type 2 0.0066 0.0121 0.0121
Echinococcus multilocularis nuclear receptor nhr 48 0.002 0.0022 0.0022
Loa Loa (eye worm) hypothetical protein 0.2081 0.4486 0.4486
Trypanosoma brucei PAB1-binding protein , putative 0.0027 0.0036 0.0038
Brugia malayi latrophilin 2 splice variant baaae 0.007 0.013 0.0126
Trypanosoma brucei hypothetical protein, conserved 0.0039 0.0062 0.0072
Loa Loa (eye worm) acetyltransferase 0.0155 0.0315 0.0315
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0189 0.0388 0.049
Echinococcus multilocularis beta LACTamase domain containing family member 0.0039 0.0062 0.0062
Echinococcus granulosus rhodopsin orphan GPCR 0.0066 0.0121 0.0121
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.0062 0.0072
Echinococcus granulosus neuropeptide FF receptor 2 0.0066 0.0121 0.0121
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0021 0.002
Echinococcus multilocularis lysosomal alpha glucosidase 0.0184 0.0377 0.0377
Echinococcus granulosus bloom syndrome protein 0.0024 0.003 0.003
Brugia malayi G protein-coupled receptor F59B2.13 0.0066 0.0121 0.0117
Onchocerca volvulus 0.0066 0.0121 0.011
Mycobacterium tuberculosis Conserved hypothetical protein 0.002 0.0021 0.0008
Toxoplasma gondii phosphoglycerate kinase PGKII 0.0189 0.0388 0.0376
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0036 0.0012
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0066 0.0121 0.0117
Onchocerca volvulus 0.0051 0.0089 0.0078
Loa Loa (eye worm) cytochrome P450 family protein 0.0059 0.0106 0.0106
Trypanosoma cruzi cytochrome P450, putative 0.0026 0.0034 0.0036
Brugia malayi Nuclear hormone receptor E75 0.002 0.0022 0.0018
Echinococcus multilocularis neuropeptide receptor 0.0066 0.0121 0.0121
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0016 0.0013 0.0009
Onchocerca volvulus Neuropeptide F receptor homolog 0.0066 0.0121 0.011
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0066 0.0121 0.0121
Trypanosoma cruzi DNA polymerase eta, putative 0.002 0.0021 0.002
Brugia malayi Smad1 0.0017 0.0016 0.0012
Loa Loa (eye worm) hypothetical protein 0.004 0.0064 0.0064
Brugia malayi hypothetical protein 0.0066 0.0121 0.0117
Mycobacterium ulcerans glutaminase 0.0309 0.0648 0.0636
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0021 0.0008
Schistosoma mansoni alpha-1 adrenergic receptor 0.0066 0.0121 0.0117
Loa Loa (eye worm) hypothetical protein 0.002 0.0022 0.0022
Schistosoma mansoni neuropeptide receptor 0.0066 0.0121 0.0117
Brugia malayi nuclear receptor NHR-67 0.002 0.0022 0.0018
Trichomonas vaginalis sucrase-isomaltase, putative 0.0041 0.0067 0.0061
Entamoeba histolytica adenosine deaminase, putative 0.4626 1 1
Loa Loa (eye worm) hypothetical protein 0.0023 0.0027 0.0027
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0155 0.0315 0.0311
Echinococcus multilocularis AMP deaminase 2 0.3617 0.7815 0.7815
Brugia malayi Nuclear hormone receptor-like 1 0.0023 0.0027 0.0023
Schistosoma mansoni integrin alpha-ps 0.0043 0.0072 0.0068
Schistosoma mansoni methyl-cpg binding protein mbd 0.0018 0.0016 0.0012
Brugia malayi hypothetical protein 0.002 0.0022 0.0018
Schistosoma mansoni hypothetical protein 0.0066 0.0121 0.0117
Schistosoma mansoni glutaminase 0.0309 0.0648 0.0644
Brugia malayi Melatonin receptor type 1A 0.0066 0.0121 0.0117
Loa Loa (eye worm) hypothetical protein 0.0066 0.0121 0.0121
Trypanosoma cruzi hypothetical protein, conserved 0.0041 0.0067 0.0078
Loa Loa (eye worm) hypothetical protein 0.002 0.0022 0.0022
Echinococcus granulosus Nuclear hormone receptor HR96 0.002 0.0022 0.0022
Loa Loa (eye worm) hypothetical protein 0.0066 0.0121 0.0121
Trypanosoma cruzi ISWI complex protein 0.0016 0.0012 0.0008
Onchocerca volvulus Protein ultraspiracle homolog 0.0043 0.0071 0.006
Loa Loa (eye worm) hypothetical protein 0.004 0.0064 0.0064
Trichomonas vaginalis alpha-glucosidase, putative 0.0015 0.0011 0.0005
Schistosoma mansoni terminal deoxycytidyl transferase 0.002 0.0021 0.0017
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0066 0.0121 0.0117
Schistosoma mansoni smad1 5 8 and 0.0017 0.0016 0.0012
Echinococcus granulosus biogenic amine 5HT receptor 0.0066 0.0121 0.0121
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.002 0.0022 0.0018
Brugia malayi hypothetical protein 0.0066 0.0121 0.0117
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0066 0.0121 0.0117
Loa Loa (eye worm) RecQ helicase 0.0024 0.003 0.003
Echinococcus multilocularis Nuclear hormone receptor HR96 0.002 0.0022 0.0022
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0043 0.0071 0.0067
Onchocerca volvulus 0.0039 0.0062 0.0051
Echinococcus multilocularis mothers against decapentaplegic 5 0.0017 0.0016 0.0016
Echinococcus granulosus methyl CpG binding domain protein 2 0.0018 0.0016 0.0016
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0066 0.0121 0.0121
Schistosoma mansoni neuropeptide receptor 0.0066 0.0121 0.0117
Loa Loa (eye worm) glutaminase 0.0309 0.0648 0.0648
Loa Loa (eye worm) hypothetical protein 0.2545 0.5492 0.5492
Schistosoma mansoni smad1 5 8 and 0.0017 0.0016 0.0012
Loa Loa (eye worm) Smad1 0.0017 0.0016 0.0016
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0036 0.0038
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0039 0.0062 0.0058
Echinococcus multilocularis smad 0.0017 0.0016 0.0016
Echinococcus granulosus adenosine deaminase 0.4626 1 1
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0066 0.0121 0.0117
Loa Loa (eye worm) transcription factor SMAD2 0.0253 0.0526 0.0526
Loa Loa (eye worm) hypothetical protein 0.0066 0.0121 0.0121
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0036 0.0038
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0043 0.0071 0.0071
Echinococcus granulosus histone acetyltransferase KAT2B 0.0047 0.0081 0.0081
Schistosoma mansoni neuropeptide f receptor 76f 0.0066 0.0121 0.0117
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0066 0.0121 0.0117
Onchocerca volvulus 0.0039 0.0062 0.0051
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0043 0.0071 0.0067
Trypanosoma brucei unspecified product 0.002 0.0021 0.002
Brugia malayi RE15519p 0.0066 0.0121 0.0117
Brugia malayi follicle stimulating hormone receptor 0.0066 0.0121 0.0117
Trichomonas vaginalis adenosine deaminase, putative 0.4626 1 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0043 0.0071 0.0067
Echinococcus granulosus rhodopsin orphan GPCR 0.0066 0.0121 0.0121
Entamoeba histolytica phosphoglycerate kinase, putative 0.0189 0.0388 0.0383
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0041 0.0067 0.0061
Echinococcus granulosus dna polymerase kappa 0.002 0.0021 0.0021
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0015 0.0011 0.0007
Schistosoma mansoni alpha-glucosidase 0.0159 0.0322 0.0318
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0066 0.0121 0.0121
Brugia malayi conserved hypotetical protein 0.002 0.0022 0.0018
Brugia malayi Dopamine receptor protein 1 0.0066 0.0121 0.0117
Loa Loa (eye worm) G-protein coupled receptor 0.0066 0.0121 0.0121
Onchocerca volvulus 0.0043 0.0071 0.006
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0066 0.0121 0.0117
Loa Loa (eye worm) hypothetical protein 0.0066 0.0121 0.0121
Schistosoma mansoni AMP deaminase 0.3617 0.7815 0.7814
Mycobacterium ulcerans esterase/lipase LipP 0.0039 0.0062 0.0049
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0066 0.0121 0.0121
Plasmodium falciparum AMP deaminase, putative 0.3617 0.7815 0.781
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0067 0.0124 0.0124
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.002 0.0022 0.0022
Loa Loa (eye worm) hypothetical protein 0.0066 0.0121 0.0121
Loa Loa (eye worm) hypothetical protein 0.002 0.0022 0.0022
Schistosoma mansoni retinoic acid receptor RXR 0.0043 0.0071 0.0067
Loa Loa (eye worm) beta-lactamase 0.0039 0.0062 0.0062
Echinococcus multilocularis thyroid hormone receptor alpha 0.0043 0.0071 0.0071
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0043 0.0071 0.0067
Loa Loa (eye worm) hypothetical protein 0.0066 0.0121 0.0121
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0103 0.02 0.02
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0021 0.002
Echinococcus multilocularis lysosomal alpha glucosidase 0.0184 0.0377 0.0377
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0066 0.0121 0.0117
Echinococcus multilocularis rhodopsin orphan GPCR 0.0066 0.0121 0.0121
Brugia malayi nuclear hormone receptor family member nhr-6 0.002 0.0022 0.0018
Loa Loa (eye worm) hypothetical protein 0.0046 0.0077 0.0077
Schistosoma mansoni cytochrome P450 0.0016 0.0013 0.0009
Brugia malayi Cytochrome P450 family protein 0.0026 0.0034 0.003
Echinococcus granulosus neuropeptide Y receptor 0.0066 0.0121 0.0121
Mycobacterium tuberculosis Probable esterase LipL 0.0039 0.0062 0.0049
Trypanosoma cruzi hypothetical protein, conserved 0.0041 0.0067 0.0078
Echinococcus multilocularis neuropeptide s receptor 0.0524 0.1113 0.1113
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0066 0.0121 0.0121
Giardia lamblia Phosphoglycerate kinase 0.0189 0.0388 1
Trichomonas vaginalis glutaminase, putative 0.0309 0.0648 0.0642
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0043 0.0071 0.0067
Brugia malayi Nuclear hormone receptor-like 1 0.0043 0.0071 0.0067
Loa Loa (eye worm) hypothetical protein 0.0066 0.0121 0.0121
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0021 0.002
Loa Loa (eye worm) hypothetical protein 0.0066 0.0121 0.0121
Schistosoma mansoni thyroid hormone receptor 0.0043 0.0071 0.0067
Schistosoma mansoni amine GPCR 0.0066 0.0121 0.0117
Loa Loa (eye worm) hypothetical protein 0.0039 0.0062 0.0062
Toxoplasma gondii AMP deaminase 0.3617 0.7815 0.7812
Echinococcus multilocularis GPCR, family 2 0.0032 0.0049 0.0049
Schistosoma mansoni hypothetical protein 0.007 0.013 0.0126
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.002 0.0021 0.0021
Toxoplasma gondii Adenosine/AMP deaminase domain-containing protein 0.4626 1 1
Brugia malayi Cytochrome P450 family protein 0.0026 0.0034 0.003
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0043 0.0071 0.0067
Brugia malayi MH1 domain containing protein 0.0017 0.0016 0.0012
Schistosoma mansoni amine GPCR 0.0066 0.0121 0.0117
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0039 0.0062 0.0049
Mycobacterium leprae Probable phosphoglycerate kinase Pgk 0.0189 0.0388 0.0376
Trichomonas vaginalis esterase, putative 0.0039 0.0062 0.0056
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0066 0.0121 0.0121
Entamoeba histolytica hypothetical protein 0.0073 0.0136 0.013
Brugia malayi glutaminase DH11.1 0.0309 0.0648 0.0644
Mycobacterium tuberculosis Probable adenosine deaminase Add (adenosine aminohydrolase) 0.4626 1 1
Plasmodium falciparum adenosine deaminase 0.4626 1 1
Trypanosoma brucei glucosidase, putative 0.0041 0.0067 0.0078
Echinococcus granulosus neuropeptides capa receptor 0.0066 0.0121 0.0121
Loa Loa (eye worm) hypothetical protein 0.0066 0.0121 0.0121
Trichomonas vaginalis maltase-glucoamylase, putative 0.0015 0.0011 0.0005
Schistosoma mansoni biogenic amine (5HT) receptor 0.0066 0.0121 0.0117
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.002 0.0021 0.0015
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0052 0.009 0.0086
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0103 0.02 0.0197
Onchocerca volvulus 0.0032 0.0049 0.0037
Echinococcus multilocularis g protein coupled receptor 0.0066 0.0121 0.0121
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0021 0.002
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0041 0.0067 0.0061
Echinococcus multilocularis neuropeptide receptor 0.0066 0.0121 0.0121
Brugia malayi larval opioid receptor 0.0066 0.0121 0.0117
Echinococcus multilocularis integrin alpha ps 0.004 0.0064 0.0064
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0043 0.0071 0.0071
Trichomonas vaginalis alpha-glucosidase, putative 0.0015 0.0011 0.0005
Loa Loa (eye worm) hypothetical protein 0.0066 0.0121 0.0121
Echinococcus granulosus alpha 1A adrenergic receptor 0.0066 0.0121 0.0121
Brugia malayi Bloom's syndrome protein homolog 0.0024 0.003 0.0026
Echinococcus granulosus Smad4 0.0017 0.0016 0.0016
Echinococcus granulosus thyroid hormone receptor alpha 0.002 0.0022 0.0022
Loa Loa (eye worm) bromodomain containing protein 0.0022 0.0026 0.0026
Loa Loa (eye worm) TYRA-2 protein 0.0066 0.0121 0.0121
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0021 0.002
Loa Loa (eye worm) hypothetical protein 0.0066 0.0121 0.0121
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0016 0.0013 0.0007
Brugia malayi Latrophilin receptor protein 2 0.0032 0.0049 0.0045
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0066 0.0121 0.0117
Trichomonas vaginalis phosphoglycerate kinase, putative 0.0189 0.0388 0.0383
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0036 0.0012
Echinococcus multilocularis rhodopsin orphan GPCR 0.0066 0.0121 0.0121

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 3.5 uM Inhibition of collagen-induced platelet aggregation ChEMBL. 7837237
IC50 (functional) = 3.5 uM Inhibition of collagen-induced platelet aggregation ChEMBL. 7837237
IC50 (functional) = 4.1 uM Inhibition of arachidonic acid-induced platelet aggregation ChEMBL. 7837237
IC50 (functional) = 4.1 uM Inhibition of arachidonic acid-induced platelet aggregation ChEMBL. 7837237
IC50 (binding) = 10 uM Inhibition of [125I]-fibrinogen binding to human Fibrinogen Receptor. ChEMBL. 7837237
IC50 (binding) = 10 uM Inhibition of [125I]-fibrinogen binding to human Fibrinogen Receptor. ChEMBL. 7837237
IC50 (functional) = 14.3 uM In vitro inhibition of thrombin-induced platelet aggregation. ChEMBL. 7837237

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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